Fold: ATP-grasp

Consists of two subdomains with different alpha+beta folds
shares functional and structural similarities with the PIPK and protein kinase superfamilies

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b) [53931]
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: ATP-grasp [56058]
   Consists of two subdomains with different alpha+beta folds
   shares functional and structural similarities with the PIPK and protein kinase superfamilies

Superfamilies:

1. Glutathione synthetase ATP-binding domain-like [56059] (9)
   uperfamily
   1. ATP-binding domain of peptide synthetases [56060] (4)
   2. Lysine biosynthesis enzyme LysX ATP-binding domain [103281] (1)
   3. BC ATP-binding domain-like [56067] (8)
   4. Synapsin C-terminal domain [56078] (3)
   5. Succinyl-CoA synthetase, beta-chain, N-terminal domain [56081] (2)
   6. Pyruvate phosphate dikinase, N-terminal domain [56085] (3)
   7. Eukaryotic glutathione synthetase ATP-binding domain [56088] (2)
      circularly permuted version of prokaryotic enzyme
   8. Glutathionylspermidine synthase ATP-binding domain-like [143890] (1)
      both terminal parts of Pfam 03738; GSP; overal similarity of the Pfam domain to the Eukaryotic glutathione synthetase
   9. PurP ATP-binding domain-like [160804] (3)
      Pfam 06973; DUF1297
2. DNA ligase/mRNA capping enzyme, catalytic domain [56091] (4)
   has a circularly permuted topology
   uperfamily
   1. ATP-dependent DNA ligase catalytic domain [56092] (3)
   2. Adenylation domain of NAD+-dependent DNA ligase [56096] (3)
   3. mRNA capping enzyme [56100] (2)
   4. RNA ligase [103286] (2)

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk