Structural Classification of Proteins
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Family: Cyclophilin (peptidylprolyl isomerase)

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Cyclophilin-like [50890]
    barrel, closed; n=8, S=10; complex topology
  4. Superfamily: Cyclophilin-like [50891]
    link to SUPERFAMILY database - Superfamily
  5. Family: Cyclophilin (peptidylprolyl isomerase) [50892]

Protein Domains:

  1. Cyclophilin (eukaryotic) [50893]
    1. Human (Homo sapiens), variant A [TaxId: 9606] [50894] (50)
      SQ P05092
      1. 1w8m picpic
        complexed with e1p
        1. chain a [114370] picpiclink
      2. 1ynd picpic
        automatically matched to d1ak4a_
        complexed with sfa
        1. region a:2-165 [123721] picpiclink
      3. 1ynd picpic
        automatically matched to d1ak4a_
        complexed with sfa
        1. region b:2-165 [123722] picpiclink
      4. 2cpl picpic
        1. chain a [27420] picpiclink
      5. 1w8v picpic
        1. chain a [114377] picpiclink
      6. 2cyh picpic
        1. chain a [27421] picpiclink
      7. 1cwk picpic
        complexed with tmd
        1. chain a [27422] picpiclink
      8. 1m9f picpicxref
        mutant
        1. chain a [84898] picpiclink
        2. chain b [84899] picpiclink
      9. 1cwl picpic
        complexed with aba, mgy, mhl
        1. chain a [27423] picpiclink
      10. 1m9x picpicxref
        mutant
        1. chain a [84905] picpiclink
        2. chain b [84906] picpiclink
        3. chain e [84909] picpiclink
        4. chain f [84910] picpiclink
      11. 1mik picpic
        complexed with dhn
        1. chain a [27424] picpiclink
      12. 1w8l picpic
        complexed with 1p3
        1. chain a [114369] picpiclink
      13. 1cwj picpic
        complexed with mnv, tbm
        1. chain a [27425] picpiclink
      14. 1fgl picpic
        1. chain a [27426] picpiclink
      15. 1m9e picpicxref
        mutant
        1. chain a [84894] picpiclink
        2. chain b [84895] picpiclink
      16. 1bck picpic
        1. chain a [27427] picpiclink
      17. 1cwf picpic
        1. chain a [27429] picpiclink
      18. 1cwc picpic
        complexed with aba, mnl
        1. chain a [27428] picpiclink
      19. 2alf picpic
        complexed with mg; mutant
        1. region a:2-165 [126975] picpiclink
      20. 1nmk picpic
        complexed with sfm
        1. chain a [85875] picpiclink
        2. chain b [85876] picpiclink
      21. 3cyh picpic
        1. chain a [27432] picpiclink
      22. 1m9d picpicxref
        mutant
        1. chain a [84890] picpiclink
        2. chain b [84891] picpiclink
      23. 1m9y picpicxref
        mutant
        1. chain a [84913] picpiclink
        2. chain b [84914] picpiclink
        3. chain e [84917] picpiclink
        4. chain f [84918] picpiclink
      24. 1cwm picpic
        complexed with aba, iml, tmb
        1. chain a [27433] picpiclink
      25. 1cwh picpic
        complexed with aba, dse
        1. chain a [27430] picpiclink
      26. 2rma picpic
        complexed with aba
        1. chain a [27435] picpiclink
        2. chain c [27436] picpiclink
        3. chain e [27437] picpiclink
        4. chain g [27438] picpiclink
        5. chain i [27439] picpiclink
        6. chain k [27440] picpiclink
        7. chain m [27441] picpiclink
        8. chain o [27442] picpiclink
        9. chain q [27443] picpiclink
        10. chain s [27444] picpiclink
      27. 1cwo picpic
        complexed with vad
        1. chain a [27445] picpiclink
      28. 1cwa picpic
        complexed with aba
        1. chain a [27434] picpiclink
      29. 2rmb picpic
        complexed with aba, dmt
        1. chain a [27446] picpiclink
        2. chain c [27447] picpiclink
        3. chain e [27448] picpiclink
        4. chain g [27449] picpiclink
        5. chain i [27450] picpiclink
        6. chain k [27451] picpiclink
        7. chain m [27452] picpiclink
        8. chain o [27453] picpiclink
        9. chain q [27454] picpiclink
        10. chain s [27455] picpiclink
      30. 1vbs picpic
        complexed with nit
        1. chain a [27456] picpiclink
      31. 4cyh picpic
        1. chain a [27457] picpiclink
      32. 1cwi picpic
        1. chain a [27458] picpiclink
      33. 1m9c picpicxref
        1. chain a [84886] picpiclink
        2. chain b [84887] picpiclink
      34. 1cwb picpic
        complexed with aba, dmt
        1. chain a [27459] picpiclink
      35. 5cyh picpic
        1. chain a [27460] picpiclink
      36. 1awq picpic
        1. chain a [27461] picpiclink
      37. 1zkf picpic
        automatically matched to d1ak4a_
        complexed with nit, sin
        1. region a:2-165 [125192] picpiclink
      38. 1zkf picpic
        automatically matched to d1ak4a_
        complexed with nit, sin
        1. region b:2-165 [125193] picpiclink
      39. 1vbt picpic
        complexed with alt, nit
        1. chain a [27462] picpiclink
        2. chain b [27463] picpiclink
      40. 1rmh picpic
        complexed with nit, sin
        1. chain a [27470] picpiclink
        2. chain b [27471] picpiclink
      41. 1awr picpic
        1. chain a [27464] picpiclink
        2. chain b [27465] picpiclink
        3. chain c [27466] picpiclink
        4. chain d [27467] picpiclink
        5. chain e [27468] picpiclink
        6. chain f [27469] picpiclink
      42. 1ak4 picpicxref
        mutant
        1. chain a [27472] picpiclink
        2. chain b [27473] picpiclink
      43. 1aws picpic
        mutant
        1. chain a [27431] picpiclink
      44. 1awu picpic
        1. chain a [27474] picpiclink
      45. 1m63 picpicxrefxref
        complexed with calcineurin and cyclosporin (chain D and H)
        complexed with aba, bmt, ca, dal, fe, mle, mva, sar, zn
        1. chain c [78679] picpiclink
        2. chain g [78682] picpiclink
      46. 1awv picpic
        1. chain a [27475] picpiclink
        2. chain b [27476] picpiclink
        3. chain c [27477] picpiclink
        4. chain d [27478] picpiclink
        5. chain e [27479] picpiclink
        6. chain f [27480] picpiclink
      47. 1mf8 picpicxrefxref
        complexed with aba, bmt, ca, dal, mle, mva, po4, sar
        1. chain c [79042] picpiclink
      48. 1awt picpic
        mutant
        1. chain a [27481] picpiclink
        2. chain b [27482] picpiclink
        3. chain c [27483] picpiclink
        4. chain d [27484] picpiclink
        5. chain e [27485] picpiclink
        6. chain f [27486] picpiclink
      49. 1oca picpic
        1. chain a [27487] picpiclink
      50. 3cys picpic
        complexed with aba
        1. chain a [27488] picpiclink
    2. Human (Homo sapiens), variant B [TaxId: 9606] [50895] (1)
      1. 1cyn picpic
        complexed with aba
        1. chain a [27489] picpiclink
    3. Human (Homo sapiens), U4/U6 snRNP-specific cyclophilin snucyp-20 [TaxId: 9606] [50896] (2)
      1. 1qoi picpic
        1. chain a [27490] picpiclink
      2. 1mzw picpic
        complexed with a 30-residue peptide from U4/U6 snRNP 60kda protein, chain B
        1. chain a [91503] picpiclink
    4. Mouse (Mus musculus), variant C [TaxId: 10090] [50897] (1)
      1. 2rmc picpic
        complexed with aba
        1. chain a [27491] picpiclink
        2. chain c [27492] picpiclink
        3. chain e [27493] picpiclink
        4. chain g [27494] picpiclink
    5. Nematode (Brugia malayi) [TaxId: 6279] [50898] (3)
      1. 1a33 picpic
        1. chain a [27496] picpiclink
      2. 1a58 picpic
        1. chain a [27495] picpiclink
      3. 1c5f picpic
        1. chain a [27497] picpiclink
        2. chain c [27498] picpiclink
        3. chain e [27499] picpiclink
        4. chain g [27500] picpiclink
        5. chain i [27501] picpiclink
        6. chain k [27502] picpiclink
        7. chain m [27503] picpiclink
        8. chain o [27504] picpiclink
    6. Caenorhabditis elegans, isoform 3 [TaxId: 6239] [50899] (5)
      1. 2igv picpic
        automatically matched to d1dywa_
        complexed with pro, ser
        1. region a:1-172 [147667] picpiclink
      2. 1dyw picpic
        1. chain a [27505] picpiclink
      3. 1e3b picpic
        complexed with 3ep, au
        1. chain a [27506] picpiclink
      4. 1e8k picpic
        complexed with ala, pro
        1. chain a [64797] picpiclink
      5. 2igw picpic
        automatically matched to d1dywa_
        complexed with gly, pro
        1. region a:1-172 [147668] picpiclink
    7. Caenorhabditis elegans, isoform 5 [TaxId: 6239] [82161] (1)
      1. 1h0p picpic
        complexed with dtt; mutant
        1. chain a [76450] picpiclink
    8. Plasmodium falciparum [TaxId: 5833] [50900] (2)
      1. 1qng picpic
        complexed with aba
        1. chain a [27507] picpiclink
      2. 1qnh picpic
        complexed with aba; mutant
        1. chain a [27508] picpiclink
        2. chain b [27509] picpiclink
    9. Baker's yeast (Saccharomyces cerevisiae), variant A [TaxId: 4932] [101878] (2)
      1. 1vdn picpic
        automatically matched to d1ista_
        complexed with ace, mcm
        1. region a:2-162 [120006] picpiclink
      2. 1ist picpic
        1. chain a [90692] picpiclink
        2. chain b [90693] picpiclink
    10. Trypanosoma cruzi [TaxId: 5693] [117269] (2)
      SQ Q4DPB9 30-194
      1. 1xo7 picpic
        Structural genomics target
        1. chain a [115694] picpiclink
        2. chain b [115695] picpiclink
        3. chain c [115696] picpiclink
        4. chain d [115697] picpiclink
      2. 1xq7 picpic
        Structural genomics target
        complexed with aba
        1. chain a [115831] picpiclink
        2. chain b [115832] picpiclink
        3. chain c [115833] picpiclink
    11. Human (Homo sapiens), variant C [TaxId: 9606] [141498] (6)
      SQ P45877 32-212
      1. 2esl picpic
        complexed with aba, ca, so4, zn
        1. region a:32-212 [132327] picpiclink
      2. 2esl picpic
        automatically matched to 2ESL A:32-212
        complexed with aba, ca, so4, zn
        1. region b:32-212 [132328] picpiclink
      3. 2esl picpic
        automatically matched to 2ESL A:32-212
        complexed with aba, ca, so4, zn
        1. region c:32-212 [132329] picpiclink
      4. 2esl picpic
        automatically matched to 2ESL A:32-212
        complexed with aba, ca, so4, zn
        1. region d:32-212 [132330] picpiclink
      5. 2esl picpic
        automatically matched to 2ESL A:32-212
        complexed with aba, ca, so4, zn
        1. region e:32-212 [132331] picpiclink
      6. 2esl picpic
        automatically matched to 2ESL A:32-212
        complexed with aba, ca, so4, zn
        1. region f:32-212 [132332] picpiclink
    12. Aspergillus fumigatus [TaxId: 5085] [141499] (2)
      SQ Q9Y7F6 8-178
      1. 2c3b picpic
        complexed with so4
        1. region a:1-171 [129723] picpiclink
      2. 2c3b picpic
        automatically matched to 2C3B A:1-171
        complexed with so4
        1. region b:1-171 [129724] picpiclink
    13. Plasmodium yoelii [TaxId: 5861] [141500] (1)
      SQ Q7RSH5 25-210
      1. 1z81 picpic
        1. region a:25-210 [124685] picpiclink
  2. Cyclophilin 40 isomerase domain [63814]
    the other domain is formed by TPR repeats
    1. Cow (Bos taurus) [TaxId: 9913] [63815] (2)
      1. 1ihg picpicxref
        complexed with gol
        1. region a:2-196 [62381] picpiclink
      2. 1iip picpicxref
        complexed with gol
        1. region a:2-196 [62452] picpiclink
  3. Peptidyl-prolyl cis-trans isomerase A, PpiA [50901]
    1. Escherichia coli [TaxId: 562] [50902] (6)
      SQ P20752
      1. 1v9t picpic
        complexed with nit, sin; mutant
        1. chain a [108451] picpiclink
        2. chain b [108452] picpiclink
      2. 1j2a picpic
        mutant
        1. chain a [90779] picpiclink
      3. 1lop picpic
        complexed with nit, sin
        1. chain a [27510] picpiclink
      4. 1vai picpic
        complexed with ace, mcm; mutant
        1. chain a [108470] picpiclink
        2. chain b [108471] picpiclink
      5. 2nul picpic
        1. chain a [27511] picpiclink
      6. 1clh picpic
        see also PDB entry 1CSA
        1. chain a [27512] picpiclink
    2. Mycobacterium tuberculosis [TaxId: 1773] [117270] (1)
      SQ P65762
      1. 1w74 picpic
        1. chain a [114311] picpiclink
        2. chain b [114312] picpiclink
  4. Cyclophilin-like allergen Mal s 6 [141501]
    1. Malassezia sympodialis [TaxId: 76777] [141502] (1)
      SQ O93970 1-162
      1. 2cfe picpic
        complexed with ala, gol, pro
        1. region a:1-162 [130375] picpiclink
  5. Peptidyl-prolyl cis-trans isomerase E, PPIE, C-terminal domain [141503]
    N-terminal domain belongs to the RBD family (scop_fa 54929)
    1. Human (Homo sapiens) [TaxId: 9606] [141504] (1)
      SQ Q9UNP9 138-301
      structure of the N-terminal RBD is known, PDB 2cqb
      1. 1zmf picpic
        automatically matched to 1ZCX A:138-301
        1. region a:139-300 [125361] picpiclink
  6. Peptidyl-prolyl cis-trans isomerase-like 2, Cyclophilin-60, PPI domain [141505]
    1. Human (Homo sapiens) [TaxId: 9606] [141506] (2)
      SQ Q13356 280-457
      1. 1zkc picpic
        includes extra C-terminal helix
        complexed with bme
        1. region a:280-457 [125182] picpiclink
      2. 1zkc picpic
        automatically matched to 1ZKC A:280-457
        complexed with bme
        1. region b:280-457 [125183] picpiclink
  7. Cyclophilin-like protein PY00693 [141507]
    1. Plasmodium yoelii [TaxId: 5861] [141508] (1)
      SQ Q7RRM6 29-197
      1. 2b71 picpic
        complexed with cl
        1. region a:23-191 [128004] picpiclink
  8. Cyclophilin-like protein PPIL3B [141509]
    1. Human (Homo sapiens) [TaxId: 9606] [141510] (4)
      SQ Q9H2H8 1-160
      1. 2ok3 picpic
        automatically matched to d1xyha1
        complexed with ni
        1. region a:1-159 [148800] picpiclink
      2. 1xyh picpic
        1. region a:1-160 [122459] picpiclink
      3. 2oju picpic
        automatically matched to d1xyha1
        complexed with aba
        1. region a:7-165 [148798] picpiclink
      4. 2oju picpic
        automatically matched to d1xyha1
        complexed with aba
        1. region b:7-165 [148799] picpiclink
  9. Mitochondrial peptidyl-prolyl cis-trans isomerase, cyclophilin F [141511]
    1. Human (Homo sapiens) [TaxId: 9606] [141512] (5)
      SQ P30405 44-207
      1. 2z6w picpic
        automatically matched to d2bitx1
        complexed with aba, cit; mutant
        1. region a:2-165 [154184] picpiclink
      2. 2z6w picpic
        automatically matched to d2bitx1
        complexed with aba, cit; mutant
        1. region b:2-165 [154185] picpiclink
      3. 2r99 picpic
        automatically matched to d2bitx1
        1. region a:139-299 [151763] picpiclink
      4. 2biu picpic
        automatically matched to 2BIT X:2-165
        complexed with dms; mutant
        1. region x:2-165 [128591] picpiclink
      5. 2bit picpic
        mutant
        1. region x:2-165 [128590] picpiclink
  10. Putative cyclophilin PFE0505w [141513]
    PPWD1 homologue
    1. Plasmodium falciparum [TaxId: 5833] [141514] (1)
      SQ Q8I402 592-746
      1. 2fu0 picpic
        1. region a:5-159 [134095] picpiclink
  11. Peptidylprolyl isomerase domain and WD repeat-containing protein 1, PPWD1, C-terminal domain [141515]
    1. Human (Homo sapiens) [TaxId: 9606] [141516] (3)
      SQ Q96BP3 483-646
      1. 2a2n picpic
        complexed with gol
        1. region a:483-646 [126041] picpiclink
      2. 2a2n picpic
        automatically matched to 2A2N A:483-646
        complexed with gol
        1. region b:483-646 [126042] picpiclink
      3. 2a2n picpic
        automatically matched to 2A2N A:483-646
        complexed with gol
        1. region c:483-646 [126043] picpiclink
  12. Peptidyl-prolyl cis-trans isomerase-like 1, PPIL1 [141517]
    1. Human (Homo sapiens) [TaxId: 9606] [141518] (1)
      SQ Q9Y3C6 1-166
      1. 1xwn picpic
        1. region a:1-166 [122404] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk