Structural Classification of Proteins
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Family: PDZ domain

Pfam 00595

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: PDZ domain-like [50155]
    contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
  4. Superfamily: PDZ domain-like [50156]
    peptide-binding domain
    link to SUPERFAMILY database - Superfamily
  5. Family: PDZ domain [50157]
    Pfam 00595

Protein Domains:

  1. Discs large protein homolog [50158]
    1. Human (Homo sapiens) [TaxId: 9606] [50159] (4) picpic
  2. Cask/Lin-2 [50160]
    1. Human (Homo sapiens) [TaxId: 9606] [50161] (1) picpic
  3. Synapse-associated protein 102 [101713]
    1. Human (Homo sapiens) [TaxId: 9606] [101714] (2) picpic
  4. Synaptic protein PSD-95 [50162]
    Synonym: synapse associated protein 90, sap90
    duplication: contains three PDZ domains
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50163] (9) picpic
      SQ P31016 62-154
    2. Human (Homo sapiens) [TaxId: 9606] [74932] (1) picpic
  5. Syntrophin [50164]
    1. Mouse (Mus musculus) [TaxId: 10090] [50165] (3) picpic
  6. Syntenin 1 [89311]
    1. Human (Homo sapiens) [TaxId: 9606] [89312] (26) picpic
  7. Segment polarity protein dishevelled homolog Dvl-2 [89313]
    1. African clawed frog (Xenopus laevis) [TaxId: 8355] [89314] (5) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [101715] (1) picpic
  8. Neuronal nitric oxide synthase, NNOS [50166]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50167] (3) picpic
  9. Phosphatase hPTP1e [50168]
    1. Human (Homo sapiens) [TaxId: 9606] [50169] (3) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [74930] (3) picpic
  10. Na+/H+ exchanger regulatory factor, NHERF [63754]
    1. Human (Homo sapiens) [TaxId: 9606] [63755] (4) picpic
  11. Inad [63756]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [63757] (1) picpic
  12. Glutamate receptor interacting protein [82083]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [82084] (3) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [110177] (1) picpic
      SQ Q925T6 461-570
  13. Erbin [82085]
    1. Human (Homo sapiens) [TaxId: 9606] [82086] (5) picpic
  14. GTPase-binding domain of the cell polarity protein par6 (Par-6B) [89315]
    1. Mouse (Mus musculus) [TaxId: 10090] [89316] (1) picpic
    2. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [101716] (3) picpic
      SQ O97111 156-253; Cg5884-pa
  15. Glutamate receptor-interacting protein 1, GRIP1 [101717]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [101718] (2) picpic
  16. Membrane associated guanylate kinase inverted-2 (MAGI-2, KIAA0705) [101719]
    1. Human (Homo sapiens) [TaxId: 9606] [101720] (5) picpic
      SQ Q86UL8 412-522, 600-682, 774-865, 913-1015, 1141-1230
  17. KIAA1526 protein [101721]
    1. Human (Homo sapiens) [TaxId: 9606] [101722] (3) picpic
  18. Hypothetical protein KIAA1095 [101723]
    1. Human (Homo sapiens) [TaxId: 9606] [101724] (2) picpic
      SQ Q9UPQ7 246-339, 404-512
  19. Discs large 5 protein KIAA0583 [101725]
    1. Human (Homo sapiens) [TaxId: 9606] [101726] (1) picpic
  20. Hypothetical protein KIAA0559 [101727]
    1. Human (Homo sapiens) [TaxId: 9606] [101728] (1) picpic
  21. Hypothetical protein KIAA1849 [101729]
    1. Human (Homo sapiens) [TaxId: 9606] [101730] (1) picpic
  22. Scribble (KIAA0147) [101731]
    1. Human (Homo sapiens) [TaxId: 9606] [101732] (3) picpic
      SQ Q14160 680-951, 1096-1193 # structure of 1st PDZ domain is also known, 1XQ5
  23. Shank1, PDZ domain [101733]
    SH3 and multiple ankyrin repeat domains protein 1
    1. Rat (Rattus norvegicus) [TaxId: 10116] [101734] (2) picpic
  24. Zasp (Cypher, Oracle 1) [101735]
    1. Human (Homo sapiens) [TaxId: 9606] [101736] (1) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [117173] (1) picpic
      SQ Q9D130 1-83
  25. Alpha-actinin-2 associated LIM protein [110178]
    1. Mouse (Mus musculus) [TaxId: 10090] [110179] (1) picpic
      SQ O70209 4-93
  26. Glutamate receptor interacting protein 2, GRIP2 (KIAA1719) [110180]
    1. Human (Homo sapiens) [TaxId: 9606] [110181] (2) picpic
      SQ Q9C0E4 238-341
  27. Harmonin [110182]
    1. Mouse (Mus musculus) [TaxId: 10090] [110183] (1) picpic
      SQ Q9ES64 741-850
    2. Human (Homo sapiens) [TaxId: 9606] [141263] (1) picpic
      SQ Q9Y6N9 201-301
  28. Rhophilin-2 [110184]
    1. Mouse (Mus musculus) [TaxId: 10090] [110185] (1) picpic
      SQ Q8BWR8 506-603
  29. PDZ-LIM protein mystique [110186]
    1. Mouse (Mus musculus) [TaxId: 10090] [110187] (1) picpic
      SQ Q8R1G6 3-83
  30. Enigma homolog ENH [117174]
    1. Mouse (Mus musculus) [TaxId: 10090] [117175] (1) picpic
      SQ Q8CI51 5-94
  31. DNA Regulating synaptic membrane exocytosis protein 2, RIMS2 [117176]
    1. Human (Homo sapiens) [TaxId: 9606] [117177] (1) picpic
      SQ Q9UQ26 637-754; the structure of the 1st C2 domain (807-934) is also known (scop_sp 101565)
  32. Partitioning-defective 3-like protein, PAR3-L (RIKEN cDNA 2810455b10) [117178]
    1. Mouse (Mus musculus) [TaxId: 10090] [117179] (1) picpic
      SQ Q5SV53 478-591
  33. Regulator of G-protein signaling 3, RGS3 [117180]
    1. Mouse (Mus musculus) [TaxId: 10090] [117181] (1) picpic
      SQ Q9DC04 18-94
    2. Human (Homo sapiens) [TaxId: 9606] [141264] (2) picpic
      SQ P49796 300-376
  34. PDZ domain containing protein 11, Pdzk11 [117182]
    1. Mouse (Mus musculus) [TaxId: 10090] [117183] (1) picpic
      SQ Q9CZG9 37-127
  35. hypothetical PDZ domain containing protein Uqcrc2 (4930408O21Rik) [117184]
    1. Mouse (Mus musculus) [TaxId: 10090] [117185] (1) picpic
      SQ Q9CR71 8-120
  36. Tight junction protein ZO-2, Tjp2 [141265]
    1. Mouse (Mus musculus) [TaxId: 10090] [141266] (1) picpic
      SQ Q9Z0U1 1-104
  37. Multiple PDZ domain protein [141267]
    1. Human (Homo sapiens) [TaxId: 9606] [141268] (4) picpic
      SQ Q5VZ62 1138-1243! SQ Q5VZ62 1955-2042
  38. Afadin [141269]
    1. Human (Homo sapiens) [TaxId: 9606] [141270] (3) picpic
      SQ P55196 985-1079! SQ P55196 987-1077
  39. Syntaxin binding protein 4 [141271]
    1. Mouse (Mus musculus) [TaxId: 10090] [141272] (1) picpic
      SQ Q9WV89 12-107
  40. Channel associated protein of synapse-110 [141273]
    Discs large homolog 2, PSD-93
    1. Human (Homo sapiens) [TaxId: 9606] [141274] (1) picpic
      SQ Q15700 190-283
  41. Maguk p55 subfamily member 5 [141275]
    1. Mouse (Mus musculus) [TaxId: 10090] [141276] (1) picpic
      SQ Q9JLB2 236-335
      Structure of the second L27 domain is known (scop_sp 101293)
  42. Neurabin-i [141277]
    1. Human (Homo sapiens) [TaxId: 9606] [141278] (1) picpic
      SQ Q9ULJ8 500-593
  43. Regulating synaptic membrane exocytosis protein 1, RIMS1 [141279]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [141280] (1) picpic
      SQ Q9JIR4 597-705
    2. Human (Homo sapiens) [TaxId: 9606] [141281] (1) picpic
      SQ Q86UR5 585-694
  44. Amyloid beta A4 precursor protein-binding family A member 1 (APBA1, X11) [141282]
    1. Human (Homo sapiens) [TaxId: 9606] [141283] (7) picpic
      SQ Q02410 656-740! SQ Q02410 657-743! SQ Q02410 657-745! SQ Q02410 743-822! SQ Q02410 745-823! SQ Q02410 746-839
      structure of the PTB domain is also known (scop_sp 50757)
  45. Presynaptic protein sap97 [141284]
    PSD-95 homologue
    1. Rat (Rattus norvegicus) [TaxId: 10116] [141285] (1) picpic
      SQ Q62696 221-313
  46. Tyrosine-protein phosphatase non-receptor type 4, PTPN4 [141286]
    1. Human (Homo sapiens) [TaxId: 9606] [141287] (1) picpic
      SQ P29074 507-612
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk