Structural Classification of Proteins
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Family: Homeodomain

Pfam 00046

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: DNA/RNA-binding 3-helical bundle [46688]
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  4. Superfamily: Homeodomain-like [46689]
    consists only of helices
    link to SUPERFAMILY database - Superfamily
  5. Family: Homeodomain [46690]
    Pfam 00046

Protein Domains:

  1. Engrailed Homeodomain [46691]
    1. Drosophila melanogaster [TaxId: 7227] [46692] (10)
      1. 1p7i picpic
        complexed with nhe; mutant
        1. chain a [94279] picpiclink
        2. chain b [94280] picpiclink
        3. chain c [94281] picpiclink
        4. chain d [94282] picpiclink
      2. 1p7j picpic
        complexed with nhe; mutant
        1. chain a [94283] picpiclink
        2. chain b [94284] picpiclink
        3. chain c [94285] picpiclink
        4. chain d [94286] picpiclink
      3. 2hdd picpic
        protein/DNA complex; mutant
        1. chain a [15971] picpiclink
        2. chain b [15972] picpiclink
      4. 1enh picpic
        1. chain a [15973] picpiclink
      5. 1du0 picpic
        protein/DNA complex; mutant
        1. chain a [15974] picpiclink
        2. chain b [15975] picpiclink
      6. 3hdd picpic
        protein/DNA complex
        1. chain a [15976] picpiclink
        2. chain b [15977] picpiclink
      7. 1hdd picpic
        protein/DNA complex
        1. chain c [15978] picpiclink
        2. chain d [15979] picpiclink
      8. 2jwt picpic
        automatically matched to d1hddc_
        1. region a:3-59 [148230] picpiclink
      9. 2p81 picpic
        automatically matched to d1hddc_
        mutant
        1. region a:17-59 [139518] picpiclink
      10. 1ztr picpic
        mutant
        1. region a:0-59 [125655] picpiclink
  2. Mating type protein A1 Homeodomain [46693]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [46694] (6)
      1. 1le8 picpicxref
        mutant
        1. chain a [73867] picpiclink
      2. 1yrn picpicxref
        protein/DNA complex
        1. chain a [15981] picpiclink
      3. 1akh picpicxref
        protein/DNA complex
        1. chain a [15980] picpiclink
      4. 1f43 picpic
        1. chain a [15982] picpiclink
      5. 1mh3 picpicxref
        chimera with maltose-binding protein
        mutant
        1. region a:472-526 [79112] picpiclink
      6. 1mh4 picpicxref
        chimera with maltose-binding protein
        mutant
        1. region a:472-523 [79114] picpiclink
  3. mat alpha2 Homeodomain [46695]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [46696] (6)
      1. 1k61 picpic
        complexed with ido
        1. chain a [77270] picpiclink
        2. chain b [77271] picpiclink
        3. chain c [77272] picpiclink
        4. chain d [77273] picpiclink
      2. 1mnm picpicxref
        protein/DNA complex
        1. chain c [15983] picpiclink
        2. chain d [15984] picpiclink
      3. 1le8 picpicxref
        mutant
        1. chain b [73868] picpiclink
      4. 1yrn picpicxref
        protein/DNA complex
        1. chain b [15986] picpiclink
      5. 1akh picpicxref
        protein/DNA complex
        1. chain b [15985] picpiclink
      6. 1apl picpic
        protein/DNA complex
        1. chain c [15987] picpiclink
        2. chain d [15988] picpiclink
  4. Hepatocyte nuclear factor 1a (LFB1/HNF1) [46697]
    atypical Homeodomain with a large insertion into HTH motif
    1. Rat (Rattus rattus) [TaxId: 10117] [46698] (2)
      1. 1lfb picpic
        1. chain a [15989] picpiclink
      2. 2lfb picpic
        mutant
        1. chain a [15990] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [81680] (1)
      1. 1ic8 picpicxref
        1. region a:201-276 [76740] picpiclink
        2. region b:201-278 [76742] picpiclink
  5. Oct-1 POU Homeodomain [46699]
    1. Human (Homo sapiens) [TaxId: 9606] [46700] (7)
      1. 1e3o picpicxref
        mutant
        1. region c:104-160 [59197] picpiclink
      2. 1gt0 picpicxrefxref
        mutant
        1. region c:97-159 [76335] picpiclink
      3. 1hf0 picpicxref
        mutant
        1. region a:102-159 [65820] picpiclink
        2. region b:102-159 [65822] picpiclink
      4. 1oct picpicxref
        protein/DNA complex
        1. region c:102-161 [15991] picpiclink
      5. 1o4x picpicxrefxref
        mutant
        1. region a:110-163 [92470] picpiclink
      6. 1cqt picpicxref
        1. region a:102-161 [15992] picpiclink
        2. region b:602-661 [15993] picpiclink
      7. 1pog picpic
        mutant
        1. chain a [15994] picpiclink
  6. Pit-1 POU homeodomain [46701]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [46702] (1)
      1. 1au7 picpicxref
        protein/DNA complex; mutant
        1. region a:103-160 [15995] picpiclink
        2. region b:103-160 [15996] picpiclink
  7. Thyroid transcription factor 1 homeodomain [46703]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [46704] (1)
      1. 1ftt picpic
        1. chain a [15997] picpiclink
  8. Oct-2 POU Homeodomain [46705]
    1. Human (Homo sapiens) [TaxId: 9606] [46706] (1)
      1. 1hdp picpic
        1. chain a [15998] picpiclink
  9. Oct-3 POU Homeodomain [46707]
    1. Mouse (Mus musculus) [TaxId: 10090] [46708] (1)
      1. 1ocp picpic
        1. chain a [15999] picpiclink
  10. Homeobox protein hox-b1 [46709]
    1. Human (Homo sapiens) [TaxId: 9606] [46710] (1)
      1. 1b72 picpicxref
        protein/DNA complex; mutant
        1. chain a [16000] picpiclink
  11. Homeobox protein hox-a9 [100994]
    1. Mouse (Mus musculus) [TaxId: 10090] [100995] (1)
      1. 1puf picpicxref
        1. chain a [95131] picpiclink
  12. pbx1 [46711]
    1. Human (Homo sapiens) [TaxId: 9606] [46712] (2)
      1. 1puf picpicxref
        1. chain b [95132] picpiclink
      2. 1b72 picpicxref
        protein/DNA complex; mutant
        1. chain b [16001] picpiclink
    2. Mouse (Mus musculus) [TaxId: 10090] [46713] (2)
      1. 1lfu picpic
        mutant
        1. chain p [77939] picpiclink
      2. 1du6 picpic
        1. chain a [16002] picpiclink
  13. Insulin gene enhancer protein isl-1 [46714]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [46715] (1)
      1. 1bw5 picpic
        1. chain a [16003] picpiclink
  14. Msx-1 homeodomain [63463]
    1. Mouse (Mus musculus) [TaxId: 10090] [63464] (1)
      1. 1ig7 picpic
        1. chain a [62365] picpiclink
  15. Antennapedia Homeodomain [46716]
    1. Drosophila melanogaster [TaxId: 7227] [46717] (5)
      1. 9ant picpic
        protein/DNA complex; complexed with ni; mutant
        1. chain a [16004] picpiclink
        2. chain b [16005] picpiclink
      2. 1ahd picpic
        protein/DNA complex; mutant
        1. chain p [16006] picpiclink
      3. 1san picpic
        mutant
        1. chain a [16008] picpiclink
      4. 1hom picpic
        1. chain a [16007] picpiclink
      5. 2hoa picpic
        mutant
        1. chain a [16009] picpiclink
  16. Ultrabithorax (ubx) homeodomain [46718]
    1. Drosophila melanogaster [TaxId: 7227] [46719] (1)
      1. 1b8i picpicxref
        mutant
        1. chain a [16010] picpiclink
  17. Extradenticle (exd) homeodomain [46720]
    1. Drosophila melanogaster [TaxId: 7227] [46721] (3)
      1. 2r5y picpic
        automatically matched to d1b8ib_
        1. region b:205-259 [151597] picpiclink
      2. 2r5z picpic
        automatically matched to d1b8ib_
        1. region b:205-259 [151598] picpiclink
      3. 1b8i picpicxref
        mutant
        1. chain b [16011] picpiclink
  18. Even-skipped homeodomain [63465]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [63466] (1)
      1. 1jgg picpic
        complexed to AT-rich DNA
        1. chain a [62950] picpiclink
        2. chain b [62951] picpiclink
  19. Fushi Tarazu protein [46722]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [46723] (1)
      1. 1ftz picpic
        1. chain a [16012] picpiclink
  20. VND/NK-2 protein [46724]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [46725] (4)
      1. 1vnd picpic
        1. chain a [16014] picpiclink
      2. 1nk3 picpic
        protein/DNA complex
        1. chain p [16013] picpiclink
      3. 1nk2 picpic
        protein/DNA complex
        1. chain p [16015] picpiclink
      4. 1qry picpic
        mutant
        1. chain a [16016] picpiclink
  21. Paired protein [46726]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [46727] (1)
      1. 1fjl picpic
        protein/DNA complex; mutant
        1. chain a [16017] picpiclink
        2. chain b [16018] picpiclink
        3. chain c [16019] picpiclink
  22. Homeo-prospero domain of Prospero protein [81681]
    single domain composed of a homeodomain-homology N-terminal region (1245-1295) and the prospero-specific C-terminal region (1296-1396) that forms a 4-helical bundle
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [81682] (2)
      1. 1mij picpic
        complexed with mse
        1. chain a [79150] picpiclink
      2. 1xpx picpic
        automatically matched to d1mija_
        1. region a:1245-1396 [122230] picpiclink
  23. Homeodomain-only protein, Hop [109647]
    1. Mouse (Mus musculus) [TaxId: 10090] [109648] (2)
      SQ Q8R1H0
      1. 1uhs picpic
        1. chain a [107853] picpiclink
      2. 2hi3 picpic
        automatically matched to d1uhsa_
        1. region a:10-73 [136522] picpiclink
  24. ZF-HD homeobox protein At5g65410 [116772]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [116773] (1)
      SQ Q9FKP8 182-248
      1. 1wh5 picpic
        Structural genomics target
        1. chain a [114633] picpiclink
  25. ZF-HD homeobox protein At4g24660 [116774]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [116775] (1)
      SQ Q9SB61 148-215
      1. 1wh7 picpic
        Structural genomics target
        1. chain a [114635] picpiclink
  26. DNA-binding protein SATB2 [116776]
    1. Human (Homo sapiens) [TaxId: 9606] [116777] (1)
      SQ Q9UPW6 615-672 # the structure of the 1st CUT domain (350-437) is also known: 1WIZ
      1. 1wi3 picpic
        Structural genomics target
        1. chain a [114660] picpiclink
  27. Homeobox-leucine zipper protein Homez [116778]
    1. Human (Homo sapiens) [TaxId: 9606] [116779] (1)
      SQ Q8IX15 337-399
      Structural genomics target
      1. 2ecc picpic
        automatically matched to d1wjha_
        1. region a:1-76 [132104] picpiclink
  28. Hepatocyte nuclear factor 6 [116780]
    1. Mouse (Mus musculus) [TaxId: 10090] [116781] (1)
      SQ O08755 291-437
      1. 1s7e picpicxref
        1. region a:103-152 [112044] picpiclink
  29. LAG1 longevity assurance homolog 5, LASS5 [140141]
    1. Mouse (Mus musculus) [TaxId: 10090] [140142] (1)
      SQ Q9D6K9 77-135
      1. 2cqx picpic
        1. region a:8-66 [130731] picpiclink
  30. Paired box protein pax6 [140143]
    1. Human (Homo sapiens) [TaxId: 9606] [140144] (1)
      SQ P26367 211-278
      1. 2cue picpic
        1. region a:7-74 [130808] picpiclink
  31. Transcriptional adaptor 2-like, TADA2L, isoform b [140145]
    1. Human (Homo sapiens) [TaxId: 9606] [140146] (1)
      SQ Q9BVJ0 72-118
      1. 1x41 picpic
        1. region a:8-54 [121676] picpiclink
  32. Lag1 longevity assurance homolog 6, LASS6 [140147]
    1. Mouse (Mus musculus) [TaxId: 10090] [140148] (1)
      SQ Q8C172 76-127
      1. 1x2m picpic
        1. region a:8-59 [121645] picpiclink
  33. Homeobox protein prh [140149]
    1. Human (Homo sapiens) [TaxId: 9606] [140150] (1)
      SQ Q03014 138-194
      1. 2e1o picpic
        1. region a:8-64 [131965] picpiclink
  34. Pituitary homeobox 2 [140151]
    1. Human (Homo sapiens) [TaxId: 9606] [140152] (1)
      SQ Q99697 85-144
      1. 1yz8 picpic
        mutant
        1. region p:1-60 [124270] picpiclink
  35. Homeobox protein pknox1 [140153]
    1. Human (Homo sapiens) [TaxId: 9606] [140154] (1)
      SQ P55347 257-318
      1. 1x2n picpic
        1. region a:6-67 [121646] picpiclink
  36. Homeotic bicoid protein [140155]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [140156] (1)
      SQ P09081 97-163
      1. 1zq3 picpic
        1. region p:2-68 [125499] picpiclink
  37. Hypothetical protein 4930532d21rik [140157]
    1. Mouse (Mus musculus) [TaxId: 10090] [140158] (1)
      SQ Q8C0V1 712-760
      1. 1x58 picpic
        1. region a:8-56 [121705] picpiclink
  38. Homeobox-containing protein 1, HMBOX1 (Flj21616) [140159]
    1. Human (Homo sapiens) [TaxId: 9606] [140160] (1)
      SQ Q6NT76 268-350
      1. 2cuf picpic
        1. region a:8-89 [130809] picpiclink
  39. Homeobox protein hox-b13 [140161]
    1. Human (Homo sapiens) [TaxId: 9606] [140162] (1)
      SQ Q92826 216-273
      1. 2cra picpic
        1. region a:7-64 [130736] picpiclink
  40. Zinc fingers and homeoboxes protein 1, ZHX1 [158242]
    1. Human (Homo sapiens) [TaxId: 9606] [158243] (1)
      SQ Q9UKY1 565-640
      1. 2ecb picpic
        1. region a:8-83 [146789] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk