Structural Classification of Proteins
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Superfamily: FAD/NAD(P)-binding domain

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: FAD/NAD(P)-binding domain [51904]
    core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
  4. Superfamily: FAD/NAD(P)-binding domain [51905]
    link to SUPERFAMILY database - Superfamily

Families:

  1. C-terminal domain of adrenodoxin reductase-like [51906] (5)
    1. Trimethylamine dehydrogenase, C-terminal domain [51907]
      N-terminal domain is beta/alpha barrel and the middle domain is alpha/beta Rossmann-fold
      1. Methylophilus methylotrophus, w3a1 [TaxId: 17] [51908] (5) picpic
    2. 2,4-dienoyl-CoA reductase, C-terminal domain [102177]
      1. Escherichia coli [TaxId: 562] [102178] (1) picpic
    3. Adrenodoxin reductase of mitochondrial p450 systems [51909]
      1. Cow (Bos taurus) [TaxId: 9913] [51910] (6) picpic
    4. Ferredoxin:NADP reductase FprA [75124]
      1. Mycobacterium tuberculosis [TaxId: 1773] [75125] (2) picpic
    5. Dihydropyrimidine dehydrogenase, domain 3 [51911]
      1. Pig (Sus scrofa) [TaxId: 9823] [51912] (5) picpic
  2. FAD-linked reductases, N-terminal domain [51913] (25)
    C-terminal domain is alpha+beta is common for the family
    1. Cholesterol oxidase of GMC family [51914]
      1. Brevibacterium sterolicum [TaxId: 1702] [51915] (2) picpic
      2. Streptomyces sp. [TaxId: 1931] [51916] (13) picpic
      3. Streptomyces sp. (strain SA-COO) (Streptomyces sp. SA-COO) [TaxId: 74576] [159428] (1) picpic
    2. Glucose oxidase [51924]
      1. Aspergillus niger [TaxId: 5061] [51925] (2) picpic
      2. Penicillium amagasakiense [TaxId: 63559] [51926] (1) picpic
    3. Hydroxynitrile lyase [82307]
      1. Almond (Prunus dulcis) [TaxId: 3755] [82308] (1) picpic
    4. Flavoprotein domain of flavocytochrome cellobiose dehydrogenase (CDH), FAD-binding domain [82309]
      1. Fungus (Phanerochaete chrysosporium) [TaxId: 5306] [82310] (2) picpic
    5. p-Hydroxybenzoate hydroxylase, PHBH [51917]
      1. Pseudomonas fluorescens [TaxId: 294] [51918] (17) picpic
      2. Pseudomonas aeruginosa [TaxId: 287] [51919] (19) picpic
    6. Sarcosine oxidase [51920]
      1. Bacillus sp., strain b0618 [TaxId: 1409] [51921] (18) picpic
    7. Glycine oxidase ThiO [89544]
      1. Bacillus sp. [TaxId: 1409] [89545] (6) picpic
    8. Phenol hydroxylase [51922]
      structurally very similar to PHBH, but contains additional C-terminal domain of the thioredoxin-like fold
      1. Soil-living yeast (Trichosporon cutaneum) [TaxId: 5554] [51923] (2) picpic
    9. Polyamine oxidase [51927]
      1. Maize (Zea mays) [TaxId: 4577] [51928] (7) picpic
    10. L-aminoacid oxidase [51929]
      1. Malayan pit viper (Calloselasma rhodostoma) [TaxId: 8717] [51930] (6) picpic
      2. Halys viper (Agkistrodon halys) [TaxId: 8714] [102179] (4) picpic
        SQ Q90W54 21-504
    11. Monoamine oxidase B [69423]
      1. Human (Homo sapiens) [TaxId: 9606] [69424] (20) picpic
      2. Rat (Rattus norvegicus) [TaxId: 10116] [102180] (27) picpic
    12. N,N-dimethylglycine oxidase [102181]
      1. Arthrobacter globiformis [TaxId: 1665] [102182] (3) picpic
    13. Protoporphyrinogen oxidase [102183]
      1. Tobacco (Nicotiana tabacum) [TaxId: 4097] [102184] (1) picpic
      2. Myxococcus xanthus [TaxId: 34] [159429] (4) picpic
        SQ P56601 10-306,415-464
    14. Pyranose 2-oxidase [117439]
      1. White-rot fungus (Peniophora sp. SG) [TaxId: 204723] [117440] (19) picpic
        SQ Q8J136 43-619
    15. Electron transfer flavoprotein-ubiquinone oxidoreductase, EFT-QO [141940]
      1. Pig (Sus scrofa) [TaxId: 9823] [141941] (4) picpic
        SQ P55931 27-259,359-505
    16. Dihydroxypyridine hydroxylase DhpH [159430]
      1. Arthrobacter nicotinovorans [TaxId: 29320] [159431] (3) picpic
        SQ Q93NG3 2-163,292-394
    17. Lysine-specific histone demethylase 1, LSD1 [159432]
      1. Human (Homo sapiens) [TaxId: 9606] [159433] (8) picpic
        SQ O60341 274-654,764-836
    18. Monooxygenase PhzS [159434]
      1. Pseudomonas aeruginosa [TaxId: 287] [159435] (1) picpic
        SQ Q9HWG9 4-182,294-402
  3. GDI-like N domain [51931] (3)
    Similar to FAD-linked reductases in both domains but does not bind FAD
    1. Guanine nucleotide dissociation inhibitor, GDI [51932]
      the inhibition function is probably associated with an insert subdomain, residues 120-220
      1. Cow (Bos taurus) [TaxId: 9913] [51933] (3) picpic
      2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110439] (13) picpic
        SQ P39958 5-446
    2. Rab escort protein 1 [89546]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [89547] (3) picpic
        SQ P37727
  4. Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [51934] (7)
    1. L-aspartate oxidase [51935]
      1. Escherichia coli [TaxId: 562] [51936] (3) picpic
    2. Succinate dehydogenase [82311]
      1. Escherichia coli [TaxId: 562] [82312] (2) picpic
    3. Fumarate reductase [51937]
      1. Escherichia coli [TaxId: 562] [51938] (7) picpic
      2. Wolinella succinogenes [TaxId: 844] [51939] (8) picpic
    4. Flavocytochrome c3 (respiratory fumarate reductase) [51940]
      contains additional N-terminal multiheme domain
      1. Shewanella frigidimarina [TaxId: 56812] [51941] (16) picpic
      2. Shewanella putrefaciens [TaxId: 24] [51942] (3) picpic
    5. Adenylylsulfate reductase A subunit [69425]
      1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [69426] (2) picpic
  5. FAD/NAD-linked reductases, N-terminal and central domains [51943] (28)
    duplication: both domains have similar folds and functions
    most members of the family contain common C-terminal alpha+beta domain
    1. Glutathione reductase [51944]
      1. Human (Homo sapiens) [TaxId: 9606] [51945] (17) picpic
      2. Plasmodium falciparum [TaxId: 5833] [89548] (1) picpic
      3. Escherichia coli [TaxId: 562] [51946] (4) picpic
    2. Trypanothione reductase [51947]
      1. Crithidia fasciculata [TaxId: 5656] [51948] (6) picpic
      2. Trypanosoma cruzi [TaxId: 5693] [51949] (8) picpic
    3. Mammalian thioredoxin reductase [63947]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [63948] (1) picpic
    4. Thioredoxin reductase [51950]
      lacks the "interface" C-terminal alpha+beta domain
      1. Escherichia coli [TaxId: 562] [51951] (5) picpic
      2. Mouse-ear cress (Arabidopsis thaliana) [TaxId: 3702] [51952] (1) picpic
    5. Apoptosis-inducing factor (AIF) [75126]
      1. Human (Homo sapiens) [TaxId: 9606] [75127] (1) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [75128] (1) picpic
    6. Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains [51953]
      1. Salmonella typhimurium [TaxId: 90371] [51954] (1) picpic
      2. Escherichia coli [TaxId: 562] [63949] (1) picpic
    7. NADH peroxidase [51955]
      1. Enterococcus faecalis [TaxId: 1351] [51956] (8) picpic
    8. NADH-dependent ferredoxin reductase, BphA4 [51957]
      1. Pseudomonas sp., KKS102 [TaxId: 306] [51958] (2) picpic
    9. Putidaredoxin reductase [102185]
      1. Pseudomonas putida [TaxId: 303] [102186] (2) picpic
    10. Dihydrolipoamide dehydrogenase [51959]
      1. Pseudomonas putida [TaxId: 303] [51960] (1) picpic
      2. Pseudomonas fluorescens [TaxId: 294] [51961] (1) picpic
      3. Azotobacter vinelandii [TaxId: 354] [51962] (1) picpic
      4. Bacillus stearothermophilus [TaxId: 1422] [51963] (1) picpic
      5. Neisseria meningitidis [TaxId: 487] [51964] (2) picpic
      6. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [63950] (5) picpic
      7. Garden pea (Pisum sativum) [TaxId: 3888] [51965] (1) picpic
      8. Mycobacterium tuberculosis [TaxId: 1773] [117441] (1) picpic
        SQ O53355
    11. NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase [82313]
      1. Xanthobacter sp., py2 [TaxId: 35809] [82314] (10) picpic
    12. Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit [51966]
      has a smaller C-terminal alpha+beta domain instead the "interface" domain
      1. Purple phototrophic bacterium (Chromatium vinosum) [TaxId: 1049] [51967] (1) picpic
    13. Phenylacetone monooxygenase [110440]
      1. Thermobifida fusca [TaxId: 2021] [110441] (1) picpic
        SQ Q5YS95 # 55% sequence identity; Nocardia farcinica TaxID:37329
    14. NADH oxidase /nitrite reductase [117442]
      1. Pyrococcus furiosus [TaxId: 2261] [117443] (1) picpic
        SQ Q8U1K9
    15. Flavin-dependent monoxygenase SPBP16F5.08c [117444]
      1. Schizosaccharomyces pombe [TaxId: 4896] [117445] (13) picpic
        SQ Q9HFE4
  6. Thi4-like [141942] (2)
    Pfam 01946; stand-alone, moderately decorated domain
    1. Thiazole biosynthetic enzyme Thi4 [141943]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141944] (2) picpic
        SQ P32318 16-326
        mitochondrial
      2. Thale cress(Arabidopsis thaliana) [TaxId: 3702] [141945] (1) picpic
        SQ Q38814 51-328
        chloroplast
  7. GidA-like [141946] (1)
    part of Pfam 01266
    1. GidA-related protein TTHA1897 [141947]
      1. Thermus thermophilus [TaxId: 274] [141948] (1) picpic
        SQ Q5SH33 2-231
  8. HI0933 N-terminal domain-like [159436] (2)
    N-terminal part of Pfam 03486
    1. Hypothetical protein HI0933 [159437]
      1. Haemophilus influenzae [TaxId: 727] [159438] (1) picpic
        SQ P44941 1-194,343-401
    2. Flavoprotein BC4706 [159439]
      1. Bacillus cereus [TaxId: 1396] [159440] (1) picpic
        SQ Q816V9 1-192,362-420
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk