Structural Classification of Proteins

Fold: alpha/beta-Hydrolases

: core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: alpha/beta-Hydrolases [53473]
core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

Superfamilies:

alpha/beta-Hydrolases [53474] (41)
many members have left-handed crossover connection between strand 8 and additional strand 9
uperfamily
1. Acetylcholinesterase-like [53475] (11)
  1. Acetylcholinesterase [53476]
    1. Pacific electric ray (Torpedo californica) [TaxId: 7787] [53477] (79)
      SQ P04058 25-556
    2. Electric eel (Electrophorus electricus) [TaxId: 8005] [53478] (3)
    3. Mouse (Mus musculus) [TaxId: 10090] [53479] (31)
    4. Human (Homo sapiens) [TaxId: 9606] [53480] (2)
    5. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [53481] (3)
  2. Butyryl cholinesterase [102612]
    1. Human (Homo sapiens) [TaxId: 9606] [102613] (9)
  3. Bile-salt activated lipase (cholesterol esterase) [53482]
    1. Cow (Bos taurus) [TaxId: 9913] [53483] (3)
    2. Human (Homo sapiens) [TaxId: 9606] [53484] (2)
  4. Mammalian carboxylesterase (liver carboxylesterase I) [75282]
    1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [75283] (1)
    2. Human (Homo sapiens) [TaxId: 9606] [89768] (48)
  5. Thermophilic para-nitrobenzyl esterase (PNB esterase) [53485]
    1. Bacillus subtilis [TaxId: 1423] [53486] (3)
2. Carboxylesterase [53487] (9)
  1. Carboxylesterase [53488]
    bacterial homologue of human hormone sensitive lipase
    1. Bacillus subtilis, brefeldin A esterase [TaxId: 1423] [53489] (1)
    2. Alicyclobacillus acidocaldarius [TaxId: 405212] [53490] (3)
      SQ Q7SIG1
    3. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [69576] (1)
  2. Feruloyl esterase domain of the cellulosomal xylanase z [69577]
    1. Clostridium thermocellum [TaxId: 1515] [69578] (2)
  3. Feruloyl esterase domain of the cellulosomal xylanase y [69579]
    1. Clostridium thermocellum [TaxId: 1515] [69580] (8)
  4. Heroin esterase [82493]
    1. Rhodococcus sp. [TaxId: 1831] [82494] (2)
  5. Enterochelin esterase, catalytic domain [142699]
    1. Shigella flexneri [TaxId: 623] [142700] (1)
      SQ Q83SB9 151-397
    2. Shigella flexneri 2a str. 2457T [TaxId: 198215] [159733] (10)
  6. Uncharacterized protein TM1040_2492 [159734]
    1. Silicibacter sp. tm1040 [TaxId: 292414] [159735] (4)
      SQ Q1GDP2 1-261
3. Mycobacterial antigens [53491] (4)
  1. Antigen 85b [53492]
    1. Mycobacterium tuberculosis [TaxId: 1773] [53493] (2)
  2. Antigen 85c [53494]
    1. Mycobacterium tuberculosis [TaxId: 1773] [53495] (3)
      SQ P31953
  3. Antigen pt51/mpb51 [102614]
    1. Mycobacterium tuberculosis [TaxId: 1773] [102615] (1)
  4. Antigen 85a [110691]
    1. Mycobacterium tuberculosis [TaxId: 1773] [110692] (1)
      SQ P17944 43-330
4. Hypothetical protein TT1662 [102616] (1)
  1. Hypothetical protein TT1662 [102617]
    1. Thermus thermophilus [TaxId: 274] [102618] (1)
5. PepX catalytic domain-like [69581] (4)
  1. Bacterial cocaine esterase N-terminal domain [69582]
    1. Rhodococcus sp. mb1 [TaxId: 51612] [69583] (4)
  2. Alpha-amino acid ester hydrolase [89769]
    1. Xanthomonas citri [TaxId: 346] [89770] (1)
    2. Acetobacter pasteurianus [TaxId: 438] [102619] (29)
  3. X-Prolyl dipeptidyl aminopeptidase PepX, middle domain [82495]
    1. Lactococcus lactis [TaxId: 1358] [82496] (1)
6. Prolyl oligopeptidase, C-terminal domain [53496] (1)
  N-terminal domain is a 7-bladed beta-propeller
  1. Prolyl oligopeptidase, C-terminal domain [53497]
    1. Pig (Sus scrofa) [TaxId: 9823] [53498] (16)
      SQ P23687
7. DPP6 catalytic domain-like [82497] (3)
  N-terminal domain is a 8-bladed beta-propeller
  1. Dipeptidyl peptidase IV/CD26, C-terminal domain [82498]
    1. Human (Homo sapiens) [TaxId: 9606] [82499] (58)
      SQ P27487 39-776 ! SQ P27487 ! SQ P27487
    2. Pig (Sus scrofa) [TaxId: 9823] [89771] (76)
  2. Dipeptidyl aminopeptidase-like protein 6, DPP6, C-terminal domain [117705]
    1. Human (Homo sapiens) [TaxId: 9606] [117706] (1)
      SQ P42658 127-849
8. Serine carboxypeptidase-like [53499] (5)
  1. Serine carboxypeptidase II [53500]
    1. Wheat (Triticum vulgare) [TaxId: 4565] [53501] (5)
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [53502] (3)
    3. Baker's yeast (Saccharomyces cerevisiae), kex1(delta)p [TaxId: 4932] [53503] (1)
      prohormone-processing carboxypeptidase
  2. Human 'protective protein', HPP [53504]
    synonyms: cathepsin A, carboxypeptidase L
    1. Human (Homo sapiens) [TaxId: 9606] [53505] (1)
  3. Hydroxynitrile lyase [82500]
    a novel cyanogenic enzyme
    1. Sorghum (Sorghum bicolor) [TaxId: 4558] [82501] (1)
9. Gastric lipase [53506] (2)
  1. Gastric lipase [53507]
    1. Human (Homo sapiens) [TaxId: 9606] [53508] (1)
    2. Dog (Canis familiaris) [TaxId: 9615] [75284] (1)
10. Proline iminopeptidase-like [53509] (3)
  1. Proline iminopeptidase [53510]
    1. Xanthomonas campestris, pv. citri [TaxId: 339] [53511] (1)
  2. Proline aminopeptidase [81303]
    1. Serratia marcescens [TaxId: 615] [81304] (4)
      SQ O32449
  3. Tricorn interacting factor F1 [82502]
    1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [82503] (3)
11. Acetyl xylan esterase-like [82504] (2)
  Pfam 05448; AXE1
  1. Cephalosporin C deacetylase [82505]
    1. Bacillus subtilis [TaxId: 1423] [82506] (3)
  2. Acetyl xylan esterase TM0077 [110693]
    1. Thermotoga maritima [TaxId: 2336] [110694] (1)
      SQ Q9WXT2
12. Haloalkane dehalogenase [53513] (3)
  1. Haloalkane dehalogenase [53514]
    1. Xanthobacter autotrophicus [TaxId: 280] [53515] (17)
    2. Rhodococcus sp. [TaxId: 1831] [53516] (3)
    3. Sphingomonas paucimobilis, UT26, LinB [TaxId: 13689] [53517] (12)
13. Dienelactone hydrolase [53518] (2)
  1. Dienelactone hydrolase [53519]
    1. Pseudomonas sp., B13 [TaxId: 306] [53520] (1)
    2. Pseudomonas putida [TaxId: 303] [53521] (1)
14. Carbon-carbon bond hydrolase [53522] (4)
  closely related to the Proline iminopeptidase-like family
  1. 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (BPHD) [53523]
    1. Rhodococcus sp., strain rha1 [TaxId: 1831] [53524] (1)
    2. Burkholderia xenovorans [TaxId: 36873] [159736] (4)
      SQ P47229 4-286
  2. Meta-cleavage product hydrolase CumD [82507]
    2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
    1. Pseudomonas fluorescens [TaxId: 294] [82508] (9)
      SQ P96965 3-273
  3. Meta cleavage compound hydrolase CarC [89772]
    involved in carbazole degradation
    1. Janthinobacterium sp. J3 [TaxId: 213804] [89773] (1)
15. Biotin biosynthesis protein BioH [82509] (1)
  1. Biotin biosynthesis protein BioH [82510]
    1. Escherichia coli [TaxId: 562] [82511] (1)
16. Aclacinomycin methylesterase RdmC [102620] (1)
  1. Aclacinomycin methylesterase RdmC [102621]
    1. Streptomyces purpurascens [TaxId: 1924] [102622] (2)
17. Carboxylesterase/lipase [102623] (1)
  1. Carboxylesterase Est [102624]
    1. Bacillus stearothermophilus [TaxId: 1422] [102625] (2)
      SQ Q06174
18. Epoxide hydrolase [53525] (4)
  1. Mammalian epoxide hydrolase, C-terminal domain [53526]
    1. Mouse (Mus musculus) [TaxId: 10090] [53527] (4)
    2. Human (Homo sapiens) [TaxId: 9606] [102626] (6)
  2. Bacterial epoxide hydrolase [53528]
    1. Agrobacterium radiobacter [TaxId: 358] [53529] (1)
    2. Aspergillus niger [TaxId: 5061] [53530] (1)
19. Haloperoxidase [53531] (7)
  1. Bromoperoxidase A2 [53532]
    1. Streptomyces aureofaciens [TaxId: 1894] [53533] (2)
  2. Bromoperoxidase A1 [53534]
    1. Streptomyces aureofaciens [TaxId: 1894] [53535] (1)
  3. Chloroperoxidase T [53536]
    1. Streptomyces aureofaciens [TaxId: 1894] [53537] (2)
  4. Chloroperoxidase L [53538]
    1. Streptomyces lividans [TaxId: 1916] [53539] (1)
  5. Chloroperoxidase F [53540]
    1. Pseudomonas fluorescens [TaxId: 294] [53541] (1)
  6. Gamma-lactamase [102627]
    haloperoxidase homologue
    1. Aureobacterium sp. [TaxId: 51671] [102628] (2)
  7. Arylesterase [110695]
    haloperoxidase homologue
    1. Pseudomonas fluorescens [TaxId: 294] [110696] (1)
      SQ P22862
20. Thioesterases [53542] (3)
  1. Myristoyl-ACP-specific thioesterase [53543]
    1. Vibrio harveyi [TaxId: 669] [53544] (1)
  2. Palmitoyl protein thioesterase 1 [53545]
    1. Cow (Bos taurus) [TaxId: 9913] [53546] (3)
  3. Palmitoyl protein thioesterase 2 [102629]
    1. Human (Homo sapiens) [TaxId: 9606] [102630] (1)
21. Carboxylesterase/thioesterase 1 [53547] (5)
  1. Carboxylesterase [53548]
    1. Pseudomonas fluorescens [TaxId: 294] [53549] (2)
    2. Bacillus cereus [TaxId: 1396] [159737] (3)
      SQ Q81AD5 1-202
      similar fold and function to the Pseudomonas fluorescens enzyme despite low sequence identity
  2. Acyl protein thioesterase 1 [53550]
    1. Human (Homo sapiens) [TaxId: 9606] [53551] (1)
  3. Uncharacterized protein Mll8374 [159738]
    1. Mesorhizobium loti [TaxId: 381] [159739] (2)
      SQ Q983D6 7-215
  4. Uncharacterized protein Atu2452 [159740]
    1. Agrobacterium tumefaciens [TaxId: 358] [159741] (2)
      SQ A9CHT9 1-203
22. Ccg1/TafII250-interacting factor B (Cib) [75285] (1)
  1. Ccg1/TafII250-interacting factor B (Cib) [75286]
    1. Human (Homo sapiens) [TaxId: 9606] [75287] (1)
23. A novel bacterial esterase [53552] (1)
  1. A novel bacterial esterase [53553]
    1. Alcaligenes sp. [TaxId: 512] [53554] (1)
24. Lipase [53555] (1)
  1. Lipase [53556]
    1. Streptomyces exfoliatus [TaxId: 1905] [53557] (1)
25. Fungal lipases [53558] (12)
  1. Triacylglycerol lipase [53559]
    1. Yeast (Candida antarctica), form b [TaxId: 34362] [53560] (11)
    2. Rhizomucor miehei [TaxId: 4839] [53561] (4)
    3. Penicillium camembertii [TaxId: 5075] [53562] (1)
    4. Thermomyces lanuginosus, formerly Humicola lanuginosa [TaxId: 5541] [53563] (7)
    5. Rhizopus niveus [TaxId: 4844] [53564] (1)
    6. Rhizopus delemar [TaxId: 64495] [53565] (1)
  2. Feruloyl esterase A [102631]
    Triacylglycerol lipase homologue
    1. Aspergillus niger [TaxId: 5061] [102632] (7)
      SQ O42807 23-281
  3. Type-B carboxylesterase/lipase [53566]
    1. Fungus (Geotrichum candidum), ATCC 34614 [TaxId: 27317] [53567] (1)
    2. Fungus (Candida rugosa), formerly Cylindracea [TaxId: 5481] [53568] (7)
    3. Candida rugosa, lipase 2 isoform [TaxId: 5481] [89774] (1)
    4. Candida cylindracea, cholesterol esterase [TaxId: 44322] [53569] (2)
  4. Esterase EstA [110697]
    1. Aspergillus niger [TaxId: 5061] [110698] (1)
      SQ Q6ED33
26. Bacterial lipase [53570] (7)
  lack the first two strands of the common fold
  1. Lipase A [64145]
    minimal alpha/beta hydrolase fold;
    1. Bacillus subtilis [TaxId: 1423] [64146] (16)
      SQ P37957 34-212
  2. Lipase [53571]
    1. Pseudomonas glumae, also known as Pseudomonas gladioli [TaxId: 337] [53572] (2)
    2. Burkholderia cepacia, formerly Pseudomonas cepacia [TaxId: 292] [63399] (7)
    3. Pseudomonas aeruginosa [TaxId: 287] [53575] (1)
    4. Chromobacterium viscosum [TaxId: 42739] [53576] (3)
  3. Lipase L1 [75288]
    1. Bacillus stearothermophilus [TaxId: 1422] [75289] (1)
    2. Bacillus stearothermophilus, P1 [TaxId: 1422] [82512] (1)
      the first thermostable bacterial lipase
27. Pancreatic lipase, N-terminal domain [53577] (6)
  1. Pancreatic lipase, N-terminal domain [53578]
    contains additional, colipase-binding domain
    1. Horse (Equus caballus) [TaxId: 9796] [53579] (1)
    2. Pig (Sus scrofa) [TaxId: 9823] [53580] (1)
    3. Human (Homo sapiens) [TaxId: 9606] [53581] (3)
    4. Guinea pig (Cavia porcellus) [TaxId: 10141] [53582] (1)
    5. Dog (Canis familiaris) [TaxId: 9615] [53583] (1)
      pancreatic lipase related protein 1
    6. Rat (Rattus norvegicus) [TaxId: 10116] [53584] (1)
      pancreatic lipase related protein 2
28. Hydroxynitrile lyase-like [53585] (3)
  1. Hydroxynitrile lyase [53586]
    1. Rubber tree (Hevea brasiliensis) [TaxId: 3981] [53587] (19)
      SQ P52704
    2. Cassava (Manihot esculenta) [TaxId: 3983] [53588] (7)
  2. Salicylic acid-binding protein 2 (SABP2) [117707]
    1. Common tobacco (Nicotiana tabacum) [TaxId: 4097] [117708] (3)
      SQ Q6RYA0
29. Thioesterase domain of polypeptide, polyketide and fatty acid synthases [69584] (4)
  Pfam 00975
  1. Erythromycin polyketide synthase [69585]
    synonym: 6-deoxyerythronolide synthase
    1. Saccharopolyspora erythraea [TaxId: 1836] [69586] (2)
  2. Picromycin polyketide synthase [82513]
    1. Streptomyces venezuelae [TaxId: 54571] [82514] (9)
  3. Surfactin synthetase, SrfA [75290]
    1. Bacillus subtilis [TaxId: 1423] [75291] (1)
  4. Fatty acid synthase [117709]
    1. Human (Homo sapiens) [TaxId: 9606] [117710] (1)
      SQ P49327 2212-2496
30. Cutinase-like [52260] (3)
  minimal alpha/beta hydrolase lacking peripheral secondary structures; similar to a flavodoxin-like fold
  1. Cutinase [52261]
    1. Fungus (Fusarium solani), subsp. pisi [TaxId: 169388] [52262] (39)
  2. Acetylxylan esterase [52263]
    1. Penicillium purpurogenum [TaxId: 28575] [52264] (3)
    2. Trichoderma reesei [TaxId: 51453] [52265] (1)
31. YdeN-like [110699] (1)
  Pfam 06821; DUF1234; lack the first two strands of the common fold
  1. Hypothetical protein YdeN [110700]
    1. Bacillus subtilis [TaxId: 1423] [110701] (1)
      SQ P96671
32. Putative serine hydrolase Ydr428c [110702] (1)
  1. Putative serine hydrolase Ydr428c [110703]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110704] (1)
      SQ Q04066
33. Acylamino-acid-releasing enzyme, C-terminal donain [117711] (1)
  closely related to the prolyl peptidase and DPP6 domains (scop_fa 53496 and 82497)
  1. Acylamino-acid-releasing enzyme, C-terminal donain [117712]
    1. Aeropyrum pernix [TaxId: 56636] [117713] (12)
      SQ Q9YBQ2
34. Hypothetical esterase YJL068C [117714] (1)
  part of Pfam 00756
  1. Hypothetical esterase YJL068C [117715]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [117716] (1)
      SQ P40363
35. Hypothetical protein VC1974 [117717] (1)
  1. Hypothetical protein VC1974 [117718]
    1. Vibrio cholerae [TaxId: 666] [117719] (1)
      SQ Q9KQM4
36. Atu1826-like [159742] (2)
  1. XC6422 protein [159743]
    XCC0260 orthologue
    1. Xanthomonas campestris [TaxId: 339] [159744] (1)
      SQ Q8PDS5 3-220
  2. Hypothetical protein Atu1826 [159745]
    1. Agrobacterium tumefaciens [TaxId: 358] [159746] (2)
      SQ Q8UED4 2-219
37. PHB depolymerase-like [159747] (1)
  1. Polyhydroxybutyrate depolymerase [159748]
    1. Penicillium funiculosum [TaxId: 28572] [159749] (2)
38. IroE-like [159750] (1)
  1. Enterobactin and salmochelin hydrolase IroE [159751]
    1. Escherichia coli [TaxId: 562] [159752] (2)
      SQ Q6KD95 41-305
39. TTHA1544-like [159753] (1)
  minimal hydrolase fold (one strand less than the cutinase-like family); there is neither catalytic triad, nor nucleopilic residue in the elbow motif
  1. Hypothetical protein TTHA1544 [159754]
    1. Thermus thermophilus [TaxId: 274] [159755] (2)
      SQ Q5SI36 2-123
40. O-acetyltransferase [159756] (3)
  1. Acetyl-CoA:deacetylcephalosporin C acetyltransferase CefG [159757]
    1. Acremonium chrysogenum [TaxId: 5044] [159758] (36)
      SQ P39058 66-441
  2. Homoserine O-acetyltransferase [159759]
    1. Leptospira interrogans [TaxId: 173] [159760] (1)
      SQ Q8F4I0 5-366
    2. Haemophilus influenzae [TaxId: 727] [159761] (1)
      SQ P45131 2-358
41. 2,6-dihydropseudooxynicotine hydrolase-like [159762] (1)
  Pfam 06500; DUF1100
  1. 2,6-dihydropseudooxynicotine hydrolase [159763]
    1. Arthrobacter nicotinovorans [TaxId: 29320] [159764] (1)
      SQ Q93NG6 8-367