Structural Classification of Proteins
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Family: Plant cytotoxins

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Ribosome inactivating proteins (RIP) [56370]
    contains mixed beta-sheet
  4. Superfamily: Ribosome inactivating proteins (RIP) [56371]
    link to SUPERFAMILY database - Superfamily
  5. Family: Plant cytotoxins [56372]

Protein Domains:

  1. alpha-Trichosanthin [56373]
    1. Mongolian snake gourd (Trichosanthes kirilowii Maxim.) [TaxId: 3677] [56374] (10)
      1. 1mrj picpic
        complexed with adn
        1. chain a [42177] picpiclink
      2. 1mrk picpic
        complexed with fmc
        1. chain a [42178] picpiclink
      3. 1gis picpic
        complexed with amp; mutant
        1. chain a [83289] picpiclink
      4. 1nli picpic
        complexed with ade; mutant
        1. chain a [80625] picpiclink
      5. 1tcs picpic
        complexed with ndp
        1. chain a [42179] picpiclink
      6. 1qd2 picpic
        complexed with ade
        1. chain a [42180] picpiclink
      7. 1j4g picpic
        complexed with ca
        1. chain a [66379] picpiclink
        2. chain b [66380] picpiclink
        3. chain c [66381] picpiclink
        4. chain d [66382] picpiclink
      8. 1giu picpic
        complexed with ade; mutant
        1. chain a [83290] picpiclink
      9. 2jdl picpic
        automatically matched to d1mrja_
        1. region a:2-247 [147987] picpiclink
      10. 2jdl picpic
        automatically matched to d1mrja_
        1. region b:2-247 [147988] picpiclink
  2. Bryodin [56375]
    1. Red briony (Bryonia dioica) [TaxId: 3652] [56376] (1)
      1. 1bry picpic
        1. chain y [42181] picpiclink
        2. chain z [42182] picpiclink
  3. Beta-luffin [103331]
    1. Smooth loofah (Luffa cylindrica) [TaxId: 3670] [103332] (1)
      1. 1nio picpic
        complexed with nag
        1. chain a [91890] picpiclink
  4. alpha-Momorcharin (momordin) [56377]
    1. Bitter gourd (Momordica charantia) [TaxId: 3673] [56378] (8)
      1. 1ahc picpic
        1. chain a [42184] picpiclink
      2. 1mrg picpic
        complexed with adn
        1. chain a [42183] picpiclink
      3. 1ahb picpic
        complexed with fmp
        1. chain a [42185] picpiclink
      4. 1aha picpic
        complexed with ade
        1. chain a [42187] picpiclink
      5. 1mom picpic
        complexed with nag
        1. chain a [42188] picpiclink
      6. 1mrh picpic
        complexed with fmc
        1. chain a [42186] picpiclink
      7. 1f8q picpic
        complexed with ccn, man, nag, ptd, xys
        1. chain a [42189] picpiclink
      8. 1mri picpic
        1. chain a [42190] picpiclink
  5. Beta-momorcharin [56379]
    (almost) identical with the anti-tumor and anti-HIV-1 protein MAP30
    1. Bitter gourd (Momordica charantia) [TaxId: 3673] [56380] (2)
      1. 1cf5 picpic
        complexed with bma, fuc, man, nag, xys
        1. chain a [42191] picpiclink
        2. chain b [42192] picpiclink
      2. 1d8v picpic
        1. chain a [42193] picpiclink
  6. Mistletoe lectin I A-chain [56381]
    1. European mistletoe (Viscum album) [TaxId: 3972] [56382] (12)
      different sequence variants
      SQ P81446 1-249
      SQ Q6ITZ3 1-240
      1. 1m2t picpicxref
        complexed with ade, fuc, gol, nag
        1. chain a [84761] picpiclink
      2. 1onk picpicxref
        complexed with azi, gol, nag, po4
        1. chain a [93359] picpiclink
      3. 1sz6 picpicxref
        complexed with azi, cl, gol, nag, so4
        1. chain a [112171] picpiclink
      4. 1puu picpicxref
        complexed with cl, dox, fuc, gol, lat, nag, so4
        1. chain a [104317] picpiclink
      5. 1pum picpicxref
        complexed with cl, fuc, glb, gol, nag, so4
        1. chain a [104314] picpiclink
      6. 1oql picpicxref
        complexed with gal, nag
        1. chain a [87306] picpiclink
      7. 2r9k picpicxrefxref
        automatically matched to d1m2ta_
        complexed with cl, gol, nag, sgi, so4
        1. region a:1-248 [151789] picpiclink
      8. 1yf8 picpicxrefxref
        automatically matched to d1pc8a_
        complexed with gal, glc, man, nag, p6c
        1. region a:1-240 [123051] picpiclink
      9. 1tfm picpicxref
        complexed with bgc, bma, glb, nag, p6c
        1. chain a [106855] picpiclink
      10. 1ce7 picpicxref
        complexed with nag
        1. chain a [42194] picpiclink
      11. 2mll picpicxref
        complexed with nag
        1. chain a [42195] picpiclink
      12. 1pc8 picpicxref
        complexed with man, nag
        1. chain a [104104] picpiclink
  7. Abrin A-chain [56383]
    1. Abrus precatorius [TaxId: 3816] [56384] (1)
      1. 1abr picpicxref
        complexed with man, nag
        1. chain a [42196] picpiclink
  8. Lectin 1 A-chain [90053]
    1. Mongolian snake-gourd (Trichosanthes kirilowii) [TaxId: 3677] [90054] (1)
      1. 1ggp picpicxref
        X-ray derived abrin-based sequence
        1. chain a [83285] picpiclink
  9. Pokeweed antiviral protein alpha [56385]
    1. Pokeweed (Phytolacca americana) [TaxId: 3527] [56386] (7)
      1. 1d6a picpic
        1. chain a [42197] picpiclink
        2. chain b [42198] picpiclink
      2. 1qcg picpic
        1. chain a [42199] picpiclink
        2. chain b [42200] picpiclink
      3. 1qci picpic
        complexed with ade
        1. chain a [42201] picpiclink
        2. chain b [42202] picpiclink
      4. 1qcj picpic
        complexed with apt
        1. chain a [42203] picpiclink
        2. chain b [42204] picpiclink
      5. 1apa picpic
        1. chain a [42205] picpiclink
      6. 1paf picpic
        1. chain a [42206] picpiclink
        2. chain b [42207] picpiclink
      7. 1pag picpic
        complexed with fmp
        1. chain a [42208] picpiclink
        2. chain b [42209] picpiclink
  10. Antiviral protein 3 [90055]
    1. Pokeweed (Phytolacca americana) [TaxId: 3527] [90056] (1)
      1. 1lln picpic
        complexed with mly
        1. chain a [84625] picpiclink
  11. Antiviral protein S [103333]
    seed isoform
    1. Pokeweed (Phytolacca americana) [TaxId: 3527] [103334] (4)
      1. 1j1q picpic
        complexed with nag
        1. chain a [90768] picpiclink
      2. 1j1r picpic
        complexed with ane, nag
        1. chain a [90769] picpiclink
      3. 1j1s picpic
        complexed with fmp, nag
        1. chain a [90770] picpiclink
      4. 1gik picpic
        complexed with nag
        1. chain a [90513] picpiclink
  12. Dianthin 30 [103335]
    1. Clove pink (Dianthus caryophyllus) [TaxId: 3570] [103336] (4)
      SQ P24476 24-278
      1. 1rl0 picpic
        1. chain a [111859] picpiclink
      2. 1lp8 picpic
        1. chain a [91082] picpiclink
      3. 1lpd picpic
        complexed with ade
        1. chain a [91098] picpiclink
      4. 1lpc picpic
        complexed with cmp
        1. chain a [91097] picpiclink
  13. Saporin So6 [56387]
    1. Common soapwort (Saponaria officinalis) [TaxId: 3572] [56388] (1)
      1. 1qi7 picpic
        complexed with sul
        1. chain a [42210] picpiclink
  14. Ricin A-chain [56389]
    1. Castor bean (Ricinus communis) [TaxId: 3988] [56390] (24)
      SQ P06750 28-286
      1. 1uq5 picpic
        complexed with act, so4; mutant
        1. chain a [99778] picpiclink
      2. 1j1m picpic
        complexed with so4, tre; mutant
        1. chain a [90767] picpiclink
      3. 1uq4 picpic
        complexed with so4; mutant
        1. chain a [99777] picpiclink
      4. 2pjo picpic
        automatically matched to d1br6a_
        complexed with nmu, so4
        1. region a:6-263 [149568] picpiclink
      5. 1ift picpic
        mutant
        1. chain a [42211] picpiclink
      6. 1ifs picpic
        complexed with ane; mutant
        1. chain a [42212] picpiclink
      7. 2r3d picpic
        automatically matched to d1br6a_
        complexed with acm, so4
        1. region a:6-263 [151557] picpiclink
      8. 2p8n picpic
        automatically matched to d1br6a_
        complexed with ade, so4
        1. region a:6-263 [149313] picpiclink
      9. 1obs picpic
        mutant
        1. chain a [42213] picpiclink
      10. 1br6 picpic
        complexed with pte
        1. chain a [42214] picpiclink
      11. 1ifu picpic
        complexed with fmc; mutant
        1. chain a [42215] picpiclink
      12. 2pjn picpic
        automatically matched to d1br6a_
        complexed with so4, ure
        1. region a:6-263 [149567] picpiclink
      13. 2r2x picpic
        automatically matched to d1br6a_
        complexed with so4, ure
        1. region a:6-263 [151543] picpiclink
      14. 1obt picpic
        complexed with amp; mutant
        1. chain a [42216] picpiclink
      15. 1il4 picpic
        complexed with 9dg
        1. chain a [66200] picpiclink
      16. 1br5 picpic
        complexed with neo
        1. chain a [42217] picpiclink
      17. 1il3 picpic
        complexed with 7dg
        1. chain a [66199] picpiclink
      18. 1il5 picpic
        complexed with ddp
        1. chain a [66201] picpiclink
        2. chain b [66202] picpiclink
      19. 1rtc picpic
        1. chain a [42218] picpiclink
      20. 2aai picpicxref
        complexed with gal, glc, man, nag
        1. chain a [42219] picpiclink
      21. 1fmp picpic
        complexed with fmp
        1. chain a [42220] picpiclink
      22. 1rzo picpicxref
        complexed with glb, so4
        1. chain a [111983] picpiclink
        2. chain c [111986] picpiclink
      23. 1il9 picpic
        complexed with mog
        1. chain a [66203] picpiclink
      24. 1apg picpic
        1. chain a [42221] picpiclink
  15. Ebulin A-chain [56391]
    1. Sambucus ebulus [TaxId: 28503] [56392] (4)
      1. 1hwm picpicxref
        complexed with gal, man, nag
        1. chain a [42222] picpiclink
      2. 1hwo picpicxref
        complexed with gal, glc, man, nag
        1. chain a [42223] picpiclink
      3. 1hwn picpicxref
        complexed with gal, nag
        1. chain a [42224] picpiclink
      4. 1hwp picpicxref
        complexed with gal, glc, man, nag, pt1
        1. chain a [42225] picpiclink
  16. Bouganin [160915]
    1. Bougainvillea (Bougainvillea spectabilis) [TaxId: 146096] [160916] (1)
      SQ Q8W4U4 27-272
      1. 3ctk picpic
        1. region a:3-248 [156985] picpiclink
  17. Agglutinin-1 chain A [160917]
    1. Abrus precatorius [TaxId: 3816] [160918] (1)
      SQ Q9M6E9 22-268
      1. 2q3n picpicxrefxref
        complexed with nag
        1. region a:2-248 [150034] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk