Structural Classification of Proteins

Fold: Metallo-dependent phosphatases

: 4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Metallo-dependent phosphatases [56299]
4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication

Superfamilies:

Metallo-dependent phosphatases [56300] (12)
different families of this superfamily are groupped in a single Pfam family, Pfam 00149
uperfamily
1. Purple acid phosphatase-like [56301] (4)
  1. Plant purple acid phosphatase, catalytic domain [56302]
    also contain an Ig-like domain
    1. Kidney bean (Phaseolus vulgaris) [TaxId: 3885] [56303] (9)
    2. Sweet potato (Ipomoea batatas) [TaxId: 4120] [118151] (1)
      SQ Q9SE00 39-462
  2. Mammalian purple acid phosphatase [56304]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [56305] (2)
    2. Pig (Sus scrofa) [TaxId: 9823] [56306] (1)
2. DNA double-strand break repair nuclease [64427] (1)
  contains C-terminal alpha/beta subdomain
  1. Mre11 [64428]
    1. Archaeon Pyrococcus furiosus [TaxId: 2261] [64429] (3)
      SQ Q8U1N9
3. 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain [56307] (3)
  1. 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain [56308]
    1. Escherichia coli [TaxId: 562] [56309] (8)
      SQ P07024 26-550
    2. Thermus thermophilus [TaxId: 274] [160867] (1)
      SQ Q5SIP1 28-534
    3. Candida albicans [TaxId: 5476] [160868] (2)
      SQ Q5A5Q7 16-337
4. Protein serine/threonine phosphatase [56310] (9)
  1. Protein phosphatase-1 (PP-1) [56311]
    1. Rabbit (Oryctolagus cuniculus), alpha isoform [TaxId: 9986] [56312] (1)
    2. Human (Homo sapiens), beta isoform [TaxId: 9606] [64430] (5)
      SQ P36873
    3. Human (Homo sapiens), gamma isoform [TaxId: 9606] [111230] (1)
      SQ P37140 1-308
    4. Rattus norvegicus [TaxId: 10116] [160869] (4)
  2. Protein phosphatase-2B (PP-2B, calcineurin A subunit) [56313]
    1. Cow (Bos taurus) [TaxId: 9913] [56314] (1)
    2. Human (Homo sapiens) [TaxId: 9606] [56315] (5)
  3. lambda ser/thr protein phosphatase [64431]
    1. Bacteriophage lambda [TaxId: 10710] [64432] (1)
  4. Serine/threonine protein phosphatase 5, PP5 [111231]
    1. Human (Homo sapiens) [TaxId: 9606] [111232] (5)
      SQ P53041 176-499
  5. Protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha [143933]
    1. Human (Homo sapiens) [TaxId: 9606] [143934] (11)
      SQ P67775 2-294
5. Phosphoesterase-related [82803] (1)
  1. Hypothetical protein PF1291 [82804]
    1. Archaeon Pyrococcus furiosus [TaxId: 2261] [82805] (1)
6. TT1561-like [103320] (2)
  similar to purple acid and protein phosphatases
  1. Hypothetical protein TT1561 [103321]
    1. Thermus thermophilus [TaxId: 274] [103322] (1)
  2. Uncharacterized protein Aq_1956 [160870]
    1. Aquifex aeolicus [TaxId: 63363] [160871] (1)
      SQ O67769 4-260
7. YfcE-like [111233] (6)
  1. Putative phosphodiesterase MJ0936 [111234]
    1. Methanococcus jannaschii [TaxId: 2190] [111235] (7)
      SQ Q58346
  2. Phosphodiesterase yfcE [111236]
    1. Escherichia coli [TaxId: 562] [111237] (1)
      SQ P76495
  3. Vacuolar protein sorting 29, VPS29 [143935]
    1. Mouse (Mus musculus) [TaxId: 10090] [143936] (5)
      SQ Q9QZ88 1-182
    2. Cryptosporidium parvum [TaxId: 5807] [143937] (2)
      SQ Q5CYJ7 5-197
    3. Homo sapiens [TaxId: 9606] [160872] (2)
  4. Uncharacterized protein SP1879 [160873]
    1. Streptococcus pneumoniae [TaxId: 1313] [160874] (1)
      SQ Q97NX4 1-173
8. Hypothetical protein aq_1666 [118152] (1)
  1. Hypothetical protein aq_1666 [118153]
    1. Aquifex aeolicus [TaxId: 63363] [118154] (1)
      SQ O67582
9. DR1281-like [118155] (2)
  1. Putative phosphatase DR1281 [118156]
    1. Deinococcus radiodurans [TaxId: 1299] [118157] (1)
      SQ Q9RUV0
  2. Hypothetical protein MPN349 [118158]
    1. Mycoplasma pneumoniae [TaxId: 2104] [118159] (1)
      SQ P75429
10. TTHA0625-like [143938] (1)
  part of Pfam 00149
  1. Hypothetical protein TTHA0625 [143939]
    1. Thermus thermophilus [TaxId: 274] [143940] (8)
      SQ Q5SKL8 1-252
11. GpdQ-like [160875] (2)
  part of Pfam 00149
  1. Rv0805 cyclic nucleotide phosphodiesterase [160876]
    1. Mycobacterium tuberculosis [TaxId: 1773] [160877] (3)
      SQ O06629 10-265
  2. Glycerophosphodiesterase GpdQ [160878]
    1. Enterobacter aerogenes [TaxId: 548] [160879] (14)
      SQ Q6XBH1 1-271
12. ADPRibase-Mn-like [160880] (1)
  contains Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase (ADPRibase-Mn); part of Pfam 00149
  1. Uncharacterized C17orf48 homolog zgc:64213 [160881]
    1. Zebrafish (Danio rerio) [TaxId: 7955] [160882] (1)
      SQ Q7T291 3-322