Structural Classification of Proteins

Superfamily: Glutathione synthetase ATP-binding domain-like

: uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: ATP-grasp [56058]
Consists of two subdomains with different alpha+beta folds
shares functional and structural similarities with the PIPK and protein kinase superfamilies
Superfamily: Glutathione synthetase ATP-binding domain-like [56059]
uperfamily

Families:

ATP-binding domain of peptide synthetases [56060] (4)
1. Prokaryotic glutathione synthetase, C-domain [56061]
  1. Escherichia coli [TaxId: 562] [56062] (4)
2. D-ala-D-ala ligase, C-domain [56063]
  1. Escherichia coli, gene ddlB [TaxId: 562] [56064] (3)
3. D-alanine:D-lactate ligase VanA, C-domain [56065]
  1. Leuconostoc mesenteroides, Ddl2 [TaxId: 1245] [56066] (1)
  2. Enterococcus faecium [TaxId: 1352] [64402] (1)
Lysine biosynthesis enzyme LysX ATP-binding domain [103281] (1)
1. Lysine biosynthesis enzyme LysX ATP-binding domain [103282]
  1. Thermus thermophilus [TaxId: 274] [103283] (2)
BC ATP-binding domain-like [56067] (8)
1. Biotin carboxylase (BC), domain 2 [56068]
  subunit of acetyl-CoA and pyruvate carboxylases
  1. Escherichia coli [TaxId: 562] [56069] (13)
  2. Aquifex aeolicus [TaxId: 63363] [103284] (1)
2. Glycinamide ribonucleotide synthetase (GAR-syn), domain 2 [56070]
  1. Escherichia coli [TaxId: 562] [56071] (1)
  2. Thermotoga maritima [TaxId: 2336] [111187] (1)
    SQ Q9X0X7
3. N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2 [56072]
  1. Escherichia coli [TaxId: 562] [56073] (6)
4. Glycinamide ribonucleotide transformylase PurT, domain 2 [56074]
  1. Escherichia coli [TaxId: 562] [56075] (7)
5. Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains [56076]
  duplication: CPS large subunit contains two full BC-like lobes: carboxyphosphate and carbamoyl phosphate domains
  1. Escherichia coli [TaxId: 562] [56077] (10)
    SQ P00968
6. Acetyl-CoA carboxylase, BC-M subdomain [118120]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [118121] (2)
    SQ Q00955 13-566
Synapsin C-terminal domain [56078] (3)
1. Synapsin [56079]
  1. Cow (Bos taurus) [TaxId: 9913] [56080] (2)
  2. Rat (Rattus norvegicus) [TaxId: 10116] [103285] (2)
2. Synapsin II [90030]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [90031] (2)
Succinyl-CoA synthetase, beta-chain, N-terminal domain [56081] (2)
1. Succinyl-CoA synthetase, beta-chain, N-terminal domain [56082]
  1. Escherichia coli [TaxId: 562] [56083] (18)
  2. Pig (Sus scrofa) [TaxId: 9823] [56084] (6)
    GTP-specific enzyme
Pyruvate phosphate dikinase, N-terminal domain [56085] (3)
1. Pyruvate phosphate dikinase, N-terminal domain [56086]
  the common fold is interrupted by a 4-helical subdomain (residues 112-198)
  1. Clostridium symbiosum [TaxId: 1512] [56087] (7)
  2. Trypanosoma brucei [TaxId: 5691] [75557] (1)
  3. Maize (Zea mays) [TaxId: 4577] [143889] (2)
    SQ P11155 74-453
Eukaryotic glutathione synthetase ATP-binding domain [56088] (2)
circularly permuted version of prokaryotic enzyme
1. Eukaryotic glutathione synthetase ATP-binding domain [56089]
  1. Human (Homo sapiens) [TaxId: 9606] [56090] (1)
  2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82788] (2)
Glutathionylspermidine synthase ATP-binding domain-like [143890] (1)
both terminal parts of Pfam 03738; GSP; overal similarity of the Pfam domain to the Eukaryotic glutathione synthetase
1. Glutathionylspermidine synthase, synthetase domain [143891]
  1. Escherichia coli [TaxId: 562] [143892] (10)
    SQ P0AES0 201-378,497-615
PurP ATP-binding domain-like [160804] (3)
Pfam 06973; DUF1297
1. 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase PurP [160805]
  1. Thermococcus kodakaraensis [TaxId: 311400] [160806] (3)
    SQ Q5JD28 98-310
  2. Methanocaldococcus jannaschii [TaxId: 2190] [160807] (4)
    SQ Q57600 124-361
  3. Pyrococcus furiosus [TaxId: 2261] [160808] (12)
    SQ Q8U0R7 100-334