Structural Classification of Proteins
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Fold: Regulator of G-protein signaling, RGS

multihelical; consists of two all-alpha subdomains
contains a 4-helical bundle with left-handed twist and up-and-down topology

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: Regulator of G-protein signaling, RGS [48096]
    multihelical; consists of two all-alpha subdomains
    contains a 4-helical bundle with left-handed twist and up-and-down topology

Superfamilies:

  1. Regulator of G-protein signaling, RGS [48097] (1)
    link to SUPERFAMILY database - Superfamily
    1. Regulator of G-protein signaling, RGS [48098] (9)
      1. Regulator of G-protein signaling 4, RGS4 [48099]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [48100] (3)
          1. 1agr picpicxrefxref
            complexed with alf, cit, gdp, mg
            1. chain e [18538] picpiclink
            2. chain h [18539] picpiclink
          2. 1ezy picpic
            1. chain a [18540] picpiclink
          3. 1ezt picpic
            1. chain a [18541] picpiclink
      2. RGS9, RGS domain [48101]
        1. Cow (Bos taurus) [TaxId: 9913] [48102] (3)
          1. 1fqi picpic
            1. chain a [18542] picpiclink
          2. 1fqj picpicxrefxrefxref
            complexed with alf, gdp, mg
            1. chain b [18543] picpiclink
            2. chain e [18544] picpiclink
          3. 1fqk picpicxrefxref
            complexed with alf, gdp, mg
            1. chain b [18545] picpiclink
            2. chain d [18546] picpiclink
      3. Galpha interacting protein, GaIP [48103]
        1. Human (Homo sapiens) [TaxId: 9606] [48104] (1)
          1. 1cmz picpic
            1. chain a [18547] picpiclink
      4. Axin RGS-homologous domain [48105]
        1. Human (Homo sapiens) [TaxId: 9606] [48106] (2)
          1. 1dk8 picpic
            complexed with dtt, gol, so4
            1. chain a [18548] picpiclink
          2. 1emu picpic
            Complex with a samp repeat from apc; chain B
            complexed with gol
            1. chain a [18549] picpiclink
      5. p115RhoGEF [63584]
        1. Human (Homo sapiens) [TaxId: 9606] [63585] (1)
          1. 1iap picpic
            N-terminal RGS domain
            1. chain a [62119] picpiclink
      6. Pdz-RhoGEF RGS-like domain [63586]
        contains extra helices in the C-terminal extension
        1. Human (Homo sapiens) [TaxId: 9606] [63587] (1)
          1. 1htj picpic
            mutant
            1. chain f [61254] picpiclink
      7. G-protein coupled receptor kinase 2, N-terminal domain [89090]
        1. Cow (Bos taurus) [TaxId: 9913] [89091] (6)
          1. 1omw picpicxrefxrefxrefxref
            complexed with cmt; mutant
            1. region a:29-185 [87086] picpiclink
          2. 2bcj picpicxrefxrefxrefxrefxrefxref
            automatically matched to d1omwa1
            complexed with ace, alf, gdp, mg; mutant
            1. region a:29-185 [128286] picpiclink
          3. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to d1omwa1
            mutant
            1. region a:29-185 [123685] picpiclink
          4. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to d1omwa1
            mutant
            1. region b:29-185 [123688] picpiclink
          5. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to d1omwa1
            mutant
            1. region c:29-185 [123691] picpiclink
          6. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to d1omwa1
            mutant
            1. region d:29-185 [123694] picpiclink
      8. Regulator of G-protein signaling 18, RGS18 [140750]
        1. Human (Homo sapiens) [TaxId: 9606] [140751] (1)
          SQ Q9NS28 75-206
          1. 2jm5 picpic
            1. region a:3-134 [138355] picpiclink
      9. Regulator of G-protein signaling 16, RGS16 [158689]
        1. Human (Homo sapiens) [TaxId: 9606] [158690] (2)
          SQ O15492 65-184
          1. 2ik8 picpicxrefxrefxrefxref
            complexed with alf, gdp, mg, so4
            1. region b:65-180 [145528] picpiclink
          2. 2ik8 picpicxrefxrefxrefxref
            automatically matched to 2IK8 B:65-180
            complexed with alf, gdp, mg, so4
            1. region d:65-180 [145529] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk