Fold: Phosphorylase/hydrolase-like

core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Phosphorylase/hydrolase-like [53162]
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

Superfamilies:

1. HybD-like [53163] (2)
   the HybD fold coincides with the consensus core structure
   uperfamily
   1. Hydrogenase maturating endopeptidase HybD [53164] (1)
   2. Germination protease [64095] (1)
      elaborated with the N-terminal alpha+beta subdomain and the insertion all-alpha dimerisation subdomain
2. Purine and uridine phosphorylases [53167] (1)
   complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8
   uperfamily
   1. Purine and uridine phosphorylases [53168] (18)
3. Peptidyl-tRNA hydrolase-like [53178] (1)
   uperfamily
   1. Peptidyl-tRNA hydrolase-like [53179] (2)
4. Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) [53182] (1)
   uperfamily
   1. Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) [53183] (4)
5. Zn-dependent exopeptidases [53187] (9)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest
   uperfamily
   1. Pancreatic carboxypeptidases [53188] (10)
   2. Carboxypeptidase T [53198] (1)
   3. Leucine aminopeptidase, C-terminal domain [53201] (2)
   4. Bacterial dinuclear zinc exopeptidases [53204] (19)
   5. FolH catalytic domain-like [53210] (2)
   6. N-acetylmuramoyl-L-alanine amidase-like [102517] (2)
   7. AstE/AspA-like [142526] (6)
      Pfam 04952; Succinylglutamate desuccinylase / Aspartoacylase family; contains extra C-terminal domain, new variant of the Barrel-sandwich hybrid fold (scop_cf 51229)
   8. Glutaminyl-peptide cyclotransferase-like [142532] (1)
      part of Pfam 04389
   9. FGase-like [159652] (2)
      Pfam 05013; N-formylglutamate amidohydrolase
6. LigB-like [53213] (1)
   circular permutation of the common fold, most similar to the PNP fold
   uperfamily
   1. LigB-like [53214] (2)
7. AF0625-like [142535] (1)
   contains extra C-terminal alpha/beta domain: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
   uperfamily
   1. AF0625-like [142536] (2)
      Pfam 04414; DUF516, binds magnesium ion and pyrophosphate in the putative active site
8. Cgl1923-like [159659] (1)
   1. Cgl1923-like [159660] (1)
      Pfam 01908; DUF75

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk