Structural Classification of Proteins
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Family: Classic zinc finger, C2H2

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: beta-beta-alpha zinc fingers [57666]
    simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC
  4. Superfamily: beta-beta-alpha zinc fingers [57667]
    link to SUPERFAMILY database - Superfamily
  5. Family: Classic zinc finger, C2H2 [57668]

Protein Domains:

  1. ZIF268 [57669]
    duplication: consists of 3 fingers
    1. Mouse (Mus musculus) [TaxId: 10090] [57670] (14)
      1. 1a1i picpic
        protein/DNA complex; complexed with zn
        1. region a:103-131 [44998] picpiclink
        2. region a:132-159 [44999] picpiclink
        3. region a:160-187 [45000] picpiclink
      2. 1aay picpic
        protein/DNA complex; complexed with zn
        1. region a:103-131 [45001] picpiclink
        2. region a:132-159 [45002] picpiclink
        3. region a:160-187 [45003] picpiclink
      3. 1a1h picpic
        protein/DNA complex; complexed with zn
        1. region a:103-131 [45004] picpiclink
        2. region a:132-159 [45005] picpiclink
        3. region a:160-187 [45006] picpiclink
      4. 1jk2 picpic
        complexed with zn; mutant
        1. region a:103-131 [66787] picpiclink
        2. region a:132-159 [66788] picpiclink
        3. region a:160-187 [66789] picpiclink
      5. 1a1j picpic
        protein/DNA complex; complexed with zn
        1. region a:103-131 [45016] picpiclink
        2. region a:132-159 [45017] picpiclink
        3. region a:160-186 [45018] picpiclink
      6. 1jk1 picpic
        complexed with zn; mutant
        1. region a:103-131 [66784] picpiclink
        2. region a:132-159 [66785] picpiclink
        3. region a:160-187 [66786] picpiclink
      7. 1a1k picpic
        protein/DNA complex; complexed with zn
        1. region a:103-131 [45007] picpiclink
        2. region a:132-159 [45008] picpiclink
        3. region a:160-187 [45009] picpiclink
      8. 1a1g picpic
        protein/DNA complex; complexed with zn
        1. region a:103-131 [45010] picpiclink
        2. region a:132-159 [45011] picpiclink
        3. region a:160-186 [45012] picpiclink
      9. 1a1f picpic
        protein/DNA complex; complexed with zn
        1. region a:103-131 [45019] picpiclink
        2. region a:132-159 [45020] picpiclink
        3. region a:160-186 [45021] picpiclink
      10. 1a1l picpic
        protein/DNA complex; complexed with zn
        1. region a:103-131 [45022] picpiclink
        2. region a:132-159 [45023] picpiclink
        3. region a:160-187 [45024] picpiclink
      11. 1zaa picpic
        protein/DNA complex; complexed with zn
        1. region c:3-31 [45013] picpiclink
        2. region c:32-59 [45014] picpiclink
        3. region c:60-87 [45015] picpiclink
      12. 1p47 picpic
        complexed with zn2
        1. region a:102-131 [87758] picpiclink
        2. region a:132-159 [87759] picpiclink
        3. region a:160-188 [87760] picpiclink
        4. region b:103-131 [87761] picpiclink
        5. region b:132-159 [87762] picpiclink
        6. region b:160-186 [87763] picpiclink
      13. 1f2i picpic
        complexed with zn
        1. region g:1093-1131 [59613] picpiclink
        2. region g:1132-1158 [59614] picpiclink
        3. region h:2093-2131 [59615] picpiclink
        4. region h:2132-2158 [59616] picpiclink
        5. region i:3093-3131 [59617] picpiclink
        6. region i:3132-3158 [59618] picpiclink
        7. region j:4093-4131 [59619] picpiclink
        8. region j:4132-4158 [59620] picpiclink
        9. region k:5096-5131 [59621] picpiclink
        10. region k:5132-5158 [59622] picpiclink
        11. region l:6093-6131 [59623] picpiclink
        12. region l:6132-6158 [59624] picpiclink
      14. 1llm picpic
        chimera with GCN4 coiled-coil region, C:157-187 and D:257-285
        complexed with zn
        1. region c:101-128 [91059] picpiclink
        2. region c:129-156 [91060] picpiclink
        3. region d:201-228 [91061] picpiclink
        4. region d:229-256 [91062] picpiclink
  2. V(D)J recombination activating protein 1 (RAG1), dimerization domain [57671]
    1. Mouse (Mus musculus) [TaxId: 10090] [57672] (1)
      1. 1rmd picpicxref
        complexed with zn
        1. region a:87-116 [45025] picpiclink
  3. Tramtrack protein (two zinc-finger peptide) [57673]
    1. Drosophila melanogaster [TaxId: 7227] [57674] (1)
      1. 2drp picpic
        protein/DNA complex; complexed with zn
        1. region a:103-139 [45026] picpiclink
        2. region a:140-165 [45027] picpiclink
        3. region d:102-139 [45028] picpiclink
        4. region d:140-166 [45029] picpiclink
  4. ADR1 [57675]
    1. Synthetic, based on Saccharomyces cerevisiae sequence [57676] (5)
      1. 2adr picpic
        complexed with zn; mutant
        1. region a:102-130 [45030] picpiclink
        2. region a:131-161 [45031] picpiclink
      2. 1ard picpic
        N-terminal domain
        complexed with zn
        1. chain a [45033] picpiclink
      3. 1are picpic
        N-terminal domain
        complexed with zn; mutant
        1. chain a [45034] picpiclink
      4. 1arf picpic
        N-terminal domain
        complexed with zn; mutant
        1. chain a [45035] picpiclink
      5. 1paa picpic
        C-terminal domain
        complexed with zn; mutant
        1. chain a [45032] picpiclink
  5. XFIN, third domain [57677]
    1. Xenopus laevis [TaxId: 8355] [57678] (1)
      1. 1znf picpic
        complexed with nh2, zn
        1. chain a [45036] picpiclink
  6. ZFY [57679]
    1. Human (Homo sapiens) [TaxId: 9606] [57680] (5)
      SQ P08048 570-598
      1. 1klr picpic
        ZFY-6T domain
        complexed with zn; mutant
        1. chain a [72722] picpiclink
      2. 7znf picpic
        ZFY-swap domain
        complexed with zn
        1. chain a [45038] picpiclink
      3. 1xrz picpic
        complexed with zn; mutant
        1. chain a [115888] picpiclink
      4. 1kls picpic
        ZFY-6T domain
        complexed with zn; mutant
        1. chain a [72723] picpiclink
      5. 5znf picpic
        ZFY-6T domain
        complexed with zn
        1. chain a [45037] picpiclink
  7. SWI5 zinc-finger domains [57681]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [57682] (2)
      1. 1zfd picpic
        domain 2
        complexed with zn
        1. chain a [45039] picpiclink
      2. 1ncs picpic
        domain 1; has an extension to the common fold at the N-terminus
        complexed with zn
        1. chain a [45040] picpiclink
  8. Five-finger GLI1 [57683]
    1. Human (Homo sapiens) [TaxId: 9606] [57684] (1)
      1. 2gli picpic
        protein/DNA complex; complexed with co
        1. region a:103-134 [45041] picpiclink
        2. region a:135-167 [45042] picpiclink
        3. region a:168-197 [45043] picpiclink
        4. region a:198-228 [45044] picpiclink
        5. region a:229-257 [45045] picpiclink
  9. Enhancer binding protein [57685]
    duplication: consists of two Zn fingers
    1. Human (Homo sapiens) [TaxId: 9606] [57686] (3)
      1. 1bbo picpic
        complexed with aba, zn; mutant
        1. region a:1-28 [45046] picpiclink
        2. region a:29-57 [45047] picpiclink
      2. 4znf picpic
        Single zinc finger
        complexed with zn
        1. chain a [45048] picpiclink
      3. 3znf picpic
        Single zinc finger
        complexed with zn
        1. chain a [45049] picpiclink
  10. Transcription factor sp1 [57687]
    1. Human (Homo sapiens) [TaxId: 9606] [57688] (4)
      1. 1sp2 picpic
        finger 2
        complexed with zn
        1. chain a [45050] picpiclink
      2. 1sp1 picpic
        finger 3
        complexed with zn
        1. chain a [45051] picpiclink
      3. 1va3 picpic
        automatically matched to d1sp1__
        complexed with zn
        1. region a:595-623 [119902] picpiclink
      4. 1va2 picpic
        automatically matched to d1sp2__
        complexed with zn
        1. region a:565-595 [119901] picpiclink
  11. Transactivation domain of cre-bp1/atf-2 [57689]
    1. Human (Homo sapiens) [TaxId: 9606] [57690] (1)
      1. 1bhi picpic
        1. chain a [45052] picpiclink
  12. Ying-yang 1 (yy1, zinc finger domain) [57691]
    duplication: consists of 4 fingers
    1. Human (Homo sapiens) [TaxId: 9606] [57692] (1)
      1. 1ubd picpic
        protein/DNA complex; complexed with zn; mutant
        1. region c:295-322 [45053] picpiclink
        2. region c:323-350 [45054] picpiclink
        3. region c:351-380 [45055] picpiclink
        4. region c:381-408 [45056] picpiclink
  13. Transcription factor IIIA, TFIIIA [57693]
    duplication: consists of 6 fingers
    1. Xenopus laevis [TaxId: 8355] [57694] (9)
      1. 2j7j picpic
        automatically matched to d1un6b1
        complexed with so4, zn
        1. region a:1-28 [147903] picpiclink
      2. 2j7j picpic
        automatically matched to d1tf6a5
        complexed with so4, zn
        1. region a:29-57 [147904] picpiclink
      3. 2j7j picpic
        automatically matched to d1un6b3
        complexed with so4, zn
        1. region a:58-85 [147905] picpiclink
      4. 1un6 picpic
        complexed with mg, zn
        1. region b:104-131 [99649] picpiclink
        2. region b:132-160 [99650] picpiclink
        3. region b:161-190 [99651] picpiclink
        4. region c:104-131 [99652] picpiclink
        5. region c:132-160 [99653] picpiclink
        6. region c:161-190 [99654] picpiclink
        7. region d:133-160 [99655] picpiclink
        8. region d:161-190 [99656] picpiclink
      5. 2hgh picpic
        automatically matched to d1un6b1
        complexed with zn
        1. region a:104-131 [136396] picpiclink
      6. 2hgh picpic
        automatically matched to d1tf6a5
        complexed with zn
        1. region a:132-160 [136397] picpiclink
      7. 2hgh picpic
        automatically matched to d1un6b3
        complexed with zn
        1. region a:161-190 [136398] picpiclink
      8. 1tf3 picpic
        fingers 1-3
        protein/DNA complex; complexed with zn; mutant
        1. region a:1-40 [45057] picpiclink
        2. region a:41-70 [45058] picpiclink
        3. region a:71-101 [45059] picpiclink
      9. 1tf6 picpic
        protein/DNA complex; complexed with zn
        1. region a:10-40 [45060] picpiclink
        2. region a:41-70 [45061] picpiclink
        3. region a:71-100 [45062] picpiclink
        4. region a:101-131 [45063] picpiclink
        5. region a:132-160 [45064] picpiclink
        6. region a:161-188 [45065] picpiclink
        7. region d:7-40 [45066] picpiclink
        8. region d:41-70 [45067] picpiclink
        9. region d:71-100 [45068] picpiclink
        10. region d:101-131 [45069] picpiclink
        11. region d:132-160 [45070] picpiclink
        12. region d:161-188 [45071] picpiclink
  14. GAGA factor [57695]
    1. Drosophila melanogaster [TaxId: 7227] [57696] (2)
      1. 1yuj picpic
        protein/DNA complex; complexed with zn
        1. chain a [45072] picpiclink
      2. 1yui picpic
        protein/DNA complex; complexed with zn
        1. chain a [45073] picpiclink
  15. Kruppel-like factor 3, Bklf [103597]
    1. Mouse (Mus musculus) [TaxId: 10090] [103598] (3)
      1. 1u85 picpic
        complexed with zn; mutant
        1. region a:3-33 [119623] picpiclink
      2. 1p7a picpic
        finger 3
        complexed with zn
        1. chain a [94216] picpiclink
      3. 1u86 picpic
        complexed with zn; mutant
        1. region a:3-35 [119624] picpiclink
  16. Zinc finger protein ZFPM1 (FOG-1) [111434]
    1. Mouse (Mus musculus) [TaxId: 10090] [111435] (1)
      SQ O35615 328-360
      1. 1srk picpic
        complexed with zn; mutant
        1. chain a [105966] picpiclink
  17. Zinc finger protein 295, ZNF295 [118267]
    1. Human (Homo sapiens) [TaxId: 9606] [118268] (1)
      SQ Q9ULJ3 713-806
      1. 1wjp picpic
        Structural genomics target
        complexed with zn
        1. region a:1-42 [114705] picpiclink
        2. region a:43-66 [114706] picpiclink
        3. region a:67-107 [114707] picpiclink
  18. Wilms' tumor protein, WT1 [118269]
    1. Human (Homo sapiens) [TaxId: 9606] [118270] (1)
      SQ P19544 381-408
      1. 1xf7 picpic
        3rd finger
        complexed with zn; mutant
        1. chain a [115244] picpiclink
  19. Zinc finger protein 292, ZNF292 [144133]
    1. Human (Homo sapiens) [TaxId: 9606] [144134] (1)
      SQ O60281 1340-1400
      1. 1x3c picpic
        complexed with zn
        1. region a:8-68 [121660] picpiclink
  20. Zinc finger protein 512, ZNF512 [144135]
    1. Human (Homo sapiens) [TaxId: 9606] [144136] (2)
      SQ Q96ME7 142-194! SQ Q96ME7 195-224
      1. 2ctd picpic
        ZnF 1
        complexed with zn
        1. region a:8-60 [130792] picpiclink
      2. 2ctd picpic
        atypical ZnF "0" with N-terminal helical extension
        complexed with zn
        1. region a:61-90 [130793] picpiclink
  21. Zinc finger protein 462, ZNF462 [144137]
    1. Human (Homo sapiens) [TaxId: 9606] [144138] (1)
      SQ Q96JM2 719-793
      1. 1x6f picpic
        ZnF 6 flanked with unstructured regions
        complexed with zn
        1. region a:8-82 [121742] picpiclink
  22. Zinc finger protein 692, ZNF692 [144139]
    1. Human (Homo sapiens) [TaxId: 9606] [144140] (2)
      SQ Q9BU19 328-357! SQ Q9BU19 358-393
      1. 2dlk picpic
        complexed with zn
        1. region a:8-37 [131558] picpiclink
      2. 2dlk picpic
        complexed with zn
        1. region a:38-73 [131559] picpiclink
  23. Zinc fingers and homeoboxes protein 1, ZHX1 [144141]
    1. Human (Homo sapiens) [TaxId: 9606] [144142] (2)
      SQ Q9UKY1 60-95! SQ Q9UKY1 96-153
      1. 2ghf picpic
        ZnF 2 with extra C-terminal beta-hairpin
        complexed with zn
        1. region a:45-102 [135175] picpiclink
      2. 2ghf picpic
        ZnF 1
        complexed with zn
        1. region a:9-44 [135176] picpiclink
  24. Zinc finger protein 24 [144143]
    1. Human (Homo sapiens) [TaxId: 9606] [144144] (2)
      SQ P17028 272-304! SQ P17028 305-330
      1. 1x6e picpic
        complexed with zn
        1. region a:8-40 [121740] picpiclink
      2. 1x6e picpic
        complexed with zn
        1. region a:41-66 [121741] picpiclink
  25. Zinc finger protein 297b [144145]
    1. Human (Homo sapiens) [TaxId: 9606] [144146] (2)
      SQ O43298 370-422! SQ O43298 423-486
      1. 2csh picpic
        complexed with zn
        1. region a:8-60 [130769] picpiclink
      2. 2csh picpic
        complexed with zn
        1. region a:61-104 [130770] picpiclink
  26. GLI-Krueppel family member HKR3 [144147]
    ZBTB48
    1. Mouse (Mus musculus) [TaxId: 10090] [144148] (4)
      SQ Q1H9T6 284-310! SQ Q1H9T6 311-338! SQ Q1H9T6 339-368! SQ Q1H9T6 369-394
      1. 2dlq picpic
        complexed with zn
        1. region a:93-118 [131562] picpiclink
      2. 2dlq picpic
        complexed with zn
        1. region a:35-62 [131563] picpiclink
      3. 2dlq picpic
        complexed with zn
        1. region a:63-92 [131564] picpiclink
      4. 2dlq picpic
        complexed with zn
        1. region a:8-34 [131565] picpiclink
  27. Zinc finger protein 64, ZFP68 [144149]
    1. Human (Homo sapiens) [TaxId: 9606] [144150] (5)
      SQ Q9NPA5 174-199! SQ Q9NPA5 200-227! SQ Q9NPA5 228-256! SQ Q9NPA5 341-368! SQ Q9NPA5 369-397
      1. 2dmd picpic
        ZnF 2
        complexed with zn
        1. region a:34-61 [131573] picpiclink
      2. 1x5w picpic
        ZnF 7
        complexed with zn
        1. region a:8-35 [121722] picpiclink
      3. 2dmd picpic
        ZnF 1
        complexed with zn
        1. region a:8-33 [131574] picpiclink
      4. 2dmd picpic
        ZnF 3
        complexed with zn
        1. region a:62-90 [131575] picpiclink
      5. 1x5w picpic
        ZnF 8
        complexed with zn
        1. region a:36-64 [121723] picpiclink
  28. Transcriptional repressor CTCF [144153]
    1. Human (Homo sapiens) [TaxId: 9606] [144154] (4)
      SQ P49711 399-434! SQ P49711 435-462! SQ P49711 515-550! SQ P49711 551-587
      1. 2ct1 picpic
        ZnF 7
        complexed with zn
        1. region a:44-71 [130788] picpiclink
      2. 2ct1 picpic
        ZnF 6
        complexed with zn
        1. region a:8-43 [130789] picpiclink
      3. 1x6h picpic
        ZnF 11, atypical
        complexed with zn
        1. region a:44-80 [121743] picpiclink
      4. 1x6h picpic
        ZnF 10
        complexed with zn
        1. region a:8-43 [121744] picpiclink
  29. Zinc finger and SCAN domain-containing protein 16, ZSCAN16 [144155]
    Zinc finger protein 435
    1. Human (Homo sapiens) [TaxId: 9606] [144156] (2)
      SQ Q9H4T2 224-261! SQ Q9H4T2 262-288
      1. 2cot picpic
        complexed with zn
        1. region a:45-71 [130684] picpiclink
      2. 2cot picpic
        complexed with zn
        1. region a:7-44 [130685] picpiclink
  30. PATZ1 [161152]
    Zinc finger protein 278
    1. Human (Homo sapiens) [TaxId: 9606] [161153] (7)
      SQ Q9HBE1 286-338! SQ Q9HBE1 350-384! SQ Q9HBE1 355-379! SQ Q9HBE1 380-409! SQ Q9HBE1 380-411! SQ Q9HBE1 407-445! SQ Q9HBE1 410-436
      1. 2epr picpic
        2nd C2H2 finger
        complexed with zn
        1. region a:350-384 [146973] picpiclink
      2. 2epp picpic
        1st C2H2 finger
        complexed with zn
        1. region a:286-338 [146971] picpiclink
      3. 2epq picpic
        3rd C2H2 finger
        complexed with zn
        1. region a:380-411 [146972] picpiclink
      4. 2eps picpic
        4th C2H2 finger
        complexed with zn
        1. region a:408-446 [146974] picpiclink
      5. 2yt9 picpic
        complexed with zn
        1. region a:417-443 [153755] picpiclink
      6. 2yt9 picpic
        complexed with zn
        1. region a:362-386 [153756] picpiclink
      7. 2yt9 picpic
        complexed with zn
        1. region a:387-416 [153757] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk