Structural Classification of Proteins
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Family: Penta-EF-hand proteins

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: EF Hand-like [47472]
    core: 4 helices; array of 2 hairpins, opened
  4. Superfamily: EF-hand [47473]
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
    link to SUPERFAMILY database - Superfamily
  5. Family: Penta-EF-hand proteins [63550]

Protein Domains:

  1. Apoptosis-linked protein alg-2 [63551]
    1. Mouse (Mus musculus) [TaxId: 10090] [63552] (1)
      1. 1hqv picpic
        complexed with ca
        1. chain a [61160] picpiclink
  2. Sorcin [69023]
    1. Human (Homo sapiens) [TaxId: 9606] [69024] (1)
      1. 1juo picpic
        1. chain a [67312] picpiclink
        2. chain b [67313] picpiclink
    2. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [74723] (1)
      1. 1gjy picpic
        complexed with so4
        1. chain a [70199] picpiclink
        2. chain b [70200] picpiclink
        3. chain c [70201] picpiclink
        4. chain d [70202] picpiclink
  3. Grancalcin [47550]
    Calpain small subunit homologue
    1. Human (Homo sapiens) [TaxId: 9606] [47551] (4)
      1. 1k94 picpic
        complexed with ca
        1. chain a [68333] picpiclink
        2. chain b [68334] picpiclink
      2. 1k95 picpic
        1. chain a [68335] picpiclink
      3. 1f4q picpic
        1. chain a [17360] picpiclink
        2. chain b [17361] picpiclink
      4. 1f4o picpic
        complexed with ca
        1. chain a [17362] picpiclink
        2. chain b [17363] picpiclink
  4. Calpain small (regulatory) subunit (domain VI) [47552]
    1. Human (Homo sapiens) [TaxId: 9606] [47553] (2)
      1. 1kfu picpicxrefxrefxref
        1. chain s [68574] picpiclink
      2. 1kfx picpicxrefxrefxref
        1. chain s [68578] picpiclink
    2. Rat (Rattus norvegicus) [TaxId: 10116] [47554] (6)
      1. 1np8 picpic
        complexed with cd
        1. chain a [92022] picpiclink
        2. chain b [92023] picpiclink
      2. 1dvi picpic
        complexed with ca
        1. chain a [17365] picpiclink
        2. chain b [17366] picpiclink
      3. 1aj5 picpic
        1. chain a [17367] picpiclink
        2. chain b [17368] picpiclink
      4. 1df0 picpicxrefxrefxref
        mutant
        1. chain b [17369] picpiclink
      5. 1u5i picpicxrefxrefxref
        automatically matched to d1np8a_
        mutant
        1. region b:11-159 [119550] picpiclink
      6. 1qxp picpicxrefxrefxref
        mu-like isoform with the large and small subunits fused in a single chain
        mutant
        1. region a:710-893 [96543] picpiclink
        2. region b:710-893 [96547] picpiclink
    3. Pig (Sus scrofa) [TaxId: 9823] [47555] (6)
      1. 1alv picpic
        complexed with ca
        1. chain a [17370] picpiclink
        2. chain b [17371] picpiclink
      2. 1nx1 picpic
        complexed with calpastatin dic
        complexed with ca
        1. chain a [92279] picpiclink
        2. chain b [92280] picpiclink
      3. 1nx2 picpic
        complexed with ca
        1. chain a [92281] picpiclink
      4. 1alw picpic
        complexed with ca, isa
        1. chain a [17372] picpiclink
        2. chain b [17373] picpiclink
      5. 1nx0 picpic
        complexed with calpastatin inhibitory domain c (dic) and peptide inhibitor
        complexed with ca
        1. chain a [92277] picpiclink
        2. chain b [92278] picpiclink
      6. 1nx3 picpic
        complexed with ca, isa
        1. chain a [92282] picpiclink
  5. Calpain large subunit, C-terminal domain (domain IV) [47556]
    1. Human (Homo sapiens), M-type [TaxId: 9606] [47557] (2)
      1. 1kfu picpicxrefxrefxref
        1. region l:515-700 [68571] picpiclink
      2. 1kfx picpicxrefxrefxref
        1. region l:515-700 [68575] picpiclink
    2. Rat (Rattus norvegicus), M-type [TaxId: 10116] [47558] (2)
      1. 1df0 picpicxrefxrefxref
        mutant
        1. region a:515-700 [17375] picpiclink
      2. 1u5i picpicxrefxrefxref
        automatically matched to d1df0a1
        mutant
        1. region a:515-700 [119547] picpiclink
    3. Rat (Rattus norvegicus), mu-type [TaxId: 10116] [101186] (1)
      1. 1qxp picpicxrefxrefxref
        mu-like isoform with the large and small subunits fused in a single chain
        mutant
        1. region a:515-702 [96544] picpiclink
        2. region b:515-702 [96548] picpiclink
  6. Programmed cell death 6 protein-like protein [116903]
    1. Leishmania major [TaxId: 5664] [116904] (1)
      SQ Q4QG08 53-234
      1. 1y1x picpic
        Structural genomics target
        complexed with ca, so4; mutant
        1. chain a [116374] picpiclink
        2. chain b [116375] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk