Structural Classification of Proteins
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Family: Triosephosphate isomerase (TIM)

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: TIM beta/alpha-barrel [51350]
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. Superfamily: Triosephosphate isomerase (TIM) [51351]
    link to SUPERFAMILY database - Superfamily
  5. Family: Triosephosphate isomerase (TIM) [51352]

Protein Domains:

  1. Triosephosphate isomerase [51353]
    1. Chicken (Gallus gallus) [TaxId: 9031] [51354] (16)
      SQ P00940
      1. 1sw3 picpic
        complexed with pga; mutant
        1. chain a [106065] picpiclink
        2. chain b [106066] picpiclink
      2. 1sw0 picpic
        complexed with pga; mutant
        1. chain a [106060] picpiclink
        2. chain b [106061] picpiclink
      3. 1spq picpic
        complexed with peg; mutant
        1. chain a [105878] picpiclink
        2. chain b [105879] picpiclink
      4. 1tph picpic
        complexed with pgh
        1. chain 1 [28439] picpiclink
        2. chain 2 [28440] picpiclink
      5. 1tpv picpic
        complexed with pgh; mutant
        1. chain a [28443] picpiclink
        2. chain b [28444] picpiclink
      6. 1tpu picpic
        complexed with pgh; mutant
        1. chain a [28441] picpiclink
        2. chain b [28442] picpiclink
      7. 1tpb picpic
        complexed with pgh; mutant
        1. chain 1 [28445] picpiclink
        2. chain 2 [28446] picpiclink
      8. 1tpc picpic
        complexed with pgh; mutant
        1. chain 1 [28447] picpiclink
        2. chain 2 [28448] picpiclink
      9. 1tpw picpic
        complexed with pgh; mutant
        1. chain a [28449] picpiclink
        2. chain b [28450] picpiclink
      10. 1sw7 picpic
        complexed with pga; mutant
        1. chain a [106073] picpiclink
        2. chain b [106074] picpiclink
      11. 1su5 picpic
        complexed with gol, pga, so4; mutant
        1. chain a [106020] picpiclink
        2. chain b [106021] picpiclink
      12. 1ssd picpic
        complexed with so4; mutant
        1. chain a [105979] picpiclink
        2. chain b [105980] picpiclink
      13. 1sq7 picpic
        mutant
        1. chain a [105886] picpiclink
        2. chain b [105887] picpiclink
      14. 1ssg picpic
        complexed with gol, pga, so4; mutant
        1. chain a [105984] picpiclink
        2. chain b [105985] picpiclink
      15. 8tim picpic
        complexed with so4
        1. chain a [28451] picpiclink
        2. chain b [28452] picpiclink
      16. 1tim picpic
        1. chain a [28453] picpiclink
        2. chain b [28454] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [51355] (5)
      1. 2jk2 picpic
        automatically matched to d1htia_
        1. region a:4-248 [148134] picpiclink
      2. 2jk2 picpic
        automatically matched to d1htia_
        1. region b:4-248 [148135] picpiclink
      3. 1wyi picpic
        automatically matched to d1htia_
        1. region a:1-248 [121446] picpiclink
      4. 1wyi picpic
        automatically matched to d1htia_
        1. region b:1-248 [121447] picpiclink
      5. 1hti picpic
        complexed with pga
        1. chain a [28455] picpiclink
        2. chain b [28456] picpiclink
    3. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [102035] (3)
      1. 1r2r picpic
        complexed with dms, mo2, mo6, trs
        1. chain a [96875] picpiclink
        2. chain b [96876] picpiclink
        3. chain c [96877] picpiclink
        4. chain d [96878] picpiclink
      2. 1r2t picpic
        1. chain a [96883] picpiclink
        2. chain b [96884] picpiclink
      3. 1r2s picpic
        1. chain a [96879] picpiclink
        2. chain b [96880] picpiclink
        3. chain c [96881] picpiclink
        4. chain d [96882] picpiclink
    4. Nematode (Caenorhabditis elegans) [TaxId: 6239] [82235] (1)
      1. 1mo0 picpic
        complexed with act, so4
        1. chain a [79329] picpiclink
        2. chain b [79330] picpiclink
    5. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [51356] (7)
      1. 1ney picpic
        complexed with 13p, ftr; mutant
        1. chain a [80449] picpiclink
        2. chain b [80450] picpiclink
      2. 1i45 picpic
        complexed with ftr; mutant
        1. chain a [61665] picpiclink
        2. chain b [61666] picpiclink
      3. 1nf0 picpic
        complexed with 13p, ftr; mutant
        1. chain a [80451] picpiclink
        2. chain b [80452] picpiclink
      4. 7tim picpic
        complexed with pgh
        1. chain a [28457] picpiclink
        2. chain b [28458] picpiclink
      5. 1ypi picpic
        1. chain a [28459] picpiclink
        2. chain b [28460] picpiclink
      6. 3ypi picpic
        complexed with pgh; mutant
        1. chain a [28463] picpiclink
        2. chain b [28464] picpiclink
      7. 2ypi picpic
        complexed with pga
        1. chain a [28461] picpiclink
        2. chain b [28462] picpiclink
    6. Trypanosoma brucei [TaxId: 5691] [51357] (19)
      1. 1kv5 picpic
        complexed with dtt, gol, pga, so4; mutant
        1. chain a [73052] picpiclink
        2. chain b [73053] picpiclink
      2. 1tpf picpic
        complexed with dms
        1. chain a [28467] picpiclink
        2. chain b [28468] picpiclink
      3. 5tim picpic
        complexed with dtt, so4
        1. chain a [28465] picpiclink
        2. chain b [28466] picpiclink
      4. 1tpe picpic
        1. chain a [28469] picpiclink
      5. 1iih picpic
        complexed with 3pg
        1. chain a [62430] picpiclink
        2. chain b [62431] picpiclink
      6. 1tpd picpic
        1. chain a [28470] picpiclink
        2. chain b [28471] picpiclink
      7. 4tim picpic
        complexed with 2pg
        1. chain a [28472] picpiclink
        2. chain b [28473] picpiclink
      8. 1ag1 picpic
        complexed with po4
        1. chain o [28474] picpiclink
        2. chain t [28475] picpiclink
      9. 1iig picpic
        complexed with 3pp
        1. chain a [62428] picpiclink
        2. chain b [62429] picpiclink
      10. 1ttj picpic
        complexed with pgh; mutant
        1. chain a [28478] picpiclink
      11. 1trd picpic
        complexed with pgh
        1. chain a [28476] picpiclink
        2. chain b [28477] picpiclink
      12. 3tim picpic
        1. chain a [28483] picpiclink
        2. chain b [28484] picpiclink
      13. 1dkw picpic
        modified substrate binding site
        complexed with tbu
        1. chain a [28487] picpiclink
        2. chain b [28488] picpiclink
      14. 1ml1 picpic
        complexed with pga
        1. chain a [28489] picpiclink
        2. chain c [28490] picpiclink
        3. chain e [28491] picpiclink
        4. chain g [28492] picpiclink
        5. chain i [28493] picpiclink
        6. chain k [28494] picpiclink
      15. 1tti picpic
        complexed with pga; mutant
        1. chain a [28482] picpiclink
      16. 1tsi picpic
        complexed with 4pb
        1. chain a [28485] picpiclink
        2. chain b [28486] picpiclink
      17. 6tim picpic
        complexed with g3p
        1. chain a [28495] picpiclink
        2. chain b [28496] picpiclink
      18. 1tri picpic
        monomeric mutant structure
        1. chain a [28479] picpiclink
      19. 1mss picpic
        different dimerisation mode mutant
        1. chain a [28480] picpiclink
        2. chain b [28481] picpiclink
    7. Trypanosoma cruzi [TaxId: 5693] [51358] (5)
      SQ P52270
      1. 1sux picpic
        complexed with bts, so4
        1. chain a [106031] picpiclink
        2. chain b [106032] picpiclink
      2. 1tcd picpic
        1. chain a [28497] picpiclink
        2. chain b [28498] picpiclink
      3. 1ci1 picpic
        structure in hexane
        complexed with hex
        1. chain a [28499] picpiclink
        2. chain b [28500] picpiclink
      4. 2oma picpic
        automatically matched to d1suxa_
        complexed with cs1, peg, pge, so4
        1. region a:2-251 [148869] picpiclink
      5. 2oma picpic
        automatically matched to d1suxa_
        complexed with cs1, peg, pge, so4
        1. region b:2-251 [148870] picpiclink
    8. Plasmodium falciparum [TaxId: 5833] [51359] (9)
      SQ Q07412
      1. 1o5x picpic
        complexed with 2pg, 3py, po3; mutant
        1. chain a [92528] picpiclink
        2. chain b [92529] picpiclink
      2. 1vga picpic
        mutant
        1. chain a [113641] picpiclink
        2. chain b [113642] picpiclink
        3. chain c [113643] picpiclink
        4. chain d [113644] picpiclink
      3. 1lyx picpic
        complexed with pga
        1. chain a [78304] picpiclink
      4. 1ydv picpic
        1. chain a [28501] picpiclink
        2. chain b [28502] picpiclink
      5. 1m7o picpic
        complexed with 3pg
        1. chain a [78740] picpiclink
        2. chain b [78741] picpiclink
      6. 1m7p picpic
        complexed with g3p
        1. chain a [78742] picpiclink
        2. chain b [78743] picpiclink
      7. 1wob picpic
        complexed with so4; mutant
        1. chain a [114774] picpiclink
        2. chain b [114775] picpiclink
        3. chain c [114776] picpiclink
        4. chain d [114777] picpiclink
      8. 1woa picpic
        complexed with g2h; mutant
        1. chain a [114770] picpiclink
        2. chain b [114771] picpiclink
        3. chain c [114772] picpiclink
        4. chain d [114773] picpiclink
      9. 1lzo picpic
        complexed with pga
        1. chain a [78307] picpiclink
        2. chain b [78308] picpiclink
        3. chain c [78309] picpiclink
        4. chain d [78310] picpiclink
    9. Leishmania mexicana [TaxId: 5665] [51360] (4)
      1. 1n55 picpic
        ultra-high resolution structure
        complexed with acy, gol, pga; mutant
        1. chain a [80007] picpiclink
      2. 1if2 picpic
        complexed with 129; mutant
        1. chain a [62342] picpiclink
      3. 1amk picpic
        complexed with pga
        1. chain a [28503] picpiclink
      4. 1qds picpic
        complexed with pga; mutant
        1. chain a [28504] picpiclink
    10. Entamoeba histolytica [TaxId: 5759] [82236] (1)
      1. 1m6j picpic
        1. chain a [78693] picpiclink
        2. chain b [78694] picpiclink
    11. Escherichia coli [TaxId: 562] [51361] (1)
      1. 1tre picpic
        1. chain a [28505] picpiclink
        2. chain b [28506] picpiclink
    12. Synthetic, hybrid between Escherichia coli and chicken TIM [51362] (1)
      1. 1tmh picpic
        complexed with so4; mutant
        1. chain a [28507] picpiclink
        2. chain b [28508] picpiclink
        3. chain c [28509] picpiclink
        4. chain d [28510] picpiclink
    13. Bacillus stearothermophilus [TaxId: 1422] [51363] (2)
      1. 2btm picpic
        complexed with pga; mutant
        1. chain a [28511] picpiclink
        2. chain b [28512] picpiclink
      2. 1btm picpic
        complexed with pga
        1. chain a [28513] picpiclink
        2. chain b [28514] picpiclink
    14. Vibrio marinus [TaxId: 90736] [51364] (2)
      1. 1aw1 picpic
        complexed with pga
        1. chain a [28515] picpiclink
        2. chain b [28516] picpiclink
        3. chain d [28517] picpiclink
        4. chain e [28518] picpiclink
        5. chain g [28519] picpiclink
        6. chain h [28520] picpiclink
        7. chain j [28521] picpiclink
        8. chain k [28522] picpiclink
      2. 1aw2 picpic
        complexed with so4
        1. chain a [28523] picpiclink
        2. chain b [28524] picpiclink
        3. chain d [28525] picpiclink
        4. chain e [28526] picpiclink
        5. chain g [28527] picpiclink
        6. chain h [28528] picpiclink
        7. chain j [28529] picpiclink
        8. chain k [28530] picpiclink
    15. Thermotoga maritima [TaxId: 2336] [51365] (1)
      1. 1b9b picpic
        1. chain a [28531] picpiclink
        2. chain b [28532] picpiclink
    16. Archaeon Pyrococcus woesei [TaxId: 2262] [63891] (1)
      1. 1hg3 picpic
        complexed with 3pp
        1. chain a [61025] picpiclink
        2. chain b [61026] picpiclink
        3. chain c [61027] picpiclink
        4. chain d [61028] picpiclink
        5. chain e [61029] picpiclink
        6. chain f [61030] picpiclink
        7. chain g [61031] picpiclink
        8. chain h [61032] picpiclink
    17. Thermoproteus tenax [TaxId: 2271] [110342] (1)
      SQ Q8NKN9
      1. 1w0m picpic
        complexed with po4
        1. chain a [109027] picpiclink
        2. chain b [109028] picpiclink
        3. chain c [109029] picpiclink
        4. chain d [109030] picpiclink
        5. chain e [109031] picpiclink
        6. chain f [109032] picpiclink
        7. chain g [109033] picpiclink
        8. chain h [109034] picpiclink
    18. Trypanosoma (Trypanozoon) brucei brucei (Trypanosoma brucei brucei) [TaxId: 39700] [159375] (2)
      1. 2v5l picpic
        automatically matched to d1tpfa_
        complexed with so4
        1. region a:2-250 [152576] picpiclink
      2. 2v5l picpic
        automatically matched to d1tpfa_
        complexed with so4
        1. region b:302-550 [152577] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk