Structural Classification of Proteins
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Family: MarR-like transcriptional regulators

The N- and C-terminal helical extensions to the common fold form the dimer interface

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: DNA/RNA-binding 3-helical bundle [46688]
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  4. Superfamily: "Winged helix" DNA-binding domain [46785]
    contains a small beta-sheet (wing)
    link to SUPERFAMILY database - Superfamily
  5. Family: MarR-like transcriptional regulators [63379]
    The N- and C-terminal helical extensions to the common fold form the dimer interface

Protein Domains:

  1. Multiple antibiotic resistance repressor, MarR [68970]
    1. Escherichia coli [TaxId: 562] [68971] (1)
      1. 1jgs picpic
        complexed with sal
        1. chain a [66683] picpiclink
  2. MexR repressor [81686]
    1. Pseudomonas aeruginosa [TaxId: 287] [81687] (1)
      1. 1lnw picpic
        complexed with mse
        1. chain a [78104] picpiclink
        2. chain b [78105] picpiclink
        3. chain c [78106] picpiclink
        4. chain d [78107] picpiclink
        5. chain e [78108] picpiclink
        6. chain f [78109] picpiclink
        7. chain g [78110] picpiclink
        8. chain h [78111] picpiclink
  3. Transcriptional regulator SlyA [81688]
    1. Enterococcus faecalis [TaxId: 1351] [81689] (1)
      1. 1lj9 picpic
        1. chain a [78035] picpiclink
        2. chain b [78036] picpiclink
    2. Salmonella typhimurium [TaxId: 90371] [158271] (2)
      SQ P40676 1-140
      1. 3deu picpic
        complexed with sal
        1. region a:2-141 [157600] picpiclink
      2. 3deu picpic
        automatically matched to 3DEU A:2-141
        complexed with sal
        1. region b:2-141 [157601] picpiclink
  4. Staphylococcal accessory regulator A homolog, SarR [63472]
    1. Staphylococcus aureus [TaxId: 1280] [63473] (1)
      1. 1hsj picpicxref
        Fusion protein with E. coli MBP
        complexed with glc
        1. region a:373-487 [61237] picpiclink
        2. region b:373-487 [61239] picpiclink
  5. Staphylococcal accessory regulator A homolog, SarS [88977]
    duplication: tandem repeat of two SarR-like domains assembled together as in the SarR dimer
    1. Staphylococcus aureus [TaxId: 1280] [88978] (1)
      1. 1p4x picpic
        1. region a:1-125 [87784] picpiclink
        2. region a:126-250 [87785] picpiclink
  6. Pleiotropic regulator of virulence genes, SarA [48292]
    closely related to SarR but adopts a different fold; possible experimental artifact?
    1. Staphylococcus aureus [TaxId: 1280] [48293] (5)
      1. 2frh picpic
        automatically matched to d1fzpb_
        complexed with ca
        1. region a:102-216 [133988] picpiclink
      2. 2frh picpic
        automatically matched to d1fzpb_
        complexed with ca
        1. region b:102-216 [133989] picpiclink
      3. 2fnp picpic
        1. region a:103-224 [133825] picpiclink
      4. 2fnp picpic
        automatically matched to 2FNP A:103-224
        1. region b:103-224 [133826] picpiclink
      5. 1fzp picpic
        protein/DNA complex; complexed with ca
        1. chain d [19007] picpiclink
        2. chain b [19008] picpiclink
  7. Putative transcriptional regulator YusO [101012]
    1. Bacillus subtilis [TaxId: 1423] [101013] (1)
      1. 1s3j picpic
        structural genomics
        1. chain a [98437] picpiclink
        2. chain b [98438] picpiclink
  8. Hypothetical protein PH1061 [101014]
    1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [101015] (1)
      1. 1ub9 picpic
        structural genomics
        1. chain a [99159] picpiclink
  9. Putative transcriptional regulator TM0816 [140241]
    1. Thermotoga maritima [TaxId: 2336] [140242] (2)
      SQ Q9WZS3 1-140
      1. 2eth picpic
        complexed with cl
        1. region a:1-140 [132358] picpiclink
      2. 2eth picpic
        automatically matched to 2ETH A:1-140
        complexed with cl
        1. region b:1-140 [132359] picpiclink
  10. Probable transcriptional regulator PA3067 [140243]
    1. Pseudomonas aeruginosa [TaxId: 287] [140244] (4)
      SQ Q9HZE1 2-146
      1. 2hr3 picpic
        1. region a:2-146 [136678] picpiclink
      2. 2hr3 picpic
        automatically matched to 2HR3 A:2-146
        1. region b:3-145 [136679] picpiclink
      3. 2hr3 picpic
        automatically matched to 2HR3 A:2-146
        1. region c:3-145 [136680] picpiclink
      4. 2hr3 picpic
        automatically matched to 2HR3 A:2-146
        1. region d:2-145 [136681] picpiclink
  11. Probable transcriptional regulator PA4135 [140245]
    1. Pseudomonas aeruginosa [TaxId: 287] [140246] (1)
      SQ Q9HWP6 5-140
      1. 2fbi picpic
        1. region a:5-140 [133246] picpiclink
  12. Organic hydroperoxide resistance transcriptional regulator OhrR [140247]
    1. Bacillus subtilis [TaxId: 1423] [140248] (7)
      SQ O34777 8-144
      1. 1z91 picpic
        mutant
        1. region a:8-144 [124736] picpiclink
      2. 1z9c picpic
        automatically matched to 1Z91 A:8-144
        mutant
        1. region a:9-144 [124747] picpiclink
      3. 1z9c picpic
        automatically matched to 1Z91 A:8-144
        mutant
        1. region b:8-144 [124748] picpiclink
      4. 1z9c picpic
        automatically matched to 1Z91 A:8-144
        mutant
        1. region c:8-144 [124749] picpiclink
      5. 1z9c picpic
        automatically matched to 1Z91 A:8-144
        mutant
        1. region d:8-144 [124750] picpiclink
      6. 1z9c picpic
        automatically matched to 1Z91 A:8-144
        mutant
        1. region e:8-144 [124751] picpiclink
      7. 1z9c picpic
        automatically matched to 1Z91 A:8-144
        mutant
        1. region f:8-144 [124752] picpiclink
  13. Transcriptional regulator PA3341 [140249]
    1. Pseudomonas aeruginosa [TaxId: 287] [140250] (1)
      SQ Q9HYQ4 8-144
      1. 2fbh picpic
        complexed with hg, so4, zn
        1. region a:8-144 [133245] picpiclink
  14. Protease production regulatory protein Hpr [140251]
    1. Bacillus subtilis [TaxId: 1423] [140252] (4)
      SQ P11065 6-167
      1. 2fxa picpic
        complexed with 1pe, edo, p6g, pge
        1. region a:6-167 [134304] picpiclink
      2. 2fxa picpic
        automatically matched to 2FXA A:6-167
        complexed with 1pe, edo, p6g, pge
        1. region b:8-167 [134305] picpiclink
      3. 2fxa picpic
        automatically matched to 2FXA A:6-167
        complexed with 1pe, edo, p6g, pge
        1. region c:8-167 [134306] picpiclink
      4. 2fxa picpic
        automatically matched to 2FXA A:6-167
        complexed with 1pe, edo, p6g, pge
        1. region d:7-167 [134307] picpiclink
  15. Transcriptional regulator TM0710 [140253]
    1. Thermotoga maritima [TaxId: 2336] [140254] (4)
      SQ Q9WZG9 5-143
      1. 2a61 picpic
        1. region a:5-143 [126187] picpiclink
      2. 2a61 picpic
        automatically matched to 2A61 A:5-143
        1. region b:5-143 [126188] picpiclink
      3. 2a61 picpic
        automatically matched to 2A61 A:5-143
        1. region c:5-143 [126189] picpiclink
      4. 2a61 picpic
        automatically matched to 2A61 A:5-143
        1. region d:5-143 [126190] picpiclink
  16. Transcriptional regulator DR1159 [140255]
    1. Deinococcus radiodurans [TaxId: 1299] [140256] (2)
      SQ Q9RV71 8-179
      1. 2fbk picpic
        complexed with cl
        1. region a:8-179 [133247] picpiclink
      2. 2fbk picpic
        automatically matched to 2FBK A:8-179
        complexed with cl
        1. region b:8-179 [133248] picpiclink
  17. Transcriptional regulator MgrA [158272]
    1. Staphylococcus aureus [TaxId: 1280] [158273] (1)
      SQ Q7A1J9 6-141
      1. 2bv6 picpic
        complexed with so4
        1. region a:5-140 [146218] picpiclink
  18. Ta1064 (RFK), N-terminal domain [158274]
    1. Thermoplasma acidophilum [TaxId: 2303] [158275] (1)
      SQ Q9HJA6 5-89
      1. 3cta picpicxref
        1. region a:5-89 [156979] picpiclink
  19. Transcriptional regulator OEOE1854 [158276]
    1. Oenococcus oeni [TaxId: 1247] [158277] (4)
      SQ Q04CY6 3-137
      1. 3bro picpic
        complexed with cl, gol
        1. region a:3-137 [155517] picpiclink
      2. 3bro picpic
        automatically matched to 3BRO A:3-137
        complexed with cl, gol
        1. region b:3-137 [155518] picpiclink
      3. 3bro picpic
        automatically matched to 3BRO A:3-137
        complexed with cl, gol
        1. region c:4-137 [155519] picpiclink
      4. 3bro picpic
        automatically matched to 3BRO A:3-137
        complexed with cl, gol
        1. region d:4-137 [155520] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk