Structural Classification of Proteins
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Family: Sialidases (neuraminidases)

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: 6-bladed beta-propeller [50938]
    consists of six 4-stranded beta-sheet motifs; meander
  4. Superfamily: Sialidases [50939]
    link to SUPERFAMILY database - Superfamily
  5. Family: Sialidases (neuraminidases) [50940]

Protein Domains:

  1. Salmonella sialidase [50941]
    1. Salmonella typhimurium, strain lt2 [TaxId: 90371] [50942] (5)
      1. 3sil picpic
        complexed with gol, k, po4; mutant
        1. chain a [27542] picpiclink
      2. 2sil picpic
        1. chain a [27543] picpiclink
      3. 1dim picpic
        complexed with eqp, k
        1. chain a [27544] picpiclink
      4. 2sim picpic
        complexed with dan
        1. chain a [27545] picpiclink
      5. 1dil picpic
        complexed with axp, eqp, k
        1. chain a [27546] picpiclink
  2. Influenza neuraminidase [50943]
    1. Influenza A virus, different strains [TaxId: 11320] [50944] (59)
      SQ P03472 84-470
      1. 1f8e picpic
        complexed with 49a, ca, man, nag
        1. chain a [59694] picpiclink
      2. 1f8d picpic
        complexed with 9am, ca, man, nag
        1. chain a [59693] picpiclink
      3. 2qwc picpic
        complexed with ca, dan, man, nag; mutant
        1. chain a [27547] picpiclink
      4. 1l7f picpic
        complexed with bcz, bma, ca, gol, man, nag
        1. chain a [73653] picpiclink
      5. 2qwa picpic
        complexed with ca, man, nag; mutant
        1. chain a [27548] picpiclink
      6. 1l7h picpic
        complexed with bcz, bma, ca, gol, man, nag; mutant
        1. chain a [73655] picpiclink
      7. 1l7g picpic
        complexed with bcz, bma, ca, gol, man, nag; mutant
        1. chain a [73654] picpiclink
      8. 1f8c picpic
        complexed with 4am, ca, man, nag
        1. chain a [59692] picpiclink
      9. 2qwh picpic
        complexed with ca, g39, man, nag; mutant
        1. chain a [27550] picpiclink
      10. 1nnc picpic
        complexed with ca, gna, man, nag
        1. chain a [27549] picpiclink
      11. 2qwg picpic
        complexed with ca, g28, man, nag; mutant
        1. chain a [27552] picpiclink
      12. 2qwf picpic
        complexed with ca, g20, man, nag; mutant
        1. chain a [27553] picpiclink
      13. 2qwk picpic
        complexed with ca, g39, man, nag
        1. chain a [27551] picpiclink
      14. 1f8b picpic
        complexed with ca, dan, man, nag
        1. chain a [59691] picpiclink
      15. 2qwe picpic
        complexed with ca, gna, man, nag; mutant
        1. chain a [27555] picpiclink
      16. 7nn9 picpic
        complexed with ca, man, nag
        1. chain a [27554] picpiclink
      17. 1mwe picpic
        complexed with ca, man, nag, sia
        1. chain a [27556] picpiclink
      18. 2qwb picpic
        complexed with ca, man, nag, sia; mutant
        1. chain a [27557] picpiclink
      19. 1bji picpic
        complexed with ca, g21, man, nag
        1. chain a [27558] picpiclink
      20. 2c4l picpic
        automatically matched to d1ncan_
        complexed with bma, ca, man, nag, sia
        1. region a:82-468 [129836] picpiclink
      21. 2qwd picpic
        complexed with 4am, ca, man, nag; mutant
        1. chain a [27559] picpiclink
      22. 2c4a picpic
        automatically matched to d1ncan_
        complexed with bma, ca, man, nag, sia
        1. region a:82-468 [129800] picpiclink
      23. 2qwj picpic
        complexed with ca, g28, man, nag
        1. chain a [27560] picpiclink
      24. 2qwi picpic
        complexed with ca, g20, man, nag
        1. chain a [27561] picpiclink
      25. 2aep picpicxref
        complexed with bma, ca, glc, man, nag, so4
        1. region a:83-469 [144805] picpiclink
      26. 5nn9 picpic
        complexed with ca, man, nag; mutant
        1. chain a [27563] picpiclink
      27. 4nn9 picpic
        complexed with ca, man, nag; mutant
        1. chain a [27562] picpiclink
      28. 1ivg picpic
        complexed with ca, fuc, man, nag
        1. chain a [27578] picpiclink
      29. 1ivg picpic
        duplicate of 1IVG
        complexed with ca, fuc, man, nag
        1. chain b [118516] picpiclink
      30. 3nn9 picpic
        complexed with ca, man, nag; mutant
        1. chain a [27566] picpiclink
      31. 6nn9 picpic
        complexed with ca, man, nag; mutant
        1. chain a [27565] picpiclink
      32. 2bat picpic
        complexed with ca, fuc, man, nag, ngl, sia
        1. chain a [27564] picpiclink
      33. 1inx picpic
        complexed with ca, eqp, man, nag
        1. chain a [27567] picpiclink
      34. 1nmb picpicxrefxref
        complexed with ca, man, nag; mutant
        1. chain n [27583] picpiclink
      35. 1ing picpic
        complexed with ca, fuc, man, nag, st5
        1. chain a [27571] picpiclink
        2. chain b [27572] picpiclink
      36. 1iny picpic
        complexed with ca, eqp, man, nag
        1. chain a [27569] picpiclink
      37. 1xoe picpic
        complexed with abx, man, nag
        1. chain a [115700] picpiclink
      38. 1nn2 picpic
        complexed with ca, fuc, man, nag, ngl
        1. chain a [27570] picpiclink
      39. 1nna picpic
        complexed with ca
        1. chain a [27575] picpiclink
      40. 1nmc picpicxrefxref
        complexed with ca, man, nag
        1. chain n [27581] picpiclink
        2. chain a [27582] picpiclink
      41. 1inw picpic
        complexed with axp, ca, man, nag
        1. chain a [27577] picpiclink
      42. 1ncb picpicxrefxrefxrefxref
        complexed with ca, man, nag; mutant
        1. chain n [27573] picpiclink
      43. 1ivc picpic
        complexed with ca, fuc, man, nag, st2
        1. chain a [27576] picpiclink
      44. 1ivc picpic
        duplicate of 1IVC
        complexed with ca, fuc, man, nag, st2
        1. chain b [118512] picpiclink
      45. 1ivf picpic
        complexed with ca, dan, fuc, man, nag
        1. chain a [27574] picpiclink
      46. 1ivf picpic
        duplicate of 1IVF
        complexed with ca, dan, fuc, man, nag
        1. chain b [118515] picpiclink
      47. 1a14 picpicxrefxref
        complexed with ca, man, nag
        1. chain n [27580] picpiclink
      48. 1nca picpicxrefxrefxrefxref
        complexed with ca, man, nag
        1. chain n [27579] picpiclink
      49. 1ivd picpic
        complexed with ca, fuc, man, nag, st1
        1. chain a [27568] picpiclink
      50. 1ivd picpic
        duplicate of 1IVD
        complexed with ca, fuc, man, nag, st1
        1. chain b [118513] picpiclink
      51. 1inh picpic
        complexed with ca, fuc, man, nag, st6
        1. chain a [27585] picpiclink
        2. chain b [27586] picpiclink
      52. 1nnb picpic
        complexed with ca, dan
        1. chain a [27584] picpiclink
      53. 1ncd picpicxrefxrefxrefxref
        complexed with ca, man, nag
        1. chain n [27589] picpiclink
      54. 1ive picpic
        complexed with ca, fuc, man, nag, st3
        1. chain a [27587] picpiclink
      55. 1ive picpic
        duplicate of 1IVE
        complexed with ca, fuc, man, nag, st3
        1. chain b [118514] picpiclink
      56. 1xog picpic
        complexed with abw, man, nag
        1. chain a [115701] picpiclink
      57. 1ncc picpicxrefxrefxrefxref
        complexed with ca, man, nag; mutant
        1. chain n [27588] picpiclink
      58. 1nma picpicxrefxref
        complexed with man, nag; mutant
        1. chain n [27590] picpiclink
      59. 2aeq picpic
        automatically matched to 2AEP A:83-469
        complexed with man, nag
        1. region a:83-469 [146052] picpiclink
    2. Influenza B virus, different strains [TaxId: 11520] [50945] (12)
      1. 1nsc picpic
        complexed with ca, nag, sia
        1. chain a [27591] picpiclink
        2. chain b [27592] picpiclink
      2. 1nsd picpic
        complexed with ca, dan, nag
        1. chain a [27593] picpiclink
        2. chain b [27594] picpiclink
      3. 1a4q picpic
        complexed with ca, dpc, nag
        1. chain a [27595] picpiclink
        2. chain b [27596] picpiclink
      4. 1nsb picpic
        complexed with ca, nag
        1. chain a [27597] picpiclink
        2. chain b [27598] picpiclink
      5. 1a4g picpic
        complexed with ca, nag, zmr
        1. chain a [27600] picpiclink
        2. chain b [27601] picpiclink
      6. 1inv picpic
        complexed with ca, eqp, nag
        1. chain a [27599] picpiclink
      7. 1inf picpic
        complexed with ca, nag, st4
        1. chain a [27602] picpiclink
      8. 1b9v picpic
        complexed with ca, nag, ra2
        1. chain a [27603] picpiclink
      9. 1vcj picpic
        complexed with iba
        1. chain a [100559] picpiclink
      10. 1ivb picpic
        complexed with ca, nag, st1
        1. chain a [27604] picpiclink
      11. 1b9s picpic
        complexed with ca, fdi, nag
        1. chain a [27605] picpiclink
      12. 1b9t picpic
        complexed with ca, nag, rai
        1. chain a [27606] picpiclink
  3. Paramyxovirus hemagglutinin-neuraminidase head domain [63823]
    1. Newcastle disease virus [TaxId: 11176] [63824] (5)
      1. 1usr picpic
        complexed with ca, dan, ndg, sia, wia
        1. chain a [99881] picpiclink
        2. chain b [99882] picpiclink
      2. 1e8u picpic
        complexed with ca, nag, sia
        1. chain a [59389] picpiclink
        2. chain b [59390] picpiclink
      3. 1e8v picpic
        complexed with ca, dan, nag
        1. chain a [59391] picpiclink
        2. chain b [59392] picpiclink
      4. 1e8t picpic
        complexed with ca, gol, nag
        1. chain a [59387] picpiclink
        2. chain b [59388] picpiclink
      5. 1usx picpic
        complexed with dan, sia, wia
        1. chain a [99896] picpiclink
        2. chain b [99897] picpiclink
        3. chain c [99898] picpiclink
  4. Hemagglutinin-neuraminidase glycoprotein [101891]
    1. Human parainfluenza virus type 3 [TaxId: 11216] [101892] (5)
      1. 1v3e picpic
        complexed with ca, nag, so4, zmr
        1. chain a [100287] picpiclink
        2. chain b [100288] picpiclink
      2. 1v3b picpic
        complexed with ca, nag, so4
        1. chain a [100281] picpiclink
        2. chain b [100282] picpiclink
      3. 1v2i picpic
        complexed with ca, man, nag, po4
        1. chain a [100272] picpiclink
        2. chain b [100273] picpiclink
      4. 1v3c picpic
        complexed with ca, nag, slb, so4
        1. chain a [100283] picpiclink
        2. chain b [100284] picpiclink
      5. 1v3d picpic
        complexed with ca, dan, nag, so4
        1. chain a [100285] picpiclink
        2. chain b [100286] picpiclink
  5. Micromonospora sialidase, N-terminal domain [50946]
    1. Micromonospora viridifaciens [TaxId: 1881] [50947] (10)
      SQ Q02834 47-647
      1. 1w8o picpicxrefxref
        complexed with cit, gol, lbt, na; mutant
        1. region a:47-402 [114376] picpiclink
      2. 2ber picpicxrefxref
        automatically matched to d1eur__
        complexed with na, slb; mutant
        1. region a:47-404 [128388] picpiclink
      3. 1eur picpic
        1. chain a [27607] picpiclink
      4. 1eus picpic
        complexed with dan
        1. chain a [27608] picpiclink
      5. 1w8n picpicxrefxref
        complexed with dan, gal, na; mutant
        1. region a:47-402 [114373] picpiclink
      6. 1wcq picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1eur__
        complexed with dan, gol, na; mutant
        1. region a:47-404 [120896] picpiclink
      7. 1wcq picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1eur__
        complexed with dan, gol, na; mutant
        1. region b:47-404 [120899] picpiclink
      8. 1wcq picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1eur__
        complexed with dan, gol, na; mutant
        1. region c:49-404 [120902] picpiclink
      9. 1eut picpicxrefxref
        complexed with na
        1. region a:47-402 [27609] picpiclink
      10. 1euu picpicxrefxref
        complexed with gal, na
        1. region a:47-402 [27610] picpiclink
  6. Leech intramolecular trans-sialidase, C-terminal domain [50948]
    contains incomplete beta-barrel subdomain inserted in the second blade
    1. North american leech (Macrobdella decora) [TaxId: 6405] [50949] (5)
      1. 2sli picpicxref
        complexed with skd
        1. region a:277-759 [27611] picpiclink
      2. 4sli picpicxref
        complexed with cnp
        1. region a:277-759 [27612] picpiclink
      3. 3sli picpicxref
        complexed with skd
        1. region a:277-759 [27613] picpiclink
      4. 1sli picpicxref
        complexed with dan
        1. region a:277-759 [27615] picpiclink
      5. 1sll picpicxref
        1. region a:277-759 [27614] picpiclink
  7. Vibrio cholerae sialidase [50950]
    contains 2 additional domains of ConA-like fold
    1. Vibrio cholerae [TaxId: 666] [50951] (3)
      SQ P37060
      1. 1w0p picpicxref
        complexed with ca, gol, sia, trs
        1. region a:217-346,a:544-777 [109040] picpiclink
      2. 1w0o picpicxref
        complexed with ca, dan, sia
        1. region a:217-346,a:544-777 [109037] picpiclink
      3. 1kit picpicxref
        complexed with ca
        1. region a:217-346,a:544-781 [27616] picpiclink
  8. Trypanosoma sialidase [82164]
    1. Parasitic flagellate protozoan (Trypanosoma cruzi) [TaxId: 5693] [89371] (12)
      SQ Q26966
      1. 2ah2 picpicxref
        automatically matched to d1ms0a2
        complexed with cl, fsi, gol, ipa; mutant
        1. region a:1-399 [126740] picpiclink
      2. 1ms9 picpicxref
        complexed with lat; mutant
        1. region a:2-399 [85089] picpiclink
        2. region b:2-399 [85091] picpiclink
      3. 1s0i picpicxref
        complexed with slt; mutant
        1. region a:1-399 [105147] picpiclink
      4. 1ms3 picpicxref
        mutant
        1. region a:1-399 [85069] picpiclink
        2. region b:1-399 [85071] picpiclink
      5. 1s0j picpicxref
        complexed with mus; mutant
        1. region a:1-399 [105149] picpiclink
      6. 3b69 picpicxref
        automatically matched to d1ms0a2
        complexed with bfn, cl, epe; mutant
        1. region a:1-399 [154881] picpiclink
      7. 1ms1 picpicxref
        complexed with dan, gol; mutant
        1. region a:1-399 [85065] picpiclink
        2. region b:1-399 [85067] picpiclink
      8. 1ms8 picpicxref
        complexed with dan; mutant
        1. region a:1-399 [85085] picpiclink
        2. region b:2-399 [85087] picpiclink
      9. 1ms5 picpicxref
        mutant
        1. region a:2-399 [85077] picpiclink
        2. region b:2-399 [85079] picpiclink
      10. 1ms4 picpicxref
        mutant
        1. region a:1-399 [85073] picpiclink
        2. region b:1-399 [85075] picpiclink
      11. 1mr5 picpicxref
        mutant
        1. region a:4-399 [85059] picpiclink
      12. 1ms0 picpicxref
        complexed with dan, lat; mutant
        1. region a:1-399 [85061] picpiclink
        2. region b:1-399 [85063] picpiclink
    2. Trypanosoma rangeli [TaxId: 5698] [82165] (10)
      SQ O44049 20-653
      1. 1n1t picpicxref
        complexed with dan, so4
        1. region a:1-406 [79822] picpiclink
      2. 1n1s picpicxref
        complexed with so4
        1. region a:1-406 [79820] picpiclink
      3. 2ags picpicxref
        automatically matched to d1n1sa2
        complexed with fkd, so4
        1. region a:-1-403 [126738] picpiclink
      4. 2a75 picpicxref
        automatically matched to d1n1sa2
        complexed with fsi, so4
        1. region a:-1-403 [126327] picpiclink
      5. 1n1v picpicxref
        complexed with dan, so4
        1. region a:1-406 [79825] picpiclink
      6. 2fhr picpicxref
        automatically matched to d1n1sa2
        complexed with fsi, gol, so4
        1. region a:0-400 [133500] picpiclink
      7. 1mz5 picpicxref
        complexed with nag
        1. region a:1-403 [79680] picpiclink
      8. 1n1y picpicxref
        complexed with sia
        1. region a:1-406 [79827] picpiclink
      9. 1wcs picpicxref
        mutant
        1. region a:1-406 [114523] picpiclink
      10. 1mz6 picpicxref
        complexed with dan, nag
        1. region a:1-403 [79682] picpiclink
  9. Sialidase 2 (Neu2) [117274]
    1. Human (Homo sapiens) [TaxId: 9606] [117275] (8)
      SQ Q9Y3R4
      1. 1so7 picpic
        complexed with cl
        1. chain a [112106] picpiclink
      2. 1snt picpic
        1. chain a [112105] picpiclink
      3. 2f12 picpic
        automatically matched to d1vcua_
        complexed with htm, po4
        1. region a:3-377 [132686] picpiclink
      4. 2f13 picpic
        automatically matched to d1vcua_
        complexed with dym, po4
        1. region a:3-376 [132687] picpiclink
      5. 2f11 picpic
        automatically matched to d1vcua_
        complexed with iem, po4
        1. region a:3-376 [132685] picpiclink
      6. 1vcu picpic
        complexed with dan, epe
        1. chain a [113610] picpiclink
        2. chain b [113611] picpiclink
      7. 2f0z picpic
        automatically matched to d1vcua_
        complexed with zmr
        1. region a:3-377 [132683] picpiclink
      8. 2f10 picpic
        automatically matched to d1vcua_
        complexed with bcz, po4
        1. region a:3-377 [132684] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk