Structural Classification of Proteins
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Fold: Pseudouridine synthase

consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Pseudouridine synthase [100877]
    consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold

Superfamilies:

  1. Pseudouridine synthase [55120] (4)
    the active site is the most conserved structural region of the superfamily and is located between the subdomains
    link to SUPERFAMILY database - Superfamily
    1. Pseudouridine synthase I TruA [55121] (1)
      1. Pseudouridine synthase I TruA [55122]
        1. Escherichia coli [TaxId: 562] [55123] (10) picpic
    2. Pseudouridine synthase II TruB [69746] (5)
      contains C-terminal PUA domain
      1. Pseudouridine synthase II TruB [69747]
        1. Escherichia coli [TaxId: 562] [69748] (3) picpic
        2. Thermotoga maritima [TaxId: 2336] [103016] (8) picpic
        3. Mycobacterium tuberculosis [TaxId: 1773] [103017] (1) picpic
        4. Archaeon Pyrococcus furiosus [TaxId: 2261] [143434] (4) picpic
          SQ Q7LWY0 5-249
        5. Archaeon Methanococcus jannaschii [TaxId: 2190] [143435] (1) picpic
          SQ Q57612 17-246
    3. Pseudouridine synthase RsuA/RluD [75459] (4)
      contains N-terminal alpha-L RNA-binding motif
      1. Ribosomal small subunit pseudouridine 516 synthase RsuA [75460]
        1. Escherichia coli [TaxId: 562] [75461] (3) picpic
        2. Haemophilus influenzae [TaxId: 727] [103018] (1) picpic
      2. Ribosomal large subunit pseudouridine synthase D, RluD [103019]
        1. Escherichia coli [TaxId: 562] [103020] (3) picpic
          SQ P33643
      3. Ribosomal large subunit pseudouridine synthase C, RluC [111010]
        1. Escherichia coli [TaxId: 562] [111011] (1) picpic
          SQ P23851
    4. tRNA pseudouridine synthase TruD [103021] (1)
      natural circular permutation in the catalytic domain; insertion of the family-specific alpha+beta subdomain
      1. tRNA pseudouridine synthase TruD [103022]
        1. Escherichia coli [TaxId: 562] [103023] (3) picpic
          SQ Q57261
          family-specific insert subdomain: res. 158-301
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk