Structural Classification of Proteins

Fold: His-Me finger endonucleases

: core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: His-Me finger endonucleases [54059]
core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures

Superfamilies:

His-Me finger endonucleases [54060] (6)
common motif contains conserved histidine residue and metal-binding site
uperfamily
1. Endonuclease I [102726] (1)
  1. Periplasmic endonuclease Vvn [102727]
    1. Vibrio vulnificus [TaxId: 672] [102728] (6)
2. HNH-motif [54061] (2)
  1. DNase domain of colicin E7 [54062]
    1. Escherichia coli [TaxId: 562] [54063] (10)
  2. DNase domain of colicin E9 [54064]
    1. Escherichia coli [TaxId: 562] [54065] (15)
      SQ P09883 456-581
3. DNA/RNA non-specific endonuclease [54066] (2)
  the core motif is inserted in a six-stranded meander beta-sheet domain
  1. Sm endonuclease [54067]
    1. Serratia marcescens [TaxId: 615] [54068] (4)
  2. Nuclease NucA [159863]
    1. Anabaena sp., PCC 7120 [TaxId: 1167] [159864] (1)
      SQ P38446 35-274
4. Intron-encoded homing endonucleases [54069] (2)
  1. Intron-encoded homing endonuclease I-PpoI [54070]
    1. Physarum polycephalum [TaxId: 5791] [54071] (7)
  2. Intron-encoded homing endonuclease I-HmuI [110776]
    1. Bacteriophage SP01 [TaxId: 10685] [110777] (1)
      SQ P34081
5. Recombination endonuclease VII, N-terminal domain [68915] (1)
  1. Recombination endonuclease VII, N-terminal domain [68916]
    1. Bacteriophage T4 [TaxId: 10665] [68917] (7)
6. Caspase-activated DNase, CAD (DffB, DFF40) [110778] (1)
  1. Caspase-activated DNase, CAD (DffB, DFF40) [110779]
    1. Mouse (Mus musculus) [TaxId: 10090] [110780] (1)
      SQ O54788 85-329 # structure of the N-terminal, CAD domain (1-87) is solved separately; scop_sp 54282