Structural Classification of Proteins

Fold: Histone-fold

: core: 3 helices; long middle helix is flanked at each end with shorter ones

Lineage:

Root: scop
Class: All alpha proteins [46456]
Fold: Histone-fold [47112]
core: 3 helices; long middle helix is flanked at each end with shorter ones

Superfamilies:

Histone-fold [47113] (4)
uperfamily
1. Nucleosome core histones [47114] (23)
  form octamers composed of two copies of each of the four histones
  1. Histone H2A [47115]
    1. Chicken (Gallus gallus), erythrocytes [TaxId: 9031] [47116] (7)
      SQ P02263
    2. African clawed frog (Xenopus laevis) [TaxId: 8355] [47117] (29)
    3. Human (Homo sapiens), variant H2A.Z [TaxId: 9606] [47118] (1)
    4. Baker's yeast (Saccharomyces cerevisiae), H2A.1 [TaxId: 4932] [68984] (2)
    5. Human (Homo sapiens), H2A.a [TaxId: 9606] [140392] (2)
      SQ P28001 11-118
    6. Mouse (Mus musculus), H2A.1 [TaxId: 10090] [158384] (1)
      SQ P22752 14-118
  2. Histone H2B [47119]
    1. Chicken (Gallus gallus), erythrocytes [TaxId: 9031] [47120] (7)
      SQ P02279
    2. African clawed frog (Xenopus laevis) [TaxId: 8355] [47121] (32)
    3. Baker's yeast (Saccharomyces cerevisiae), H2B.2 [TaxId: 4932] [68985] (2)
    4. Mouse (Mus musculus), H2Ba [TaxId: 10090] [140393] (3)
      SQ Q9D2U9 34-126
    5. Human (Homo sapiens), H2B.k [TaxId: 9606] [140394] (2)
      SQ O60814 30-125
    6. Xenopus (Silurana) tropicalis [TaxId: 8364] [158385] (4)
  3. Histone H3 [47122]
    1. Chicken (Gallus gallus), erythrocytes [TaxId: 9031] [47123] (9)
      SQ P84229
    2. African clawed frog (Xenopus laevis) [TaxId: 8355] [47124] (34)
    3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [68986] (1)
    4. Mouse(Mus musculus), H3.1 [TaxId: 10090] [140395] (4)
      SQ P68433 38-135
    5. fruit fly (Drosophila melanogaster) [TaxId: 7227] [158386] (4)
  4. Histone H4 [47125]
    1. Chicken (Gallus gallus), erythrocytes [TaxId: 9031] [47126] (5)
      SQ P62801
    2. African clawed frog (Xenopus laevis) [TaxId: 8355] [47127] (45)
    3. Mouse (Mus musculus) [TaxId: 10090] [47128] (1)
    4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [68987] (1)
    5. fruit fly (Drosophila melanogaster) [TaxId: 7227] [158387] (4)
  5. macro-H2A.1, histone domain [140396]
    1. Human (Homo sapiens) [TaxId: 9606] [140397] (3)
      SQ O75367 11-116
2. Archaeal histone [47129] (4)
  1. Archaeal histone [68897]
    1. Archaeon Methanothermus fervidus, histone A [TaxId: 2180] [68895] (2)
    2. Archaeon Methanothermus fervidus, histone B [TaxId: 2180] [68896] (3)
    3. Archaeon Methanopyrus kandleri [TaxId: 2320] [68988] (1)
    4. Archaeon (Pyrococcus horikoshii) [TaxId: 53953] [101106] (1)
3. TBP-associated factors, TAFs [47134] (13)
  1. TAF(II)42 [47135]
    TAFii42 and TAFii62 form heterotetramer similar to (H3-H4)2
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [47136] (1)
  2. TAF(II)62 [47137]
    TAFii42 and TAFii62 form heterotetramer similar to (H3-H4)2
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [47138] (1)
  3. TAF(II)18 [47139]
    1. Human (Homo sapiens) [TaxId: 9606] [47140] (2)
  4. TAF(II)28 [47141]
    1. Human (Homo sapiens) [TaxId: 9606] [47142] (2)
  5. TAF(II)-135, (TAF(II)-130, hTAF4), histone fold domain [81720]
    lacks the third helix, forms a heterodimer with TAF(II)-20 similar to H2A-H2B
    1. Human (Homo sapiens) [TaxId: 9606] [81721] (1)
  6. TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain [81722]
    forms a heterodimer with TAF(II)-135 similar to H2A-H2B
    1. Human (Homo sapiens) [TaxId: 9606] [81723] (1)
  7. Negative cofactor 2, NC2, alpha chain [63507]
    1. Human (Homo sapiens) [TaxId: 9606] [63508] (1)
  8. Negative cofactor 2, NC2, beta chain [63509]
    1. Human (Homo sapiens) [TaxId: 9606] [63510] (1)
  9. Nuclear transcription factor Y subunit beta (Nf-Yb3) [81724]
    forms a heterodimer with Nf-Yc2 similar to H2A/H2B
    1. Human (Homo sapiens) [TaxId: 9606] [81725] (1)
  10. Nuclear transcription factor Y subunit gamma (Nf-Yc2) [81726]
    forms a heterodimer with Nf-Yb3 similar to H2A/H2B
    1. Human (Homo sapiens) [TaxId: 9606] [81727] (1)
  11. Histone domain of Son of sevenless protein [101107]
    1. Human (Homo sapiens) [TaxId: 9606] [101108] (1)
  12. Chrac-14 [140398]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [140399] (4)
      SQ Q9V444 11-99
  13. Chrac-16 [140400]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [140401] (4)
      SQ Q9V452 29-100
4. Bacterial histone-fold protein [101318] (2)
  duplication: two repeats of histone fold are arranged as subunits in the archael histone dimer; new structure from Thermus thermophilus (1wws) comprised of dimers similar the to the H3-H4 tetramer
  1. Hypothetical protein Aq_328 [101319]
    1. Aquifex aeolicus [TaxId: 63363] [101320] (1)
  2. Hypothetical protein TTHA1479 [140402]
    1. Thermus thermophilus [TaxId: 274] [140403] (9)
      SQ Q5SI95 1-148