Structural Classification of Proteins
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Family: beta-Lactamase/D-ala carboxypeptidase

Lineage:

  1. Root: scop
  2. Class: Multi-domain proteins (alpha and beta) [56572]
    Folds consisting of two or more domains belonging to different classes
  3. Fold: beta-lactamase/transpeptidase-like [56600]
    contains a cluster of helices and an alpha+beta sandwich
  4. Superfamily: beta-lactamase/transpeptidase-like [56601]
    link to SUPERFAMILY database - Superfamily
  5. Family: beta-Lactamase/D-ala carboxypeptidase [56602]

Protein Domains:

  1. D-ala carboxypeptidase/transpeptidase [56603]
    1. Streptomyces sp., K15 [TaxId: 1931] [56604] (7) picpic
    2. Streptomyces sp., R61 [TaxId: 1931] [56605] (15) picpic
      SQ P15555 34-378 ! SQ P15555
  2. Esterase EstB [69873]
    1. Burkholderia gladioli [TaxId: 28095] [69874] (2) picpic
  3. beta-Lactamase, class A [56606]
    1. Escherichia coli, TEM-1 [TaxId: 562] [56607] (35) picpic
    2. Klebsiella pneumoniae, TEM52 [TaxId: 573] [64473] (1) picpic
    3. Escherichia coli, TOHO-1 [TaxId: 562] [56608] (5) picpic
    4. Proteus vulgaris [TaxId: 585] [75596] (1) picpic
    5. Klebsiella pneumoniae, SHV-1 [TaxId: 573] [56609] (15) picpic
      SQ Q5PSW7 ! SQ P14557 22-286
      inhibited by tazobactam
    6. Klebsiella pneumoniae, SHV-2 [TaxId: 573] [90082] (1) picpic
      almost identical sequence to SHV-1
    7. Pseudomonas aeruginosa, PSE-4 carbenicillinase [TaxId: 287] [56610] (2) picpic
    8. Staphylococcus aureus [TaxId: 1280] [56611] (16) picpic
    9. Bacillus licheniformis [TaxId: 1402] [56612] (5) picpic
    10. Enterobacter cloacae, NMC-A carbapenemase [TaxId: 550] [56613] (2) picpic
    11. Streptomyces albus G [TaxId: 1962] [56614] (1) picpic
    12. Mycobacterium fortuitum [TaxId: 1766] [56615] (1) picpic
    13. Pseudomonas aeruginosa, PER-1 [TaxId: 287] [56616] (1) picpic
    14. Serratia marcescens, Sme-1 [TaxId: 615] [56617] (1) picpic
      imipenem-hydrolyzing
    15. Stenotrophomonas maltophilia, L2 [TaxId: 40324] [103374] (2) picpic
  4. AMPC beta-Lactamase, class C [56618]
    contains small alpha+beta subdomain inserted in the common fold
    1. Citrobacter freundii [TaxId: 546] [56619] (3) picpic
    2. Enterobacter cloacae, P99, cephalosporinase [TaxId: 550] [56620] (10) picpic
      SQ P05364 22-380 ! SQ P05364 22-381
    3. Escherichia coli, cephalosporinase [TaxId: 562] [56621] (60) picpic
  5. Class D beta-lactamase [56622]
    1. Escherichia coli, OXA-1 [TaxId: 562] [82837] (1) picpic
    2. Salmonella typhimurium, OXA-2 [TaxId: 90371] [90083] (1) picpic
    3. Pseudomonas aeruginosa, OXA-10 [TaxId: 287] [56623] (12) picpic
    4. Pseudomonas aeruginosa, OXA-13 [TaxId: 287] [64474] (3) picpic
  6. Penicillin receptor BlaR, C-terminal domain [103375]
    closely related to class D beta-lactamase
    1. Bacillus licheniformis [TaxId: 1402] [103376] (1) picpic
  7. Penicillin-binding protein 2x (pbp-2x), transpeptidase domain [56624]
    1. Streptococcus pneumoniae [TaxId: 1313] [56625] (14) picpic
  8. Penicillin binding protein 2a (PBP2A), C-terminal domain [82838]
    1. Staphylococcus aureus [TaxId: 1280] [82839] (5) picpic
      SQ O54286 27-668
  9. Penicillin-binding protein 5, N-terminal domain [69875]
    1. Escherichia coli [TaxId: 562] [69876] (8) picpic
  10. D-aminopeptidase, N-terminal domain [56626]
    1. Ochrobactrum anthropi [TaxId: 529] [56627] (1) picpic
  11. Pencillin binding protein 4 (PbpD), N-terminal domain [111287]
    1. Staphylococcus aureus [TaxId: 1280] [111288] (1) picpic
      SQ Q53613 21-383
  12. Regulatory protein BlaR1 [111289]
    1. Staphylococcus aureus [TaxId: 1280] [111290] (3) picpic
      SQ P18357 338-582 ! SQ P18357 334-581 ! SQ P18357 338-583
  13. D,D-carboxypeptidase DacA, N-terminal domain [118181]
    1. Streptococcus pneumoniae [TaxId: 1313] [118182] (1) picpic
      SQ P72518 25-393
  14. Penicillin-binding protein 1a, transpeptidase domain [144034]
    1. Streptococcus pneumoniae [TaxId: 1313] [144035] (2) picpic
      SQ Q8DR59 266-650! SQ Q8DR59 267-650
  15. Penicillin-binding protein 1b, transpeptidase domain [144036]
    1. Streptococcus pneumoniae [TaxId: 1313] [144037] (3) picpic
      SQ O70038 337-789! SQ O70038 337-791
  16. D-Amino acid amidase DaaA [144038]
    1. Ochrobactrum anthropi [TaxId: 529] [144039] (24) picpic
      SQ Q9LCC8 2-363
  17. Penicillin-binding protein 2, PBP2 [160970]
    1. Staphylococcus aureus [TaxId: 1280] [160971] (7) picpic
      SQ Q2YY56 293-692
  18. 6-aminohexanoate-dimer hydrolase NylC [160972]
    NylB'
    1. Flavobacterium sp. [TaxId: 239] [160973] (3) picpic
      SQ P07062 5-392
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk