Structural Classification of Proteins

Fold: PreATP-grasp domain

: 3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
possible rudiment form of Rossmann-fold domain

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: PreATP-grasp domain [52439]
3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
possible rudiment form of Rossmann-fold domain

Superfamilies:

PreATP-grasp domain [52440] (8)
precedes the ATP-grasp domain common to all superfamily members, can contain a substrate-binding function
uperfamily
1. BC N-terminal domain-like [52441] (8)
  1. Biotin carboxylase (BC), N-terminal domain [52442]
    subunit of acetyl-CoA and pyruvate carboxylases
    1. Escherichia coli [TaxId: 562] [52443] (13)
    2. Aquifex aeolicus [TaxId: 63363] [102283] (1)
  2. Glycinamide ribonucleotide synthetase (GAR-syn), N-domain [52444]
    1. Escherichia coli [TaxId: 562] [52445] (1)
    2. Thermotoga maritima [TaxId: 2336] [110500] (1)
      SQ Q9X0X7
  3. N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain [52446]
    1. Escherichia coli [TaxId: 562] [52447] (6)
  4. Glycinamide ribonucleotide transformylase PurT, N-domain [52448]
    1. Escherichia coli [TaxId: 562] [52449] (7)
  5. Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains [52450]
    duplication: CPS large subunit contains two full BC-like lobes: carboxyphosphate and carbamoyl phosphate domains
    1. Escherichia coli [TaxId: 562] [52451] (10)
      SQ P00968
  6. Acetyl-CoA carboxylase, BC-N subdomain [117496]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [117497] (2)
      SQ Q00955 13-566
2. D-Alanine ligase N-terminal domain [52452] (3)
  1. D-Ala-D-Ala ligase, N-domain [52453]
    1. Escherichia coli, gene ddlB [TaxId: 562] [52454] (3)
  2. D-alanine:D-lactate ligase VanA, N-domain [52455]
    1. Leuconostoc mesenteroides, Ddl2 [TaxId: 1245] [52456] (1)
    2. Enterococcus faecium [TaxId: 1352] [63983] (1)
3. Lysine biosynthesis enzyme LysX, N-terminal domain [102284] (1)
  1. Lysine biosynthesis enzyme LysX, N-terminal domain [102285]
    1. Thermus thermophilus [TaxId: 274] [102286] (2)
4. Prokaryotic glutathione synthetase, N-terminal domain [52457] (1)
  1. Prokaryotic glutathione synthetase, N-terminal domain [52458]
    1. Escherichia coli [TaxId: 562] [52459] (4)
5. Eukaryotic glutathione synthetase, substrate-binding domain [52460] (2)
  circularly permuted version of prokaryotic enzyme
  1. Eukaryotic glutathione synthetase, substrate-binding domain [52461]
    1. Human (Homo sapiens) [TaxId: 9606] [52462] (1)
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82378] (2)
6. Synapsin domain [52463] (3)
  1. Synapsin I [52464]
    1. Cow (Bos taurus) [TaxId: 9913] [52465] (2)
    2. Rat (Rattus norvegicus) [TaxId: 10116] [102287] (2)
  2. Synapsin II [89635]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [89636] (2)
7. Glutathionylspermidine synthase substrate-binding domain-like [142119] (1)
  central part of Pfam 03738; GSP; overal similarity of the Pfam domain to the Eukaryotic glutathione synthetase
  1. Glutathionylspermidine synthase, synthetase domain [142120]
    1. Escherichia coli [TaxId: 562] [142121] (10)
      SQ P0AES0 379-496
8. PurP N-terminal domain-like [159526] (3)
  Pfam 06849; DUF1246
  1. 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase PurP [159527]
    1. Pyrococcus furiosus [TaxId: 2261] [159528] (12)
      SQ Q8U0R7 1-99
    2. Thermococcus kodakaraensis [TaxId: 311400] [159529] (3)
      SQ Q5JD28 2-97
    3. Methanocaldococcus jannaschii [TaxId: 2190] [159530] (4)
      SQ Q57600 1-123