Structural Classification of Proteins

Fold: Insulin-like

: nearly all-alpha
can be classified as disulfide-rich

Lineage:

Root: scop
Class: Small proteins [56992]
Usually dominated by metal ligand, heme, and/or disulfide bridges
Fold: Insulin-like [56993]
nearly all-alpha
can be classified as disulfide-rich

Superfamilies:

Insulin-like [56994] (1)
uperfamily
1. Insulin-like [56995] (6)
  1. Insulin [56996]
    1. Cow (Bos taurus) [TaxId: 9913] [56997] (6)
      1. 1pid
        
        chain b,a [43829]
        chain d,c [43830]
      2. 1dph
        complexed with dce, na
        
        chain b,a [43832]
      3. 1cph
        complexed with dce, na
        
        chain b,a [43831]
      4. 1bph
        complexed with dce, na
        
        chain b,a [43833]
      5. 1aph
        complexed with dce
        
        chain b,a [43834]
      6. 2ins
        complexed with zn1, zn2
        
        chain b,a [43835]
        chain d,c [43836]
    2. Human (Homo sapiens) [TaxId: 9606] [56998] (60)
      SQ P01308
      1. 1mso
        complexed with zn
        
        chain b,a [85092]
        chain d,c [85093]
      2. 1g7a
        complexed with acn, cl, cry, zn
        
        chain b,a [60322]
        chain d,c [60323]
        chain f,e [60324]
        chain h,g [60325]
      3. 1g7b
        complexed with acn, cl, cry, zn
        
        chain b,a [60326]
        chain d,c [60327]
        chain f,e [60328]
        chain h,g [60329]
      4. 1ben
        complexed with cl, hbd, zn
        
        chain b,a [43837]
        chain d,c [43838]
      5. 1zeh
        complexed with cl, crs, zn; mutant
        
        chain b,a [43839]
        chain d,c [43840]
      6. 1zeg
        complexed with cl, iph, zn; mutant
        
        chain b,a [43841]
        chain d,c [43842]
      7. 1guj
        structure at pH 2: the conditions promoting insulin fibre formation
        complexed with so4
        
        chain b,a [70582]
        chain d,c [70583]
      8. 1ev3
        complexed with cl, crs, zn
        
        chain b,a [43845]
        chain d,c [43846]
      9. 1trz
        complexed with cl, na, zn
        
        chain b,a [43843]
        chain d,c [43844]
      10. 1xda
        complexed with cl, iph, myr, zn
        
        chain b,a [43847]
        chain d,c [43848]
        chain f,e [43849]
        chain h,g [43850]
      11. 1evr
        complexed with cl, na, rco, zn
        
        chain b,a [43851]
        chain d,c [43852]
        chain f,e [43853]
        chain h,g [43854]
        chain j,i [43855]
        chain l,k [43856]
      12. 1ev6
        complexed with cl, crs, na, zn
        
        chain b,a [43857]
        chain d,c [43858]
        chain f,e [43859]
        chain h,g [43860]
        chain j,i [43861]
        chain l,k [43862]
      13. 1tym
        complexed with cl, tyl, zn
        
        chain b,a [43863]
        chain d,c [43864]
      14. 1os3
        complexed with cl, zn
        
        chain b,a [87372]
        chain d,c [87373]
      15. 1tyl
        complexed with cl, tyl, zn
        
        chain b,a [43865]
        chain d,c [43866]
      16. 1htv
        complexed with zn
        
        chain b,a [61255]
        chain d,c [61256]
        chain f,e [61257]
        chain h,g [61258]
        chain j,i [61259]
        chain l,k [61260]
      17. 1znj
        complexed with cl, iph, zn
        
        chain b,a [43867]
        chain d,c [43868]
        chain f,e [43869]
        chain h,g [43870]
        chain j,i [43871]
        chain l,k [43872]
      18. 1qiz
        complexed with cl, rco, zn; mutant
        
        chain b,a [43873]
        chain d,c [43874]
        chain f,e [43875]
        chain h,g [43876]
        chain j,i [43877]
        chain l,k [43878]
      19. 1q4v
        complexed with iph, zn
        
        chain b,a [95830]
        chain d,c [95831]
      20. 1j73
        an unstable insulin analog with native activity
        complexed with dab, zn; mutant
        
        chain b,a [62670]
        chain d,c [62671]
      21. 1qiy
        complexed with cl, iph, zn; mutant
        
        chain b,a [43879]
        chain d,c [43880]
        chain f,e [43881]
        chain h,g [43882]
        chain j,i [43883]
        chain l,k [43884]
      22. 1jca
        an unstable insulin analog with enhanced(?) activity
        complexed with zn; mutant
        
        chain b,a [62874]
        chain d,c [62875]
      23. 1b9e
        
        chain b,a [43885]
        chain d,c [43886]
      24. 1os4
        complexed with zn
        
        chain b,a [87374]
        chain d,c [87375]
        chain f,e [87376]
        chain h,g [87377]
        chain j,i [87378]
        chain l,k [87379]
      25. 1qj0
        complexed with cl, zn; mutant
        
        chain b,a [43889]
        chain d,c [43890]
      26. 1lph
        complexed with cl, iph, zn; mutant
        
        chain b,a [43887]
        chain d,c [43888]
      27. 1efe
        an active mini-proinsulin, m2pi
        
        chain a [43891]
      28. 1fub
        complexed with cl, na, zn
        
        chain b,a [43892]
        chain d,c [43893]
      29. 1fu2
        complexed with cl, na, zn
        
        chain b,a [43906]
        chain d,c [43907]
        chain f,e [43908]
        chain h,g [43909]
      30. 2aiy
        complexed with iph
        
        chain b,a [43918]
        chain d,c [43919]
        chain f,e [43920]
        chain h,g [43921]
        chain j,i [43922]
        chain l,k [43923]
      31. 1hiq
        mutant
        
        chain b,a [43936]
      32. 1hit
        mutant
        
        chain b,a [43937]
      33. 5aiy
        complexed with iph
        
        chain b,a [43894]
        chain d,c [43895]
        chain f,e [43896]
        chain h,g [43897]
        chain j,i [43898]
        chain l,k [43899]
      34. 1bzv
        superpotent single-replacement insulin analogue
        mutant
        
        chain b,a [43942]
      35. 1his
        
        chain b,a [43938]
      36. 4aiy
        complexed with iph
        
        chain b,a [43900]
        chain d,c [43901]
        chain f,e [43902]
        chain h,g [43903]
        chain j,i [43904]
        chain l,k [43905]
      37. 1xgl
        
        chain b,a [43939]
      38. 1aiy
        complexed with iph, zn
        
        chain b,a [43930]
        chain d,c [43931]
        chain f,e [43932]
        chain h,g [43933]
        chain j,i [43934]
        chain l,k [43935]
      39. 1ai0
        complexed with iph, zn
        
        chain b,a [43924]
        chain d,c [43925]
        chain f,e [43926]
        chain h,g [43927]
        chain j,i [43928]
        chain l,k [43929]
      40. 1hls
        mutant
        
        chain b,a [43910]
      41. 1a7f
        mutant
        
        chain b,a [43943]
      42. 1kmf
        mutant
        
        chain b,a [68694]
      43. 1mhi
        mutant
        
        chain b,a [43945]
      44. 1lnp
        mutant
        
        chain b,a [74048]
      45. 1t1q
        complexed with aba; mutant
        
        chain b,a [106261]
      46. 1lkq
        mutant
        
        chain b,a [73979]
      47. 3aiy
        complexed with iph
        
        chain b,a [43911]
        chain d,c [43912]
        chain f,e [43913]
        chain h,g [43914]
        chain j,i [43915]
        chain l,k [43916]
      48. 1t1p
        mutant
        
        chain b,a [106260]
      49. 1t1k
        mutant
        
        chain b,a [106251]
      50. 1mhj
        mutant
        
        chain b,a [43947]
      51. 1hui
        mutant
        
        chain b,a [43940]
      52. 1ioh
        mutant
        
        chain b,a [43941]
      53. 1k3m
        mutant
        
        chain b,a [68117]
      54. 2hiu
        
        chain b,a [43948]
      55. 1iog
        mutant
        
        chain b,a [43944]
      56. 1sjt
        mutant
        
        chain b,a [43946]
      57. 1vkt
        mutant
        
        chain b,a [43949]
      58. 1sf1
        solution structure under amyloidogenic condition
        
        chain b,a [98827]
      59. 1jco
        a monomeric mutant (PT insulin)
        Alpha-galactosidase agl1
        mutant
        
        chain b,a [66503]
      60. 1sju
        single chain insulin analog mutant
        
        chain a [43950]
    3. Pig (Sus scrofa) [TaxId: 9823] [56999] (26)
      1. 1m5a
        complexed with co
        
        chain b,a [74491]
        chain d,c [74492]
      2. 1zni
        complexed with cl, zn
        
        chain b,a [43955]
        chain d,c [43956]
      3. 4ins
        complexed with zn
        
        chain b,a [43951]
        chain d,c [43952]
      4. 3ins
        complexed with zn1, zn2
        
        chain b,a [43953]
        chain d,c [43954]
      5. 1b17
        complexed with so4
        
        chain b,a [83148]
      6. 1b2d
        complexed with so4
        
        chain b,a [83154]
      7. 1dei
        mutant
        
        chain b,a [43957]
        chain d,c [43958]
      8. 9ins
        
        chain b,a [43959]
      9. 1b2a
        complexed with so4
        
        chain b,a [83151]
      10. 1b18
        complexed with so4
        
        chain b,a [83149]
      11. 1b2b
        complexed with so4
        
        chain b,a [83152]
      12. 1b2c
        complexed with so4
        
        chain b,a [83153]
      13. 1b2g
        
        chain b,a [83157]
      14. 1sdb
        
        chain b,a [43960]
      15. 1b2f
        
        chain b,a [83156]
      16. 1b19
        complexed with so4
        
        chain b,a [83150]
      17. 1b2e
        complexed with so4
        
        chain b,a [83155]
      18. 2tci
        complexed with scn, zn
        
        chain b,a [43961]
        chain d,c [43962]
      19. 1zei
        cross-linked b28 asp single-chain design
        complexed with cl, crs, zn; mutant
        
        chain a [43963]
        chain b [43964]
        chain c [43965]
        chain d [43966]
        chain e [43967]
        chain f [43968]
      20. 3mth
        complexed with cl, mpb, zn
        
        chain b,a [43969]
        chain d,c [43970]
      21. 1izb
        complexed with zn; mutant
        
        chain b,a [43971]
        chain d,c [43972]
      22. 6ins
        complexed with zn
        
        chain f [43973]
        chain e [43974]
      23. 7ins
        complexed with crs, zn
        
        chain b,a [43975]
        chain d,c [43976]
        chain f,e [43977]
      24. 1mpj
        complexed with cl, iph, zn
        
        chain b,a [43978]
        chain d,c [43979]
      25. 1iza
        mutant
        
        chain b,a [43980]
        chain d,c [43981]
      26. 1wav
        complexed with iph, zn
        
        chain b,a [43982]
        chain d,c [43983]
        chain f,e [43984]
        chain h,g [43985]
        chain j,i [43986]
        chain l,k [43987]
  2. Relaxin [57000]
    1. Human (Homo sapiens) [TaxId: 9606] [57001] (1)
      1. 6rlx
        
        chain b,a [43988]
        chain d,c [43989]
  3. Insulin-like growth factor [57002]
    1. Human (Homo sapiens) [TaxId: 9606] [57003] (21)
      SQ P05019 49-110
      1. 1wqj
        automatically matched to d1bqt__
        
        region i:2-63 [121169]
      2. 1imx
        complexed with br, cpq
        
        chain a [62593]
      3. 1h59
        complex with IGFBP-5
        
        chain a [70880]
      4. 2dsr
        automatically matched to d1bqt__
        
        region i:2-64 [131698]
      5. 1gzr
        complexed with c15
        
        chain b [70821]
      6. 1h02
        complexed with c15
        
        chain b [70831]
      7. 2dsp
        automatically matched to d1bqt__
        
        region i:2-68 [131695]
      8. 1gzz
        complexed with c15
        
        chain b [70830]
      9. 1gzy
        complexed with c15
        
        chain b [70829]
      10. 2dsq
        automatically matched to d1bqt__
        
        region c:2-63 [131696]
      11. 2dsq
        automatically matched to d1bqt__
        
        region i:2-64 [131697]
      12. 2v5p
        automatically matched to d1igla_
        complexed with bma, nag
        
        region c:6-63 [152578]
      13. 2v5p
        automatically matched to d1igla_
        complexed with bma, nag
        
        region d:6-63 [152579]
      14. 1pmx
        bound to a phage-derived peptide, chain B
        
        chain a [94917]
      15. 3gf1
        
        chain a [43992]
      16. 2gf1
        
        chain a [43990]
      17. 1igl
        
        chain a [43993]
      18. 1bqt
        
        chain a [43994]
      19. 1b9g
        C-region deleted
        
        chain a [43991]
      20. 3lri
        mutant
        
        chain a [43995]
      21. 1tgr
        mini-IGF-IB deletion mutant
        
        chain a [112427]
        chain b [112428]
  4. Bombyxin-II [57004]
    1. Silkworm (Bombyx mori) [TaxId: 7091] [57005] (2)
      1. 1bon
        
        chain b,a [43997]
      2. 1bom
        
        chain b,a [43996]