Structural Classification of Proteins
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Fold: Acid proteases

barrel, closed; n=6, S=10, complex topology

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Acid proteases [50629]
    barrel, closed; n=6, S=10, complex topology

Superfamilies:

  1. Acid proteases [50630] (3)
    link to SUPERFAMILY database - Superfamily
    1. Retroviral protease (retropepsin) [50631] (8)
      dimer of identical mono-domain chains, each containing (6,10) barrel
      1. Human immunodeficiency virus type 1 protease [50632]
        1. Human immunodeficiency virus type 1 [TaxId: 11676] [50633] (317) picpic
          SQ P35963 57-155 ! SQ P04587 69-167 ! SQ P03366 69-167 ! SQ P03367 69-167 ! SQ P03368 69-167
      2. Human immunodeficiency virus type 2 (HIV-2) protease [50634]
        1. Human immunodeficiency virus type 2 [TaxId: 11709] [50635] (21) picpic
      3. Simian immunodeficiency virus (SIV) protease [50636]
        1. Simian immunodeficiency virus, different strains [TaxId: 11723] [50637] (18) picpic
      4. Feline immunodeficiency virus (FIV) protease [50638]
        1. Feline immunodeficiency virus [TaxId: 11673] [50639] (7) picpic
      5. Rous sarcoma virus protease [50640]
        1. Rous sarcoma virus, strain pr-C [TaxId: 11886] [50641] (2) picpic
      6. Myeloblastosis-associated viral protease [50642]
        1. Avian myeloblastosis associated virus [TaxId: 11960] [50643] (1) picpic
      7. EIAV protease [50644]
        1. Equine infectious anemia virus [TaxId: 11665] [50645] (2) picpic
      8. Mason-Pfizer monkey virus protease [82131]
        1. Simian retrovirus 1, SRV-1 [TaxId: 11942] [82132] (1) picpic
    2. Pepsin-like [50646] (26)
      duplication: consists of two similar barrel domains
      N-terminal: barrel, partly opened; n*=6, S*=10
      1. Endothiapepsin [50647]
        1. Chestnut blight fungus (Endothia parasitica) [TaxId: 5116] [50648] (36) picpic
      2. Acid protease [50649]
        1. Fungus (Penicillium janthinellum), penicillopepsin [TaxId: 5079] [50650] (14) picpic
        2. Fungus (Aspergillus phoenicis), aspergillopepsin [TaxId: 5063] [63794] (1) picpic
        3. Fungus (Aspergillus oryzae) [TaxId: 5062] [89352] (2) picpic
        4. Bread mold (Rhizopus chinensis) [TaxId: 4843] [50651] (8) picpic
          SQ P06026 69-393
        5. Rhizomucor miehei [TaxId: 4839] [50652] (2) picpic
        6. Yeast (Candida albicans) [TaxId: 5476] [50653] (2) picpic
        7. Yeast (Candida tropicalis) [TaxId: 5482] [63795] (1) picpic
        8. Baker's yeast (Saccharomyces cerevisiae), proteinase A [TaxId: 4932] [50654] (11) picpic
          synonym: saccharopepsin
        9. Irpex lacteus (Polyporus tulipiferae), Polyporopepsin [TaxId: 5319] [110246] (1) picpic
          SQ P17576 1-329
      3. Plant acid proteinase, phytepsin [50655]
        1. Cynara cardunculus [TaxId: 4265] [50656] (1) picpic
        2. Barley (Hordeum vulgare) [TaxId: 4513] [50657] (1) picpic
      4. Pepsin(ogen) [50658]
        1. Pig (Sus scrofa) [TaxId: 9823] [50659] (8) picpic
        2. Human (Homo sapiens), isoform 3A [TaxId: 9606] [50660] (4) picpic
        3. Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId: 9606] [50661] (2) picpic
        4. Atlantic cod (Gadus morhua) [TaxId: 8049] [50662] (1) picpic
      5. Pepsin [50663]
        1. Mucor pusillus [TaxId: 4840] [50664] (1) picpic
      6. Cathepsin D [50665]
        1. Human (Homo sapiens) [TaxId: 9606] [50666] (3) picpic
      7. Chymosin (synonym: renin) [50667]
        1. Cow (Bos taurus) [TaxId: 9913] [50668] (4) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [50669] (7) picpic
        3. Mouse (Mus musculus) [TaxId: 10090] [50670] (4) picpic
      8. beta-secretase (memapsin) [50671]
        1. Human (Homo sapiens) [TaxId: 9606] [50672] (90) picpic
          SQ P56817 58-446 ! SQ P56817 60-447
      9. Plasmepsin (a hemoglobin-degrading enzyme) [50673]
        1. Plasmodium falciparum, plasmepsin II [TaxId: 5833] [50674] (24) picpic
        2. Plasmodium falciparum, plasmepsin IV [TaxId: 5833] [74986] (1) picpic
        3. Plasmodium vivax [TaxId: 5855] [50675] (2) picpic
      10. Xylanase inhibitor TAXI-I [110247]
        pepsin-like protein that probably lost the protease activity
        1. Wheat (Triticum aestivum) [TaxId: 4565] [110248] (3) picpic
          SQ Q8H0K8 22-402
    3. LPG0085-like [159190] (1)
      Pfam 05618; DUF785; single-domain protein similar to one pepsin domain with the conserved catalytic Asp motif (not in a few archaeal members of this Pfam family)
      1. Uncharacterized protein LPG0085 [159191]
        1. Legionella pneumophila [TaxId: 446] [159192] (2) picpic
          SQ Q5ZZC6 26-166
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk