Structural Classification of Proteins

Family: Reverse transcriptase

Lineage:

Root: scop
Class: Multi-domain proteins (alpha and beta) [56572]
Folds consisting of two or more domains belonging to different classes
Fold: DNA/RNA polymerases [56671]
divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
Superfamily: DNA/RNA polymerases [56672]
"palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
uperfamily
Family: Reverse transcriptase [56686]

Protein Domains:

MMLV reverse transcriptase [56687]
1. Moloney murine leukemia virus, MoMLV [TaxId: 11801] [56688] (22)
  SQ P03355 RE 144-594
  1. 1ztw
    automatically matched to d1d0ea_
    1. region a:24-278 [125657]
  2. 2fjx
    automatically matched to d1d0ea_
    complexed with hxl
    1. region a:24-278 [133625]
  3. 1ztt
    automatically matched to d1d0ea_
    complexed with nt
    1. region a:24-278 [125656]
  4. 1mml
    fragment of "palm" and "fingers" domains
    1. chain a [43015]
  5. 1i6j
    fragment of "palm" and "fingers" domains
    1. chain a [61845]
  6. 2r2t
    automatically matched to d1d0ea_
    1. region a:24-278 [151539]
  7. 2fjw
    automatically matched to d1d0ea_
    mutant
    1. region a:24-278 [133624]
  8. 2fjv
    automatically matched to d1d0ea_
    complexed with hxl
    1. region a:24-278 [133623]
  9. 2fvr
    automatically matched to d1d0ea_
    1. region a:24-278 [134223]
  10. 1n4l
    fragment of "palm" and "fingers" domains
    1. chain a [85323]
  11. 2r2r
    automatically matched to d1d0ea_
    1. region a:24-278 [151537]
  12. 1nnd
    mutant
    1. chain a [92002]
  13. 2fvp
    automatically matched to d1d0ea_
    1. region a:24-278 [134221]
  14. 1qaj
    fragment of "palm" and "fingers" domains
    protein/DNA complex
    1. chain a [43016]
    2. chain b [43017]
  15. 2r2u
    automatically matched to d1d0ea_
    complexed with btz
    1. region a:24-278 [151540]
  16. 2fvq
    automatically matched to d1d0ea_
    1. region a:24-278 [134222]
  17. 2fvs
    automatically matched to d1d0ea_
    1. region a:24-278 [134224]
  18. 1d1u
    fragment of "palm" and "fingers" domains
    protein/DNA complex
    1. chain a [43018]
  19. 1qai
    fragment of "palm" and "fingers" domains
    protein/DNA complex; complexed with hg
    1. chain a [43019]
    2. chain b [43020]
  20. 2r2s
    automatically matched to d1d0ea_
    complexed with 3co, blb
    1. region a:24-278 [151538]
  21. 1d0e
    fragment of "palm" and "fingers" domains
    protein/DNA complex
    1. chain a [43021]
    2. chain b [43022]
  22. 1rw3
    'full length enzyme' fragment
    mutant
    1. chain a [105112]
HIV-1 reverse transcriptase [56689]
1. Human immunodeficiency virus type 1 [TaxId: 11676] [56690] (191)
  SQ P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! SQ P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! SQ P04585 158-698 # chain A coverage; chain B is shorter: 159-595
  1. 2zd1
    automatically matched to d1bqmb_
    complexed with edo, so4, t27; mutant
    1. region b:5-428 [154388]
  2. 3dlk
    automatically matched to d1bqmb_
    complexed with so4; mutant
    1. region b:6-428 [157774]
  3. 3bgr
    automatically matched to d1bqmb_
    complexed with edo, t27; mutant
    1. region b:5-428 [155252]
  4. 1har
    fragment of "palm" and "fingers" domains
    1. chain a [43025]
  5. 3dlg
    automatically matched to d1c1cb_
    complexed with gwe, po4
    1. region b:7-428 [157773]
  6. 1vrt
    complexed with cya, mg, nev
    1. region a:4-429 [43023]
  7. 1vrt
    complexed with cya, mg, nev
    1. chain b [43024]
  8. 1s1t
    complexed with po4, uc1; mutant
    1. region a:3-429 [105206]
    2. region b:4-429 [105207]
  9. 2rki
    automatically matched to d1c1cb_
    complexed with cl, gol, mg, so4, tt1
    1. region a:5-440 [152109]
  10. 2rki
    automatically matched to d1c1cb_
    complexed with cl, gol, mg, so4, tt1
    1. region b:6-428 [152110]
  11. 2ops
    automatically matched to d1c1cb_
    complexed with hbq, po4; mutant
    1. region a:5-440 [148968]
  12. 2ops
    automatically matched to d1c1cb_
    complexed with hbq, po4; mutant
    1. region b:6-440 [148969]
  13. 1c1b
    complexed with gca
    1. chain b [43077]
  14. 1c1b
    complexed with gca
    1. region a:1-429 [43076]
  15. 3dle
    automatically matched to d1c1cb_
    complexed with gfa
    1. region b:5-428 [157772]
  16. 3dol
    automatically matched to d1c1cb_
    complexed with gwi, po4; mutant
    1. region b:5-428 [157820]
  17. 1vru
    complexed with aap, cya
    1. chain b [43027]
  18. 1vru
    complexed with aap, cya
    1. region a:3-429 [43026]
  19. 1jla
    complexed with tnk; mutant
    1. region a:1-429 [66834]
  20. 1jla
    complexed with tnk; mutant
    1. chain b [66835]
  21. 1rt1
    complexed with mkc
    1. region a:1-429 [43030]
    2. region b:6-431 [43031]
  22. 2be2
    automatically matched to d1bqmb_
    complexed with gol, mn, r22, suc; mutant
    1. region b:4-427 [128348]
  23. 3di6
    automatically matched to d1c1cb_
    complexed with pdz
    1. region a:5-440 [157743]
  24. 3di6
    automatically matched to d1c1cb_
    complexed with pdz
    1. region b:5-428 [157744]
  25. 1rth
    complexed with cya, u05
    1. region a:1-429 [43028]
    2. region b:3-431 [43029]
  26. 2opp
    automatically matched to d1c1cb_
    complexed with hbq, mg, po4
    1. region b:5-431 [139213]
  27. 1eet
    complexed with bfu; mutant
    1. region a:1-429 [43078]
  28. 1eet
    complexed with bfu; mutant
    1. chain b [43079]
  29. 2opp
    automatically matched to d1c1cb_
    complexed with hbq, mg, po4
    1. region a:5-440 [145725]
  30. 2rf2
    automatically matched to d1c1cb_
    complexed with mrx
    1. region a:5-440 [151993]
  31. 2rf2
    automatically matched to d1c1cb_
    complexed with mrx
    1. region b:5-428 [151994]
  32. 1jkh
    complexed with efz; mutant
    1. chain b [66799]
  33. 1jkh
    complexed with efz; mutant
    1. region a:2-429 [66798]
  34. 1c0u
    complexed with bm5
    1. chain b [43085]
  35. 1ikx
    complexed with pnu; mutant
    1. region a:1-429 [62534]
  36. 1ikx
    complexed with pnu; mutant
    1. chain b [62535]
  37. 1c0u
    complexed with bm5
    1. region a:1-429 [43084]
  38. 1rt2
    complexed with tnk
    1. region a:1-429 [43032]
  39. 1rt2
    complexed with tnk
    1. chain b [43033]
  40. 1tkt
    complexed with h12, mg, po4
    1. region a:7-427 [112483]
    2. region b:7-427 [112484]
  41. 1rev
    complexed with mg, trb
    1. region a:4-429 [43036]
  42. 1rev
    complexed with mg, trb
    1. chain b [43037]
  43. 1c0t
    complexed with bm1
    1. region a:4-429 [43082]
  44. 1c0t
    complexed with bm1
    1. chain b [43083]
  45. 1fk9
    complexed with efz
    1. region a:4-429 [43080]
  46. 1fk9
    complexed with efz
    1. chain b [43081]
  47. 1klm
    complexed with spp
    1. region a:2-429 [43038]
  48. 1klm
    complexed with spp
    1. chain b [43039]
  49. 1c1c
    complexed with 612
    1. region a:1-429 [43086]
  50. 1c1c
    complexed with 612
    1. chain b [43087]
  51. 2b6a
    automatically matched to d1bqmb_
    complexed with t50; mutant
    1. region b:1-427 [127975]
  52. 1lwc
    complexed with csd, nvp, po4; mutant
    1. chain b [78264]
  53. 1lwc
    complexed with csd, nvp, po4; mutant
    1. region a:4-429 [78263]
  54. 1s1w
    complexed with uc1; mutant
    1. region a:4-429 [105215]
    2. region b:5-428 [105216]
  55. 1jlg
    complexed with uc1; mutant
    1. chain b [66850]
  56. 1jlg
    complexed with uc1; mutant
    1. region a:2-429 [66849]
  57. 1s1v
    complexed with tnk; mutant
    1. region a:1-429 [105212]
    2. region b:6-429 [105213]
  58. 1hmv
    complexed with mg
    1. region a:1-429 [43046]
  59. 1hmv
    duplicate of 1HMV A:1-429
    complexed with mg
    1. region c:1-429 [118503]
  60. 1hmv
    duplicate of 1HMV A:1-429
    complexed with mg
    1. region e:1-429 [118506]
  61. 1hmv
    duplicate of 1HMV A:1-429
    complexed with mg
    1. region g:1-429 [118509]
  62. 1hmv
    complexed with mg
    1. chain b [43047]
  63. 1hmv
    duplicate of 1HMV B
    complexed with mg
    1. chain d [118504]
  64. 1hmv
    duplicate of 1HMV B
    complexed with mg
    1. chain f [118507]
  65. 1hmv
    duplicate of 1HMV B
    complexed with mg
    1. chain h [118510]
  66. 1rtj
    complexed with cya
    1. region a:1-429 [43034]
    2. region b:2-431 [43035]
  67. 1tkx
    complexed with gwb
    1. region a:7-427 [112486]
    2. region b:7-427 [112487]
  68. 3drp
    automatically matched to d1c1cb_
    complexed with r8e
    1. region a:5-440 [157830]
  69. 3drp
    automatically matched to d1c1cb_
    complexed with r8e
    1. region b:6-428 [157831]
  70. 1lwe
    complexed with csd, nvp, po4; mutant
    1. chain b [78269]
  71. 1ep4
    complexed with s11
    1. region a:4-429 [43092]
  72. 1ep4
    complexed with s11
    1. chain b [43093]
  73. 1lwe
    complexed with csd, nvp, po4; mutant
    1. region a:1-429 [78268]
  74. 1dtt
    complexed with ftc
    1. chain b [43089]
  75. 1dtt
    complexed with ftc
    1. region a:1-429 [43088]
  76. 1tl3
    complexed with h20, po4
    1. region a:7-427 [112497]
    2. region b:7-427 [112498]
  77. 1tkz
    complexed with h16, po4
    1. region a:7-427 [112491]
    2. region b:7-427 [112492]
  78. 1jlf
    complexed with nvp; mutant
    1. chain b [66847]
  79. 1jlf
    complexed with nvp; mutant
    1. region a:1-429 [66846]
  80. 1ikw
    complexed with efz; mutant
    1. region a:1-429 [62531]
  81. 1ikw
    complexed with efz; mutant
    1. chain b [62532]
  82. 1iky
    complexed with msd; mutant
    1. chain b [62538]
  83. 1iky
    complexed with msd; mutant
    1. region a:1-429 [62537]
  84. 1rt6
    complexed with po4, uc3
    1. region a:1-429 [43090]
    2. region b:6-431 [43091]
  85. 1fko
    complexed with efz; mutant
    1. region a:1-429 [43094]
  86. 1fko
    complexed with efz; mutant
    1. chain b [43095]
  87. 1rt4
    complexed with po4, uc1
    1. chain b [43101]
  88. 1rt4
    complexed with po4, uc1
    1. region a:1-429 [43100]
  89. 1rt5
    complexed with po4, uc2
    1. chain b [43103]
  90. 1rt5
    complexed with po4, uc2
    1. region a:1-429 [43102]
  91. 1rti
    complexed with cya, hef
    1. region a:1-429 [43042]
    2. region b:5-431 [43043]
  92. 3dm2
    automatically matched to d1fkpb_
    complexed with gwe, po4; mutant
    1. region b:7-428 [157803]
  93. 2opq
    automatically matched to d1s1tb1
    complexed with hbq, po4; mutant
    1. region b:5-428 [139214]
  94. 1jlb
    complexed with nvp; mutant
    1. region a:1-429 [66837]
  95. 1jlb
    complexed with nvp; mutant
    1. chain b [66838]
  96. 1lw0
    complexed with csd, nvp, po4; mutant
    1. region a:4-429 [78249]
  97. 1lw0
    complexed with csd, nvp, po4; mutant
    1. chain b [78250]
  98. 1lwf
    complexed with csd, nvp; mutant
    1. chain b [78272]
  99. 1lwf
    complexed with csd, nvp; mutant
    1. region a:1-429 [78271]
  100. 1dlo
    mutant
    1. chain b [43041]
  101. 1dlo
    mutant
    1. region a:1-429 [43040]
  102. 1s1x
    complexed with nvp; mutant
    1. region a:2-429 [105218]
    2. region b:6-428 [105219]
  103. 1dtq
    complexed with fpt
    1. chain b [43097]
  104. 1dtq
    complexed with fpt
    1. region a:4-429 [43096]
  105. 3c6t
    automatically matched to d1c1cb_
    complexed with m14
    1. region a:5-440 [155989]
  106. 3c6t
    automatically matched to d1c1cb_
    complexed with m14
    1. region b:6-428 [155990]
  107. 1fkp
    complexed with nvp; mutant
    1. chain b [43099]
  108. 1fkp
    complexed with nvp; mutant
    1. region a:1-429 [43098]
  109. 1tl1
    complexed with h18, po4
    1. region a:7-427 [112494]
    2. region b:7-427 [112495]
  110. 1tv6
    complexed with cp9
    1. region a:1-429 [107348]
    2. region b:6-428 [107349]
  111. 1jlq
    complexed with sbn
    1. region a:1-429 [63174]
  112. 1jlq
    complexed with sbn
    1. chain b [63175]
  113. 1s9e
    complexed with adb; mutant
    1. region a:1-429 [98753]
  114. 1s9e
    complexed with adb; mutant
    1. chain b [98754]
  115. 1lw2
    complexed with csd, po4, u05; mutant
    1. chain b [78253]
  116. 1lw2
    complexed with csd, po4, u05; mutant
    1. region a:1-429 [78252]
  117. 1r0a
    complexed with 2da, glc, gol, mg
    1. region a:1-429 [104677]
    2. region b:1-429 [104678]
  118. 1ikv
    complexed with efz; mutant
    1. region a:1-429 [62528]
  119. 1ikv
    complexed with efz; mutant
    1. chain b [62529]
  120. 2vg5
    automatically matched to d1c1bb_
    complexed with nnc
    1. region b:1005-1427 [153031]
  121. 2ze2
    automatically matched to d1bqmb_
    complexed with t27; mutant
    1. region b:5-428 [154402]
  122. 3dok
    automatically matched to d1fkpb_
    complexed with gwj, po4; mutant
    1. region b:7-428 [157819]
  123. 1rt3
    complexed with u05; mutant
    1. region a:2-429 [43052]
  124. 1rt3
    complexed with u05; mutant
    1. chain b [43053]
  125. 1jlc
    complexed with ftc; mutant
    1. region a:1-429 [66840]
  126. 1jlc
    complexed with ftc; mutant
    1. chain b [66841]
  127. 3c6u
    automatically matched to d1c1cb_
    complexed with m22
    1. region a:5-440 [155991]
  128. 3c6u
    automatically matched to d1c1cb_
    complexed with m22
    1. region b:6-428 [155992]
  129. 1hqe
    mutant
    1. chain b [61132]
  130. 1hqe
    mutant
    1. region a:1-429 [61131]
  131. 1s9g
    complexed with abz; mutant
    1. region a:1-429 [98756]
  132. 1s9g
    complexed with abz; mutant
    1. chain b [98757]
  133. 1s1u
    complexed with nvp; mutant
    1. region a:4-429 [105209]
    2. region b:5-428 [105210]
  134. 1rt7
    complexed with po4, uc4
    1. region a:4-429 [43104]
    2. region b:6-431 [43105]
  135. 2vg7
    automatically matched to d1c1bb_
    complexed with nni
    1. region b:1005-1427 [153033]
  136. 1hni
    complexed with aaa; mutant
    1. chain b [43045]
  137. 1hni
    complexed with aaa; mutant
    1. region a:1-429 [43044]
  138. 1rtd
    complexed with mg, ttp; mutant
    1. region a:1-429 [43048]
    2. region c:1-429 [43050]
  139. 1rtd
    complexed with mg, ttp; mutant
    1. chain b [43049]
    2. chain d [43051]
  140. 3drr
    automatically matched to d1jlab_
    complexed with r8e; mutant
    1. region a:6-440 [157832]
  141. 3drr
    automatically matched to d1jlab_
    complexed with r8e; mutant
    1. region b:6-428 [157833]
  142. 1jle
    mutant
    1. region a:1-429 [66843]
  143. 1jle
    mutant
    1. chain b [66844]
  144. 2i5j
    automatically matched to d1bqmb_
    complexed with glc, k05, mg, suc; mutant
    1. region b:1-429 [137062]
  145. 1hqu
    complexed with hby; mutant
    1. region a:1-429 [61158]
  146. 1hqu
    complexed with hby; mutant
    1. chain b [61159]
  147. 1qe1
    mutant
    1. region a:1-429 [43054]
  148. 1qe1
    mutant
    1. chain b [43055]
  149. 1s6q
    complexed with tpb; mutant
    1. region a:1-429 [98602]
  150. 1s6q
    complexed with tpb; mutant
    1. chain b [98603]
  151. 1hpz
    complexed with aap; mutant
    1. chain b [61121]
  152. 1hpz
    complexed with aap; mutant
    1. region a:1-429 [61120]
  153. 1t03
    complexed with mg, mrg, tfo; mutant
    1. region a:1-429 [99054]
  154. 1t03
    complexed with mg, mrg, tfo; mutant
    1. chain b [99055]
  155. 1sv5
    complexed with 65b; mutant
    1. region a:1-429 [99017]
  156. 1sv5
    complexed with 65b; mutant
    1. chain b [99018]
  157. 2vg6
    automatically matched to d1c1bb_
    complexed with nnb
    1. region b:1005-1427 [153032]
  158. 2hmi
    protein/protein/DNA complex; mutant
    1. chain b [43107]
  159. 2hmi
    less ordered regions are modeled as poly-ALA
    protein/protein/DNA complex; mutant
    1. region a:1-429 [43106]
  160. 1hnv
    complexed with tbo; mutant
    1. region a:1-429 [43056]
  161. 1hnv
    complexed with tbo; mutant
    1. chain b [43057]
  162. 1s6p
    complexed with iet, mg; mutant
    1. region a:1-429 [98599]
  163. 1s6p
    complexed with iet, mg; mutant
    1. chain b [98600]
  164. 2b5j
    automatically matched to d1bqmb_
    complexed with 3ac, mn; mutant
    1. region b:1-427 [127902]
  165. 2ban
    automatically matched to d1bqmb_
    complexed with 357, mn; mutant
    1. region b:1-427 [128241]
  166. 1suq
    complexed with 185, mg; mutant
    1. region a:1-429 [99004]
  167. 1suq
    complexed with 185, mg; mutant
    1. chain b [99005]
  168. 1n6q
    complexed with atm, mg, mrg; mutant
    1. chain b [80206]
  169. 1n6q
    complexed with atm, mg, mrg; mutant
    1. region a:1-429 [80205]
  170. 3drs
    automatically matched to d1fkpb_
    complexed with r8d; mutant
    1. region a:5-438 [157834]
  171. 3drs
    automatically matched to d1fkpb_
    complexed with r8d; mutant
    1. region b:5-428 [157835]
  172. 1t05
    complexed with ddg, gol, mg, mrg, tnv; mutant
    1. region a:1-429 [99061]
  173. 1t05
    complexed with ddg, gol, mg, mrg, tnv; mutant
    1. chain b [99062]
  174. 1n5y
    complexed with atm, mg, mrg; mutant
    1. chain b [80059]
  175. 1n5y
    complexed with atm, mg, mrg; mutant
    1. region a:1-429 [80058]
  176. 1uwb
    complexed with tbo; mutant
    1. chain b [43063]
  177. 1uwb
    complexed with tbo; mutant
    1. region a:1-429 [43062]
  178. 1bqm
    complexed with hby; mutant
    1. region a:1-429 [43060]
  179. 1bqm
    complexed with hby; mutant
    1. chain b [43061]
  180. 1tvr
    complexed with tb9; mutant
    1. region a:1-429 [43058]
  181. 1tvr
    complexed with tb9; mutant
    1. chain b [43059]
  182. 1hys
    mutant
    1. chain b [61419]
  183. 1hys
    mutant
    1. region a:1-429 [61418]
  184. 1bqn
    complexed with hby; mutant
    1. region a:1-429 [43064]
  185. 1bqn
    complexed with hby; mutant
    1. chain b [43065]
  186. 3hvt
    complexed with nev
    1. region a:2-429 [43066]
  187. 3hvt
    complexed with nev
    1. chain b [43067]
  188. 1j5o
    mutant
    1. chain b [71570]
  189. 1j5o
    mutant
    1. region a:1-429 [71569]
  190. 1hvu
    protein/RNA complex
    1. region a:1-429 [43068]
    2. region d:1-429 [43070]
    3. region g:1-429 [43072]
    4. region j:1-429 [43074]
  191. 1hvu
    protein/RNA complex
    1. chain b [43069]
    2. chain e [43071]
    3. chain h [43073]
    4. chain k [43075]
2. Human immunodeficiency virus type 2 [TaxId: 11709] [82840] (2)
  1. 1mu2
    complexed with gol, so4; mutant
    1. chain b [79471]
  2. 1mu2
    complexed with gol, so4; mutant
    1. region a:3-429 [79470]