Structural Classification of Proteins
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Fold: Metallo-dependent phosphatases

4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Metallo-dependent phosphatases [56299]
    4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication

Superfamilies:

  1. Metallo-dependent phosphatases [56300] (12)
    different families of this superfamily are groupped in a single Pfam family, Pfam 00149
    link to SUPERFAMILY database - Superfamily
    1. Purple acid phosphatase-like [56301] (4)
      1. Plant purple acid phosphatase, catalytic domain [56302]
        also contain an Ig-like domain
        1. Kidney bean (Phaseolus vulgaris) [TaxId: 3885] [56303] (9)
          1. 2qfr picpicxrefxref
            automatically matched to d1kbpa2
            complexed with fe, nag, ndg, so4, zn
            1. region a:121-432 [150751] picpiclink
          2. 2qfr picpicxrefxref
            automatically matched to d1kbpa2
            complexed with fe, nag, ndg, so4, zn
            1. region b:121-432 [150753] picpiclink
          3. 2qfp picpicxrefxrefxrefxref
            automatically matched to d1kbpa2
            complexed with f, fe, na, nag, ndg, so4, zn
            1. region a:121-432 [150743] picpiclink
          4. 2qfp picpicxrefxrefxrefxref
            automatically matched to d1kbpa2
            complexed with f, fe, na, nag, ndg, so4, zn
            1. region b:121-432 [150745] picpiclink
          5. 2qfp picpicxrefxrefxrefxref
            automatically matched to d1kbpa2
            complexed with f, fe, na, nag, ndg, so4, zn
            1. region c:121-432 [150747] picpiclink
          6. 2qfp picpicxrefxrefxrefxref
            automatically matched to d1kbpa2
            complexed with f, fe, na, nag, ndg, so4, zn
            1. region d:121-432 [150749] picpiclink
          7. 1kbp picpicxref
            complexed with fe, nag, zn
            1. region a:121-432 [42068] picpiclink
            2. region b:121-432 [42069] picpiclink
            3. region c:121-432 [42070] picpiclink
            4. region d:121-432 [42071] picpiclink
          8. 4kbp picpicxref
            complexed with fe, nag, po4, zn
            1. region a:121-432 [42064] picpiclink
            2. region b:121-432 [42065] picpiclink
            3. region c:121-432 [42066] picpiclink
            4. region d:121-432 [42067] picpiclink
          9. 3kbp picpicxref
            complexed with fe, nag, wo4, zn
            1. region a:121-432 [42072] picpiclink
            2. region b:121-432 [42073] picpiclink
            3. region c:121-432 [42074] picpiclink
            4. region d:121-432 [42075] picpiclink
        2. Sweet potato (Ipomoea batatas) [TaxId: 4120] [118151] (1)
          SQ Q9SE00 39-462
          1. 1xzw picpicxref
            complexed with fe, fuc, man, mn, nag, po4
            1. region a:120-424 [116271] picpiclink
            2. region b:620-926 [116273] picpiclink
      2. Mammalian purple acid phosphatase [56304]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [56305] (2)
          1. 1qhw picpic
            complexed with fe, nag, so4, zn
            1. chain a [42076] picpiclink
          2. 1qfc picpic
            complexed with fe, nag, po4
            1. chain a [42077] picpiclink
        2. Pig (Sus scrofa) [TaxId: 9823] [56306] (1)
          1. 1ute picpic
            complexed with feo, ipa, nag, po4
            1. chain a [42078] picpiclink
    2. DNA double-strand break repair nuclease [64427] (1)
      contains C-terminal alpha/beta subdomain
      1. Mre11 [64428]
        1. Archaeon Pyrococcus furiosus [TaxId: 2261] [64429] (3)
          SQ Q8U1N9
          1. 1ii7 picpic
            complexed with 101, mn, po4, so4
            1. chain a [62415] picpiclink
            2. chain b [62416] picpiclink
          2. 1s8e picpic
            complexed with mn; mutant
            1. chain a [105368] picpiclink
            2. chain b [105369] picpiclink
          3. 3dsc picpic
            automatically matched to d1ii7a_
            1. region a:1-333 [157840] picpiclink
    3. 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain [56307] (3)
      1. 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain [56308]
        1. Escherichia coli [TaxId: 562] [56309] (8)
          SQ P07024 26-550
          1. 1ush picpicxref
            complexed with co3, so4, zn
            1. region a:26-362 [42079] picpiclink
          2. 1hp1 picpicxref
            complexed with atp, co3, so4, zn
            1. region a:26-362 [70977] picpiclink
          3. 1hpu picpicxref
            complexed with a12, mn
            1. region a:26-362 [70980] picpiclink
            2. region b:26-362 [70982] picpiclink
            3. region c:26-362 [70984] picpiclink
            4. region d:26-362 [70986] picpiclink
          4. 1oi8 picpicxref
            complexed with co3, mn, so4; mutant
            1. region a:26-362 [103943] picpiclink
            2. region b:26-362 [103945] picpiclink
          5. 2ush picpicxref
            complexed with wo4, zn
            1. region a:26-362 [42080] picpiclink
            2. region b:26-362 [42081] picpiclink
          6. 1oid picpicxref
            complexed with ni; mutant
            1. region a:26-362 [103953] picpiclink
            2. region b:26-362 [103955] picpiclink
          7. 1oie picpicxref
            complexed with ni; mutant
            1. region a:26-362 [103957] picpiclink
          8. 1ho5 picpicxref
            complexed with adn, mn, po4
            1. region a:26-362 [70969] picpiclink
            2. region b:26-362 [70971] picpiclink
        2. Thermus thermophilus [TaxId: 274] [160867] (1)
          SQ Q5SIP1 28-534
          1. 2z1a picpicxref
            complexed with po4, thm, zn
            1. region a:28-329 [153928] picpiclink
        3. Candida albicans [TaxId: 5476] [160868] (2)
          SQ Q5A5Q7 16-337
          1. 3c9f picpicxrefxref
            complexed with fmt, na, zn; mutant
            1. region a:16-337 [156126] picpiclink
          2. 3c9f picpicxrefxref
            automatically matched to 3C9F A:16-337
            complexed with fmt, na, zn; mutant
            1. region b:16-337 [156128] picpiclink
    4. Protein serine/threonine phosphatase [56310] (9)
      1. Protein phosphatase-1 (PP-1) [56311]
        1. Rabbit (Oryctolagus cuniculus), alpha isoform [TaxId: 9986] [56312] (1)
          1. 1fjm picpic
            complexed with acb, add, bme, cab, mn
            1. chain a [42082] picpiclink
            2. chain b [42083] picpiclink
        2. Human (Homo sapiens), beta isoform [TaxId: 9606] [64430] (5)
          SQ P36873
          1. 1jk7 picpic
            complexed with bme, mn, oka, so4
            1. chain a [63144] picpiclink
          2. 1it6 picpic
            complexed with cyu, mn
            1. chain a [71407] picpiclink
            2. chain b [71408] picpiclink
          3. 1u32 picpic
            complexed with bme, mn, oka
            1. chain a [107631] picpiclink
          4. 2bcd picpic
            automatically matched to d1jk7a_
            complexed with bme, mn, moq
            1. region a:6-298 [128281] picpiclink
          5. 2bdx picpic
            automatically matched to d1jk7a_
            complexed with dlq, mn
            1. region a:6-298 [128346] picpiclink
        3. Human (Homo sapiens), gamma isoform [TaxId: 9606] [111230] (1)
          SQ P37140 1-308
          1. 1s70 picpicxref
            complexed with mn, pge; mutant
            1. chain a [105316] picpiclink
        4. Rattus norvegicus [TaxId: 10116] [160869] (4)
          1. 2o8g picpic
            automatically matched to d1jk7a_
            complexed with mn
            1. region a:6-299 [148674] picpiclink
          2. 2o8g picpic
            automatically matched to d1jk7a_
            complexed with mn
            1. region b:6-299 [148675] picpiclink
          3. 2o8a picpic
            automatically matched to d1jk7a_
            1. region a:6-299 [148672] picpiclink
          4. 2o8a picpic
            automatically matched to d1jk7a_
            1. region b:6-299 [148673] picpiclink
      2. Protein phosphatase-2B (PP-2B, calcineurin A subunit) [56313]
        1. Cow (Bos taurus) [TaxId: 9913] [56314] (1)
          1. 1tco picpicxrefxref
            complexed with ca, fe, fk5, myr, po4, zn
            1. chain a [42084] picpiclink
        2. Human (Homo sapiens) [TaxId: 9606] [56315] (5)
          1. 1aui picpicxref
            complexed with ca, fe, zn
            1. chain a [42085] picpiclink
          2. 2p6b picpicxrefxref
            automatically matched to d1m63a_
            complexed with ca, fe, nh2, po4, zn
            1. region a:14-370 [139511] picpiclink
          3. 2p6b picpicxrefxref
            automatically matched to d1m63a_
            complexed with ca, fe, nh2, po4, zn
            1. region c:14-370 [139513] picpiclink
          4. 1m63 picpicxrefxref
            complexed with aba, bmt, ca, dal, fe, mle, mva, sar, zn
            1. chain a [78677] picpiclink
            2. chain e [78680] picpiclink
          5. 1mf8 picpicxrefxref
            complexed with aba, bmt, ca, dal, mle, mva, po4, sar
            1. chain a [79040] picpiclink
      3. lambda ser/thr protein phosphatase [64431]
        1. Bacteriophage lambda [TaxId: 10710] [64432] (1)
          1. 1g5b picpic
            complexed with hg, mn, so4
            1. chain a [60261] picpiclink
            2. chain b [60262] picpiclink
            3. chain c [60263] picpiclink
      4. Serine/threonine protein phosphatase 5, PP5 [111231]
        1. Human (Homo sapiens) [TaxId: 9606] [111232] (5)
          SQ P53041 176-499
          1. 1s95 picpic
            complexed with mn, mpd, pi
            1. chain a [105375] picpiclink
            2. chain b [105376] picpiclink
          2. 1wao picpicxrefxrefxrefxref
            automatically matched to d1s95b_
            complexed with mn
            1. region 1:176-499 [120814] picpiclink
          3. 1wao picpicxrefxrefxrefxref
            automatically matched to d1s95b_
            complexed with mn
            1. region 2:176-497 [120816] picpiclink
          4. 1wao picpicxrefxrefxrefxref
            automatically matched to d1s95b_
            complexed with mn
            1. region 3:176-499 [120818] picpiclink
          5. 1wao picpicxrefxrefxrefxref
            automatically matched to d1s95b_
            complexed with mn
            1. region 4:176-494 [120820] picpiclink
      5. Protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha [143933]
        1. Human (Homo sapiens) [TaxId: 9606] [143934] (11)
          SQ P67775 2-294
          1. 3c5w picpic
            automatically matched to 2IE4 C:6-293
            1. region c:6-293 [155952] picpiclink
          2. 2ie3 picpicxref
            complexed with acb, add, cab, mn
            1. region c:6-293 [145523] picpiclink
          3. 2ie4 picpicxref
            complexed with mn, oka
            1. region c:6-293 [145524] picpiclink
          4. 3dw8 picpicxrefxref
            automatically matched to 2IE4 C:6-293
            complexed with acb, add, cab, mn; mutant
            1. region c:6-293 [157909] picpiclink
          5. 3dw8 picpicxrefxref
            automatically matched to 2IE4 C:6-293
            complexed with acb, add, cab, mn; mutant
            1. region f:6-293 [157911] picpiclink
          6. 2npp picpicxrefxrefxrefxref
            automatically matched to 2IE4 C:6-293
            complexed with acb, add, cab, mn
            1. region c:6-293 [145692] picpiclink
          7. 2npp picpicxrefxrefxrefxref
            automatically matched to 2IE4 C:6-293
            complexed with acb, add, cab, mn
            1. region f:6-293 [145693] picpiclink
          8. 2nym picpicxrefxrefxrefxref
            automatically matched to 2NYL C:2-294
            complexed with acb, add, cab, mn
            1. region c:2-294 [138823] picpiclink
          9. 2nym picpicxrefxrefxrefxref
            automatically matched to 2NYL C:2-294
            complexed with acb, add, cab, mn
            1. region f:2-294 [138826] picpiclink
          10. 2nyl picpicxrefxrefxrefxref
            complexed with acb, add, cab, mn
            1. region c:2-294 [138817] picpiclink
          11. 2nyl picpicxrefxrefxrefxref
            automatically matched to 2NYL C:2-294
            complexed with acb, add, cab, mn
            1. region f:2-294 [138820] picpiclink
    5. Phosphoesterase-related [82803] (1)
      1. Hypothetical protein PF1291 [82804]
        1. Archaeon Pyrococcus furiosus [TaxId: 2261] [82805] (1)
          1. 1nnw picpic
            structural genomics; pfu-1218608
            complexed with na, pt
            1. chain a [80674] picpiclink
            2. chain b [80675] picpiclink
    6. TT1561-like [103320] (2)
      similar to purple acid and protein phosphatases
      1. Hypothetical protein TT1561 [103321]
        1. Thermus thermophilus [TaxId: 274] [103322] (1)
          1. 1uf3 picpic
            structural genomics
            complexed with ca
            1. chain a [99317] picpiclink
            2. chain b [99318] picpiclink
            3. chain c [99319] picpiclink
            4. chain d [99320] picpiclink
            5. chain e [99321] picpiclink
            6. chain f [99322] picpiclink
            7. chain g [99323] picpiclink
            8. chain h [99324] picpiclink
      2. Uncharacterized protein Aq_1956 [160870]
        1. Aquifex aeolicus [TaxId: 63363] [160871] (1)
          SQ O67769 4-260
          1. 2yvt picpic
            1. region a:4-260 [153779] picpiclink
    7. YfcE-like [111233] (6)
      1. Putative phosphodiesterase MJ0936 [111234]
        1. Methanococcus jannaschii [TaxId: 2190] [111235] (7)
          SQ Q58346
          1. 1s3l picpic
            Structural genomics target
            complexed with po4, unx
            1. chain a [105241] picpiclink
            2. chain b [105242] picpiclink
          2. 1s3m picpic
            Structural genomics target
            complexed with ni
            1. chain a [105243] picpiclink
            2. chain b [105244] picpiclink
          3. 1s3n picpic
            Structural genomics target
            complexed with mn
            1. chain a [105245] picpiclink
            2. chain b [105246] picpiclink
          4. 2ahd picpic
            automatically matched to d1s3la_
            1. region a:1-165 [126752] picpiclink
          5. 2ahd picpic
            automatically matched to d1s3la_
            1. region b:201-365 [126753] picpiclink
          6. 2ahd picpic
            automatically matched to d1s3la_
            1. region c:1-165 [126754] picpiclink
          7. 2ahd picpic
            automatically matched to d1s3la_
            1. region d:201-365 [126755] picpiclink
      2. Phosphodiesterase yfcE [111236]
        1. Escherichia coli [TaxId: 562] [111237] (1)
          SQ P76495
          1. 1su1 picpic
            Structural genomics target
            complexed with so4, zn
            1. chain a [106016] picpiclink
            2. chain b [106017] picpiclink
            3. chain c [106018] picpiclink
            4. chain d [106019] picpiclink
      3. Vacuolar protein sorting 29, VPS29 [143935]
        1. Mouse (Mus musculus) [TaxId: 10090] [143936] (5)
          SQ Q9QZ88 1-182
          1. 1z2w picpic
            complexed with gol, mn
            1. region a:1-182 [124390] picpiclink
          2. 1z2w picpic
            automatically matched to 1Z2W A:1-182
            complexed with gol, mn
            1. region b:1-182 [124391] picpiclink
          3. 1z2x picpic
            automatically matched to 1Z2W A:1-182
            1. region a:1-182 [124392] picpiclink
          4. 1z2x picpic
            automatically matched to 1Z2W A:1-182
            1. region b:1-182 [124393] picpiclink
          5. 1w24 picpic
            automatically matched to 1Z2W A:1-182
            1. region a:1-181 [120579] picpiclink
        2. Cryptosporidium parvum [TaxId: 5807] [143937] (2)
          SQ Q5CYJ7 5-197
          1. 2a22 picpic
            1. region a:4-196 [126025] picpiclink
          2. 2a22 picpic
            automatically matched to 2A22 A:4-196
            1. region b:4-196 [126026] picpiclink
        3. Homo sapiens [TaxId: 9606] [160872] (2)
          1. 2r17 picpic
            automatically matched to d1z2wa1
            complexed with gol
            1. region a:1-181 [151510] picpiclink
          2. 2r17 picpic
            automatically matched to d1z2wa1
            complexed with gol
            1. region b:1-181 [151511] picpiclink
      4. Uncharacterized protein SP1879 [160873]
        1. Streptococcus pneumoniae [TaxId: 1313] [160874] (1)
          SQ Q97NX4 1-173
          1. 3ck2 picpic
            complexed with cl, mn, srt
            1. region a:1-173 [156724] picpiclink
    8. Hypothetical protein aq_1666 [118152] (1)
      1. Hypothetical protein aq_1666 [118153]
        1. Aquifex aeolicus [TaxId: 63363] [118154] (1)
          SQ O67582
          1. 1xm7 picpic
            Structural genomics target
            1. chain a [115473] picpiclink
            2. chain b [115474] picpiclink
    9. DR1281-like [118155] (2)
      1. Putative phosphatase DR1281 [118156]
        1. Deinococcus radiodurans [TaxId: 1299] [118157] (1)
          SQ Q9RUV0
          1. 1t70 picpic
            Structural genomics target
            1. chain a [112275] picpiclink
            2. chain b [112276] picpiclink
            3. chain c [112277] picpiclink
            4. chain d [112278] picpiclink
            5. chain e [112279] picpiclink
            6. chain f [112280] picpiclink
            7. chain g [112281] picpiclink
            8. chain h [112282] picpiclink
      2. Hypothetical protein MPN349 [118158]
        1. Mycoplasma pneumoniae [TaxId: 2104] [118159] (1)
          SQ P75429
          1. 1t71 picpic
            Structural genomics target
            complexed with fe
            1. chain a [112283] picpiclink
    10. TTHA0625-like [143938] (1)
      part of Pfam 00149
      1. Hypothetical protein TTHA0625 [143939]
        1. Thermus thermophilus [TaxId: 274] [143940] (8)
          SQ Q5SKL8 1-252
          1. 2z06 picpic
            automatically matched to d2cv9a1
            complexed with co
            1. region a:1-252 [153906] picpiclink
          2. 2z06 picpic
            automatically matched to d2cv9a1
            complexed with co
            1. region b:1-252 [153907] picpiclink
          3. 2z06 picpic
            automatically matched to d2cv9a1
            complexed with co
            1. region c:1-252 [153908] picpiclink
          4. 2z06 picpic
            automatically matched to d2cv9a1
            complexed with co
            1. region d:1-252 [153909] picpiclink
          5. 2cv9 picpic
            1. region a:1-252 [130855] picpiclink
          6. 2cv9 picpic
            automatically matched to 2CV9 A:1-252
            1. region b:1-252 [130856] picpiclink
          7. 2cv9 picpic
            automatically matched to 2CV9 A:1-252
            1. region c:1-252 [130857] picpiclink
          8. 2cv9 picpic
            automatically matched to 2CV9 A:1-252
            1. region d:1-252 [130858] picpiclink
    11. GpdQ-like [160875] (2)
      part of Pfam 00149
      1. Rv0805 cyclic nucleotide phosphodiesterase [160876]
        1. Mycobacterium tuberculosis [TaxId: 1773] [160877] (3)
          SQ O06629 10-265
          1. 2hy1 picpic
            complexed with fe, mn, po4
            1. region a:10-265 [147437] picpiclink
          2. 2hyp picpic
            complexed with br, cac, fe, mn; mutant
            1. region a:10-265 [147459] picpiclink
          3. 2hyo picpic
            complexed with fe, mn; mutant
            1. region a:10-265 [147458] picpiclink
      2. Glycerophosphodiesterase GpdQ [160878]
        1. Enterobacter aerogenes [TaxId: 548] [160879] (14)
          SQ Q6XBH1 1-271
          1. 3d03 picpic
            automatically matched to 2ZO9 B:1-271
            complexed with co
            1. region a:1-271 [157161] picpiclink
          2. 3d03 picpic
            automatically matched to 2ZO9 B:1-271
            complexed with co
            1. region b:1-271 [157162] picpiclink
          3. 3d03 picpic
            automatically matched to 2ZO9 B:1-271
            complexed with co
            1. region c:1-271 [157163] picpiclink
          4. 3d03 picpic
            automatically matched to 2ZO9 B:1-271
            complexed with co
            1. region d:1-271 [157164] picpiclink
          5. 3d03 picpic
            automatically matched to 2ZO9 B:1-271
            complexed with co
            1. region e:1-271 [157165] picpiclink
          6. 3d03 picpic
            automatically matched to 2ZO9 B:1-271
            complexed with co
            1. region f:1-271 [157166] picpiclink
          7. 2zo9 picpic
            complexed with fe2, mli
            1. region b:1-271 [154714] picpiclink
          8. 2zo9 picpic
            automatically matched to 2ZO9 B:1-271
            complexed with fe2, mli
            1. region c:1-271 [154715] picpiclink
          9. 2zoa picpic
            automatically matched to 2ZO9 B:1-271
            complexed with fe2, mli
            1. region a:1-271 [154716] picpiclink
          10. 2zoa picpic
            automatically matched to 2ZO9 B:1-271
            complexed with fe2, mli
            1. region b:1-271 [154717] picpiclink
          11. 2dxl picpic
            complexed with co
            1. region a:1-271 [146601] picpiclink
          12. 2dxl picpic
            automatically matched to 2DXL A:1-271
            complexed with co
            1. region b:1-271 [146602] picpiclink
          13. 2dxn picpic
            automatically matched to 2DXL A:1-271
            complexed with zn
            1. region a:1-271 [146605] picpiclink
          14. 2dxn picpic
            automatically matched to 2DXL A:1-271
            complexed with zn
            1. region b:1-271 [146606] picpiclink
    12. ADPRibase-Mn-like [160880] (1)
      contains Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase (ADPRibase-Mn); part of Pfam 00149
      1. Uncharacterized C17orf48 homolog zgc:64213 [160881]
        1. Zebrafish (Danio rerio) [TaxId: 7955] [160882] (1)
          SQ Q7T291 3-322
          1. 2nxf picpic
            complexed with eoh, po4, zn
            1. region a:3-322 [148499] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk