Fold: T-fold

beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
tunnel-shaped: its known members form wide oligomeric barrels different sizes

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b) [53931]
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: T-fold [55619]
   beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
   tunnel-shaped: its known members form wide oligomeric barrels different sizes

Superfamilies:

1. Tetrahydrobiopterin biosynthesis enzymes-like [55620] (4)
   bind purine or pterin in topologically similar sites between subunits
   uperfamily
   1. GTP cyclohydrolase I [55621] (4)
   2. 6-pyruvoyl tetrahydropterin synthase [55625] (4)
   3. DHN aldolase/epimerase [55628] (4)
      beta-sheets of four subunits form a barrel, closed: n=16, S=16
   4. Urate oxidase (uricase) [55633] (3)
2. ApbE-like [143631] (2)
   duplication: contains two differently decorated beta(2)-alpha(2)-beta(2) subdomains, similar to other T-fold domains; probably does not form the tunnel-shaped oligomers
   uperfamily
   1. ApbE-like [143632] (1)
      Pfam 02424
   2. DVU1097-like [160566] (1)
      Pfam 04040; DUF375

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk