Structural Classification of Proteins
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Family: Pleckstrin-homology domain (PH domain)

Pfam 00169

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: PH domain-like barrel [50728]
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. Superfamily: PH domain-like [50729]
    link to SUPERFAMILY database - Superfamily
  5. Family: Pleckstrin-homology domain (PH domain) [50730]
    Pfam 00169

Protein Domains:

  1. Phospholipase C delta-1 [50731]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50732] (1)
      1. 1mai picpic
        complexed with i3p
        1. chain a [26951] picpiclink
  2. beta-spectrin [50733]
    1. Mouse (Mus musculus), brain [TaxId: 10090] [50734] (2)
      1. 1btn picpic
        complexed with i3p
        1. chain a [26952] picpiclink
      2. 1mph picpic
        1. chain a [26953] picpiclink
    2. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [50735] (1)
      1. 1dro picpic
        1. chain a [26954] picpiclink
    3. Human (Homo sapiens), brain 2 isoform [TaxId: 9606] [117243] (1)
      SQ O15020 2219-2324
      1. 1wjm picpic
        Structural genomics target
        1. chain a [114702] picpiclink
  3. Dynamin [50736]
    1. Human (Homo sapiens) [TaxId: 9606] [50737] (2)
      1. 2dyn picpic
        1. chain a [26957] picpiclink
        2. chain b [26958] picpiclink
      2. 1dyn picpic
        1. chain a [26955] picpiclink
        2. chain b [26956] picpiclink
  4. Bruton's tyrosine kinase [50738]
    contains Btk zinc-binding motif
    1. Human (Homo sapiens) [TaxId: 9606] [50739] (7)
      1. 1btk picpic
        complexed with na, zn; mutant
        1. chain a [26959] picpiclink
        2. chain b [26960] picpiclink
      2. 1bwn picpic
        complexed with 4ip, zn; mutant
        1. chain a [26961] picpiclink
        2. chain b [26962] picpiclink
      3. 2z0p picpic
        automatically matched to d1b55a_
        complexed with 4pt, zn
        1. region a:2-168 [153912] picpiclink
      4. 2z0p picpic
        automatically matched to d1b55a_
        complexed with 4pt, zn
        1. region b:2-168 [153913] picpiclink
      5. 2z0p picpic
        automatically matched to d1b55a_
        complexed with 4pt, zn
        1. region c:2-168 [153914] picpiclink
      6. 2z0p picpic
        automatically matched to d1b55a_
        complexed with 4pt, zn
        1. region d:2-168 [153915] picpiclink
      7. 1b55 picpic
        complexed with its, zn
        1. chain a [26963] picpiclink
        2. chain b [26964] picpiclink
  5. Pleckstrin [50740]
    1. Human (Homo sapiens) [TaxId: 9606] [50741] (9)
      1. 2i5f picpic
        automatically matched to d1xx0a1
        complexed with 5ip
        1. region a:244-347 [147512] picpiclink
      2. 2i5c picpic
        automatically matched to d1xx0a1
        complexed with ip5
        1. region a:244-347 [147507] picpiclink
      3. 2i5c picpic
        automatically matched to d1xx0a1
        complexed with ip5
        1. region b:244-347 [147508] picpiclink
      4. 2i5c picpic
        automatically matched to d1xx0a1
        complexed with ip5
        1. region c:244-347 [147509] picpiclink
      5. 1zm0 picpic
        2nd PH domain
        1. region a:243-347 [125276] picpiclink
      6. 1zm0 picpic
        automatically matched to 1ZM0 A:243-347
        1. region b:243-347 [125277] picpiclink
      7. 1xx0 picpic
        2nd PH domain
        1. region a:234-350 [122412] picpiclink
      8. 1x05 picpic
        2nd PH domain
        1. region a:8-123 [121543] picpiclink
      9. 1pls picpic
        mutant
        1. chain a [26965] picpiclink
  6. Son of sevenless-1 (sos-1) [50742]
    1. Mouse (Mus musculus) [TaxId: 10090] [50743] (1)
      1. 1pms picpic
        mutant
        1. chain a [26966] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [50744] (4)
      SQ Q07889 189-1046
      1. 1dbh picpicxref
        1. region a:418-550 [26967] picpiclink
      2. 1xdv picpicxrefxref
        1. region a:419-549 [115182] picpiclink
        2. region b:419-549 [115185] picpiclink
      3. 1xd4 picpicxrefxref
        1. region a:419-549 [115151] picpiclink
        2. region b:419-549 [115154] picpiclink
      4. 1awe picpic
        1. chain a [26968] picpiclink
  7. GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745]
    1. Mouse (Mus musculus) [TaxId: 10090] [50746] (1)
      1. 1foe picpicxrefxref
        complexed with so4; mutant
        1. region a:1240-1401 [26969] picpiclink
        2. region c:1240-1401 [26970] picpiclink
        3. region e:1240-1401 [26971] picpiclink
        4. region g:1240-1401 [26972] picpiclink
  8. Dbl's big sister, Dbs [74989]
    1. Mouse (Mus musculus) [TaxId: 10090] [74990] (4)
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
      1. 1kz7 picpicxrefxref
        complexed with mse; mutant
        1. region a:819-965 [73334] picpiclink
        2. region c:1819-1960 [73337] picpiclink
      2. 1kzg picpicxrefxref
        mutant
        1. region a:819-965 [73356] picpiclink
        2. region c:1819-1960 [73359] picpiclink
      3. 1lb1 picpicxrefxref
        mutant
        1. region a:819-953 [73785] picpiclink
        2. region c:819-953 [73788] picpiclink
        3. region e:819-953 [73791] picpiclink
        4. region g:819-953 [73794] picpiclink
      4. 1rj2 picpicxref
        1. region a:819-950 [104955] picpiclink
        2. region d:819-950 [104957] picpiclink
        3. region g:819-950 [104959] picpiclink
        4. region j:819-950 [104961] picpiclink
  9. GEF of intersectin [74991]
    1. Human (Homo sapiens) [TaxId: 9606] [74992] (1)
      1. 1ki1 picpicxrefxref
        complexed with so4; mutant
        1. region b:1439-1580 [72498] picpiclink
        2. region d:1439-1580 [72501] picpiclink
  10. G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747]
    1. Human (Homo sapiens) [TaxId: 9606] [50748] (1)
      1. 1bak picpic
        mutant
        1. chain a [26973] picpiclink
    2. Cow (Bos taurus) [TaxId: 9913] [89354] (6)
      1. 1omw picpicxrefxrefxrefxref
        complexed with cmt; mutant
        1. region a:550-668 [87087] picpiclink
      2. 2bcj picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1omwa2
        complexed with ace, alf, gdp, mg; mutant
        1. region a:550-656 [128287] picpiclink
      3. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1omwa2
        mutant
        1. region a:550-656 [123686] picpiclink
      4. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1omwa2
        mutant
        1. region b:550-656 [123689] picpiclink
      5. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1omwa2
        mutant
        1. region c:550-656 [123692] picpiclink
      6. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1omwa2
        mutant
        1. region d:552-656 [123695] picpiclink
  11. Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749]
    1. Human (Homo sapiens) [TaxId: 9606] [50750] (2)
      1. 1fao picpic
        complexed with its
        1. chain a [26974] picpiclink
      2. 1fb8 picpic
        complexed with po4
        1. chain a [26975] picpiclink
  12. Grp1 [50751]
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
    1. Mouse (Mus musculus) [TaxId: 10090] [50752] (8)
      1. 1fgy picpic
        complexed with 4ip
        1. chain a [26976] picpiclink
      2. 2r09 picpicxrefxref
        automatically matched to d1fhwb_
        complexed with 4ip, pe5, pge, so4; mutant
        1. region a:266-391 [151493] picpiclink
      3. 2r09 picpicxrefxref
        automatically matched to d1fhwb_
        complexed with 4ip, pe5, pge, so4; mutant
        1. region b:266-391 [151495] picpiclink
      4. 1fhw picpic
        complexed with i5p, so4
        1. chain a [26977] picpiclink
        2. chain b [26978] picpiclink
      5. 2r0d picpicxrefxref
        automatically matched to d1fhwb_
        complexed with 4ip, peg, so4; mutant
        1. region a:266-391 [151497] picpiclink
      6. 2r0d picpicxrefxref
        automatically matched to d1fhwb_
        complexed with 4ip, peg, so4; mutant
        1. region b:266-391 [151499] picpiclink
      7. 1fgz picpic
        complexed with so4
        1. chain a [26979] picpiclink
      8. 1fhx picpic
        complexed with 4ip, so4
        1. chain a [26980] picpiclink
        2. chain b [26981] picpiclink
  13. UNC-89 [50753]
    1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [50754] (1)
      1. 1fho picpic
        1. chain a [26982] picpiclink
  14. Tapp1 [74993]
    1. Human (Homo sapiens) [TaxId: 9606] [74994] (1)
      1. 1eaz picpic
        phosphoinositol (3,4)-bisphosphate binding PH domain
        complexed with cit
        1. chain a [70113] picpiclink
  15. Rac-alpha serine/threonine kinase [89355]
    1. Human (Homo sapiens) [TaxId: 9606] [89356] (5)
      SQ P31749 1-117
      1. 1unq picpic
        complexed with ace, its
        1. chain a [107968] picpiclink
      2. 1unr picpic
        complexed with so4
        1. chain a [107969] picpiclink
      3. 1h10 picpic
        complexed with ace, its, mse
        1. chain a [83446] picpiclink
      4. 1unp picpic
        1. chain a [107967] picpiclink
      5. 2uvm picpic
        automatically matched to d1unpa_
        complexed with gvf, na
        1. region a:3-116 [139979] picpiclink
  16. Rac-beta serine/threonine protein kinase (PKB/AKT) [110254]
    1. Human (Homo sapiens) [TaxId: 9606] [110255] (1)
      SQ P31751 1-111
      1. 1p6s picpic
        1. chain a [104075] picpiclink
  17. SH2 and PH domain-containing adapter protein APS [110256]
    1. Mouse (Mus musculus) [TaxId: 10090] [110257] (1)
      SQ Q9JID9 178-299
      1. 1v5m picpic
        Structural genomics target
        mutant
        1. chain a [108379] picpiclink
  18. Tapp2 [110258]
    1. Mouse (Mus musculus) [TaxId: 10090] [110259] (1)
      SQ Q9ERS5 1-113
      1. 1v5p picpic
        Structural genomics target
        1. chain a [108382] picpiclink
  19. SET binding factor 1, Sbf1 [110260]
    1. Mouse (Mus musculus) [TaxId: 10090] [110261] (1)
      SQ Q8K2Z0 256-367
      1. 1v5u picpic
        Structural genomics target
        1. chain a [108386] picpiclink
  20. Rac/CDC42 GEF 6, alpha-pix [110262]
    1. Mouse (Mus musculus) [TaxId: 10090] [110263] (1)
      SQ Q8K4I3 429-551
      1. 1v61 picpic
        Structural genomics target
        1. chain a [108389] picpiclink
  21. Triple functional domain protein TRIO [110264]
    1. Human (Homo sapiens) [TaxId: 9606] [110265] (2)
      SQ O75962 1231-1535
      1. 1nty picpicxref
        1. region a:1415-1535 [103874] picpiclink
      2. 2nz8 picpicxrefxref
        automatically matched to d1ntya2
        1. region b:1415-1535 [138839] picpiclink
  22. Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266]
    1. Human (Homo sapiens) [TaxId: 9606] [110267] (1)
      SQ Q9BZF1 149-265
      1. 1v88 picpic
        Structural genomics target
        1. chain a [108423] picpiclink
  23. Rho-GTPase-activating protein 25 (KIAA0053) [110268]
    1. Human (Homo sapiens) [TaxId: 9606] [110269] (1)
      SQ P42331 40-144
      1. 1v89 picpic
        Structural genomics target
        1. chain a [108424] picpiclink
  24. Rho guanine nucleotide exchange factor 12 [110270]
    1. Human (Homo sapiens), gamma isoform [TaxId: 9606] [110271] (2)
      SQ Q9NZN5 766-1138
      1. 1txd picpicxref
        1. region a:1020-1133 [107423] picpiclink
      2. 1x86 picpicxrefxref
        complexed with po4; mutant
        1. region a:1020-1133 [109505] picpiclink
        2. region c:1020-1133 [109508] picpiclink
        3. region e:1020-1133 [109511] picpiclink
        4. region g:1020-1133 [109514] picpiclink
  25. Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244]
    1. Human (Homo sapiens) [TaxId: 9606] [117245] (2)
      SQ Q9H4M7 47-153
      1. 1upq picpic
        complexed with so4
        1. chain a [113392] picpiclink
      2. 1upr picpic
        complexed with its
        1. chain a [113393] picpiclink
  26. 3-phosphoinositide dependent protein kinase-1 [117246]
    1. Human (Homo sapiens) [TaxId: 9606] [117247] (3)
      SQ O15530 409-550
      1. 1w1h picpic
        complexed with gol, so4
        1. chain a [114076] picpiclink
        2. chain b [114077] picpiclink
        3. chain c [114078] picpiclink
        4. chain d [114079] picpiclink
      2. 1w1d picpic
        complexed with 4ip, au, gol
        1. chain a [114074] picpiclink
      3. 1w1g picpic
        complexed with 4pt
        1. chain a [114075] picpiclink
  27. Dedicator of cytokinesis protein 9, DOCK9 [117248]
    1. Human (Homo sapiens) [TaxId: 9606] [117249] (1)
      SQ Q9BZ29 165-301
      1. 1wg7 picpic
        Structural genomics target
        1. chain a [114604] picpiclink
  28. FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250]
    1. Mouse (Mus musculus) [TaxId: 10090] [117251] (1)
      SQ Q69ZL1 1303-1389
      1. 1wgq picpic
        Structural genomics target
        1. chain a [114620] picpiclink
  29. Calcium-dependent activator protein for secretion, CAPS [117252]
    1. Human (Homo sapiens) [TaxId: 9606] [117253] (1)
      SQ Q8NFR0 522-634
      1. 1wi1 picpic
        Structural genomics target
        1. chain a [114658] picpiclink
  30. Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254]
    1. Human (Homo sapiens) [TaxId: 9606] [117255] (1)
      SQ O15085 714-1081
      1. 1xcg picpicxrefxref
        mutant
        1. region a:942-1081 [115121] picpiclink
        2. region e:942-1081 [115124] picpiclink
  31. Centaurin-delta 1 [141395]
    1. Human (Homo sapiens) [TaxId: 9606] [141396] (1)
      SQ Q8WZ64 483-584
      1. 2cod picpic
        1. region a:8-109 [130675] picpiclink
  32. Cytohesin 3 [141397]
    1. Mouse (Mus musculus) [TaxId: 10090] [141398] (1)
      SQ O08967 261-387
      1. 1u2b picpic
        complexed with so4
        1. region a:261-387 [119474] picpiclink
  33. Exocyst complex protein EXO84 [141399]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [141400] (4)
      SQ O54924 171-283
      1. 1zc3 picpicxrefxref
        automatically matched to 1ZC4 B:171-283
        complexed with gnp, mg; mutant
        1. region b:171-279 [124881] picpiclink
      2. 1zc3 picpicxrefxref
        automatically matched to 1ZC4 B:171-283
        complexed with gnp, mg; mutant
        1. region d:171-279 [124883] picpiclink
      3. 1zc4 picpicxrefxref
        complexed with gnp, mg; mutant
        1. region b:171-283 [124885] picpiclink
      4. 1zc4 picpicxrefxref
        automatically matched to 1ZC4 B:171-283
        complexed with gnp, mg; mutant
        1. region d:171-283 [124887] picpiclink
  34. Cytohesin 2 [141401]
    1. Mouse (Mus musculus) [TaxId: 10090] [141402] (2)
      SQ P63034 260-378
      1. 1u29 picpic
        automatically matched to 1U27 A:260-378
        complexed with i3p
        1. region a:260-378 [119473] picpiclink
      2. 1u27 picpic
        complexed with 4ip
        1. region a:260-378 [119467] picpiclink
  35. Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403]
    1. Human (Homo sapiens) [TaxId: 9606] [141404] (4)
      SQ O15268 108-213
      1. 1u5d picpic
        complexed with so4; mutant
        1. region a:108-213 [119536] picpiclink
      2. 1u5d picpic
        automatically matched to 1U5D A:108-213
        complexed with so4; mutant
        1. region b:108-212 [119537] picpiclink
      3. 1u5d picpic
        automatically matched to 1U5D A:108-213
        complexed with so4; mutant
        1. region c:108-212 [119538] picpiclink
      4. 1u5d picpic
        automatically matched to 1U5D A:108-213
        complexed with so4; mutant
        1. region d:108-213 [119539] picpiclink
  36. Signal-transducing adaptor protein 1, STAP-1 [141405]
    1. Human (Homo sapiens) [TaxId: 9606] [141406] (1)
      SQ Q9ULZ2 16-151
      1. 1x1f picpic
        1. region a:8-143 [121579] picpiclink
  37. KIAA1914 [141407]
    1. Human (Homo sapiens) [TaxId: 9606] [141408] (1)
      SQ Q8N4X5 354-448
      1. 2cof picpic
        1. region a:8-102 [130676] picpiclink
  38. Pleckstrin-2 [141409]
    1. Human (Homo sapiens) [TaxId: 9606] [141410] (1)
      SQ Q9NYT0 238-353
      1. 1x1g picpic
        2nd PH domain
        1. region a:8-123 [121580] picpiclink
  39. Alpha-1-syntrophin [141411]
    1. Mouse (Mus musculus) [TaxId: 10090] [141412] (1)
      SQ Q61234 2-44,203-264
      1. 2adz picpic
        split PH domain; excluded region 44-116 contains disordered bits of truncated PDZ domain-containing insert region
        1. region a:1-43,a:117-178 [126599] picpiclink
  40. Phosphoinositide phospholipase C, PLC-gamma-1 [141413]
    contains split PH domain
    1. Rat (Rattus norvegicus) [TaxId: 10116] [141414] (1)
      SQ P10686 489-525,870-933
      1. 2fjl picpic
        split PH domain; disordered bits of insert domains and an artificial linker are excluded
        1. region a:1-37,a:87-150 [133611] picpiclink
  41. FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415]
    1. Human (Homo sapiens) [TaxId: 9606] [141416] (1)
      SQ Q5JSP0 605-703
      1. 2coc picpic
        1. region a:8-106 [130674] picpiclink
  42. Src-associated adaptor protein Skap2 [141417]
    1. Mouse (Mus musculus) [TaxId: 10090] [141418] (9)
      SQ Q9Z2K4 105-212! SQ Q9Z2K4 109-219! SQ Q9Z2K4 14-222
      1. 1u5f picpic
        complexed with so4; mutant
        1. region a:109-219 [119542] picpiclink
      2. 1u5g picpic
        mutant
        1. region a:105-219 [119543] picpiclink
      3. 1u5g picpic
        automatically matched to 1U5G A:105-219
        mutant
        1. region b:105-219 [119544] picpiclink
      4. 1u5g picpic
        automatically matched to 1U5G A:105-219
        mutant
        1. region c:105-219 [119545] picpiclink
      5. 1u5g picpic
        automatically matched to 1U5G A:105-219
        mutant
        1. region d:105-219 [119546] picpiclink
      6. 1u5e picpic
        includes extra N-terminal alpha-hairpin, dimerisation subdomain
        mutant
        1. region a:14-222 [119540] picpiclink
      7. 1u5e picpic
        automatically matched to 1U5E A:14-222
        mutant
        1. region b:14-222 [119541] picpiclink
      8. 2otx picpic
        automatically matched to 1U5E A:14-222
        mutant
        1. region a:14-222 [139373] picpiclink
      9. 2otx picpic
        automatically matched to 1U5E A:14-222
        mutant
        1. region b:14-222 [139374] picpiclink
  43. Protein kinase c, d2 type [141419]
    1. Human (Homo sapiens) [TaxId: 9606] [141420] (1)
      SQ Q9BZL6 398-509
      1. 2coa picpic
        1. region a:8-119 [130672] picpiclink
  44. Phospholipase C-beta-2 [159207]
    1. Human (Homo sapiens) [TaxId: 9606] [159208] (2)
      SQ Q00722 11-141
      1. 2zkm picpicxrefxrefxref
        automatically matched to 2FJU B:11-141
        complexed with ca
        1. region x:11-141 [154589] picpiclink
      2. 2fju picpicxrefxrefxrefxref
        complexed with ca, gsp, mg
        1. region b:11-141 [145172] picpiclink
  45. Rho guanine nucleotide exchange factor 9, Collybistin [159209]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [159210] (1)
      SQ Q9QX73 300-461
      1. 2dfk picpicxrefxrefxref
        complexed with gol, so4
        1. region a:240-401 [145078] picpiclink
  46. DCC-interacting protein 13-alpha, APPL1 [159211]
    1. Human (Homo sapiens) [TaxId: 9606] [159212] (1)
      SQ Q9UKG1 274-374
      1. 2elb picpicxref
        1. region a:274-374 [146896] picpiclink
  47. Rho GTPase-activating protein 21 [159213]
    1. Human (Homo sapiens) [TaxId: 9606] [159214] (6)
      SQ Q5T5U3 931-1063
      1. 2j59 picpicxrefxrefxrefxrefxrefxref
        complexed with dio, edo, gtp, mg, so4; mutant
        1. region m:931-1063 [145656] picpiclink
      2. 2j59 picpicxrefxrefxrefxrefxrefxref
        automatically matched to 2J59 M:931-1063
        complexed with dio, edo, gtp, mg, so4; mutant
        1. region n:931-1063 [145657] picpiclink
      3. 2j59 picpicxrefxrefxrefxrefxrefxref
        automatically matched to 2J59 M:931-1063
        complexed with dio, edo, gtp, mg, so4; mutant
        1. region o:931-1061 [145658] picpiclink
      4. 2j59 picpicxrefxrefxrefxrefxrefxref
        automatically matched to 2J59 M:931-1063
        complexed with dio, edo, gtp, mg, so4; mutant
        1. region p:931-1063 [145659] picpiclink
      5. 2j59 picpicxrefxrefxrefxrefxrefxref
        automatically matched to 2J59 M:931-1063
        complexed with dio, edo, gtp, mg, so4; mutant
        1. region q:931-1063 [145660] picpiclink
      6. 2j59 picpicxrefxrefxrefxrefxrefxref
        automatically matched to 2J59 M:931-1063
        complexed with dio, edo, gtp, mg, so4; mutant
        1. region r:931-1063 [145661] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk