Structural Classification of Proteins
home mail help root up expand collapse

Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

contains a conserved all-alpha subdomain at the C-terminal extension

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Adenine nucleotide alpha hydrolase-like [52373]
    core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
  4. Superfamily: Nucleotidylyl transferase [52374]
    link to SUPERFAMILY database - Superfamily
  5. Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain [52375]
    contains a conserved all-alpha subdomain at the C-terminal extension

Protein Domains:

  1. Tyrosyl-tRNA synthetase (TyrRS) [52376]
    1. Bacillus stearothermophilus, nca 1503 [TaxId: 1422] [52377] (7) picpic
    2. Staphylococcus aureus [TaxId: 1280] [69453] (4) picpic
    3. Thermus thermophilus [TaxId: 274] [82354] (2) picpic
    4. Archaeon Methanococcus jannaschii [TaxId: 2190] [89611] (3) picpic
    5. Human (Homo sapiens) [TaxId: 9606] [82355] (2) picpic
  2. Tryptophanyl-tRNA synthetase (TrpRS) [52378]
    overall structure is similar to TyrRS
    1. Bacillus stearothermophilus [TaxId: 1422] [52379] (9) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [102256] (16) picpic
      SQ P23381 94-471
  3. Glutaminyl-tRNA synthetase (GlnRS) [52380]
    1. Escherichia coli [TaxId: 562] [52381] (14) picpic
    2. Escherichia coli K12 (Escherichia coli K-12) [TaxId: 83333] [159495] (2) picpic
  4. Glutamyl-tRNA synthetase (GluRS) [52382]
    Catalytic domain is very similar to that of GlnRS
    1. Thermus thermophilus [TaxId: 274] [52383] (15) picpic
  5. Glutamyl-Q tRNA-Asp synthetase YadB [102257]
    truncated GluRS and GlnRS homologue lacking the anticodon-binding domain; glutamylates the modified base queuosine (Q) of tRNA-Asp
    1. Escherichia coli [TaxId: 562] [102258] (2) picpic
  6. Class I lysyl-tRNA synthetase [75159]
    similar domain organization to GluRS
    1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [75160] (1) picpic
  7. Methionyl-tRNA synthetase (MetRS) [52384]
    1. Thermus thermophilus [TaxId: 274] [52385] (4) picpic
    2. Escherichia coli [TaxId: 562] [52386] (9) picpic
    3. Pyrococcus abyssi [TaxId: 29292] [110490] (1) picpic
      SQ Q9V011 1-606 # C-domain 616-722 is solved separately: 1MKH
  8. Cysteinyl-tRNA synthetase (CysRS) [75161]
    1. Escherichia coli [TaxId: 562] [75162] (3) picpic
      SQ P21888
  9. Isoleucyl-tRNA synthetase (IleRS) [52387]
    1. Thermus thermophilus [TaxId: 274] [52388] (3) picpic
    2. Staphylococcus aureus [TaxId: 1280] [52389] (3) picpic
  10. Valyl-tRNA synthetase (ValRS) [52390]
    1. Thermus thermophilus [TaxId: 274] [52391] (3) picpic
  11. Leucyl-tRNA synthetase (LeuRS) [82356]
    1. Thermus thermophilus [TaxId: 274] [82357] (3) picpic
      contains a non-conserved insertion (residues 581-633) that forms a separate subdomain; possible rudiment Zn finger
  12. Arginyl-tRNA synthetase (ArgRS) [52392]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52393] (3) picpic
    2. Thermus thermophilus [TaxId: 274] [69454] (1) picpic
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk