Structural Classification of Proteins

Superfamily: Insulin-like

: uperfamily

Lineage:

Root: scop
Class: Small proteins [56992]
Usually dominated by metal ligand, heme, and/or disulfide bridges
Fold: Insulin-like [56993]
nearly all-alpha
can be classified as disulfide-rich
Superfamily: Insulin-like [56994]
uperfamily

Families:

Insulin-like [56995] (6)
1. Insulin [56996]
  1. Cow (Bos taurus) [TaxId: 9913] [56997] (6)
    1. 1pid
      1. chain b,a [43829]
      2. chain d,c [43830]
    2. 1dph
      complexed with dce, na
      1. chain b,a [43832]
    3. 1cph
      complexed with dce, na
      1. chain b,a [43831]
    4. 1bph
      complexed with dce, na
      1. chain b,a [43833]
    5. 1aph
      complexed with dce
      1. chain b,a [43834]
    6. 2ins
      complexed with zn1, zn2
      1. chain b,a [43835]
      2. chain d,c [43836]
  2. Human (Homo sapiens) [TaxId: 9606] [56998] (60)
    SQ P01308
    1. 1mso
      complexed with zn
      1. chain b,a [85092]
      2. chain d,c [85093]
    2. 1g7a
      complexed with acn, cl, cry, zn
      1. chain b,a [60322]
      2. chain d,c [60323]
      3. chain f,e [60324]
      4. chain h,g [60325]
    3. 1g7b
      complexed with acn, cl, cry, zn
      1. chain b,a [60326]
      2. chain d,c [60327]
      3. chain f,e [60328]
      4. chain h,g [60329]
    4. 1ben
      complexed with cl, hbd, zn
      1. chain b,a [43837]
      2. chain d,c [43838]
    5. 1zeh
      complexed with cl, crs, zn; mutant
      1. chain b,a [43839]
      2. chain d,c [43840]
    6. 1zeg
      complexed with cl, iph, zn; mutant
      1. chain b,a [43841]
      2. chain d,c [43842]
    7. 1guj
      structure at pH 2: the conditions promoting insulin fibre formation
      complexed with so4
      1. chain b,a [70582]
      2. chain d,c [70583]
    8. 1ev3
      complexed with cl, crs, zn
      1. chain b,a [43845]
      2. chain d,c [43846]
    9. 1trz
      complexed with cl, na, zn
      1. chain b,a [43843]
      2. chain d,c [43844]
    10. 1xda
      complexed with cl, iph, myr, zn
      1. chain b,a [43847]
      2. chain d,c [43848]
      3. chain f,e [43849]
      4. chain h,g [43850]
    11. 1evr
      complexed with cl, na, rco, zn
      1. chain b,a [43851]
      2. chain d,c [43852]
      3. chain f,e [43853]
      4. chain h,g [43854]
      5. chain j,i [43855]
      6. chain l,k [43856]
    12. 1ev6
      complexed with cl, crs, na, zn
      1. chain b,a [43857]
      2. chain d,c [43858]
      3. chain f,e [43859]
      4. chain h,g [43860]
      5. chain j,i [43861]
      6. chain l,k [43862]
    13. 1tym
      complexed with cl, tyl, zn
      1. chain b,a [43863]
      2. chain d,c [43864]
    14. 1os3
      complexed with cl, zn
      1. chain b,a [87372]
      2. chain d,c [87373]
    15. 1tyl
      complexed with cl, tyl, zn
      1. chain b,a [43865]
      2. chain d,c [43866]
    16. 1htv
      complexed with zn
      1. chain b,a [61255]
      2. chain d,c [61256]
      3. chain f,e [61257]
      4. chain h,g [61258]
      5. chain j,i [61259]
      6. chain l,k [61260]
    17. 1znj
      complexed with cl, iph, zn
      1. chain b,a [43867]
      2. chain d,c [43868]
      3. chain f,e [43869]
      4. chain h,g [43870]
      5. chain j,i [43871]
      6. chain l,k [43872]
    18. 1qiz
      complexed with cl, rco, zn; mutant
      1. chain b,a [43873]
      2. chain d,c [43874]
      3. chain f,e [43875]
      4. chain h,g [43876]
      5. chain j,i [43877]
      6. chain l,k [43878]
    19. 1q4v
      complexed with iph, zn
      1. chain b,a [95830]
      2. chain d,c [95831]
    20. 1j73
      an unstable insulin analog with native activity
      complexed with dab, zn; mutant
      1. chain b,a [62670]
      2. chain d,c [62671]
    21. 1qiy
      complexed with cl, iph, zn; mutant
      1. chain b,a [43879]
      2. chain d,c [43880]
      3. chain f,e [43881]
      4. chain h,g [43882]
      5. chain j,i [43883]
      6. chain l,k [43884]
    22. 1jca
      an unstable insulin analog with enhanced(?) activity
      complexed with zn; mutant
      1. chain b,a [62874]
      2. chain d,c [62875]
    23. 1b9e
      1. chain b,a [43885]
      2. chain d,c [43886]
    24. 1os4
      complexed with zn
      1. chain b,a [87374]
      2. chain d,c [87375]
      3. chain f,e [87376]
      4. chain h,g [87377]
      5. chain j,i [87378]
      6. chain l,k [87379]
    25. 1qj0
      complexed with cl, zn; mutant
      1. chain b,a [43889]
      2. chain d,c [43890]
    26. 1lph
      complexed with cl, iph, zn; mutant
      1. chain b,a [43887]
      2. chain d,c [43888]
    27. 1efe
      an active mini-proinsulin, m2pi
      1. chain a [43891]
    28. 1fub
      complexed with cl, na, zn
      1. chain b,a [43892]
      2. chain d,c [43893]
    29. 1fu2
      complexed with cl, na, zn
      1. chain b,a [43906]
      2. chain d,c [43907]
      3. chain f,e [43908]
      4. chain h,g [43909]
    30. 2aiy
      complexed with iph
      1. chain b,a [43918]
      2. chain d,c [43919]
      3. chain f,e [43920]
      4. chain h,g [43921]
      5. chain j,i [43922]
      6. chain l,k [43923]
    31. 1hiq
      mutant
      1. chain b,a [43936]
    32. 1hit
      mutant
      1. chain b,a [43937]
    33. 5aiy
      complexed with iph
      1. chain b,a [43894]
      2. chain d,c [43895]
      3. chain f,e [43896]
      4. chain h,g [43897]
      5. chain j,i [43898]
      6. chain l,k [43899]
    34. 1bzv
      superpotent single-replacement insulin analogue
      mutant
      1. chain b,a [43942]
    35. 1his
      1. chain b,a [43938]
    36. 4aiy
      complexed with iph
      1. chain b,a [43900]
      2. chain d,c [43901]
      3. chain f,e [43902]
      4. chain h,g [43903]
      5. chain j,i [43904]
      6. chain l,k [43905]
    37. 1xgl
      1. chain b,a [43939]
    38. 1aiy
      complexed with iph, zn
      1. chain b,a [43930]
      2. chain d,c [43931]
      3. chain f,e [43932]
      4. chain h,g [43933]
      5. chain j,i [43934]
      6. chain l,k [43935]
    39. 1ai0
      complexed with iph, zn
      1. chain b,a [43924]
      2. chain d,c [43925]
      3. chain f,e [43926]
      4. chain h,g [43927]
      5. chain j,i [43928]
      6. chain l,k [43929]
    40. 1hls
      mutant
      1. chain b,a [43910]
    41. 1a7f
      mutant
      1. chain b,a [43943]
    42. 1kmf
      mutant
      1. chain b,a [68694]
    43. 1mhi
      mutant
      1. chain b,a [43945]
    44. 1lnp
      mutant
      1. chain b,a [74048]
    45. 1t1q
      complexed with aba; mutant
      1. chain b,a [106261]
    46. 1lkq
      mutant
      1. chain b,a [73979]
    47. 3aiy
      complexed with iph
      1. chain b,a [43911]
      2. chain d,c [43912]
      3. chain f,e [43913]
      4. chain h,g [43914]
      5. chain j,i [43915]
      6. chain l,k [43916]
    48. 1t1p
      mutant
      1. chain b,a [106260]
    49. 1t1k
      mutant
      1. chain b,a [106251]
    50. 1mhj
      mutant
      1. chain b,a [43947]
    51. 1hui
      mutant
      1. chain b,a [43940]
    52. 1ioh
      mutant
      1. chain b,a [43941]
    53. 1k3m
      mutant
      1. chain b,a [68117]
    54. 2hiu
      1. chain b,a [43948]
    55. 1iog
      mutant
      1. chain b,a [43944]
    56. 1sjt
      mutant
      1. chain b,a [43946]
    57. 1vkt
      mutant
      1. chain b,a [43949]
    58. 1sf1
      solution structure under amyloidogenic condition
      1. chain b,a [98827]
    59. 1jco
      a monomeric mutant (PT insulin)
      Alpha-galactosidase agl1
      mutant
      1. chain b,a [66503]
    60. 1sju
      single chain insulin analog mutant
      1. chain a [43950]
  3. Pig (Sus scrofa) [TaxId: 9823] [56999] (26)
    1. 1m5a
      complexed with co
      1. chain b,a [74491]
      2. chain d,c [74492]
    2. 1zni
      complexed with cl, zn
      1. chain b,a [43955]
      2. chain d,c [43956]
    3. 4ins
      complexed with zn
      1. chain b,a [43951]
      2. chain d,c [43952]
    4. 3ins
      complexed with zn1, zn2
      1. chain b,a [43953]
      2. chain d,c [43954]
    5. 1b17
      complexed with so4
      1. chain b,a [83148]
    6. 1b2d
      complexed with so4
      1. chain b,a [83154]
    7. 1dei
      mutant
      1. chain b,a [43957]
      2. chain d,c [43958]
    8. 9ins
      1. chain b,a [43959]
    9. 1b2a
      complexed with so4
      1. chain b,a [83151]
    10. 1b18
      complexed with so4
      1. chain b,a [83149]
    11. 1b2b
      complexed with so4
      1. chain b,a [83152]
    12. 1b2c
      complexed with so4
      1. chain b,a [83153]
    13. 1b2g
      1. chain b,a [83157]
    14. 1sdb
      1. chain b,a [43960]
    15. 1b2f
      1. chain b,a [83156]
    16. 1b19
      complexed with so4
      1. chain b,a [83150]
    17. 1b2e
      complexed with so4
      1. chain b,a [83155]
    18. 2tci
      complexed with scn, zn
      1. chain b,a [43961]
      2. chain d,c [43962]
    19. 1zei
      cross-linked b28 asp single-chain design
      complexed with cl, crs, zn; mutant
      1. chain a [43963]
      2. chain b [43964]
      3. chain c [43965]
      4. chain d [43966]
      5. chain e [43967]
      6. chain f [43968]
    20. 3mth
      complexed with cl, mpb, zn
      1. chain b,a [43969]
      2. chain d,c [43970]
    21. 1izb
      complexed with zn; mutant
      1. chain b,a [43971]
      2. chain d,c [43972]
    22. 6ins
      complexed with zn
      1. chain f [43973]
      2. chain e [43974]
    23. 7ins
      complexed with crs, zn
      1. chain b,a [43975]
      2. chain d,c [43976]
      3. chain f,e [43977]
    24. 1mpj
      complexed with cl, iph, zn
      1. chain b,a [43978]
      2. chain d,c [43979]
    25. 1iza
      mutant
      1. chain b,a [43980]
      2. chain d,c [43981]
    26. 1wav
      complexed with iph, zn
      1. chain b,a [43982]
      2. chain d,c [43983]
      3. chain f,e [43984]
      4. chain h,g [43985]
      5. chain j,i [43986]
      6. chain l,k [43987]
2. Relaxin [57000]
  1. Human (Homo sapiens) [TaxId: 9606] [57001] (1)
    1. 6rlx
      1. chain b,a [43988]
      2. chain d,c [43989]
3. Insulin-like growth factor [57002]
  1. Human (Homo sapiens) [TaxId: 9606] [57003] (21)
    SQ P05019 49-110
    1. 1wqj
      automatically matched to d1bqt__
      1. region i:2-63 [121169]
    2. 1imx
      complexed with br, cpq
      1. chain a [62593]
    3. 1h59
      complex with IGFBP-5
      1. chain a [70880]
    4. 2dsr
      automatically matched to d1bqt__
      1. region i:2-64 [131698]
    5. 1gzr
      complexed with c15
      1. chain b [70821]
    6. 1h02
      complexed with c15
      1. chain b [70831]
    7. 2dsp
      automatically matched to d1bqt__
      1. region i:2-68 [131695]
    8. 1gzz
      complexed with c15
      1. chain b [70830]
    9. 1gzy
      complexed with c15
      1. chain b [70829]
    10. 2dsq
      automatically matched to d1bqt__
      1. region c:2-63 [131696]
    11. 2dsq
      automatically matched to d1bqt__
      1. region i:2-64 [131697]
    12. 2v5p
      automatically matched to d1igla_
      complexed with bma, nag
      1. region c:6-63 [152578]
    13. 2v5p
      automatically matched to d1igla_
      complexed with bma, nag
      1. region d:6-63 [152579]
    14. 1pmx
      bound to a phage-derived peptide, chain B
      1. chain a [94917]
    15. 3gf1
      1. chain a [43992]
    16. 2gf1
      1. chain a [43990]
    17. 1igl
      1. chain a [43993]
    18. 1bqt
      1. chain a [43994]
    19. 1b9g
      C-region deleted
      1. chain a [43991]
    20. 3lri
      mutant
      1. chain a [43995]
    21. 1tgr
      mini-IGF-IB deletion mutant
      1. chain a [112427]
      2. chain b [112428]
4. Bombyxin-II [57004]
  1. Silkworm (Bombyx mori) [TaxId: 7091] [57005] (2)
    1. 1bon
      1. chain b,a [43997]
    2. 1bom
      1. chain b,a [43996]