Structural Classification of Proteins
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Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase

8-stranded mixed beta-sheet; 2 layers: alpha/beta

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873]
    8-stranded mixed beta-sheet; 2 layers: alpha/beta

Superfamilies:

  1. ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (4)
    link to SUPERFAMILY database - Superfamily
    1. Heat shock protein 90, HSP90, N-terminal domain [55875] (3)
      1. HSP90 [55876]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55877] (21) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [55878] (53) picpic
          SQ P08238 10-220 # HSP 90-beta isoform ! SQ P07900 16-223
        3. Dog (Canis familiaris) [TaxId: 9615] [103225] (29) picpic
          SQ P41148 76-285; Endoplasmin, GRP94
    2. DNA gyrase/MutL, N-terminal domain [55879] (7)
      1. DNA gyrase B [55880]
        1. Escherichia coli [TaxId: 562] [55881] (3) picpic
        2. Thermus thermophilus [TaxId: 274] [75534] (1) picpic
      2. DNA topoisomerase II [103226]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [103227] (2) picpic
      3. Topoisomerase IV subunit B [103228]
        1. Escherichia coli [TaxId: 562] [103229] (2) picpic
      4. DNA mismatch repair protein MutL [55882]
        1. Escherichia coli [TaxId: 562] [55883] (6) picpic
      5. DNA mismatch repair protein PMS2 [69800]
        1. Human (Homo sapiens) [TaxId: 9606] [69801] (3) picpic
      6. Topoisomerase VI-B subunit [82778]
        contains an H2TH domain inserted after this domain and before the second family-specific domain
        1. Archaeon Sulfolobus shibatae [TaxId: 2286] [82779] (10) picpic
    3. Histidine kinase [55884] (7)
      1. Histidine kinase domain of the osmosensor EnvZ [55885]
        1. Escherichia coli [TaxId: 562] [55886] (1) picpic
      2. Histidine kinase CheA [55887]
        1. Thermotoga maritima [TaxId: 2336] [55888] (9) picpic
      3. Histidine kinase PhoQ domain [69802]
        1. Escherichia coli [TaxId: 562] [69803] (1) picpic
      4. Anti-sigma factor spoIIab [75535]
        1. Bacillus stearothermophilus [TaxId: 1422] [75536] (5) picpic
          SQ O32727
      5. Nitrogen regulation protein NtrB, C-terminal domain [111143]
        1. Escherichia coli [TaxId: 562] [111144] (1) picpic
          SQ P06712 194-349
      6. Sensor histidine kinase TM0853 [143795]
        1. Thermotoga maritima [TaxId: 2336] [143796] (1) picpic
          SQ Q9WZV7 321-481
      7. Sensor-type histidine kinase PrrB [143797]
        1. Mycobacterium tuberculosis [TaxId: 1773] [143798] (6) picpic
          SQ P0A5Z8 299-446
    4. alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3)
      1. Branched-chain alpha-ketoacid dehydrogenase kinase (BCK) [69805]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [69806] (3) picpic
      2. Pyruvate dehydrogenase kinase [69807]
        1. Rat (Rattus norvegicus), isozyme 2 [TaxId: 10116] [69808] (1) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [160702] (8) picpic
          SQ Q15120 177-301
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk