Structural Classification of Proteins
home mail help root up expand collapse

Fold: PreATP-grasp domain

3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
possible rudiment form of Rossmann-fold domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: PreATP-grasp domain [52439]
    3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
    possible rudiment form of Rossmann-fold domain

Superfamilies:

  1. PreATP-grasp domain [52440] (8)
    precedes the ATP-grasp domain common to all superfamily members, can contain a substrate-binding function
    link to SUPERFAMILY database - Superfamily
    1. BC N-terminal domain-like [52441] (8)
      1. Biotin carboxylase (BC), N-terminal domain [52442]
        subunit of acetyl-CoA and pyruvate carboxylases
        1. Escherichia coli [TaxId: 562] [52443] (13)
          1. 2j9g picpicxrefxrefxrefxref
            automatically matched to d1dv2a2
            complexed with adp, anp, mg, so4
            1. region a:1-114 [147938] picpiclink
          2. 2j9g picpicxrefxrefxrefxref
            automatically matched to d1dv2a2
            complexed with adp, anp, mg, so4
            1. region b:1-114 [147941] picpiclink
          3. 2gpw picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to d1dv2a2
            mutant
            1. region a:-2-114 [135498] picpiclink
          4. 2gpw picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to d1dv2a2
            mutant
            1. region b:-2-114 [135501] picpiclink
          5. 2gpw picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to d1dv2a2
            mutant
            1. region c:-2-114 [135504] picpiclink
          6. 2gpw picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to d1dv2a2
            mutant
            1. region d:-2-114 [135507] picpiclink
          7. 1dv1 picpicxrefxref
            complexed with po4
            1. region a:1-114 [31641] picpiclink
            2. region b:1-114 [31642] picpiclink
          8. 2vr1 picpicxrefxrefxrefxref
            automatically matched to d1dv2a2
            complexed with atf, cl
            1. region a:1-114 [153490] picpiclink
          9. 2vr1 picpicxrefxrefxrefxref
            automatically matched to d1dv2a2
            complexed with atf, cl
            1. region b:1-114 [153493] picpiclink
          10. 1bnc picpicxrefxref
            complexed with po4
            1. region a:1-114 [31643] picpiclink
            2. region b:1-114 [31644] picpiclink
          11. 1dv2 picpicxrefxref
            complexed with atp; mutant
            1. region a:1c-114 [31645] picpiclink
            2. region b:1a-114 [31646] picpiclink
          12. 2gps picpicxrefxrefxrefxref
            automatically matched to d1dv2a2
            mutant
            1. region a:-2-114 [135488] picpiclink
          13. 2gps picpicxrefxrefxrefxref
            automatically matched to d1dv2a2
            mutant
            1. region b:-2-114 [135491] picpiclink
        2. Aquifex aeolicus [TaxId: 63363] [102283] (1)
          1. 1ulz picpicxrefxref
            mutant
            1. region a:1-114 [99576] picpiclink
      2. Glycinamide ribonucleotide synthetase (GAR-syn), N-domain [52444]
        1. Escherichia coli [TaxId: 562] [52445] (1)
          1. 1gso picpicxrefxref
            mutant
            1. region a:-2-103 [31647] picpiclink
        2. Thermotoga maritima [TaxId: 2336] [110500] (1)
          SQ Q9X0X7
          1. 1vkz picpicxrefxref
            Structural genomics target
            complexed with edo; mutant
            1. region a:4-93 [108699] picpiclink
            2. region b:4-93 [108702] picpiclink
      3. N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain [52446]
        1. Escherichia coli [TaxId: 562] [52447] (6)
          1. 3etj picpicxrefxrefxrefxref
            automatically matched to d1b6ra2
            complexed with adp, cl, mg, pi; mutant
            1. region a:1-78 [158205] picpiclink
          2. 3etj picpicxrefxrefxrefxref
            automatically matched to d1b6ra2
            complexed with adp, cl, mg, pi; mutant
            1. region b:1-78 [158208] picpiclink
          3. 3eth picpicxrefxrefxrefxref
            automatically matched to d1b6ra2
            complexed with atp, mg; mutant
            1. region a:1-78 [158199] picpiclink
          4. 3eth picpicxrefxrefxrefxref
            automatically matched to d1b6ra2
            complexed with atp, mg; mutant
            1. region b:1-78 [158202] picpiclink
          5. 1b6r picpicxrefxref
            1. region a:1-78 [31648] picpiclink
          6. 1b6s picpicxrefxref
            1. region a:1-78 [31649] picpiclink
            2. region b:1-78 [31650] picpiclink
            3. region c:1-78 [31651] picpiclink
            4. region d:1-78 [31652] picpiclink
      4. Glycinamide ribonucleotide transformylase PurT, N-domain [52448]
        1. Escherichia coli [TaxId: 562] [52449] (7)
          1. 1kjq picpicxrefxref
            complexed with adp, cl, edo, mg, mpo, na
            1. region a:2-112 [72617] picpiclink
            2. region b:2-112 [72620] picpiclink
          2. 1kj9 picpicxrefxref
            complexed with atp, cl, edo, mg, mpo, na
            1. region a:2-112 [72590] picpiclink
            2. region b:2-112 [72593] picpiclink
          3. 1kj8 picpicxrefxref
            complexed with atp, cl, edo, gar, mg, mpo, na
            1. region a:2-112 [72584] picpiclink
            2. region b:2-112 [72587] picpiclink
          4. 1kji picpicxrefxref
            complexed with acp, cl, edo, mg, mpo, na
            1. region a:2-112 [72602] picpiclink
            2. region b:2-112 [72605] picpiclink
          5. 1kjj picpicxrefxref
            complexed with ags, cl, mg, mpo, na
            1. region a:2-112 [72608] picpiclink
            2. region b:2-112 [72611] picpiclink
          6. 1ez1 picpicxrefxref
            complexed with act, anp, gar, mg, mpo, na
            1. region a:2-112 [31655] picpiclink
            2. region b:2-112 [31656] picpiclink
          7. 1eyz picpicxrefxref
            complexed with anp, cl, mg, mpo, na
            1. region a:2-112 [31653] picpiclink
            2. region b:2-112 [31654] picpiclink
      5. Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains [52450]
        duplication: CPS large subunit contains two full BC-like lobes: carboxyphosphate and carbamoyl phosphate domains
        1. Escherichia coli [TaxId: 562] [52451] (10)
          SQ P00968
          1. 1a9x picpicxrefxrefxrefxrefxref
            complexed with adp, cl, k, mn, net, orn, po4; mutant
            1. region a:1-127 [31657] picpiclink
            2. region a:556-676 [31658] picpiclink
            3. region c:2001-2127 [31659] picpiclink
            4. region c:2556-2676 [31660] picpiclink
            5. region e:4001-4127 [31661] picpiclink
            6. region e:4556-4676 [31662] picpiclink
            7. region g:6001-6127 [31663] picpiclink
            8. region g:6556-6676 [31664] picpiclink
          2. 1c30 picpicxrefxrefxrefxrefxref
            1. region a:1-127 [31665] picpiclink
            2. region a:556-676 [31666] picpiclink
            3. region c:1-127 [31667] picpiclink
            4. region c:556-676 [31668] picpiclink
            5. region e:1-127 [31669] picpiclink
            6. region e:556-676 [31670] picpiclink
            7. region g:1-127 [31671] picpiclink
            8. region g:556-676 [31672] picpiclink
          3. 1cs0 picpicxrefxrefxrefxrefxref
            1. region a:1-127 [31673] picpiclink
            2. region a:556-676 [31674] picpiclink
            3. region c:1-127 [31675] picpiclink
            4. region c:556-676 [31676] picpiclink
            5. region e:1-127 [31677] picpiclink
            6. region e:556-676 [31678] picpiclink
            7. region g:1-127 [31679] picpiclink
            8. region g:556-676 [31680] picpiclink
          4. 1t36 picpicxrefxrefxrefxrefxref
            complexed with adp, cl, k, mn, net, orn, po4, u; mutant
            1. region a:1-127 [106303] picpiclink
            2. region a:556-676 [106304] picpiclink
            3. region c:1-127 [106311] picpiclink
            4. region c:556-676 [106312] picpiclink
            5. region e:1-127 [106319] picpiclink
            6. region e:556-676 [106320] picpiclink
            7. region g:1-127 [106327] picpiclink
            8. region g:556-676 [106328] picpiclink
          5. 1jdb picpicxrefxrefxrefxrefxref
            complexed with adp, cl, e4n, k, mn, orn, po4
            1. region b:0-127 [31705] picpiclink
            2. region b:556-676 [31706] picpiclink
            3. region e:1-127 [31707] picpiclink
            4. region e:556-676 [31708] picpiclink
            5. region h:0-127 [31709] picpiclink
            6. region h:556-676 [31710] picpiclink
            7. region k:0-127 [31711] picpiclink
            8. region k:556-676 [31712] picpiclink
          6. 1kee picpicxrefxrefxrefxrefxref
            complexed with 143, adp, cl, k, mn, net, orn, pi
            1. region a:1-127 [68494] picpiclink
            2. region a:556-676 [68495] picpiclink
            3. region c:1-127 [68502] picpiclink
            4. region c:556-676 [68503] picpiclink
            5. region e:1-127 [68510] picpiclink
            6. region e:556-676 [68511] picpiclink
            7. region g:1-127 [68518] picpiclink
            8. region g:556-676 [68519] picpiclink
          7. 1m6v picpicxrefxrefxrefxrefxref
            complexed with adp, cl, k, mn, net, orn, pi; mutant
            1. region a:1-127 [74538] picpiclink
            2. region a:556-676 [74539] picpiclink
            3. region c:1-127 [74546] picpiclink
            4. region c:556-676 [74547] picpiclink
            5. region e:1-127 [74554] picpiclink
            6. region e:556-676 [74555] picpiclink
            7. region g:1-127 [74562] picpiclink
            8. region g:556-676 [74563] picpiclink
          8. 1c3o picpicxrefxrefxrefxrefxref
            1. region a:1-127 [31681] picpiclink
            2. region a:556-676 [31682] picpiclink
            3. region c:1-127 [31683] picpiclink
            4. region c:556-676 [31684] picpiclink
            5. region e:1-127 [31685] picpiclink
            6. region e:556-676 [31686] picpiclink
            7. region g:1-127 [31687] picpiclink
            8. region g:556-676 [31688] picpiclink
          9. 1ce8 picpicxrefxrefxrefxrefxref
            complexed with adp, cl, imp, k, mn, net, orn, pi
            1. region a:1-127 [31689] picpiclink
            2. region a:556-676 [31690] picpiclink
            3. region c:1-127 [31691] picpiclink
            4. region c:556-676 [31692] picpiclink
            5. region e:1-127 [31693] picpiclink
            6. region e:556-676 [31694] picpiclink
            7. region g:1-127 [31695] picpiclink
            8. region g:556-676 [31696] picpiclink
          10. 1bxr picpicxrefxrefxrefxrefxref
            complexed with anp, cl, k, mn, net, orn
            1. region a:1-127 [31697] picpiclink
            2. region a:556-676 [31698] picpiclink
            3. region c:1-127 [31699] picpiclink
            4. region c:556-676 [31700] picpiclink
            5. region e:1-127 [31701] picpiclink
            6. region e:556-676 [31702] picpiclink
            7. region g:1-127 [31703] picpiclink
            8. region g:556-676 [31704] picpiclink
      6. Acetyl-CoA carboxylase, BC-N subdomain [117496]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [117497] (2)
          SQ Q00955 13-566
          1. 1w96 picpicxrefxref
            complexed with s1a
            1. region a:14-183 [114398] picpiclink
            2. region b:14-183 [114401] picpiclink
            3. region c:14-183 [114404] picpiclink
          2. 1w93 picpicxrefxref
            1. region a:14-183 [114395] picpiclink
    2. D-Alanine ligase N-terminal domain [52452] (3)
      1. D-Ala-D-Ala ligase, N-domain [52453]
        1. Escherichia coli, gene ddlB [TaxId: 562] [52454] (3)
          1. 1iow picpicxref
            complexed with adp, mg, phy; mutant
            1. region a:1-96 [31713] picpiclink
          2. 2dln picpicxref
            complexed with adp, mg, phy
            1. region a:1-96 [31715] picpiclink
          3. 1iov picpicxref
            complexed with adp, mg, pob
            1. region a:1-96 [31714] picpiclink
      2. D-alanine:D-lactate ligase VanA, N-domain [52455]
        1. Leuconostoc mesenteroides, Ddl2 [TaxId: 1245] [52456] (1)
          1. 1ehi picpicxref
            complexed with adp, mg, phy
            1. region a:3-134 [31716] picpiclink
            2. region b:402-534 [31717] picpiclink
        2. Enterococcus faecium [TaxId: 1352] [63983] (1)
          1. 1e4e picpicxref
            complexed with adp, gol, mg, phy, so4
            1. region a:2-131 [59221] picpiclink
            2. region b:2-131 [59223] picpiclink
    3. Lysine biosynthesis enzyme LysX, N-terminal domain [102284] (1)
      1. Lysine biosynthesis enzyme LysX, N-terminal domain [102285]
        1. Thermus thermophilus [TaxId: 274] [102286] (2)
          1. 1uc8 picpicxref
            1. region a:1-88 [99165] picpiclink
            2. region b:1-88 [99167] picpiclink
          2. 1uc9 picpicxref
            complexed with adp
            1. region a:1-88 [99169] picpiclink
            2. region b:1-88 [99171] picpiclink
    4. Prokaryotic glutathione synthetase, N-terminal domain [52457] (1)
      1. Prokaryotic glutathione synthetase, N-terminal domain [52458]
        1. Escherichia coli [TaxId: 562] [52459] (4)
          1. 1gsa picpicxref
            complexed with adp, gtt, mg, so4
            1. region a:1-122 [31718] picpiclink
          2. 1gsh picpicxref
            1. region a:1-122 [31719] picpiclink
          3. 2glt picpicxref
            1. region a:1-122 [31720] picpiclink
          4. 1glv picpicxref
            mutant
            1. region a:1-122 [31721] picpiclink
    5. Eukaryotic glutathione synthetase, substrate-binding domain [52460] (2)
      circularly permuted version of prokaryotic enzyme
      1. Eukaryotic glutathione synthetase, substrate-binding domain [52461]
        1. Human (Homo sapiens) [TaxId: 9606] [52462] (1)
          1. 2hgs picpicxref
            complexed with adp, gsh, mg, sul
            1. region a:202-303 [31722] picpiclink
        2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82378] (2)
          1. 1m0w picpicxref
            complexed with 3gc, anp, mg, so4
            1. region a:216-323 [78363] picpiclink
            2. region b:1217-1323 [78365] picpiclink
          2. 1m0t picpicxref
            complexed with so4
            1. region a:214-323 [78355] picpiclink
            2. region b:1214-1323 [78357] picpiclink
    6. Synapsin domain [52463] (3)
      1. Synapsin I [52464]
        1. Cow (Bos taurus) [TaxId: 9913] [52465] (2)
          1. 1auv picpicxref
            1. region a:112-213 [31723] picpiclink
            2. region b:110-213 [31724] picpiclink
          2. 1aux picpicxref
            complexed with ca, sap
            1. region a:112-213 [31725] picpiclink
            2. region b:112-213 [31726] picpiclink
        2. Rat (Rattus norvegicus) [TaxId: 10116] [102287] (2)
          1. 1pk8 picpicxref
            complexed with atp, ca, egl
            1. region a:112-213 [94807] picpiclink
            2. region b:113-213 [94809] picpiclink
            3. region c:113-213 [94811] picpiclink
            4. region d:112-213 [94813] picpiclink
            5. region e:112-213 [94815] picpiclink
            6. region f:113-213 [94817] picpiclink
            7. region g:112-213 [94819] picpiclink
            8. region h:112-213 [94821] picpiclink
          2. 1px2 picpicxref
            complexed with atp, ca
            1. region a:112-213 [95273] picpiclink
            2. region b:113-213 [95275] picpiclink
      2. Synapsin II [89635]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [89636] (2)
          1. 1i7n picpicxref
            1. region a:113-214 [83681] picpiclink
            2. region b:113-214 [83683] picpiclink
          2. 1i7l picpicxref
            complexed with atp
            1. region a:113-214 [83677] picpiclink
            2. region b:113-214 [83679] picpiclink
    7. Glutathionylspermidine synthase substrate-binding domain-like [142119] (1)
      central part of Pfam 03738; GSP; overal similarity of the Pfam domain to the Eukaryotic glutathione synthetase
      1. Glutathionylspermidine synthase, synthetase domain [142120]
        1. Escherichia coli [TaxId: 562] [142121] (10)
          SQ P0AES0 379-496
          1. 2io8 picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            complexed with adp, cys, mg
            1. region a:379-496 [137549] picpiclink
          2. 2io8 picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            complexed with adp, cys, mg
            1. region b:379-496 [137552] picpiclink
          3. 2io9 picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            complexed with adp, gsh, mg
            1. region a:379-496 [137555] picpiclink
          4. 2io9 picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            complexed with adp, gsh, mg
            1. region b:379-496 [137558] picpiclink
          5. 2iob picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            1. region a:379-496 [137567] picpiclink
          6. 2iob picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            1. region b:379-496 [137570] picpiclink
          7. 2ioa picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            complexed with adp, gga, mg
            1. region a:379-496 [137561] picpiclink
          8. 2ioa picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            complexed with adp, gga, mg
            1. region b:379-496 [137564] picpiclink
          9. 2io7 picpicxrefxrefxrefxref
            complexed with anp, mg
            1. region a:379-496 [137543] picpiclink
          10. 2io7 picpicxrefxrefxrefxref
            automatically matched to 2IO7 A:379-496
            complexed with anp, mg
            1. region b:379-496 [137546] picpiclink
    8. PurP N-terminal domain-like [159526] (3)
      Pfam 06849; DUF1246
      1. 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase PurP [159527]
        1. Pyrococcus furiosus [TaxId: 2261] [159528] (12)
          SQ Q8U0R7 1-99
          1. 2r85 picpicxrefxref
            automatically matched to 2R84 A:1-99
            complexed with amp, cl, mpd, na
            1. region a:1-99 [151676] picpiclink
          2. 2r85 picpicxrefxref
            automatically matched to 2R84 A:1-99
            complexed with amp, cl, mpd, na
            1. region b:1-99 [151678] picpiclink
          3. 2r84 picpicxrefxref
            complexed with amp, amz, cl, mpd, na
            1. region a:1-99 [151672] picpiclink
          4. 2r84 picpicxrefxref
            automatically matched to 2R84 A:1-99
            complexed with amp, amz, cl, mpd, na
            1. region b:1-99 [151674] picpiclink
          5. 2r87 picpicxrefxrefxrefxrefxrefxref
            automatically matched to 2R84 A:1-99
            complexed with adp, po4
            1. region a:1-99 [151684] picpiclink
          6. 2r87 picpicxrefxrefxrefxrefxrefxref
            automatically matched to 2R84 A:1-99
            complexed with adp, po4
            1. region b:1-99 [151686] picpiclink
          7. 2r87 picpicxrefxrefxrefxrefxrefxref
            automatically matched to 2R84 A:1-99
            complexed with adp, po4
            1. region c:1-99 [151688] picpiclink
          8. 2r87 picpicxrefxrefxrefxrefxrefxref
            automatically matched to 2R84 A:1-99
            complexed with adp, po4
            1. region d:1-99 [151690] picpiclink
          9. 2r87 picpicxrefxrefxrefxrefxrefxref
            automatically matched to 2R84 A:1-99
            complexed with adp, po4
            1. region e:1-99 [151692] picpiclink
          10. 2r87 picpicxrefxrefxrefxrefxrefxref
            automatically matched to 2R84 A:1-99
            complexed with adp, po4
            1. region f:1-99 [151694] picpiclink
          11. 2r86 picpicxrefxref
            automatically matched to 2R84 A:1-99
            complexed with atp, mpd, na, po4
            1. region a:1-99 [151680] picpiclink
          12. 2r86 picpicxrefxref
            automatically matched to 2R84 A:1-99
            complexed with atp, mpd, na, po4
            1. region b:1-99 [151682] picpiclink
        2. Thermococcus kodakaraensis [TaxId: 311400] [159529] (3)
          SQ Q5JD28 2-97
          1. 2pbz picpicxrefxrefxref
            complexed with atp
            1. region a:4-99 [149371] picpiclink
          2. 2pbz picpicxrefxrefxref
            automatically matched to 2PBZ A:4-99
            complexed with atp
            1. region b:4-99 [149373] picpiclink
          3. 2pbz picpicxrefxrefxref
            automatically matched to 2PBZ A:4-99
            complexed with atp
            1. region c:4-99 [149375] picpiclink
        3. Methanocaldococcus jannaschii [TaxId: 2190] [159530] (4)
          SQ Q57600 1-123
          1. 2r7k picpicxref
            complexed with acp, amz, cl, so4
            1. region a:1-123 [151647] picpiclink
          2. 2r7l picpicxref
            automatically matched to 2R7K A:1-123
            complexed with amz, atp, cl, so4
            1. region a:1-123 [151649] picpiclink
          3. 2r7m picpicxref
            automatically matched to 2R7K A:1-123
            complexed with amp, cl, so4
            1. region a:1-123 [151651] picpiclink
          4. 2r7n picpicxref
            automatically matched to 2R7K A:1-123
            complexed with adp, cl, fai, so4
            1. region a:1-123 [151653] picpiclink
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk