Structural Classification of Proteins
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Superfamily: PH domain-like

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: PH domain-like barrel [50728]
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. Superfamily: PH domain-like [50729]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Pleckstrin-homology domain (PH domain) [50730] (51)
    Pfam 00169
    1. Phospholipase C delta-1 [50731]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [50732] (1) picpic
    2. beta-spectrin [50733]
      1. Mouse (Mus musculus), brain [TaxId: 10090] [50734] (2) picpic
      2. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [50735] (1) picpic
      3. Human (Homo sapiens), brain 2 isoform [TaxId: 9606] [117243] (1) picpic
        SQ O15020 2219-2324
    3. Dynamin [50736]
      1. Human (Homo sapiens) [TaxId: 9606] [50737] (2) picpic
    4. Bruton's tyrosine kinase [50738]
      contains Btk zinc-binding motif
      1. Human (Homo sapiens) [TaxId: 9606] [50739] (7) picpic
    5. Pleckstrin [50740]
      1. Human (Homo sapiens) [TaxId: 9606] [50741] (9) picpic
    6. Son of sevenless-1 (sos-1) [50742]
      1. Mouse (Mus musculus) [TaxId: 10090] [50743] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [50744] (4) picpic
        SQ Q07889 189-1046
    7. GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745]
      1. Mouse (Mus musculus) [TaxId: 10090] [50746] (1) picpic
    8. Dbl's big sister, Dbs [74989]
      1. Mouse (Mus musculus) [TaxId: 10090] [74990] (4) picpic
        SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
    9. GEF of intersectin [74991]
      1. Human (Homo sapiens) [TaxId: 9606] [74992] (1) picpic
    10. G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747]
      1. Human (Homo sapiens) [TaxId: 9606] [50748] (1) picpic
      2. Cow (Bos taurus) [TaxId: 9913] [89354] (6) picpic
    11. Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749]
      1. Human (Homo sapiens) [TaxId: 9606] [50750] (2) picpic
    12. Grp1 [50751]
      ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
      1. Mouse (Mus musculus) [TaxId: 10090] [50752] (8) picpic
    13. UNC-89 [50753]
      1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [50754] (1) picpic
    14. Tapp1 [74993]
      1. Human (Homo sapiens) [TaxId: 9606] [74994] (1) picpic
    15. Rac-alpha serine/threonine kinase [89355]
      1. Human (Homo sapiens) [TaxId: 9606] [89356] (5) picpic
        SQ P31749 1-117
    16. Rac-beta serine/threonine protein kinase (PKB/AKT) [110254]
      1. Human (Homo sapiens) [TaxId: 9606] [110255] (1) picpic
        SQ P31751 1-111
    17. SH2 and PH domain-containing adapter protein APS [110256]
      1. Mouse (Mus musculus) [TaxId: 10090] [110257] (1) picpic
        SQ Q9JID9 178-299
    18. Tapp2 [110258]
      1. Mouse (Mus musculus) [TaxId: 10090] [110259] (1) picpic
        SQ Q9ERS5 1-113
    19. SET binding factor 1, Sbf1 [110260]
      1. Mouse (Mus musculus) [TaxId: 10090] [110261] (1) picpic
        SQ Q8K2Z0 256-367
    20. Rac/CDC42 GEF 6, alpha-pix [110262]
      1. Mouse (Mus musculus) [TaxId: 10090] [110263] (1) picpic
        SQ Q8K4I3 429-551
    21. Triple functional domain protein TRIO [110264]
      1. Human (Homo sapiens) [TaxId: 9606] [110265] (2) picpic
        SQ O75962 1231-1535
    22. Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266]
      1. Human (Homo sapiens) [TaxId: 9606] [110267] (1) picpic
        SQ Q9BZF1 149-265
    23. Rho-GTPase-activating protein 25 (KIAA0053) [110268]
      1. Human (Homo sapiens) [TaxId: 9606] [110269] (1) picpic
        SQ P42331 40-144
    24. Rho guanine nucleotide exchange factor 12 [110270]
      1. Human (Homo sapiens), gamma isoform [TaxId: 9606] [110271] (2) picpic
        SQ Q9NZN5 766-1138
    25. Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244]
      1. Human (Homo sapiens) [TaxId: 9606] [117245] (2) picpic
        SQ Q9H4M7 47-153
    26. 3-phosphoinositide dependent protein kinase-1 [117246]
      1. Human (Homo sapiens) [TaxId: 9606] [117247] (3) picpic
        SQ O15530 409-550
    27. Dedicator of cytokinesis protein 9, DOCK9 [117248]
      1. Human (Homo sapiens) [TaxId: 9606] [117249] (1) picpic
        SQ Q9BZ29 165-301
    28. FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250]
      1. Mouse (Mus musculus) [TaxId: 10090] [117251] (1) picpic
        SQ Q69ZL1 1303-1389
    29. Calcium-dependent activator protein for secretion, CAPS [117252]
      1. Human (Homo sapiens) [TaxId: 9606] [117253] (1) picpic
        SQ Q8NFR0 522-634
    30. Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254]
      1. Human (Homo sapiens) [TaxId: 9606] [117255] (1) picpic
        SQ O15085 714-1081
    31. Centaurin-delta 1 [141395]
      1. Human (Homo sapiens) [TaxId: 9606] [141396] (1) picpic
        SQ Q8WZ64 483-584
    32. Cytohesin 3 [141397]
      1. Mouse (Mus musculus) [TaxId: 10090] [141398] (1) picpic
        SQ O08967 261-387
    33. Exocyst complex protein EXO84 [141399]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [141400] (4) picpic
        SQ O54924 171-283
    34. Cytohesin 2 [141401]
      1. Mouse (Mus musculus) [TaxId: 10090] [141402] (2) picpic
        SQ P63034 260-378
    35. Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403]
      1. Human (Homo sapiens) [TaxId: 9606] [141404] (4) picpic
        SQ O15268 108-213
    36. Signal-transducing adaptor protein 1, STAP-1 [141405]
      1. Human (Homo sapiens) [TaxId: 9606] [141406] (1) picpic
        SQ Q9ULZ2 16-151
    37. KIAA1914 [141407]
      1. Human (Homo sapiens) [TaxId: 9606] [141408] (1) picpic
        SQ Q8N4X5 354-448
    38. Pleckstrin-2 [141409]
      1. Human (Homo sapiens) [TaxId: 9606] [141410] (1) picpic
        SQ Q9NYT0 238-353
    39. Alpha-1-syntrophin [141411]
      1. Mouse (Mus musculus) [TaxId: 10090] [141412] (1) picpic
        SQ Q61234 2-44,203-264
    40. Phosphoinositide phospholipase C, PLC-gamma-1 [141413]
      contains split PH domain
      1. Rat (Rattus norvegicus) [TaxId: 10116] [141414] (1) picpic
        SQ P10686 489-525,870-933
    41. FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415]
      1. Human (Homo sapiens) [TaxId: 9606] [141416] (1) picpic
        SQ Q5JSP0 605-703
    42. Src-associated adaptor protein Skap2 [141417]
      1. Mouse (Mus musculus) [TaxId: 10090] [141418] (9) picpic
        SQ Q9Z2K4 105-212! SQ Q9Z2K4 109-219! SQ Q9Z2K4 14-222
    43. Protein kinase c, d2 type [141419]
      1. Human (Homo sapiens) [TaxId: 9606] [141420] (1) picpic
        SQ Q9BZL6 398-509
    44. Phospholipase C-beta-2 [159207]
      1. Human (Homo sapiens) [TaxId: 9606] [159208] (2) picpic
        SQ Q00722 11-141
    45. Rho guanine nucleotide exchange factor 9, Collybistin [159209]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [159210] (1) picpic
        SQ Q9QX73 300-461
    46. DCC-interacting protein 13-alpha, APPL1 [159211]
      1. Human (Homo sapiens) [TaxId: 9606] [159212] (1) picpic
        SQ Q9UKG1 274-374
    47. Rho GTPase-activating protein 21 [159213]
      1. Human (Homo sapiens) [TaxId: 9606] [159214] (6) picpic
        SQ Q5T5U3 931-1063
  2. Phosphotyrosine-binding domain (PTB) [50755] (14)
    Pfam 00640
    1. X11 [50756]
      1. Human (Homo sapiens) [TaxId: 9606] [50757] (2) picpic
    2. Insulin receptor substrate 1, IRS-1 [50758]
      duplication: contains two domains of this fold
      1. Human (Homo sapiens) [TaxId: 9606] [50759] (2) picpic
    3. Shc adaptor protein [50760]
      1. Human (Homo sapiens) [TaxId: 9606] [50761] (3) picpic
    4. Numb [50762]
      1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [50763] (2) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [117256] (1) picpic
        SQ Q9QZS3 19-172
    5. Disabled homolog 1 (Dab1) [89357]
      1. Mouse (Mus musculus) [TaxId: 10090] [89358] (3) picpic
    6. Disabled homolog 2 (Dab2) [101830]
      1. Mouse (Mus musculus) [TaxId: 10090] [101831] (2) picpic
    7. Downstream of tyrosine kinase 5, Dok-5 [101832]
      1. Human (Homo sapiens) [TaxId: 9606] [101833] (1) picpic
    8. Docking protein 1, Dok1 [101834]
      1. Mouse (Mus musculus) [TaxId: 10090] [101835] (2) picpic
        SQ P97465 152-254
    9. FGFR substrate 2 (SNT-1) [117257]
      1. Human (Homo sapiens) [TaxId: 9606] [117258] (1) picpic
        SQ Q7LDQ6 11-129
    10. Amyloid beta A4 precursor protein-binding family B member 2, Apbb2 [117259]
      1. Mouse (Mus musculus) [TaxId: 10090] [117260] (2) picpic
        SQ Q9DBR4 582-704
    11. Tensin [141421]
      1. Human (Homo sapiens) [TaxId: 9606] [141422] (1) picpic
        SQ Q9UPS7 1139-1285
        Tensin2
      2. Chicken (Gallus gallus) [TaxId: 9031] [141423] (1) picpic
        SQ Q04205 1606-1738
    12. EPS8-like protein 1, EPS8L1 [141424]
      1. Mouse (Mus musculus) [TaxId: 10090] [141425] (2) picpic
        SQ Q8R5F8 31-159
  3. Ran-binding domain [50764] (4)
    1. Nuclear pore complex protein Nup358 [50765]
      1. Human (Homo sapiens) [TaxId: 9606] [50766] (1) picpic
    2. Ran-binding protein 1, Ranbp1 [69292]
      1. Human (Homo sapiens) [TaxId: 9606] [69293] (2) picpic
    3. Ran binding protein 3 [141426]
      1. Human (Homo sapiens) [TaxId: 9606] [141427] (1) picpic
        SQ Q9H6Z4 380-516
    4. Ran-binding protein 2 [141428]
      1. Human (Homo sapiens) [TaxId: 9606] [141429] (1) picpic
        SQ P49792 2027-2154
  4. Enabled/VASP homology 1 domain (EVH1 domain) [50767] (8)
    1. Enabled [50768]
      1. Mouse (Mus musculus) [TaxId: 10090] [50769] (1) picpic
      2. Homo sapiens [TaxId: 9606] [159215] (4) picpic
    2. Ena/vasp-like protein [50770]
      1. Mouse (Mus musculus) [TaxId: 10090] [50771] (1) picpic
    3. Vasodilator-stimulated phosphoprotein (VASP) [50772]
      1. Human (Homo sapiens) [TaxId: 9606] [50773] (1) picpic
    4. Homer [50774]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [50775] (3) picpic
      2. Mouse (Mus musculus), 2b/vesl 2 [TaxId: 10090] [63800] (1) picpic
    5. Actin regulatory protein WASP [82140]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [82141] (1) picpic
    6. Sprouty-related, EVH1 domain-containing protein 1, Spred-1 [141430]
      1. Western clawed frog (Xenopus tropicalis) [TaxId: 8364] [141431] (4) picpic
        SQ Q66JG9 10-123! SQ Q66JG9 9-123
  5. Dcp1 [101836] (1)
    close structural similarity to EVH1 domain
    1. Dcp1 [101837]
      decapping protein involved in mRNA degradation
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [101838] (1) picpic
  6. Third domain of FERM [50776] (9)
    1. Moesin [50777]
      1. Human (Homo sapiens) [TaxId: 9606] [50778] (3) picpic
        SQ P26038 4-297
    2. Radixin [50779]
      1. Mouse (Mus musculus) [TaxId: 10090] [50780] (20) picpic
    3. Ezrin [82142]
      complexed with the icam-2 cytoplasmic peptide, chain B
      1. Human (Homo sapiens) [TaxId: 9606] [82143] (1) picpic
    4. Erythroid membrane protein 4.1R [50781]
      1. Human (Homo sapiens) [TaxId: 9606] [50782] (1) picpic
    5. Merlin [69294]
      the neurofibromatosis 2 tumor suppressor protein
      1. Human (Homo sapiens) [TaxId: 9606] [69295] (1) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [74995] (1) picpic
    6. Talin [82144]
      1. Chicken (Gallus gallus) [TaxId: 9031] [82145] (6) picpic
    7. Talin-1 [117261]
      1. Mouse (Mus musculus) [TaxId: 10090] [117262] (1) picpic
        SQ P26039 209-410
    8. Focal adhesion kinase 1 [141432]
      1. Chicken (Gallus gallus) [TaxId: 9031] [141433] (5) picpic
        SQ Q00944 254-363
  7. PreBEACH PH-like domain [82146] (2)
    1. PH-like domain of neurobeachin [82147]
      1. Human (Homo sapiens) [TaxId: 9606] [82148] (1) picpic
    2. Lipopolysaccharide-responsive and beige-like anchor protein LRBA [117263]
      1. Human (Homo sapiens) [TaxId: 9606] [117264] (1) picpic
        SQ P50851 2076-2489
  8. GRAM domain [101839] (1)
    1. Myotubularin-related protein 2, N-terminal domain [101840]
      1. Human (Homo sapiens) [TaxId: 9606] [101841] (4) picpic
  9. TFIIH domain [110272] (2)
    1. TFIIH basal transcription factor complex p62 subunit (BTF2-p62), N-terminal domain [110273]
      1. Human (Homo sapiens) [TaxId: 9606] [110274] (2) picpic
        SQ P32780 1-108
    2. RNA polymerase II transcription factor B 73 kDa, TFB1 [141434]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141435] (3) picpic
        SQ P32776 2-115
  10. SSRP1-like [141436] (1)
    Pfam 03531; Structure-specific recognition protein family; duplication: comprises tandem repeat of two domains of this fold
    1. FACT complex subunit POB3, middle domain [141437]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141438] (6) picpic
        SQ Q04636 237-474! SQ Q04636 238-474
  11. Necap1 N-terminal domain-like [141439] (1)
    Pfam 07933; DUF1681
    1. Necap1 [141440]
      1. Mouse (Mus musculus) [TaxId: 10090] [141441] (1) picpic
        SQ Q9CR95 1-133
  12. VPS36 N-terminal domain-like [141442] (3)
    PfamB 030385
    1. Vacuolar protein sorting protein 36, VPS36 [141443]
      1. Human (Homo sapiens) [TaxId: 9606] [141444] (1) picpic
        SQ Q86VN1 3-131
      2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141445] (2) picpic
        SQ Q06696 1-99,252-282
      3. Mouse (Mus musculus) [TaxId: 10090] [141446] (1) picpic
        SQ Q91XD6 10-130
  13. BPHL domain [159216] (2)
    Pfam 08000; DUF1696, bacterial proteins with PH-like domain
    1. Uncharacterized protein Exig2160 [159217]
      homododecameric ring assembly; olizomerization is mediated by the C-terminal alpha-hairpin extension
      1. Exiguobacterium sibiricum 255-15 [TaxId: 262543] [159218] (6) picpic
        SQ B1YJX4 14-203
    2. Uncharacterized protein Shew0819 [159219]
      homopentameric ring assembly through the pairing of the beta-barrel edge strands
      1. Shewanella loihica [TaxId: 359303] [159220] (5) picpic
        SQ A3QB43 9-124
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk