Structural Classification of Proteins

Superfamily: HMA, heavy metal-associated domain

: uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Ferredoxin-like [54861]
alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
Superfamily: HMA, heavy metal-associated domain [55008]
uperfamily

Families:

HMA, heavy metal-associated domain [55009] (12)
1. Mercuric ion binding protein MerP [55010]
  1. Shigella flexneri [TaxId: 623] [55011] (3)
    1. 1afj
      complexed with hg
      1. chain a [39338]
    2. 2hqi
      1. chain a [39340]
    3. 1afi
      1. chain a [39339]
  2. Ralstonia metallidurans CH34 [TaxId: 266264] [110979] (1)
    SQ O66016 Q58AI1 Q5NUU9 Q6UP70 Q7BRH5 Q7BRH6 Q7X3A5 # 100% identity
    1. 1osd
      1. chain a [104022]
      2. chain b [104023]
2. Potential copper-translocating P-type ATPase CopA (YvgX) [75441]
  duplication: contains tandem repeat of two HMA domains in the N-terminal region
  1. Bacillus subtilis [TaxId: 1423] [75442] (6)
    1. 1p6t
      mutant
      1. region a:1-72 [94188]
      2. region a:73-151 [94189]
    2. 1kqk
      domain 2
      complexed with cu1
      1. chain a [72880]
    3. 1jww
      domain 2
      1. chain a [71919]
    4. 1oq3
      domain 1
      mutant
      1. chain a [93412]
    5. 1opz
      domain 1
      mutant
      1. chain a [93407]
    6. 1oq6
      domain 1
      complexed with cu; mutant
      1. chain a [93414]
3. Metal ion-transporting ATPase ZntA, N-terminal domain [82683]
  1. Escherichia coli [TaxId: 562] [82684] (2)
    1. 1mwz
      complexed with zn
      1. chain a [79617]
    2. 1mwy
      1. chain a [79616]
4. Copper transporter domain ccc2a [64279]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64280] (3)
    1. 2ggp
      automatically matched to d1fvqa_
      complexed with cu1
      1. region b:1-72 [135155]
    2. 1fvq
      apo form
      1. chain a [60046]
    3. 1fvs
      Cu(I) form
      complexed with cu
      1. chain a [60049]
5. Menkes copper-transporting ATPase [55012]
  1. Human (Homo sapiens) [TaxId: 9606] [55013] (7)
    1. 2aw0
      4th metal-binding domain
      complexed with ag
      1. chain a [39341]
    2. 1aw0
      4th metal-binding domain
      1. chain a [39342]
    3. 1q8l
      2nd metal-binding domain
      1. chain a [96214]
    4. 1s6u
      2nd metal-binding domain
      complexed with cu1
      1. chain a [98608]
    5. 1s6o
      2nd metal-binding domain
      1. chain a [98597]
    6. 1kvj
      1st metal-binding domain
      complexed with cu1
      1. chain a [91043]
    7. 1kvi
      1st metal-binding domain
      1. chain a [91042]
6. ATX1 metallochaperone protein (ATOX1) [55014]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55015] (5)
    1. 1cc8
      1. chain a [39343]
    2. 1cc7
      1. chain a [39344]
    3. 2ggp
      automatically matched to d1fd8a_
      complexed with cu1
      1. region a:1-73 [135154]
    4. 1fd8
      Cu(I) form
      complexed with cu1
      1. chain a [59770]
    5. 1fes
      apo form
      1. chain a [59800]
  2. Human (Homo sapiens), HAH1 [TaxId: 9606] [55016] (5)
    SQ O00244
    1. 1fe0
      complexed with cd, so4, suc
      1. chain a [39345]
      2. chain b [39346]
    2. 1fe4
      complexed with hg, ium, so4, suc
      1. chain a [39347]
      2. chain b [39348]
    3. 1fee
      complexed with cu1, so4, suc
      1. chain a [39349]
      2. chain b [39350]
    4. 1tl5
      1. chain a [112500]
    5. 1tl4
      complexed with cu1
      1. chain a [112499]
7. Copper chaperone [55017]
  1. Enterococcus hirae [TaxId: 1354] [55018] (1)
    1. 1cpz
      mutant
      1. chain a [39351]
  2. Bacillus subtilis, CopZ [TaxId: 1423] [69736] (4)
    1. 2qif
      automatically matched to d1k0va_
      complexed with act, ca, cu1, gol
      1. region a:1-69 [150808]
    2. 2qif
      automatically matched to d1k0va_
      complexed with act, ca, cu1, gol
      1. region b:1-68 [150809]
    3. 1k0v
      complexed with cu1
      1. chain a [67986]
    4. 1p8g
      1. chain a [94360]
  3. Synechocystis sp. pcc 6803, Scatx1 [TaxId: 1148] [102998] (1)
    1. 1sb6
      1. chain a [98790]
8. Copper chaperone for superoxide dismutase, N-terminal domain [55019]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55020] (2)
    1. 1qup
      1. region a:2-73 [39352]
      2. region b:5-73 [39353]
    2. 1jk9
      complexed with so4, zn; mutant
      1. region b:3-73 [63151]
      2. region d:3-73 [63154]