Structural Classification of Proteins
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Family: (Glycosyl)asparaginase

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Ntn hydrolase-like [56234]
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235]
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
    link to SUPERFAMILY database - Superfamily
  5. Family: (Glycosyl)asparaginase [56261]

Protein Domains:

  1. Glycosylasparaginase (aspartylglucosaminidase, AGA) [56262]
    the precursor chain is cleaved onto 2 fragments by autoproteolysis
    1. Human (Homo sapiens) [TaxId: 9606] [56263] (2)
      1. 1apy picpic
        complexed with man, nag
        1. chain a,b [42004] picpiclink
        2. chain c,d [42005] picpiclink
      2. 1apz picpic
        complexed with man, nag
        1. chain a,b [42006] picpiclink
        2. chain c,d [42007] picpiclink
    2. Flavobacterium meningosepticum [TaxId: 238] [56264] (8)
      1. 2gac picpic
        mutant
        1. chain a,b [42012] picpiclink
        2. chain c,d [42013] picpiclink
      2. 2gaw picpic
        1. chain a,b [42018] picpiclink
        2. chain c,d [42019] picpiclink
      3. 1ayy picpic
        1. chain a,b [42016] picpiclink
        2. chain c,d [42017] picpiclink
      4. 1p4k picpic
        precursor D151N mutant
        1. chain a [87772] picpiclink
        2. chain c [87773] picpiclink
      5. 9gaf picpic
        Precursor W11F mutant
        1. chain a [42008] picpiclink
        2. chain c [42009] picpiclink
      6. 1p4v picpic
        precursor D151N mutant
        1. chain a [87781] picpiclink
        2. chain c [87782] picpiclink
      7. 9gac picpic
        Precursor of the T152C mutant
        1. chain a [42010] picpiclink
        2. chain c [42011] picpiclink
      8. 9gaa picpic
        Precursor T152A mutant
        1. chain a [42014] picpiclink
        2. chain c [42015] picpiclink
    3. Escherichia coli [TaxId: 562] [103315] (3)
      SQ P37595
      isoaspartyl peptidase with L-asparaginase activity
      putative L-asparaginase YbiK
      1. 1k2x picpic
        complexed with cl, na
        1. chain a,b [90929] picpiclink
        2. chain c,d [90930] picpiclink
      2. 1t3m picpic
        complexed with na, no3
        1. chain a,b [106361] picpiclink
        2. chain c,d [106362] picpiclink
      3. 1jn9 picpic
        complexed with ca, cl, na
        1. chain a,b [90898] picpiclink
        2. chain c,d [90899] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk