Structural Classification of Proteins

Fold: Nudix

: beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
contains beta-grasp motif

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Nudix [55810]
beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
contains beta-grasp motif

Superfamilies:

Nudix [55811] (7)
uperfamily
1. MutT-like [55812] (20)
  1. Nucleoside triphosphate pyrophosphorylase (MutT) [55813]
    1. Escherichia coli [TaxId: 562] [55814] (6)
  2. Coenzyme A pyrophosphatase [90022]
    1. Deinococcus radiodurans [TaxId: 1299] [90023] (2)
  3. ADP-ribose pyrophosphatase [64365]
    1. Escherichia coli [TaxId: 562] [64366] (5)
    2. Mycobacterium tuberculosis [TaxId: 1773] [103200] (5)
      gene Rv1700
    3. Thermus thermophilus [TaxId: 274] [118083] (11)
      SQ Q84CU3
  4. ADP-ribose pyrophosphatase homologue YffH [103201]
    1. Escherichia coli [TaxId: 562] [103202] (1)
  5. ADP compounds hydrolase NudE [103203]
    1. Escherichia coli [TaxId: 562] [103204] (2)
  6. NUDT9 (mitochondrial ADP-ribose pyrophosphatase) [103205]
    1. Human (Homo sapiens) [TaxId: 9606] [103206] (2)
  7. 7,8-dihydro-8-oxoguanine triphosphatase Hmth1 [103207]
    1. Human (Homo sapiens) [TaxId: 9606] [103208] (1)
  8. Hypothetical protein DR1025 [103209]
    1. Deinococcus radiodurans [TaxId: 1299] [103210] (4)
  9. Diadenosine tetraphosphate hydrolase (Ap4A hydrolase) [64367]
    1. Narrow-leaved blue lupine (Lupinus angustifolius) [TaxId: 3871] [64368] (2)
    2. Caenorhabditis elegans [TaxId: 6239] [75526] (2)
    3. Human (Homo sapiens) [TaxId: 9606] [118084] (3)
      SQ P50583
  10. Hypothetical protein PAE3301 [75527]
    1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [75528] (3)
  11. Hypothetical protein EF1141 [143756]
    1. Enterococcus faecalis [TaxId: 1351] [143757] (1)
      SQ Q836H1 2-148
  12. AP6A hydrolase Ndx1 [143758]
    1. Thermus thermophilus [TaxId: 274] [143759] (6)
      SQ Q75UV1 1-126
  13. Hypothetical protein NE0184 [143760]
    1. Nitrosomonas europaea [TaxId: 915] [143761] (1)
      SQ Q82XR9 4-149
  14. Hypothetical protein SP1235 (spr1115) [143762]
    1. Streptococcus pneumoniae [TaxId: 1313] [143763] (1)
      SQ Q97QH6 1-155
  15. U8 snorna-binding protein x29 [143764]
    nuclear decapping enzyme
    1. African clawed frog (Xenopus laevis) [TaxId: 8355] [143765] (12)
      SQ Q6TEC1 14-209
  16. Diphosphoinositol polyphosphate phosphohydrolase [143766]
    1. Human (Homo sapiens) [TaxId: 9606] [143767] (2)
      SQ O95989 8-142
2. MutY C-terminal domain-like [103211] (2)
  1. Adenine glycosylase MutY, C-terminal domain [103212]
    1. Bacillus stearothermophilus [TaxId: 1422] [103213] (3)
  2. A/G-specific adenine DNA glycosylase [143768]
    MutY homolog
    1. Human (Homo sapiens) [TaxId: 9606] [143769] (1)
      SQ Q9UIF7 356-497
3. NADH pyrophosphatase [103214] (1)
  duplication: consists of two structurally similar domains separated by a rubredoxin-like zinc finger; the N-terminal domain has a rudiment Nudix fold, the C-terminal, probably catalytic, domain has the canonical fold
  1. NADH pyrophosphatase [103215]
    1. Escherichia coli [TaxId: 562] [103216] (1)
4. IPP isomerase-like [64369] (4)
  1. Isopentenyl diphosphate isomerase [64370]
    1. Escherichia coli [TaxId: 562] [64371] (25)
      SQ Q46822
  2. Hypothetical protein DR0079 [103217]
    1. Deinococcus radiodurans [TaxId: 1299] [103218] (1)
    2. Deinococcus radiodurans str. R1 (Deinococcus radiodurans R1) [TaxId: 243230] [160692] (2)
  3. Hypothetical protein YfcD [143770]
    1. Escherichia coli [TaxId: 562] [143771] (3)
      SQ P65556 8-168
5. GDP-mannose mannosyl hydrolase NudD [111132] (1)
  1. GDP-mannose mannosyl hydrolase NudD [111133]
    1. Escherichia coli [TaxId: 562] [111134] (5)
      SQ P32056
6. BT0354 N-terminal domain-like [143772] (2)
  accosiated with the C-terminal "winged helix" domain (scop_sf 46785)
  1. Hypothetical protein EF2700, N-terminal domain [143773]
    includes extra N-terminal alpha-hairpin, separated by a linker peptide
    1. Enterococcus faecalis [TaxId: 1351] [143774] (2)
      SQ Q830S2 3-204
  2. Hypothetical protein BT0354, N-terminal domain [143775]
    1. Bacteroides thetaiotaomicron [TaxId: 818] [143776] (4)
      SQ Q8AAV8 3-149
7. mRNA decapping enzyme-like [143777] (1)
  part of Pfam 00293
  1. mRNA decapping enzyme Dcp2p catalytic domain [143778]
    1. Schizosaccharomyces pombe [TaxId: 4896] [143779] (1)
      SQ O13828 95-245