Structural Classification of Proteins
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Superfamily: Kringle-like

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Kringle-like [57439]
    disulfide-rich fold; nearly all-beta
  4. Superfamily: Kringle-like [57440]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Kringle modules [57441] (9)
    1. Plasminogen [63400]
      1. Human (Homo sapiens) [TaxId: 9606] [63401] (22)
        1. 1krn picpic
          kringle 4
          complexed with so4
          1. chain a [44629] picpiclink
        2. 5hpg picpic
          kringle 5
          1. chain a [44642] picpiclink
          2. chain b [44643] picpiclink
        3. 1pk4 picpic
          kringle 4
          complexed with so4
          1. chain a [44630] picpiclink
        4. 1ki0 picpic
          Angiostatin: the N-terminal fragment containing three kringles
          complexed with bcn; mutant
          1. region a:81-163 [72493] picpiclink
          2. region a:164-250 [72494] picpiclink
          3. region a:251-333 [72495] picpiclink
        5. 2doh picpic
          automatically matched to d1ki0a1
          complexed with dio; mutant
          1. region x:81-163 [131598] picpiclink
        6. 2doh picpic
          automatically matched to d1ki0a2
          complexed with dio; mutant
          1. region x:164-245 [131599] picpiclink
        7. 1pml picpic
          kringle 4
          complexed with cl
          1. chain a [44632] picpiclink
          2. chain b [44633] picpiclink
          3. chain c [44634] picpiclink
        8. 1tpk picpic
          kringle 2
          complexed with cl
          1. chain a [44637] picpiclink
          2. chain b [44638] picpiclink
          3. chain c [44639] picpiclink
        9. 1cea picpic
          kringle 1
          complexed with aca
          1. chain a [44644] picpiclink
          2. chain b [44645] picpiclink
        10. 2pk4 picpic
          kringle 4
          complexed with aca
          1. chain a [44631] picpiclink
        11. 1pkr picpic
          kringle 1
          complexed with cl
          1. chain a [44646] picpiclink
        12. 1ceb picpic
          kringle 1
          complexed with amh
          1. chain a [44647] picpiclink
          2. chain b [44648] picpiclink
        13. 1i5k picpic
          kringle 2; complexed to an internal peptide from a group A streptococcal surface protein
          mutant
          1. chain a [61789] picpiclink
          2. chain b [61790] picpiclink
        14. 1pmk picpic
          kringle 4
          1. chain a [44635] picpiclink
          2. chain b [44636] picpiclink
        15. 2doi picpic
          automatically matched to d1ki0a1
          mutant
          1. region a:81-163 [131600] picpiclink
        16. 2doi picpic
          automatically matched to d1ki0a2
          mutant
          1. region a:164-244 [131601] picpiclink
        17. 2doi picpic
          automatically matched to d1ki0a1
          mutant
          1. region x:81-163 [131602] picpiclink
        18. 2doi picpic
          automatically matched to d1ki0a2
          mutant
          1. region x:164-245 [131603] picpiclink
        19. 1b2i picpic
          kringle 2
          1. chain a [44640] picpiclink
        20. 1pk2 picpic
          kringle 2
          complexed with aha
          1. chain a [44641] picpiclink
        21. 1hpj picpic
          kringle 1
          1. chain a [44649] picpiclink
        22. 1hpk picpic
          kringle 1
          complexed with aca
          1. chain a [44650] picpiclink
    2. Prothrombin [57448]
      1. Cow (Bos taurus) [TaxId: 9913] [57449] (5)
        1. 1nl1 picpicxref
          complexed with ca, nag
          1. region a:66-147 [91949] picpiclink
        2. 1nl2 picpicxref
          complexed with ca, cl, lps, nag
          1. region a:66-146 [91951] picpiclink
        3. 2pf2 picpicxref
          complexed with ca
          1. region a:66-146 [44651] picpiclink
        4. 2spt picpicxref
          complexed with nag, sr
          1. region a:66-145 [44653] picpiclink
        5. 2pf1 picpicxref
          1. region a:66-156 [44652] picpiclink
    3. Meizothrombin [57450]
      1. Cow (Bos taurus) [TaxId: 9913] [57451] (2)
        1. 2hpp picpicxref
          complexed with ch2
          1. chain p [44654] picpiclink
        2. 1a0h picpicxref
          complexed with ch2, nag
          1. region a:164-270 [44655] picpiclink
          2. region d:164-270 [44656] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [57452] (1)
        1. 2hpq picpicxref
          complexed with ch2
          1. chain p [44657] picpiclink
    4. Urokinase-type plasminogen activator [57453]
      1. Human (Homo sapiens) [TaxId: 9606] [57454] (13)
        1. 2i9a picpicxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with po4
          1. region a:50-132 [137111] picpiclink
        2. 2i9a picpicxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with po4
          1. region b:50-132 [137113] picpiclink
        3. 2i9a picpicxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with po4
          1. region c:50-132 [137115] picpiclink
        4. 2i9a picpicxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with po4
          1. region d:50-132 [137117] picpiclink
        5. 2fd6 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with edo, etx, fuc, nag, pg4, pge, so4
          1. region a:50-132 [133294] picpiclink
        6. 3bt2 picpicxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1urka2
          complexed with nag
          1. region a:50-132 [155541] picpiclink
        7. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with bma, nag, so4; mutant
          1. region a:50-132 [137119] picpiclink
        8. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with bma, nag, so4; mutant
          1. region b:50-132 [137121] picpiclink
        9. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with bma, nag, so4; mutant
          1. region c:50-132 [137123] picpiclink
        10. 2i9b picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1urk_2
          complexed with bma, nag, so4; mutant
          1. region d:50-132 [137125] picpiclink
        11. 3bt1 picpicxrefxrefxrefxrefxref
          automatically matched to d1urka2
          complexed with man, nag
          1. region a:50-132 [155535] picpiclink
        12. 1kdu picpic
          1. chain a [44658] picpiclink
        13. 1urk picpicxref
          complexed with fuc
          1. region a:50-135 [44659] picpiclink
    5. Apolipoprotein A [57455]
      1. Human (Homo sapiens), IV-10/M66 variant [TaxId: 9606] [57456] (3)
        1. 3kiv picpic
          complexed with aca
          1. chain a [44660] picpiclink
        2. 1kiv picpic
          1. chain a [44661] picpiclink
        3. 4kiv picpic
          mutant
          1. chain a [44662] picpiclink
      2. Human (Homo sapiens), IV-6 variant [TaxId: 9606] [75673] (1)
        1. 1jfn picpic
          1. chain a [71660] picpiclink
      3. Human (Homo sapiens), IV-7 variant [TaxId: 9606] [64559] (1)
        1. 1i71 picpic
          complexed with so4
          1. chain a [61864] picpiclink
    6. NK1 fragment of hepatocyte growth factor [57457]
      1. Human (Homo sapiens) [TaxId: 9606] [57458] (7)
        1. 2qj2 picpicxrefxref
          automatically matched to d1bhta2
          complexed with so4
          1. region a:127-209 [150818] picpiclink
        2. 2qj2 picpicxrefxref
          automatically matched to d1bhta2
          complexed with so4
          1. region b:1127-1209 [150820] picpiclink
        3. 1bht picpicxref
          complexed with epe, so4
          1. region a:127-210 [44663] picpiclink
          2. region b:427-509 [44664] picpiclink
        4. 1gmn picpicxref
          complexed with epe, ids, sgn; mutant
          1. region a:126-207 [65316] picpiclink
          2. region b:126-209 [65318] picpiclink
        5. 1gp9 picpicxref
          complexed with epe
          1. region a:126-208 [65443] picpiclink
          2. region b:126-208 [65445] picpiclink
          3. region c:126-208 [65447] picpiclink
          4. region d:126-208 [65449] picpiclink
        6. 1nk1 picpicxref
          mutant
          1. region a:126-209 [44665] picpiclink
          2. region b:126-209 [44666] picpiclink
        7. 1gmo picpicxref
          complexed with epe, ids, sgn, so4; mutant
          1. region a:126-208 [65320] picpiclink
          2. region b:126-208 [65322] picpiclink
          3. region c:126-208 [65324] picpiclink
          4. region d:126-208 [65326] picpiclink
          5. region e:126-209 [65328] picpiclink
          6. region f:126-209 [65330] picpiclink
          7. region g:126-208 [65332] picpiclink
          8. region h:126-208 [65334] picpiclink
  2. Fibronectin type II module [57459] (4)
    shorter two-disulfide version of a kringle module
    1. PDC-109, collagen-binding type II domain [57460]
      1. Cow (Bos taurus) [TaxId: 9913] [57461] (2)
        1. 1h8p picpic
          complexed with poc
          1. region a:22-67 [70916] picpiclink
          2. region a:68-109 [70917] picpiclink
          3. region b:22-67 [70918] picpiclink
          4. region b:68-109 [70919] picpiclink
        2. 1pdc picpic
          1. chain a [44667] picpiclink
    2. Fibronectin [57462]
      1. Human (Homo sapiens) [TaxId: 9606] [57463] (4)
        1. 1e88 picpicxref
          complexed with nag
          1. region a:42-101 [44669] picpiclink
          2. region a:102-160 [44670] picpiclink
        2. 2fn2 picpic
          complexed with nag
          1. chain a [44668] picpiclink
        3. 1qo6 picpicxref
          1. region a:42-101 [44673] picpiclink
        4. 1e8b picpicxref
          complexed with nag
          1. region a:42-101 [44671] picpiclink
          2. region a:102-160 [44672] picpiclink
    3. Gelatinase A (MMP-2) type II modules [57464]
      duplication: tandem repeat of three modules inserted in the catalytic domain
      1. Human (Homo sapiens) [TaxId: 9606] [57465] (6)
        1. 1eak picpicxrefxref
          complexed with ca, so4, zn; mutant
          1. region a:217-277 [70095] picpiclink
          2. region a:278-335 [70096] picpiclink
          3. region a:336-393 [70097] picpiclink
          4. region b:217-277 [70100] picpiclink
          5. region b:278-335 [70101] picpiclink
          6. region b:336-393 [70102] picpiclink
          7. region c:217-277 [70105] picpiclink
          8. region c:278-335 [70106] picpiclink
          9. region c:336-393 [70107] picpiclink
          10. region d:217-277 [70110] picpiclink
          11. region d:278-335 [70111] picpiclink
          12. region d:336-393 [70112] picpiclink
        2. 1ck7 picpicxrefxrefxref
          complexed with ca, cl, na, so4, zn; mutant
          1. region a:217-277 [44674] picpiclink
          2. region a:278-335 [44675] picpiclink
          3. region a:336-393 [44676] picpiclink
        3. 1gxd picpicxrefxrefxrefxref
          complexed with ca, so4, zn; mutant
          1. region a:188-248 [70694] picpiclink
          2. region a:249-308 [70695] picpiclink
          3. region a:309-364 [70696] picpiclink
          4. region b:188-248 [70700] picpiclink
          5. region b:249-308 [70701] picpiclink
          6. region b:309-364 [70702] picpiclink
        4. 1cxw picpic
          second module only
          1. chain a [44677] picpiclink
        5. 1ks0 picpic
          first module only
          1. chain a [68856] picpiclink
        6. 1j7m picpic
          third module only
          mutant
          1. chain a [62699] picpiclink
    4. Gelatinase B (MMP-9) type II modules [75674]
      duplication: tandem repeat of three modules inserted in the catalytic domain
      1. Human (Homo sapiens) [TaxId: 9606] [75675] (1)
        1. 1l6j picpicxrefxref
          complexed with ca, zn
          1. region a:216-274 [73621] picpiclink
          2. region a:275-331 [73622] picpiclink
          3. region a:332-390 [73623] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk