Structural Classification of Proteins
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Family: Pepsin-like

duplication: consists of two similar barrel domains
N-terminal: barrel, partly opened; n*=6, S*=10

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Acid proteases [50629]
    barrel, closed; n=6, S=10, complex topology
  4. Superfamily: Acid proteases [50630]
    link to SUPERFAMILY database - Superfamily
  5. Family: Pepsin-like [50646]
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10

Protein Domains:

  1. Endothiapepsin [50647]
    1. Chestnut blight fungus (Endothia parasitica) [TaxId: 5116] [50648] (36) picpic
  2. Acid protease [50649]
    1. Fungus (Penicillium janthinellum), penicillopepsin [TaxId: 5079] [50650] (14) picpic
    2. Fungus (Aspergillus phoenicis), aspergillopepsin [TaxId: 5063] [63794] (1) picpic
    3. Fungus (Aspergillus oryzae) [TaxId: 5062] [89352] (2) picpic
    4. Bread mold (Rhizopus chinensis) [TaxId: 4843] [50651] (8) picpic
      SQ P06026 69-393
    5. Rhizomucor miehei [TaxId: 4839] [50652] (2) picpic
    6. Yeast (Candida albicans) [TaxId: 5476] [50653] (2) picpic
    7. Yeast (Candida tropicalis) [TaxId: 5482] [63795] (1) picpic
    8. Baker's yeast (Saccharomyces cerevisiae), proteinase A [TaxId: 4932] [50654] (11) picpic
      synonym: saccharopepsin
    9. Irpex lacteus (Polyporus tulipiferae), Polyporopepsin [TaxId: 5319] [110246] (1) picpic
      SQ P17576 1-329
  3. Plant acid proteinase, phytepsin [50655]
    1. Cynara cardunculus [TaxId: 4265] [50656] (1) picpic
    2. Barley (Hordeum vulgare) [TaxId: 4513] [50657] (1) picpic
  4. Pepsin(ogen) [50658]
    1. Pig (Sus scrofa) [TaxId: 9823] [50659] (8) picpic
    2. Human (Homo sapiens), isoform 3A [TaxId: 9606] [50660] (4) picpic
    3. Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId: 9606] [50661] (2) picpic
    4. Atlantic cod (Gadus morhua) [TaxId: 8049] [50662] (1) picpic
  5. Pepsin [50663]
    1. Mucor pusillus [TaxId: 4840] [50664] (1) picpic
  6. Cathepsin D [50665]
    1. Human (Homo sapiens) [TaxId: 9606] [50666] (3) picpic
  7. Chymosin (synonym: renin) [50667]
    1. Cow (Bos taurus) [TaxId: 9913] [50668] (4) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [50669] (7) picpic
    3. Mouse (Mus musculus) [TaxId: 10090] [50670] (4) picpic
  8. beta-secretase (memapsin) [50671]
    1. Human (Homo sapiens) [TaxId: 9606] [50672] (90) picpic
      SQ P56817 58-446 ! SQ P56817 60-447
  9. Plasmepsin (a hemoglobin-degrading enzyme) [50673]
    1. Plasmodium falciparum, plasmepsin II [TaxId: 5833] [50674] (24) picpic
    2. Plasmodium falciparum, plasmepsin IV [TaxId: 5833] [74986] (1) picpic
    3. Plasmodium vivax [TaxId: 5855] [50675] (2) picpic
  10. Xylanase inhibitor TAXI-I [110247]
    pepsin-like protein that probably lost the protease activity
    1. Wheat (Triticum aestivum) [TaxId: 4565] [110248] (3) picpic
      SQ Q8H0K8 22-402
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk