Structural Classification of Proteins
home mail help root up expand collapse

Family: Tissue inhibitor of metalloproteinases, TIMP

contains an irregular alpha+beta subdomain in the C-terminal extension

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: OB-fold [50198]
    barrel, closed or partly opened n=5, S=10 or S=8; greek-key
  4. Superfamily: TIMP-like [50242]
    link to SUPERFAMILY database - Superfamily
  5. Family: Tissue inhibitor of metalloproteinases, TIMP [50243]
    contains an irregular alpha+beta subdomain in the C-terminal extension

Protein Domains:

  1. TIMP-1 [50244]
    1. Human (Homo sapiens) [TaxId: 9606] [50245] (6)
      1. 2j0t picpicxrefxrefxref
        automatically matched to d1d2ba_
        complexed with ca, zn
        1. region d:1-124 [137920] picpiclink
      2. 2j0t picpicxrefxrefxref
        automatically matched to d1d2ba_
        complexed with ca, zn
        1. region e:1-124 [137921] picpiclink
      3. 2j0t picpicxrefxrefxref
        automatically matched to d1d2ba_
        complexed with ca, zn
        1. region f:1-124 [137922] picpiclink
      4. 1uea picpicxref
        complexed with ca, zn; mutant
        1. chain b [25232] picpiclink
        2. chain d [25233] picpiclink
      5. 1oo9 picpicxref
        1. chain b [87191] picpiclink
      6. 1d2b picpic
        1. chain a [25234] picpiclink
  2. TIMP-2 [50246]
    1. Human (Homo sapiens) [TaxId: 9606] [50247] (3)
      1. 1br9 picpic
        1. chain a [25235] picpiclink
      2. 1gxd picpicxrefxrefxrefxref
        complexed with proMMP-2
        complexed with ca, so4, zn; mutant
        1. chain c [70703] picpiclink
        2. chain d [70704] picpiclink
      3. 2tmp picpic
        mutant
        1. chain a [25236] picpiclink
    2. Cow (Bos taurus) [TaxId: 9913] [50248] (3)
      1. 2e2d picpicxref
        automatically matched to d1bqqt_
        complexed with ca, zn
        1. region c:1001-1180 [131980] picpiclink
      2. 1bqq picpicxref
        complexed with k, zn
        1. chain t [25237] picpiclink
      3. 1buv picpicxref
        complexed with ca, zn
        1. chain t [25238] picpiclink
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk