Superfamily: PreATP-grasp domain

precedes the ATP-grasp domain common to all superfamily members, can contain a substrate-binding function
uperfamily

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: PreATP-grasp domain [52439]
   3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
   possible rudiment form of Rossmann-fold domain
4. Superfamily: PreATP-grasp domain [52440]
   precedes the ATP-grasp domain common to all superfamily members, can contain a substrate-binding function
   uperfamily

Families:

1. BC N-terminal domain-like [52441] (8)
   1. Biotin carboxylase (BC), N-terminal domain [52442]
      subunit of acetyl-CoA and pyruvate carboxylases
      1. Escherichia coli [TaxId: 562] [52443] (13)
      2. Aquifex aeolicus [TaxId: 63363] [102283] (1)
   2. Glycinamide ribonucleotide synthetase (GAR-syn), N-domain [52444]
      1. Escherichia coli [TaxId: 562] [52445] (1)
      2. Thermotoga maritima [TaxId: 2336] [110500] (1)
         SQ Q9X0X7
   3. N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain [52446]
      1. Escherichia coli [TaxId: 562] [52447] (6)
   4. Glycinamide ribonucleotide transformylase PurT, N-domain [52448]
      1. Escherichia coli [TaxId: 562] [52449] (7)
   5. Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains [52450]
      duplication: CPS large subunit contains two full BC-like lobes: carboxyphosphate and carbamoyl phosphate domains
      1. Escherichia coli [TaxId: 562] [52451] (10)
         SQ P00968
   6. Acetyl-CoA carboxylase, BC-N subdomain [117496]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [117497] (2)
         SQ Q00955 13-566
2. D-Alanine ligase N-terminal domain [52452] (3)
   1. D-Ala-D-Ala ligase, N-domain [52453]
      1. Escherichia coli, gene ddlB [TaxId: 562] [52454] (3)
   2. D-alanine:D-lactate ligase VanA, N-domain [52455]
      1. Leuconostoc mesenteroides, Ddl2 [TaxId: 1245] [52456] (1)
      2. Enterococcus faecium [TaxId: 1352] [63983] (1)
3. Lysine biosynthesis enzyme LysX, N-terminal domain [102284] (1)
   1. Lysine biosynthesis enzyme LysX, N-terminal domain [102285]
      1. Thermus thermophilus [TaxId: 274] [102286] (2)
4. Prokaryotic glutathione synthetase, N-terminal domain [52457] (1)
   1. Prokaryotic glutathione synthetase, N-terminal domain [52458]
      1. Escherichia coli [TaxId: 562] [52459] (4)
5. Eukaryotic glutathione synthetase, substrate-binding domain [52460] (2)
   circularly permuted version of prokaryotic enzyme
   1. Eukaryotic glutathione synthetase, substrate-binding domain [52461]
      1. Human (Homo sapiens) [TaxId: 9606] [52462] (1)
      2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82378] (2)
6. Synapsin domain [52463] (3)
   1. Synapsin I [52464]
      1. Cow (Bos taurus) [TaxId: 9913] [52465] (2)
      2. Rat (Rattus norvegicus) [TaxId: 10116] [102287] (2)
   2. Synapsin II [89635]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [89636] (2)
7. Glutathionylspermidine synthase substrate-binding domain-like [142119] (1)
   central part of Pfam 03738; GSP; overal similarity of the Pfam domain to the Eukaryotic glutathione synthetase
   1. Glutathionylspermidine synthase, synthetase domain [142120]
      1. Escherichia coli [TaxId: 562] [142121] (10)
         SQ P0AES0 379-496
8. PurP N-terminal domain-like [159526] (3)
   Pfam 06849; DUF1246
   1. 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase PurP [159527]
      1. Pyrococcus furiosus [TaxId: 2261] [159528] (12)
         SQ Q8U0R7 1-99
      2. Thermococcus kodakaraensis [TaxId: 311400] [159529] (3)
         SQ Q5JD28 2-97
      3. Methanocaldococcus jannaschii [TaxId: 2190] [159530] (4)
         SQ Q57600 1-123

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk