Structural Classification of Proteins

Fold: Double-stranded beta-helix

: one turn of helix is made by two pairs of antiparallel strands linked with short turns
has appearance of a sandwich of distinct architecture and jelly-roll topology

Lineage:

Root: scop
Class: All beta proteins [48724]
Fold: Double-stranded beta-helix [51181]
one turn of helix is made by two pairs of antiparallel strands linked with short turns
has appearance of a sandwich of distinct architecture and jelly-roll topology

Superfamilies:

RmlC-like cupins [51182] (24)
uperfamily
1. dTDP-sugar isomerase [51183] (9)
2. Glucose-6-phosphate isomerase, GPI [89403] (2)
3. Hypothetical protein TM1112 [89406] (1)
4. TM1287-like [89409] (4)
5. TM1459-like [101976] (2)
6. Germin/Seed storage 7S protein [51187] (9)
7. YlbA-like [101979] (4)
  Pfam 05899; formerly pfam06038; duplication: consists of two germin-like domains
8. Pirin-like [101984] (2)
  Share a common two-domain fold with the 7S protein; there is a metal-binding site in the N-terminal domain similar to the metal-binding site of germin
9. Quercetin 2,3-dioxygenase-like [75035] (2)
  Share a common two-domain fold with the 7S protein; there is a metal-binding site in the N-terminal domain similar to the metal-binding site of germin
10. Type I phosphomannose isomerase [51191] (3)
  Share a common two-domain fold with the 7S protein; there is a metal-binding site in the N-terminal domain similar to the metal-binding site of germin
11. Homogentisate dioxygenase [51194] (1)
  Share a common two-domain fold with the 7S protein; there is a metal-binding site in the C-terminal domain similar to the metal-binding site of germin
12. Acireductone dioxygenase [82191] (2)
13. KduI-like [110318] (2)
  Pfam 04962: duplication: consists of two germin-like domains
14. Ureidoglycolate hydrolase AllA [117312] (3)
  Pfam 04115; beta-hairpin-swapped dimeric protein of the germin-like fold
15. Probable transcriptional regulator VC1968, C-terminal domain [117315] (1)
16. YML079-like [117318] (3)
  Pfam 06172; DUF985
17. PA5104-like [141609] (1)
  Pfam 05962; DUF886; duplication: consists of two germin-like domains; overall structural similarity to the YlbA-like family (scop_fa 101979) except a deletion in the interdomain linker region
18. MJ0764-like [141612] (1)
19. Cysteine dioxygenase type I [141615] (4)
  Pfam 05995, CDO_I
20. 3-hydroxyanthranilic acid dioxygenase-like [141618] (2)
  Pfam 06052; 3-HAO
21. Acetylacetone-cleaving enzyme-like [159293] (1)
  PfamB 026844
22. VPA0057-like [159296] (1)
  Pfam 06865; DUF1255; non-canonical dimerisation mode
23. Gentisate 1,2-dioxygenase-like [159299] (3)
  Share a common two-domain fold with the 7S protein; there is a metal-binding site in the N-terminal domain similar to the metal-binding site of germin; homotetramer
24. EutQ-like [159304] (1)
  Pfam 06249
Clavaminate synthase-like [51197] (13)
Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold
uperfamily
1. Penicillin synthase-like [51198] (4)
  common fold is rather distorted
2. Clavaminate synthase [51203] (1)
3. Gab protein (hypothetical protein YgaT) [63855] (1)
4. YhcH-like [89413] (1)
5. Type II Proline 3-hydroxylase (proline oxidase) [63858] (1)
6. TauD/TfdA-like [75038] (2)
7. gamma-Butyrobetaine hydroxylase [89416] (2)
  Pfam 03322
8. Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (1)
9. PhyH-like [141623] (2)
  Pfam 05721
10. AlkB-like [141628] (2)
11. Asparaginyl hydroxylase-like [141633] (1)
  Pfam 08007
12. YbiU-like [141636] (1)
  Pfam 07350; DUF1479
13. TehB-like [159307] (2)
  Pfam 09313; DUF1971
cAMP-binding domain-like [51206] (3)
uperfamily
1. CO-sensing protein CooA, N-terminal domain [51207] (1)
  heme-binding domain
2. Listeriolysin regulatory protein PrfA, N-terminal domain [89419] (1)
3. cAMP-binding domain [51210] (14)
  Pfam 00027
Regulatory protein AraC [51215] (1)
uperfamily
1. Regulatory protein AraC [51216] (1)
Thiamin pyrophosphokinase, substrate-binding domain [63862] (1)
uperfamily
1. Thiamin pyrophosphokinase, substrate-binding domain [63863] (2)
Calcium ATPase, transduction domain A [81653] (1)
a distorted variant of double-helix
uperfamily
1. Calcium ATPase, transduction domain A [81652] (1)
TRAP-like [51219] (2)
shorter variant of double-helix; assembles in large ring-like structures containing from 9 to 11 domains
uperfamily
1. Trp RNA-binding attenuation protein (TRAP) [51220] (2)
  oligomeric ring consists of 11 single-domain subunits
2. PA3696/SPS0176-like [101995] (2)
  duplication: there are three structural repeats per subunit; nine domains per ring-like trimer