Structural Classification of Proteins

Family: Phosphotyrosine-binding domain (PTB)

: Pfam 00640

Lineage:

Root: scop
Class: All beta proteins [48724]
Fold: PH domain-like barrel [50728]
barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
Superfamily: PH domain-like [50729]
uperfamily
Family: Phosphotyrosine-binding domain (PTB) [50755]
Pfam 00640

Protein Domains:

X11 [50756]
1. Human (Homo sapiens) [TaxId: 9606] [50757] (2)
  1. 1aqc
    1. chain a [26983]
    2. chain b [26984]
  2. 1x11
    1. chain a [26985]
    2. chain b [26986]
Insulin receptor substrate 1, IRS-1 [50758]
duplication: contains two domains of this fold
1. Human (Homo sapiens) [TaxId: 9606] [50759] (2)
  1. 1qqg
    1. region a:12-114 [26987]
    2. region a:159-262 [26988]
    3. region b:11-114 [26989]
    4. region b:159-264 [26990]
  2. 1irs
    second domain complexed with a IL-4 receptor phosphopeptide
    1. chain a [26991]
Shc adaptor protein [50760]
1. Human (Homo sapiens) [TaxId: 9606] [50761] (3)
  1. 1oy2
    1. chain a [93717]
  2. 1shc
    1. chain a [26992]
  3. 1n3h
    1. chain a [91564]
Numb [50762]
1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [50763] (2)
  1. 2nmb
    complexed with a phosphotyrosine peptide
    1. chain a [26994]
  2. 1ddm
    complexed to a nak peptide
    1. chain a [26993]
2. Mouse (Mus musculus) [TaxId: 10090] [117256] (1)
  SQ Q9QZS3 19-172
  1. 1wj1
    Structural genomics target
    1. chain a [114688]
Disabled homolog 1 (Dab1) [89357]
1. Mouse (Mus musculus) [TaxId: 10090] [89358] (3)
  1. 1ntv
    complexed with apoer2 peptide
    complexed with po4
    1. chain a [86168]
  2. 1nu2
    complexed with apoer2 peptide and PI-4,5P2
    complexed with i3p
    1. chain a [86169]
  3. 1oqn
    complexed with peptide and I3P
    complexed with i3p
    1. chain a [93420]
    2. chain b [93421]
Disabled homolog 2 (Dab2) [101830]
1. Mouse (Mus musculus) [TaxId: 10090] [101831] (2)
  1. 1p3r
    1. chain a [94065]
    2. chain b [94066]
    3. chain c [94067]
  2. 1m7e
    complexed with peptide
    1. chain a [91220]
    2. chain b [91221]
    3. chain c [91222]
Downstream of tyrosine kinase 5, Dok-5 [101832]
1. Human (Homo sapiens) [TaxId: 9606] [101833] (1)
  1. 1j0w
    1. chain a [90748]
    2. chain b [90749]
Docking protein 1, Dok1 [101834]
1. Mouse (Mus musculus) [TaxId: 10090] [101835] (2)
  SQ P97465 152-254
  1. 1p5t
    1. chain a [94148]
    2. chain b [94149]
  2. 1uef
    complexed with po3
    1. chain a [107788]
    2. chain b [107789]
FGFR substrate 2 (SNT-1) [117257]
1. Human (Homo sapiens) [TaxId: 9606] [117258] (1)
  SQ Q7LDQ6 11-129
  1. 1xr0
    complexed with BFGFR-1 peptide (SQ Q04589 409-430), chain A
    1. chain b [115858]
Amyloid beta A4 precursor protein-binding family B member 2, Apbb2 [117259]
1. Mouse (Mus musculus) [TaxId: 10090] [117260] (2)
  SQ Q9DBR4 582-704
  1. 1wgu
    Structural genomics target
    1. chain a [114623]
  2. 2roz
    automatically matched to d1wgua_
    1. region b:1-136 [152178]
Tensin [141421]
1. Human (Homo sapiens) [TaxId: 9606] [141422] (1)
  SQ Q9UPS7 1139-1285
  Tensin2
  1. 2dkq
    1. region a:8-154 [131556]
2. Chicken (Gallus gallus) [TaxId: 9031] [141423] (1)
  SQ Q04205 1606-1738
  1. 1wvh
    1. region a:1606-1738 [121341]
EPS8-like protein 1, EPS8L1 [141424]
1. Mouse (Mus musculus) [TaxId: 10090] [141425] (2)
  SQ Q8R5F8 31-159
  1. 2cy5
    automatically matched to 2CY4 A:31-159
    complexed with ca
    1. region a:31-159 [131018]
  2. 2cy4
    complexed with ca
    1. region a:31-159 [131017]