Structural Classification of Proteins
home mail help root up expand collapse

Family: HMA, heavy metal-associated domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Ferredoxin-like [54861]
    alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
  4. Superfamily: HMA, heavy metal-associated domain [55008]
    link to SUPERFAMILY database - Superfamily
  5. Family: HMA, heavy metal-associated domain [55009]

Protein Domains:

  1. Mercuric ion binding protein MerP [55010]
    1. Shigella flexneri [TaxId: 623] [55011] (3)
      1. 1afj picpic
        complexed with hg
        1. chain a [39338] picpiclink
      2. 2hqi picpic
        1. chain a [39340] picpiclink
      3. 1afi picpic
        1. chain a [39339] picpiclink
    2. Ralstonia metallidurans CH34 [TaxId: 266264] [110979] (1)
      SQ O66016 Q58AI1 Q5NUU9 Q6UP70 Q7BRH5 Q7BRH6 Q7X3A5 # 100% identity
      1. 1osd picpic
        1. chain a [104022] picpiclink
        2. chain b [104023] picpiclink
  2. Potential copper-translocating P-type ATPase CopA (YvgX) [75441]
    duplication: contains tandem repeat of two HMA domains in the N-terminal region
    1. Bacillus subtilis [TaxId: 1423] [75442] (6)
      1. 1p6t picpic
        mutant
        1. region a:1-72 [94188] picpiclink
        2. region a:73-151 [94189] picpiclink
      2. 1kqk picpic
        domain 2
        complexed with cu1
        1. chain a [72880] picpiclink
      3. 1jww picpic
        domain 2
        1. chain a [71919] picpiclink
      4. 1oq3 picpic
        domain 1
        mutant
        1. chain a [93412] picpiclink
      5. 1opz picpic
        domain 1
        mutant
        1. chain a [93407] picpiclink
      6. 1oq6 picpic
        domain 1
        complexed with cu; mutant
        1. chain a [93414] picpiclink
  3. Metal ion-transporting ATPase ZntA, N-terminal domain [82683]
    1. Escherichia coli [TaxId: 562] [82684] (2)
      1. 1mwz picpic
        complexed with zn
        1. chain a [79617] picpiclink
      2. 1mwy picpic
        1. chain a [79616] picpiclink
  4. Copper transporter domain ccc2a [64279]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64280] (3)
      1. 2ggp picpicxref
        automatically matched to d1fvqa_
        complexed with cu1
        1. region b:1-72 [135155] picpiclink
      2. 1fvq picpic
        apo form
        1. chain a [60046] picpiclink
      3. 1fvs picpic
        Cu(I) form
        complexed with cu
        1. chain a [60049] picpiclink
  5. Menkes copper-transporting ATPase [55012]
    1. Human (Homo sapiens) [TaxId: 9606] [55013] (7)
      1. 2aw0 picpic
        4th metal-binding domain
        complexed with ag
        1. chain a [39341] picpiclink
      2. 1aw0 picpic
        4th metal-binding domain
        1. chain a [39342] picpiclink
      3. 1q8l picpic
        2nd metal-binding domain
        1. chain a [96214] picpiclink
      4. 1s6u picpic
        2nd metal-binding domain
        complexed with cu1
        1. chain a [98608] picpiclink
      5. 1s6o picpic
        2nd metal-binding domain
        1. chain a [98597] picpiclink
      6. 1kvj picpic
        1st metal-binding domain
        complexed with cu1
        1. chain a [91043] picpiclink
      7. 1kvi picpic
        1st metal-binding domain
        1. chain a [91042] picpiclink
  6. ATX1 metallochaperone protein (ATOX1) [55014]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55015] (5)
      1. 1cc8 picpic
        1. chain a [39343] picpiclink
      2. 1cc7 picpic
        1. chain a [39344] picpiclink
      3. 2ggp picpicxref
        automatically matched to d1fd8a_
        complexed with cu1
        1. region a:1-73 [135154] picpiclink
      4. 1fd8 picpic
        Cu(I) form
        complexed with cu1
        1. chain a [59770] picpiclink
      5. 1fes picpic
        apo form
        1. chain a [59800] picpiclink
    2. Human (Homo sapiens), HAH1 [TaxId: 9606] [55016] (5)
      SQ O00244
      1. 1fe0 picpic
        complexed with cd, so4, suc
        1. chain a [39345] picpiclink
        2. chain b [39346] picpiclink
      2. 1fe4 picpic
        complexed with hg, ium, so4, suc
        1. chain a [39347] picpiclink
        2. chain b [39348] picpiclink
      3. 1fee picpic
        complexed with cu1, so4, suc
        1. chain a [39349] picpiclink
        2. chain b [39350] picpiclink
      4. 1tl5 picpic
        1. chain a [112500] picpiclink
      5. 1tl4 picpic
        complexed with cu1
        1. chain a [112499] picpiclink
  7. Copper chaperone [55017]
    1. Enterococcus hirae [TaxId: 1354] [55018] (1)
      1. 1cpz picpic
        mutant
        1. chain a [39351] picpiclink
    2. Bacillus subtilis, CopZ [TaxId: 1423] [69736] (4)
      1. 2qif picpic
        automatically matched to d1k0va_
        complexed with act, ca, cu1, gol
        1. region a:1-69 [150808] picpiclink
      2. 2qif picpic
        automatically matched to d1k0va_
        complexed with act, ca, cu1, gol
        1. region b:1-68 [150809] picpiclink
      3. 1k0v picpic
        complexed with cu1
        1. chain a [67986] picpiclink
      4. 1p8g picpic
        1. chain a [94360] picpiclink
    3. Synechocystis sp. pcc 6803, Scatx1 [TaxId: 1148] [102998] (1)
      1. 1sb6 picpic
        1. chain a [98790] picpiclink
  8. Copper chaperone for superoxide dismutase, N-terminal domain [55019]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55020] (2)
      1. 1qup picpicxref
        1. region a:2-73 [39352] picpiclink
        2. region b:5-73 [39353] picpiclink
      2. 1jk9 picpicxrefxref
        complexed with so4, zn; mutant
        1. region b:3-73 [63151] picpiclink
        2. region d:3-73 [63154] picpiclink
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk