Structural Classification of Proteins
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Family: Viral cysteine protease of trypsin fold

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Trypsin-like serine proteases [50493]
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. Superfamily: Trypsin-like serine proteases [50494]
    link to SUPERFAMILY database - Superfamily
  5. Family: Viral cysteine protease of trypsin fold [50603]

Protein Domains:

  1. 3C cysteine protease (picornain 3C) [50604]
    1. Human rhinovirus 2 [TaxId: 12130] [50605] (1)
      1. 1cqq picpic
        complexed with ag7
        1. chain a [26422] picpiclink
    2. Human hepatitis A virus [TaxId: 208726] [50606] (7)
      1. 2hal picpic
        automatically matched to d1hava_
        complexed with ace, bbl, eke, mke; mutant
        1. region a:1-212 [136289] picpiclink
      2. 2h6m picpic
        automatically matched to d1hava_
        complexed with bbl, epq; mutant
        1. region a:1-212 [136200] picpiclink
      3. 2h9h picpic
        automatically matched to d1hava_
        complexed with ace, bbl, epq; mutant
        1. region a:1-212 [136264] picpiclink
      4. 2cxv picpic
        automatically matched to d1hava_
        complexed with bbl; mutant
        1. region a:1-212 [131012] picpiclink
      5. 2a4o picpic
        automatically matched to d1hava_
        complexed with ace, bbl, nfa, val; mutant
        1. region a:1-212 [126161] picpiclink
      6. 1hav picpic
        complexed with cl; mutant
        1. chain a [26423] picpiclink
        2. chain b [26424] picpiclink
      7. 1qa7 picpic
        complexed with ace, dms, gol, nfa; mutant
        1. chain a [26425] picpiclink
        2. chain b [26426] picpiclink
        3. chain c [26427] picpiclink
        4. chain d [26428] picpiclink
    3. Human poliovirus 1 Mahoney [TaxId: 12081] [74978] (3)
      1. 1l1n picpic
        1. chain a [73476] picpiclink
        2. chain b [73477] picpiclink
      2. 2ijd picpicxrefxref
        automatically matched to d1l1na_
        complexed with so4, zn; mutant
        1. region 1:1-180 [137474] picpiclink
      3. 2ijd picpicxrefxref
        automatically matched to d1l1na_
        complexed with so4, zn; mutant
        1. region 2:1-180 [137476] picpiclink
    4. Foot-and-mouth disease virus FMDV [TaxId: 12110] [159189] (4)
      SQ P49303 1657-1755! SQ P49303 1657-1857
      1. 2bhg picpic
        mutant
        1. region a:7-205 [146141] picpiclink
      2. 2bhg picpic
        automatically matched to 2BHG A:7-205
        mutant
        1. region b:7-205 [146142] picpiclink
      3. 2j92 picpic
        mutant
        1. region a:7-207 [147933] picpiclink
      4. 2j92 picpic
        automatically matched to 2J92 A:7-207
        mutant
        1. region b:7-206 [147934] picpiclink
  2. 2A cysteine proteinase [50607]
    1. Human rhinovirus 2 [TaxId: 12130] [50608] (1)
      1. 2hrv picpic
        complexed with zn
        1. chain a [26429] picpiclink
        2. chain b [26430] picpiclink
  3. Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979]
    contains an extra alpha-helical domain
    1. Transmissible gastroenteritis virus [TaxId: 11149] [74980] (4)
      1. 1lvo picpic
        complexed with dox, mpd, so4
        1. chain a [74284] picpiclink
        2. chain b [74285] picpiclink
        3. chain c [74286] picpiclink
        4. chain d [74287] picpiclink
        5. chain e [74288] picpiclink
        6. chain f [74289] picpiclink
      2. 1p9u picpic
        complexed with ch2, mpd, so4
        1. chain a [88001] picpiclink
        2. chain b [88002] picpiclink
        3. chain c [88003] picpiclink
        4. chain d [88004] picpiclink
        5. chain e [88005] picpiclink
        6. chain f [88006] picpiclink
      3. 2amp picpic
        automatically matched to d1lvod_
        complexed with i12
        1. region a:1-299 [127021] picpiclink
      4. 2amp picpic
        automatically matched to d1lvod_
        complexed with i12
        1. region b:1-299 [127022] picpiclink
    2. Human coronavirus 229E [TaxId: 11137] [89348] (1)
      1. 1p9s picpic
        complexed with dox, mse; mutant
        1. chain a [87999] picpiclink
        2. chain b [88000] picpiclink
    3. SARS coronavirus [TaxId: 227859] [89349] (26)
      1. 2duc picpic
        automatically matched to d1q2wb_
        1. region a:2-301 [146586] picpiclink
      2. 2duc picpic
        automatically matched to d1q2wb_
        1. region b:2-301 [146587] picpiclink
      3. 2z94 picpic
        automatically matched to d1q2wb_
        complexed with tld, zn
        1. region a:2-301 [154232] picpiclink
      4. 2z9g picpic
        automatically matched to d1q2wb_
        complexed with bnz, hg
        1. region a:2-301 [154241] picpiclink
      5. 2op9 picpic
        automatically matched to d1q2wb_
        complexed with wr1
        1. region a:2-301 [148961] picpiclink
      6. 2op9 picpic
        automatically matched to d1q2wb_
        complexed with wr1
        1. region b:2-301 [148962] picpiclink
      7. 2v6n picpic
        automatically matched to d1q2wb_
        complexed with mes, so4, xp1
        1. region a:2-301 [152716] picpiclink
      8. 2z9k picpic
        automatically matched to d1q2wb_
        complexed with dms, doz
        1. region a:2-301 [154256] picpiclink
      9. 2z9k picpic
        automatically matched to d1q2wb_
        complexed with dms, doz
        1. region b:2-301 [154257] picpiclink
      10. 2z3c picpic
        automatically matched to d1q2wb_
        complexed with ace, ecq, gol, kcq, mbn
        1. region a:2-301 [153983] picpiclink
      11. 1q2w picpic
        complexed with mpd
        1. chain a [88355] picpiclink
        2. chain b [88356] picpiclink
      12. 2z9j picpic
        automatically matched to d1q2wb_
        complexed with dms, dtz
        1. region a:2-301 [154254] picpiclink
      13. 2z9j picpic
        automatically matched to d1q2wb_
        complexed with dms, dtz
        1. region b:2-301 [154255] picpiclink
      14. 1uj1 picpic
        1. chain a [99450] picpiclink
        2. chain b [99451] picpiclink
      15. 2qiq picpic
        automatically matched to d1q2wb_
        complexed with cyv
        1. region a:2-301 [150811] picpiclink
      16. 2z9l picpic
        automatically matched to d1q2wb_
        complexed with daz, dms
        1. region a:2-301 [154258] picpiclink
      17. 2z9l picpic
        automatically matched to d1q2wb_
        complexed with daz, dms
        1. region b:2-301 [154259] picpiclink
      18. 2alv picpic
        automatically matched to d1q2wb_
        complexed with cy6
        1. region a:2-301 [126982] picpiclink
      19. 2z3d picpic
        automatically matched to d1q2wb_
        complexed with ace, ecq, gol, ocq
        1. region a:2-301 [153984] picpiclink
      20. 2vj1 picpic
        automatically matched to d1q2wb_
        complexed with bez, dms, xp1
        1. region a:2-301 [153178] picpiclink
      21. 2vj1 picpic
        automatically matched to d1q2wb_
        complexed with bez, dms, xp1
        1. region b:2-301 [153179] picpiclink
      22. 2z3e picpic
        automatically matched to d1q2wb_
        complexed with ace, gol, kcq, mbn
        1. region a:2-301 [153985] picpiclink
      23. 1uk2 picpic
        1. chain a [99481] picpiclink
        2. chain b [99482] picpiclink
      24. 1uk3 picpic
        1. chain a [99483] picpiclink
        2. chain b [99484] picpiclink
      25. 1uk4 picpic
        complexed with ato
        1. chain a [99485] picpiclink
        2. chain b [99486] picpiclink
      26. 3d62 picpic
        automatically matched to d1q2wb_
        complexed with 959
        1. region a:3-301 [157411] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk