Structural Classification of Proteins

Fold: FAD/NAD(P)-binding domain

: core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: FAD/NAD(P)-binding domain [51904]
core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

Superfamilies:

FAD/NAD(P)-binding domain [51905] (8)
uperfamily
1. C-terminal domain of adrenodoxin reductase-like [51906] (5)
  1. Trimethylamine dehydrogenase, C-terminal domain [51907]
    N-terminal domain is beta/alpha barrel and the middle domain is alpha/beta Rossmann-fold
    1. Methylophilus methylotrophus, w3a1 [TaxId: 17] [51908] (5)
  2. 2,4-dienoyl-CoA reductase, C-terminal domain [102177]
    1. Escherichia coli [TaxId: 562] [102178] (1)
  3. Adrenodoxin reductase of mitochondrial p450 systems [51909]
    1. Cow (Bos taurus) [TaxId: 9913] [51910] (6)
  4. Ferredoxin:NADP reductase FprA [75124]
    1. Mycobacterium tuberculosis [TaxId: 1773] [75125] (2)
  5. Dihydropyrimidine dehydrogenase, domain 3 [51911]
    1. Pig (Sus scrofa) [TaxId: 9823] [51912] (5)
2. FAD-linked reductases, N-terminal domain [51913] (25)
  C-terminal domain is alpha+beta is common for the family
  1. Cholesterol oxidase of GMC family [51914]
    1. Brevibacterium sterolicum [TaxId: 1702] [51915] (2)
    2. Streptomyces sp. [TaxId: 1931] [51916] (13)
    3. Streptomyces sp. (strain SA-COO) (Streptomyces sp. SA-COO) [TaxId: 74576] [159428] (1)
  2. Glucose oxidase [51924]
    1. Aspergillus niger [TaxId: 5061] [51925] (2)
    2. Penicillium amagasakiense [TaxId: 63559] [51926] (1)
  3. Hydroxynitrile lyase [82307]
    1. Almond (Prunus dulcis) [TaxId: 3755] [82308] (1)
  4. Flavoprotein domain of flavocytochrome cellobiose dehydrogenase (CDH), FAD-binding domain [82309]
    1. Fungus (Phanerochaete chrysosporium) [TaxId: 5306] [82310] (2)
  5. p-Hydroxybenzoate hydroxylase, PHBH [51917]
    1. Pseudomonas fluorescens [TaxId: 294] [51918] (17)
    2. Pseudomonas aeruginosa [TaxId: 287] [51919] (19)
  6. Sarcosine oxidase [51920]
    1. Bacillus sp., strain b0618 [TaxId: 1409] [51921] (18)
  7. Glycine oxidase ThiO [89544]
    1. Bacillus sp. [TaxId: 1409] [89545] (6)
  8. Phenol hydroxylase [51922]
    structurally very similar to PHBH, but contains additional C-terminal domain of the thioredoxin-like fold
    1. Soil-living yeast (Trichosporon cutaneum) [TaxId: 5554] [51923] (2)
  9. Polyamine oxidase [51927]
    1. Maize (Zea mays) [TaxId: 4577] [51928] (7)
  10. L-aminoacid oxidase [51929]
    1. Malayan pit viper (Calloselasma rhodostoma) [TaxId: 8717] [51930] (6)
    2. Halys viper (Agkistrodon halys) [TaxId: 8714] [102179] (4)
      SQ Q90W54 21-504
  11. Monoamine oxidase B [69423]
    1. Human (Homo sapiens) [TaxId: 9606] [69424] (20)
    2. Rat (Rattus norvegicus) [TaxId: 10116] [102180] (27)
  12. N,N-dimethylglycine oxidase [102181]
    1. Arthrobacter globiformis [TaxId: 1665] [102182] (3)
  13. Protoporphyrinogen oxidase [102183]
    1. Tobacco (Nicotiana tabacum) [TaxId: 4097] [102184] (1)
    2. Myxococcus xanthus [TaxId: 34] [159429] (4)
      SQ P56601 10-306,415-464
  14. Pyranose 2-oxidase [117439]
    1. White-rot fungus (Peniophora sp. SG) [TaxId: 204723] [117440] (19)
      SQ Q8J136 43-619
  15. Electron transfer flavoprotein-ubiquinone oxidoreductase, EFT-QO [141940]
    1. Pig (Sus scrofa) [TaxId: 9823] [141941] (4)
      SQ P55931 27-259,359-505
  16. Dihydroxypyridine hydroxylase DhpH [159430]
    1. Arthrobacter nicotinovorans [TaxId: 29320] [159431] (3)
      SQ Q93NG3 2-163,292-394
  17. Lysine-specific histone demethylase 1, LSD1 [159432]
    1. Human (Homo sapiens) [TaxId: 9606] [159433] (8)
      SQ O60341 274-654,764-836
  18. Monooxygenase PhzS [159434]
    1. Pseudomonas aeruginosa [TaxId: 287] [159435] (1)
      SQ Q9HWG9 4-182,294-402
3. GDI-like N domain [51931] (3)
  Similar to FAD-linked reductases in both domains but does not bind FAD
  1. Guanine nucleotide dissociation inhibitor, GDI [51932]
    the inhibition function is probably associated with an insert subdomain, residues 120-220
    1. Cow (Bos taurus) [TaxId: 9913] [51933] (3)
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110439] (13)
      SQ P39958 5-446
  2. Rab escort protein 1 [89546]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [89547] (3)
      SQ P37727
4. Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [51934] (7)
  1. L-aspartate oxidase [51935]
    1. Escherichia coli [TaxId: 562] [51936] (3)
  2. Succinate dehydogenase [82311]
    1. Escherichia coli [TaxId: 562] [82312] (2)
  3. Fumarate reductase [51937]
    1. Escherichia coli [TaxId: 562] [51938] (7)
    2. Wolinella succinogenes [TaxId: 844] [51939] (8)
  4. Flavocytochrome c3 (respiratory fumarate reductase) [51940]
    contains additional N-terminal multiheme domain
    1. Shewanella frigidimarina [TaxId: 56812] [51941] (16)
    2. Shewanella putrefaciens [TaxId: 24] [51942] (3)
  5. Adenylylsulfate reductase A subunit [69425]
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [69426] (2)
5. FAD/NAD-linked reductases, N-terminal and central domains [51943] (28)
  duplication: both domains have similar folds and functions
  most members of the family contain common C-terminal alpha+beta domain
  1. Glutathione reductase [51944]
    1. Human (Homo sapiens) [TaxId: 9606] [51945] (17)
    2. Plasmodium falciparum [TaxId: 5833] [89548] (1)
    3. Escherichia coli [TaxId: 562] [51946] (4)
  2. Trypanothione reductase [51947]
    1. Crithidia fasciculata [TaxId: 5656] [51948] (6)
    2. Trypanosoma cruzi [TaxId: 5693] [51949] (8)
  3. Mammalian thioredoxin reductase [63947]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [63948] (1)
  4. Thioredoxin reductase [51950]
    lacks the "interface" C-terminal alpha+beta domain
    1. Escherichia coli [TaxId: 562] [51951] (5)
    2. Mouse-ear cress (Arabidopsis thaliana) [TaxId: 3702] [51952] (1)
  5. Apoptosis-inducing factor (AIF) [75126]
    1. Human (Homo sapiens) [TaxId: 9606] [75127] (1)
    2. Mouse (Mus musculus) [TaxId: 10090] [75128] (1)
  6. Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains [51953]
    1. Salmonella typhimurium [TaxId: 90371] [51954] (1)
    2. Escherichia coli [TaxId: 562] [63949] (1)
  7. NADH peroxidase [51955]
    1. Enterococcus faecalis [TaxId: 1351] [51956] (8)
  8. NADH-dependent ferredoxin reductase, BphA4 [51957]
    1. Pseudomonas sp., KKS102 [TaxId: 306] [51958] (2)
  9. Putidaredoxin reductase [102185]
    1. Pseudomonas putida [TaxId: 303] [102186] (2)
  10. Dihydrolipoamide dehydrogenase [51959]
    1. Pseudomonas putida [TaxId: 303] [51960] (1)
    2. Pseudomonas fluorescens [TaxId: 294] [51961] (1)
    3. Azotobacter vinelandii [TaxId: 354] [51962] (1)
    4. Bacillus stearothermophilus [TaxId: 1422] [51963] (1)
    5. Neisseria meningitidis [TaxId: 487] [51964] (2)
    6. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [63950] (5)
    7. Garden pea (Pisum sativum) [TaxId: 3888] [51965] (1)
    8. Mycobacterium tuberculosis [TaxId: 1773] [117441] (1)
      SQ O53355
  11. NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase [82313]
    1. Xanthobacter sp., py2 [TaxId: 35809] [82314] (10)
  12. Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit [51966]
    has a smaller C-terminal alpha+beta domain instead the "interface" domain
    1. Purple phototrophic bacterium (Chromatium vinosum) [TaxId: 1049] [51967] (1)
  13. Phenylacetone monooxygenase [110440]
    1. Thermobifida fusca [TaxId: 2021] [110441] (1)
      SQ Q5YS95 # 55% sequence identity; Nocardia farcinica TaxID:37329
  14. NADH oxidase /nitrite reductase [117442]
    1. Pyrococcus furiosus [TaxId: 2261] [117443] (1)
      SQ Q8U1K9
  15. Flavin-dependent monoxygenase SPBP16F5.08c [117444]
    1. Schizosaccharomyces pombe [TaxId: 4896] [117445] (13)
      SQ Q9HFE4
6. Thi4-like [141942] (2)
  Pfam 01946; stand-alone, moderately decorated domain
  1. Thiazole biosynthetic enzyme Thi4 [141943]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141944] (2)
      SQ P32318 16-326
      mitochondrial
    2. Thale cress(Arabidopsis thaliana) [TaxId: 3702] [141945] (1)
      SQ Q38814 51-328
      chloroplast
7. GidA-like [141946] (1)
  part of Pfam 01266
  1. GidA-related protein TTHA1897 [141947]
    1. Thermus thermophilus [TaxId: 274] [141948] (1)
      SQ Q5SH33 2-231
8. HI0933 N-terminal domain-like [159436] (2)
  N-terminal part of Pfam 03486
  1. Hypothetical protein HI0933 [159437]
    1. Haemophilus influenzae [TaxId: 727] [159438] (1)
      SQ P44941 1-194,343-401
  2. Flavoprotein BC4706 [159439]
    1. Bacillus cereus [TaxId: 1396] [159440] (1)
      SQ Q816V9 1-192,362-420