Structural Classification of Proteins
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Family: Histidine biosynthesis enzymes

structural evidence for the gene duplication within the barrel fold

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: TIM beta/alpha-barrel [51350]
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. Superfamily: Ribulose-phoshate binding barrel [51366]
    link to SUPERFAMILY database - Superfamily
  5. Family: Histidine biosynthesis enzymes [51367]
    structural evidence for the gene duplication within the barrel fold

Protein Domains:

  1. Phosphoribosylformimino-5-aminoimidazole carboxamide ribotite isomerase HisA [51368]
    1. Thermotoga maritima [TaxId: 2336] [51369] (1)
      1. 1qo2 picpic
        1. chain a [28533] picpiclink
        2. chain b [28534] picpiclink
    2. Streptomyces coelicolor [TaxId: 1902] [141744] (2)
      SQ P16250 2-240
      1. 1vzw picpic
        complexed with gol, so4
        1. region a:2-240 [120553] picpiclink
      2. 2vep picpic
        automatically matched to d1vzwa1
        complexed with so4
        1. region a:2-240 [153025] picpiclink
  2. Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF [51370]
    1. Thermotoga maritima [TaxId: 2336] [51371] (4)
      1. 1thf picpic
        complexed with po4
        1. chain d [28535] picpiclink
      2. 2a0n picpic
        automatically matched to d1vh7a_
        complexed with iod, po4, unl
        1. region a:2-251 [125961] picpiclink
      3. 1vh7 picpic
        structural genomics
        complexed with po4
        1. chain a [100646] picpiclink
      4. 1gpw picpicxref
        complexed with po4; mutant
        1. chain a [65460] picpiclink
        2. chain c [65462] picpiclink
        3. chain e [65464] picpiclink
    2. Thermus thermophilus [TaxId: 274] [82237] (1)
      1. 1ka9 picpicxref
        1. chain f [77307] picpiclink
    3. Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId: 4932] [69379] (4)
      1. 1jvn picpicxref
        complexed with 143, ni, pop, so4
        1. region a:230-552 [67355] picpiclink
        2. region b:230-552 [67357] picpiclink
      2. 1ox6 picpicxref
        complexed with ni, pop, so4
        1. region a:230-550 [87505] picpiclink
        2. region b:230-550 [87507] picpiclink
      3. 1ox5 picpicxref
        complexed with 1pr, 5cs, ni; mutant
        1. region a:230-550 [87501] picpiclink
        2. region b:230-550 [87503] picpiclink
      4. 1ox4 picpicxref
        complexed with cyd, ni, pop, so4
        1. region a:230-550 [87497] picpiclink
        2. region b:230-550 [87499] picpiclink
    4. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [69380] (1)
      1. 1h5y picpic
        complexed with gol, po4
        1. chain a [65638] picpiclink
        2. chain b [65639] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk