Structural Classification of Proteins

Superfamily: SH3-domain

: uperfamily

Lineage:

Root: scop
Class: All beta proteins [48724]
Fold: SH3-like barrel [50036]
barrel, partly opened; n*=4, S*=8; meander
the last strand is interrupted by a turn of 3-10 helix
Superfamily: SH3-domain [50044]
uperfamily

Families:

SH3-domain [50045] (48)
1. C-Crk, N-terminal SH3 domain [50046]
  1. Mouse (Mus musculus) [TaxId: 10090] [50047] (9)
    1. 1cka
      1. chain a [24459]
    2. 1ckb
      1. chain a [24460]
    3. 1b07
      complexed with psg
      1. chain a [24461]
    4. 2eyw
      automatically matched to d1m3ca_
      1. region a:134-190 [132603]
    5. 1m30
      mutant
      1. chain a [91171]
    6. 2eyy
      automatically matched to d1m3ca_
      1. region a:134-190 [132604]
    7. 1m3b
      a circular form
      mutant
      1. chain a [91174]
    8. 1m3a
      a circular form
      mutant
      1. chain a [91173]
    9. 1m3c
      a circular form
      mutant
      1. chain a [91175]
2. Fyn proto-oncogene tyrosine kinase, SH3 domain [50048]
  1. Human (Homo sapiens) [TaxId: 9606] [50049] (11)
    1. 1shf
      1. chain a [24462]
      2. chain b [24463]
    2. 1fyn
      1. chain a [24464]
    3. 1m27
      complex with Sap SH2 domain bound to slam peptide, chain B
      complexed with flc
      1. chain c [84749]
    4. 1efn
      complexed with pbm; mutant
      1. chain a [24465]
      2. chain c [24466]
    5. 1g83
      mutant
      1. region a:85-141 [60341]
      2. region b:85-141 [60343]
    6. 1avz
      mutant
      1. chain c [24467]
    7. 1nyf
      mutant
      1. chain a [24468]
    8. 1nyg
      mutant
      1. chain a [24470]
    9. 1a0n
      mutant
      1. chain b [24469]
    10. 1azg
      mutant
      1. chain b [24471]
    11. 1zbj
      automatically matched to d1fyna_
      1. region a:1-59 [124855]
3. SH3 domain from nebulin [50050]
  1. Human (Homo sapiens) [TaxId: 9606] [50051] (2)
    1. 1ark
      1. chain a [24473]
    2. 1neb
      1. chain a [24472]
4. Abl tyrosine kinase, SH3 domain [50052]
  1. Mouse (Mus musculus) [TaxId: 10090] [50053] (4)
    1. 1opk
      complexed with gol, myr, p16; mutant
      1. region a:83-139 [87232]
    2. 1abo
      complexed with so4
      1. chain a [24474]
      2. chain b [24475]
    3. 1abq
      1. chain a [24476]
    4. 1opl
      complexed with myr, p16; mutant
      1. region a:81-139 [87235]
  2. Human (Homo sapiens) [TaxId: 9606] [50054] (5)
    1. 1bbz
      complexed with ace, so4
      1. chain a [24477]
      2. chain c [24478]
      3. chain e [24479]
      4. chain g [24480]
    2. 2fo0
      automatically matched to d2abl_1
      complexed with gol, myr, p16; mutant
      1. region a:76-138 [133862]
    3. 2abl
      mutant
      1. region a:75-139 [24481]
    4. 1awo
      mutant
      1. chain a [24482]
    5. 1ju5
      complexed with phs; mutant
      1. chain c [77174]
5. Phosphatidylinositol 3-kinase (p85-alpha subunit, pi3k), SH3 domain [50055]
  1. Human (Homo sapiens) [TaxId: 9606] [50056] (3)
    1. 1pht
      1. chain a [24483]
    2. 1pks
      1. chain a [24484]
    3. 1pkt
      1. chain a [24485]
  2. Cow (Bos taurus) [TaxId: 9913] [50057] (2)
    1. 2pni
      1. chain a [24486]
    2. 1pnj
      1. chain a [24487]
6. alpha-Spectrin, SH3 domain [50058]
  1. Chicken (Gallus gallus) [TaxId: 9031] [50059] (21)
    1. 1u06
      automatically matched to d1pwt__
      complexed with azi
      1. region a:7-61 [119404]
    2. 2nuz
      automatically matched to d1pwt__
      1. region a:7-61 [138624]
    3. 1pwt
      mutant
      1. chain a [24490]
    4. 2f2v
      automatically matched to d1pwt__
      complexed with fmt; mutant
      1. region a:4-62 [132849]
    5. 1qkx
      mutant
      1. chain a [24491]
    6. 1qkw
      complexed with gol, so4; mutant
      1. chain a [24494]
    7. 1shg
      1. chain a [24493]
    8. 1hd3
      complexed with gol, so4; mutant
      1. chain a [65802]
    9. 1neg
      N-and C-terminal labeled protein
      complexed with azi
      1. chain a [80425]
    10. 1e6h
      mutant
      1. chain a [70084]
    11. 1bk2
      mutant
      1. chain a [24495]
    12. 1e6g
      complexed with so4; mutant
      1. chain a [70083]
    13. 1uue
      mutant
      1. chain a [100005]
    14. 2cdt
      automatically matched to d1pwt__
      mutant
      1. region a:6-62 [130296]
    15. 1h8k
      mutant
      1. chain a [70915]
    16. 1aey
      1. chain a [24496]
    17. 1e7o
      complexed with gol; mutant
      1. chain a [83169]
    18. 1m8m
      Solid-state MAS NMR structure
      1. chain a [78770]
    19. 1g2b
      circular permutant
      1. chain a [24488]
    20. 1tud
      circular permutant
      1. chain a [24489]
    21. 1tuc
      circular permutant
      1. chain a [24492]
7. IL-2 inducible T-cell (Itc) kinase [50060]
  1. Mouse (Mus musculus) [TaxId: 10090] [50061] (1)
    1. 1awj
      1. chain a [24497]
8. Hemapoetic cell kinase Hck [50062]
  1. Human (Homo sapiens) [TaxId: 9606] [50063] (6)
    1. 1qcf
      complexed with pp1; mutant
      1. region a:80-145 [24498]
    2. 1bu1
      1. chain a [24499]
      2. chain b [24500]
      3. chain c [24501]
      4. chain d [24502]
      5. chain e [24503]
      6. chain f [24504]
    3. 1ad5
      complexed with anp, ca
      1. region a:82-145 [24505]
      2. region b:82-145 [24506]
    4. 2hck
      complexed with ca, que
      1. region a:82-145 [24507]
      2. region b:82-145 [24508]
    5. 5hck
      1. chain a [24509]
    6. 4hck
      1. chain a [24510]
9. Carboxyl-terminal src kinase (csk) [74654]
  1. Human (Homo sapiens) [TaxId: 9606] [74658] (2)
    1. 1k9a
      1. region a:6-76 [72188]
      2. region b:4-76 [72191]
      3. region c:6-76 [72194]
      4. region d:6-76 [72197]
      5. region e:6-76 [72200]
      6. region f:6-76 [72203]
    2. 1csk
      1. chain a [24513]
      2. chain b [24514]
      3. chain c [24515]
      4. chain d [24516]
  2. Mouse (Mus musculus) [TaxId: 10090] [74655] (1)
    1. 1jeg
      complexed with peptide
      1. chain a [66610]
10. c-src protein tyrosine kinase [50064]
  1. Human (Homo sapiens) [TaxId: 9606] [50065] (5)
    1. 1fmk
      1. region a:82-145 [24511]
    2. 1y57
      automatically matched to d1nloc_
      complexed with mpz, so4
      1. region a:85-140 [145903]
    3. 2src
      complexed with anp
      1. region a:84-145 [24512]
    4. 2h8h
      automatically matched to d1nloc_
      complexed with h8h
      1. region a:85-140 [147240]
    5. 1ksw
      complexed with nbs; mutant
      1. region a:84-145 [68860]
  2. Chicken (Gallus gallus) [TaxId: 9031] [50066] (9)
    1. 2ptk
      1. region a:83-145 [24517]
    2. 1nlp
      complexed with ace, mn1, mn8, nh2
      1. chain c [24520]
    3. 1nlo
      complexed with ace, mn1, mn2, mn7, nh2
      1. chain c [24519]
    4. 1rlq
      1. chain c [24521]
    5. 1prm
      1. chain c [24523]
    6. 1rlp
      1. chain c [24518]
    7. 1prl
      1. chain c [24524]
    8. 1srl
      1. chain a [24525]
    9. 1srm
      1. chain a [24522]
  3. Avian sarcoma virus [TaxId: 11876] [50067] (2)
    v-src
    1. 1qwf
      1. chain a [24527]
    2. 1qwe
      1. chain a [24526]
11. Bruton's tyrosine kinase [50068]
  1. Human (Homo sapiens) [TaxId: 9606] [50069] (3)
    1. 1aww
      1. chain a [24529]
    2. 1awx
      1. chain a [24528]
    3. 1qly
      1. chain a [24530]
  2. Mus musculus [TaxId: 10090] [159018] (2)
    1. 2rn8
      automatically matched to d1awwa_
      1. region a:176-228 [152170]
    2. 2rna
      automatically matched to d1awwa_
      1. region a:176-228 [152171]
12. tyrosine kinase tec [69246]
  1. Mouse (Mus musculus) [TaxId: 10090] [69247] (1)
    1. 1gl5
      1. chain a [65289]
13. Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains [50070]
  1. Human (Homo sapiens) [TaxId: 9606] [50071] (6)
    1. 1gcq
      C-terminal domain
      complexed with mpd
      1. chain a [60434]
      2. chain b [60435]
    2. 1gri
      1. region a:1-56 [24531]
      2. region a:157-217 [24532]
      3. region b:1-56 [24533]
      4. region b:157-217 [24534]
    3. 1aze
      N-terminal domain
      mutant
      1. chain a [24536]
    4. 1gfd
      C-terminal domain
      1. chain a [24538]
    5. 1io6
      C-terminal domain
      1. chain a [24535]
    6. 1gfc
      C-terminal domain
      1. chain a [24537]
  2. Mouse (Mus musculus) [TaxId: 10090] [50072] (5)
    1. 1gbq
      N-terminal domain
      complexed with ace, nh2
      1. chain a [24539]
    2. 2gbq
      N-terminal domain
      complexed with ace, nh2
      1. chain a [24540]
    3. 3gbq
      N-terminal domain
      complexed with ace, nh2
      1. chain a [24542]
    4. 4gbq
      N-terminal domain
      complexed with ace, nh2
      1. chain a [24541]
    5. 1gbr
      N-terminal domain
      1. chain a [24543]
  3. Caenorhabditis elegans, SEM-5 [TaxId: 6239] [50073] (5)
    Sex muscle abnormal protein 5
    1. 1sem
      C-terminal domain
      1. chain a [24544]
      2. chain b [24545]
    2. 2sem
      C-terminal domain
      complexed with ace, nip
      1. chain a [24546]
      2. chain b [24547]
    3. 3sem
      C-terminal domain
      1. chain a [24548]
      2. chain b [24549]
    4. 1kfz
      C-terminal domain
      mutant
      1. chain a [84391]
    5. 1k76
      C-terminal domain
      mutant
      1. chain a [84343]
14. Grb2-related adaptor protein 2 (Mona/Gads) [89293]
  1. Mouse (Mus musculus) [TaxId: 10090] [89294] (5)
    1. 1uti
      C-terminal domain; complexed with a mitogen-activated protein kinase kinase peptide, chain D
      1. chain a [99962]
    2. 1oeb
      C-terminal domain; complexed with a peptide from the lymphocyte cytosolic protein 2, chains C and D
      complexed with cd
      1. chain a [86909]
      2. chain b [86910]
    3. 2d0n
      automatically matched to d1h3ha_
      1. region a:267-322 [131073]
    4. 2d0n
      automatically matched to d1h3ha_
      1. region c:267-321 [131074]
    5. 1h3h
      C-terminal domain; complexed with an RxxK-containing slp-76 peptide, chain B
      1. chain a [83468]
15. Phospholipase C, SH3 domain [50074]
  1. Human (Homo sapiens) [TaxId: 9606] [50075] (2)
    1. 2hsp
      1. chain a [24550]
    2. 1hsq
      1. chain a [24551]
16. p56-lck tyrosine kinase, SH3 domain [50076]
  1. Human (Homo sapiens) [TaxId: 9606] [50077] (10)
    1. 2iim
      automatically matched to d1h92a_
      complexed with ca, pg4, zn
      1. region a:58-119 [137434]
    2. 1lck
      complexed with phs; mutant
      1. region a:63-116 [24552]
    3. 1x27
      automatically matched to d1h92a_
      complexed with na
      1. region a:64-118 [121621]
    4. 1x27
      automatically matched to d1h92a_
      complexed with na
      1. region b:64-118 [121623]
    5. 1x27
      automatically matched to d1h92a_
      complexed with na
      1. region c:64-118 [121625]
    6. 1x27
      automatically matched to d1h92a_
      complexed with na
      1. region d:64-118 [121627]
    7. 1x27
      automatically matched to d1h92a_
      complexed with na
      1. region e:64-118 [121629]
    8. 1x27
      automatically matched to d1h92a_
      complexed with na
      1. region f:64-118 [121631]
    9. 1h92
      1. chain a [65741]
    10. 1kik
      1. chain a [68632]
17. 53BP2 [50078]
  1. Human (Homo sapiens) [TaxId: 9606] [50079] (1)
    1. 1ycs
      complexed with zn
      1. region b:457-519 [24553]
18. Amphiphysin 2 [50080]
  synonyms: Myc box dependent interacting protein 1, bin1
  1. Rat (Rattus norvegicus) [TaxId: 10116] [50081] (4)
    1. 1bb9
      1. chain a [24554]
    2. 1mv0
      complexed with c-Myc peptide, chain A
      1. chain b [91467]
    3. 1muz
      1. chain a [91466]
    4. 1mv3
      the remaining residues, 270-401 are not ordered apart a short bound segment 303-312
      1. region a:402-482 [91468]
19. EPS8 SH3 domain [50082]
  1. Mouse (Mus musculus) [TaxId: 10090] [50083] (3)
    1. 1i07
      segment-swapped dimer
      1. chain a [61477]
      2. chain b [61478]
    2. 1i0c
      1. chain a [61485]
      2. chain b [61486]
    3. 1aoj
      segment-swapped dimer
      1. chain a [24555]
      2. chain b [24556]
20. Vav N-terminal SH3 domain [63744]
  1. Mouse (Mus musculus) [TaxId: 10090] [63745] (3)
    1. 1gcq
      complexed to Grb2 SH3 domains
      complexed with mpd
      1. chain c [60436]
    2. 1gcp
      1. chain a [60430]
      2. chain b [60431]
      3. chain c [60432]
      4. chain d [60433]
    3. 1k1z
      mutant
      1. chain a [68026]
21. Melanoma inhibitory activity protein [63746]
  1. Human (Homo sapiens) [TaxId: 9606] [63747] (3)
    1. 1i1j
      1. chain a [61531]
      2. chain b [61532]
    2. 1k0x
      1. chain a [71977]
    3. 1hjd
      1. chain a [65846]
22. Psd-95 [69248]
  associates with a guanylate kinase domain
  1. Rat (Rattus norvegicus) [TaxId: 10116] [69249] (3)
    1. 1kjw
      complexed with so4
      1. region a:430-525 [68643]
    2. 1jxm
      complexed with 5gp, gai, mpd
      1. region a:430-525 [67420]
    3. 1jxo
      1. region a:430-525 [67422]
      2. region b:430-525 [67424]
23. Actin binding protein ABP1 [74920]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [74921] (2)
    1. 1jo8
      complexed with sul
      1. chain a [71774]
    2. 2k3b
      automatically matched to d1jo8a_
      1. region a:2-59 [148264]
24. p47pox (neutrophil cytosolic factor 1) [89295]
  1. Human (Homo sapiens) [TaxId: 9606] [89296] (5)
    1. 1ng2
      N-terminal domain forms a segment-swapped dimer; C-terminal domain includes the autoinhibition tail region, residues 284-333
      1. region a:157-214 [85660]
      2. region a:215-332 [85661]
    2. 1uec
      N-terminal domain forms a segment-swapped dimer; C-terminal domain includes the autoinhibition tail region, residues 284-336
      1. region a:157-214 [88481]
      2. region a:215-336 [88482]
    3. 1ov3
      N-terminal domain forms a segment-swapped dimer; C-terminal domain binds a peptide from p22phox, chains C and D
      1. region a:150-214 [87451]
      2. region a:215-283 [87452]
      3. region b:152-214 [87453]
      4. region b:215-283 [87454]
    4. 1wlp
      automatically matched to d1ov3a1
      1. region b:229-281 [121010]
    5. 1wlp
      1. region b:149-214 [144558]
25. p67phox [74922]
  1. Human (Homo sapiens) [TaxId: 9606] [74923] (1)
    1. 1k4u
      C-terminal SH3 domain complexed with the C-terminal tail of p47phox (chain P)
      mutant
      1. chain s [72065]
26. Peroxisomal membrane protein Pex13p [82055]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82056] (5)
    1. 2v1r
      automatically matched to d1jqqb_
      complexed with ace
      1. region a:10-76 [152411]
    2. 2v1r
      automatically matched to d1jqqb_
      complexed with ace
      1. region b:10-76 [152412]
    3. 1jqq
      1. chain a [77164]
      2. chain b [77165]
      3. chain c [77166]
      4. chain d [77167]
    4. 1n5z
      complexed with a peptide of pex14p, chains P and Q
      1. chain a [80064]
      2. chain b [80065]
    5. 1nm7
      1. chain a [85871]
27. Intersectin 2 (KIAA1256) [101669]
  1. Human (Homo sapiens) [TaxId: 9606] [101670] (5)
    SQ Q9NZM3 761-841, 897-957, 982-1037, 1055-1121, 1102-1186
    1. 1j3t
      structural genomics; second SH3 domain
      1. chain a [103839]
    2. 1ue9
      structural genomics; fourth SH3 domain
      1. chain a [99255]
    3. 1uhf
      structural genomics; third SH3 domain
      1. chain a [107848]
    4. 1udl
      structural genomics; fifth SH3 domain
      1. chain a [99212]
    5. 1uff
      structural genomics; first SH3 domain
      1. chain a [99335]
28. Hypothetical protein Baa76854.1 (KIAA1010) [101671]
  1. Human (Homo sapiens) [TaxId: 9606] [101672] (2)
    1. 1uhc
      structural genomics; C-terminal SH3 domain
      1. chain a [99397]
    2. 1ug1
      structural genomics; second last SH3 domain
      1. chain a [99360]
29. Olygophrenin-1 like protein (KIAA0621) [101673]
  1. Human (Homo sapiens) [TaxId: 9606] [101674] (1)
    1. 1ugv
      structural genomics
      1. chain a [99367]
30. Signal transducing adaptor molecule Stam2 [101675]
  1. Mouse (Mus musculus) [TaxId: 10090] [101676] (1)
    1. 1uj0
      complexed with a ubpy-derived peptide
      complexed with po4
      1. chain a [99449]
31. Rac/CDC42 GEF 6 [101677]
  1. Human (Homo sapiens) [TaxId: 9606] [101678] (1)
    1. 1ujy
      1. chain a [99474]
32. Hypothetical protein YFR024c [101679]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [101680] (2)
    1. 1oot
      structural genomics; C-terminal domain
      complexed with cl
      1. chain a [93386]
    2. 1ssh
      automatically matched to d1oota_
      1. region a:3-60 [119048]
33. Fyn-binding protein (T-cell adapter protein adap) [101681]
  1. Human (Homo sapiens) [TaxId: 9606] [101682] (1)
    1. 1ri9
      helically extended ant the N-terminus
      1. chain a [97506]
34. SH3-like domain of the L-type calcium channel [110158]
  1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [110159] (4)
    SQ P54288
    1. 1t0h
      complexed with cl
      1. chain a [106207]
    2. 1t0j
      complexed with cl
      1. chain a [106211]
    3. 1t3l
      mutant
      1. region a:35-141 [106358]
    4. 1t3s
      complexed with hg; mutant
      1. region a:35-141 [106379]
  2. Rat (Rattus norvegicus) [TaxId: 10116] [110160] (3)
    SQ P54287 38-362
    1. 1vyu
      1. region a:39-174 [108914]
      2. region b:38-174 [108916]
    2. 1vyt
      1. region a:38-174 [108908]
      2. region b:38-174 [108910]
    3. 1vyv
      beta4 isoform with odd numbering
      1. region a:71-215 [108918]
      2. region b:71-215 [108920]
35. BAI1-associated protein 2-like 1 (RIKEN cDNA 1300006m19) [110161]
  1. Mouse (Mus musculus) [TaxId: 10090] [110162] (1)
    SQ Q9DBJ3 343-401
    1. 1spk
      Structural genomics target
      1. chain a [105877]
36. Kalirin-9a [117147]
  1. Mouse (Mus musculus) [TaxId: 10090] [117148] (1)
    SQ Q8BTT9 594-651
    1. 1wfw
      Structural genomics target
      mutant
      1. chain a [114595]
37. RIM binding protein 2, RIMBP2 [117149]
  1. Human (Homo sapiens) [TaxId: 9606] [117150] (1)
    SQ O15034 160-242
    1. 1wie
      Structural genomics target
      1. chain a [114668]
38. BZZ1 [141188]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141189] (1)
    SQ P38822 497-552
    1. 1zuu
      complexed with mg, unx
      1. region a:2-57 [125688]
39. Nck-2 [159019]
  1. Human (Homo sapiens) [TaxId: 9606] [159020] (1)
    SQ O43639 192-262
    unclassified SH3 domains of this protein species are: 1WX6, 2B86, 2FRW, 2FRY
    1. 1u5s
      third SH3 domain
      complexed with zn
      1. region a:1-71 [144389]