Structural Classification of Proteins
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Fold: Serpins

contains a cluster of helices and a beta-sandwich

Lineage:

  1. Root: scop
  2. Class: Multi-domain proteins (alpha and beta) [56572]
    Folds consisting of two or more domains belonging to different classes
  3. Fold: Serpins [56573]
    contains a cluster of helices and a beta-sandwich

Superfamilies:

  1. Serpins [56574] (1)
    link to SUPERFAMILY database - Superfamily
    1. Serpins [56575] (17)
      1. Elastase inhibitor [56576]
        1. Horse (Equus caballus) [TaxId: 9796] [56577] (1)
          1. 1hle picpic
            complexed with ca
            1. chain a,b [42618] picpiclink
      2. Ovalbumin [56578]
        1. Hen (Gallus gallus) [TaxId: 9031] [56579] (3)
          1. 1uhg picpic
            complexed with dsn, nag, sep, so4
            1. chain a [88491] picpiclink
            2. chain b [88492] picpiclink
            3. chain c [88493] picpiclink
            4. chain d [88494] picpiclink
          2. 1ova picpic
            complexed with ca, nag, po3
            1. chain a [42619] picpiclink
            2. chain b [42620] picpiclink
            3. chain c [42621] picpiclink
            4. chain d [42622] picpiclink
          3. 1jti picpic
            mutant
            1. chain a [63280] picpiclink
            2. chain b [63281] picpiclink
      3. Antichymotrypsin, alpha-1 [56580]
        1. Human (Homo sapiens) [TaxId: 9606] [56581] (5)
          1. 1as4 picpic
            complexed with act; mutant
            1. chain a,b [42623] picpiclink
          2. 1qmn picpic
            intact, in the delta conformation (partial loop insertion)
            1. chain a [42624] picpiclink
          3. 3caa picpic
            mutant
            1. chain a,b [42625] picpiclink
          4. 2ach picpic
            complexed with man, nag, po4
            1. chain a,b [42626] picpiclink
          5. 4caa picpic
            mutant
            1. chain a,b [42627] picpiclink
      4. Antitrypsin, alpha-1 [56582]
        1. Human (Homo sapiens) [TaxId: 9606] [56583] (15)
          1. 1qlp picpic
            intact chain: a canonical template for active serpins
            1. chain a [42628] picpiclink
          2. 1oph picpicxref
            complexed with trypsinogen
            mutant
            1. chain a [93404] picpiclink
          3. 1hp7 picpic
            intact chain
            complexed with seo, zn; mutant
            1. chain a [61117] picpiclink
          4. 1iz2 picpic
            intact chain
            complexed with sum; mutant
            1. chain a [76975] picpiclink
          5. 1oo8 picpic
            intact chain in the native conformation
            mutant
            1. chain a [93376] picpiclink
          6. 1ezx picpicxref
            complex with trypsin
            1. chain a,b [42629] picpiclink
          7. 1qmb picpic
            1. chain a,b [42633] picpiclink
          8. 9api picpic
            complexed with man, nag
            1. chain a,b [42630] picpiclink
          9. 1psi picpic
            intact chain
            complexed with scc; mutant
            1. chain a [42634] picpiclink
          10. 1d5s picpic
            cleaved polymer
            mutant
            1. chain a,b [42635] picpiclink
          11. 7api picpic
            complexed with man, nag
            1. chain a,b [42631] picpiclink
          12. 8api picpic
            complexed with man, nag
            1. chain a,b [42632] picpiclink
          13. 1atu picpic
            intact chain
            mutant
            1. chain a [42636] picpiclink
          14. 2d26 picpicxref
            1. region a:23-358 [145062] picpiclink
          15. 1kct picpic
            intact chain
            mutant
            1. chain a [42637] picpiclink
      5. Antithrombin [56584]
        1. Cow (Bos taurus) [TaxId: 9913] [56585] (1)
          1. 1att picpic
            1. chain a [42638] picpiclink
            2. chain b [42639] picpiclink
        2. Human (Homo sapiens) [TaxId: 9606] [56586] (33)
          SQ P01008
          1. 2b5t picpic
            automatically matched to d1tb6i_
            complexed with bma, fuc, gol, gu0, gu1, gu2, gu3, gu4, gu5, gu6, gu8, gu9, man, nag, ndg, so4; mutant
            1. region i:6-431 [127905] picpiclink
          2. 1tb6 picpicxref
            complexed with fuc, gu0, gu1, gu2, gu3, gu4, gu5, gu6, gu8, gu9, man, mpd, nag; mutant
            1. chain i [106738] picpiclink
          3. 1jvq picpic
            complexed with peptides, chains C and D
            complexed with ace, nag, nh2
            1. chain i [84232] picpiclink
            2. chain l [84233] picpiclink
          4. 1nq9 picpic
            complexed with nag, ntp
            1. chain i [92048] picpiclink
            2. chain l [92049] picpiclink
          5. 1r1l picpic
            complexed with ace, for, gol, nag
            1. chain i [111665] picpiclink
            2. chain l [111666] picpiclink
          6. 1e05 picpic
            complexed with gal, gol, man, nag, po4
            1. chain i [42640] picpiclink
            2. chain l [42641] picpiclink
          7. 1oyh picpic
            complexed with man, nag; mutant
            1. chain i [93727] picpiclink
            2. chain l [93728] picpiclink
          8. 2znh picpic
            automatically matched to d2anti_
            complexed with cit, man, nag
            1. region a:1-430 [154705] picpiclink
          9. 2znh picpic
            automatically matched to d2anti_
            complexed with cit, man, nag
            1. region b:1-430 [154706] picpiclink
          10. 1lk6 picpic
            complexed with peptides, chains C and D
            complexed with ace, for, gol, nag
            1. chain i [84620] picpiclink
            2. chain l [84621] picpiclink
          11. 1e04 picpic
            complexed with gol, man, nag, po4
            1. chain i [42642] picpiclink
            2. chain l [42643] picpiclink
          12. 2beh picpic
            automatically matched to d2anti_
            complexed with gol, man, nag, ndg; mutant
            1. region l:5-430 [128378] picpiclink
          13. 2beh picpic
            automatically matched to d1tb6i_
            complexed with gol, man, nag, ndg; mutant
            1. region i:4-431 [128377] picpiclink
          14. 1azx picpic
            complexed with nag, ntp
            1. chain i [42644] picpiclink
            2. chain l [42645] picpiclink
          15. 1t1f picpic
            automatically matched to d1tb6i_
            complexed with bma, gol, iod, nag; mutant
            1. region a:4-431 [119107] picpiclink
          16. 1t1f picpic
            automatically matched to d1tb6i_
            complexed with bma, gol, iod, nag; mutant
            1. region b:4-431 [119108] picpiclink
          17. 1t1f picpic
            automatically matched to d1tb6i_
            complexed with bma, gol, iod, nag; mutant
            1. region c:4-431 [119109] picpiclink
          18. 2hij picpic
            automatically matched to d2anti_
            complexed with gol, man, nag; mutant
            1. region l:5-430 [136528] picpiclink
          19. 2hij picpic
            complexed with gol, man, nag; mutant
            1. region i:5-431 [145394] picpiclink
          20. 1br8 picpic
            mutant
            1. chain i [42654] picpiclink
            2. chain l [42655] picpiclink
          21. 1ath picpic
            1. chain a [42646] picpiclink
            2. chain b [42647] picpiclink
          22. 1dzh picpic
            complexed with cyf, gol, man, nag; mutant
            1. chain i [42652] picpiclink
            2. chain l [42653] picpiclink
          23. 1e03 picpic
            complexed with man, nag, ntp
            1. chain i [42648] picpiclink
            2. chain l [42649] picpiclink
          24. 2ant picpic
            complexed with nag
            1. chain i [42650] picpiclink
            2. chain l [42651] picpiclink
          25. 2b4x picpic
            automatically matched to d2anti_
            complexed with nag; mutant
            1. region l:5-431 [127867] picpiclink
          26. 2b4x picpic
            complexed with nag; mutant
            1. region i:5-431 [144951] picpiclink
          27. 1dzg picpic
            complexed with gol, nag; mutant
            1. chain i [42656] picpiclink
            2. chain l [42657] picpiclink
          28. 3evj picpic
            automatically matched to d2anti_
            complexed with man, nag, nto
            1. region i:6-430 [158210] picpiclink
          29. 3evj picpic
            automatically matched to d2anti_
            complexed with man, nag, nto
            1. region l:5-430 [158211] picpiclink
          30. 1ant picpic
            1. chain i [42658] picpiclink
            2. chain l [42659] picpiclink
          31. 1sr5 picpicxref
            complexed with nag, nt1, nt2
            1. chain a [105952] picpiclink
          32. 2gd4 picpicxrefxrefxrefxref
            complexed with bma, ca, man, nag, nto; mutant
            1. region c:4-431 [145193] picpiclink
          33. 2gd4 picpicxrefxrefxrefxref
            automatically matched to 2GD4 C:4-431
            complexed with bma, ca, man, nag, nto; mutant
            1. region i:5-431 [145195] picpiclink
      6. Plasminogen activator inhibitor-1 [56587]
        1. Human (Homo sapiens) [TaxId: 9606] [56588] (9)
          1. 1lj5 picpic
            complexed with acy, dms
            1. chain a [73928] picpiclink
          2. 1a7c picpic
            complexed with man, nga, thc; mutant
            1. chain a [42660] picpiclink
          3. 1oc0 picpicxref
            mutant
            1. chain a [86790] picpiclink
          4. 1dvn picpic
            mutant
            1. chain a [42662] picpiclink
          5. 1c5g picpic
            1. chain a [42661] picpiclink
          6. 1dvm picpic
            complexed with cl; mutant
            1. chain a [42663] picpiclink
            2. chain b [42664] picpiclink
            3. chain c [42665] picpiclink
            4. chain d [42666] picpiclink
          7. 9pai picpic
            mutant
            1. chain a [42667] picpiclink
          8. 1b3k picpic
            1. chain a [42668] picpiclink
            2. chain b [42669] picpiclink
            3. chain c [42670] picpiclink
            4. chain d [42671] picpiclink
          9. 1db2 picpic
            1. chain a [42672] picpiclink
            2. chain b [42673] picpiclink
      7. Plasminogen activator inhibitor-2 [56589]
        1. Human (Homo sapiens) [TaxId: 9606] [56590] (2)
          1. 1by7 picpic
            mutant
            1. chain a [42674] picpiclink
          2. 1jrr picpic
            deletion mutant complexed with peptide mimicking the reactive center loop, chain P
            1. chain a [63256] picpiclink
      8. Heparin cofactor II (Hc-II, leuserpin 2) [82833]
        1. Human (Homo sapiens) [TaxId: 9606] [82834] (2)
          1. 1jmj picpic
            complexed with ca, man, nag
            1. chain a [77135] picpiclink
            2. chain b [77136] picpiclink
          2. 1jmo picpicxref
            complexed with mpd, na, nag, sty; mutant
            1. chain a [77138] picpiclink
      9. Protein C inhibitor [82835]
        1. Human (Homo sapiens) [TaxId: 9606] [82836] (1)
          1. 1lq8 picpic
            complexed with ioh, man, nag
            1. chain a,b [78125] picpiclink
            2. chain c,d [78126] picpiclink
            3. chain e,f [78127] picpiclink
            4. chain g,h [78128] picpiclink
      10. Neuroserpin [69871]
        1. Mouse (Mus musculus) [TaxId: 10090] [69872] (1)
          1. 1jjo picpic
            cleaved form
            1. chain a,c,e [66770] picpiclink
            2. chain b,d,f [66771] picpiclink
      11. Serpin K [56591]
        1. Tobacco hawkmoth (Manduca sexta) [TaxId: 7130] [56592] (1)
          1. 1sek picpic
            1. chain a [42675] picpiclink
      12. Alaserpin (serpin 1) [64469]
        1. Tobacco hornworm (Manduca sexta) [TaxId: 7130] [64470] (1)
          Michaelis serpin-trypsin complex
          1. 1k9o picpicxref
            Michaelis serpin-trypsin complex
            mutant
            1. chain i [68356] picpiclink
      13. Viral serpin crmA (cytokine response modifier protein) [56593]
        1. Cowpox virus [TaxId: 10243] [56594] (3)
          1. 1m93 picpic
            cleaved form
            complexed with po4; mutant
            1. chain a,b,c [91235] picpiclink
          2. 1f0c picpic
            cleaved form
            complexed with dtt
            1. chain a,b [42676] picpiclink
          3. 1c8o picpic
            cleaved form
            mutant
            1. chain a,b [42677] picpiclink
      14. Pigment epithelium-derived factor, PEDF [64471]
        1. Human (Homo sapiens) [TaxId: 9606] [64472] (1)
          1. 1imv picpic
            complexed with nag
            1. chain a [62591] picpiclink
      15. Thermopin [90080]
        Serpin from a thermophilic prokaryote
        1. Thermobifida fusca [TaxId: 2021] [90081] (2)
          SQ Q47NK3
          1. 1mtp picpic
            structural genomics
            1. chain a,b [85107] picpiclink
          2. 1sng picpic
            complexed with caf, so4
            1. chain a [112104] picpiclink
      16. Maspin [118179]
        1. Human (Homo sapiens) [TaxId: 9606] [118180] (2)
          SQ P36952
          1. 1xqg picpic
            mutant
            1. chain a [115844] picpiclink
            2. chain b [115845] picpiclink
          2. 1xqj picpic
            mutant
            1. chain a [115850] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk