Structural Classification of Proteins
home mail help root up expand collapse

Superfamily: SAM/Pointed domain

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: SAM domain-like [47768]
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
  4. Superfamily: SAM/Pointed domain [47769]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Pointed domain [47770] (7)
    1. Ets-1 transcription factor pointed domain [47771]
      1. Mouse (Mus musculus) [TaxId: 10090] [47772] (1) picpic
    2. Etv6 transcription factor pointed domain (Tel SAM) [74735]
      1. Human (Homo sapiens) [TaxId: 9606] [74736] (2) picpic
      2. Escherichia coli [TaxId: 562] [158525] (2) picpic
    3. Ets DNA-binding protein pokkuri (Yan) [109863]
      1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [109864] (2) picpic
        SQ Q01842 42-118
    4. Modulator of the activity of Ets (MAE, CG15085-PA) [109865]
      1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [109866] (1) picpic
        SQ Q9I7G2 94-173
    5. GABP-alpha subunit [109867]
      1. Mouse (Mus musculus) [TaxId: 10090] [109868] (1) picpic
        SQ Q00422 168-254 # structure of the Ets domain (320-429) is also known (scop_sp 46868)
    6. Transcriptional regulator ERG [109869]
      1. Human (Homo sapiens) [TaxId: 9606] [109870] (1) picpic
        SQ P11308 115-208
  2. SAM (sterile alpha motif) domain [47773] (16)
    1. EphA4 receptor tyrosine kinases [47774]
      1. Mouse (Mus musculus) [TaxId: 10090] [47775] (1) picpic
    2. EphB2 receptor [47776]
      1. Human (Homo sapiens) [TaxId: 9606] [47777] (2) picpic
      2. Chicken (Gallus gallus) [TaxId: 9031] [47778] (1) picpic
    3. C-terminal domain of p73 [47779]
      1. Human (Homo sapiens) [TaxId: 9606] [47780] (2) picpic
    4. Polyhomeotic [74737]
      1. Drosophila melanogaster [TaxId: 7227] [74738] (3) picpic
    5. RNA-binding protein Smaug [89075]
      1. Drosophila melanogaster [TaxId: 7227] [89076] (1) picpic
    6. Ephrin type-A receptor 8, C-terminal domain [101242]
      1. Human (Homo sapiens) [TaxId: 9606] [101243] (1) picpic
    7. Ste50p, N-terminal domain [101244]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [101245] (2) picpic
    8. Serine/threonine-protein kinase ste11 [101246]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [101247] (3) picpic
    9. Sam-domain protein samsn-1 [101248]
      1. Mouse (Mus musculus) [TaxId: 10090] [101249] (1) picpic
    10. C-terminal domain of p63 [116934]
      1. Human (Homo sapiens) [TaxId: 9606] [116935] (1) picpic
        SQ Q9H3D4 544-610
    11. Sh3 and multiple ankyrin repeat domains 3 (Shank3) [140616]
      1. Rat(Rattus norvegicus) [TaxId: 10116] [140617] (6) picpic
        SQ Q9JLU4 1749-1815
    12. Connector enhancer of kinase suppressor of Ras 1, CNK1 [140618]
      1. Human (Homo sapiens) [TaxId: 9606] [140619] (1) picpic
        SQ Q969H4 1-78
    13. Polycomb protein Scm [140620]
      1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [140621] (5) picpic
        SQ Q9VHA0 795-871
    14. Sphingomyelin synthase 1, SMS1 [140622]
      Phosphatidylcholine:ceramide cholinephosphotransferase 1
      1. Mouse (Mus musculus) [TaxId: 10090] [140623] (1) picpic
        SQ Q8VCQ6 1-84
    15. Centaurin-delta 1 (Arap2) [140624]
      1. Human(Homo sapiens) [TaxId: 9606] [140625] (1) picpic
        SQ Q8WZ64 1-78
  3. Variant SAM domain [158526] (2)
    shares a sequence motif with Pfam 07647, but has a distinct packing of helices
    1. Deleted in Liver Cancer 2, DLC2 [158527]
      1. Human (Homo sapiens) [TaxId: 9606] [158528] (2) picpic
        SQ Q9Y3M8 50-120
    2. Deleted in liver cancer 1 protein, DLC-1 [158529]
      1. Human (Homo sapiens) [TaxId: 9606] [158530] (2) picpic
        SQ Q96QB1 1-76! SQ Q96QB1 1-78
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk