Structural Classification of Proteins
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Superfamily: Lipocalins

bind hydrophobic ligands in their interior
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Lipocalins [50813]
    barrel, closed or opened; n=8, S=12; meander
  4. Superfamily: Lipocalins [50814]
    bind hydrophobic ligands in their interior
    link to SUPERFAMILY database - Superfamily

Families:

  1. Retinol binding protein-like [50815] (30)
    barrel, closed; n=8, S=12, meander
    1. Retinol binding protein [50816]
      1. Cow (Bos taurus) [TaxId: 9913] [50817] (13) picpic
      2. Pig (Sus scrofa domestica) [TaxId: 9823] [50818] (1) picpic
      3. Human (Homo sapiens) [TaxId: 9606] [50819] (4) picpic
      4. Chicken (Gallus gallus) [TaxId: 9031] [50820] (1) picpic
      5. Chicken (Gallus gallus), plasma isoform [TaxId: 9031] [69297] (1) picpic
    2. Odorant-binding protein [50821]
      C-termini swapping dimer
      1. Cow (Bos taurus) [TaxId: 9913] [50822] (8) picpic
      2. Pig (Sus scrofa) [TaxId: 9823] [50823] (9) picpic
    3. Lipocalin allergen [50824]
      1. Cow (Bos taurus), bos d 2 [TaxId: 9913] [50825] (1) picpic
      2. Horse (Equus caballus), equ c 1 [TaxId: 9796] [50826] (1) picpic
    4. Salivary lipocalin [74996]
      1. Pig (Sus scrofa) [TaxId: 9823] [74997] (1) picpic
    5. Aphrodisin, a sex pheromone [63805]
      1. Golden hamster (Mesocricetus auratus) [TaxId: 10036] [63806] (1) picpic
    6. beta-Lactoglobulin [50827]
      1. Cow (Bos taurus) [TaxId: 9913] [50828] (26) picpic
        SQ P02754
      2. Pig (Sus scrofa) [TaxId: 9823] [50829] (1) picpic
      3. Reindeer (Rangifer tarandus) [TaxId: 9870] [141461] (6) picpic
        SQ P02755 19-180
    7. Retinoic acid-binding protein [50830]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [50831] (2) picpic
    8. Major urinary protein/alpha-2u-globulin [50832]
      1. Mouse (Mus musculus) [TaxId: 10090] [50833] (19) picpic
      2. Rat (Rattus norvegicus) [TaxId: 10116] [50834] (2) picpic
    9. Neutrophil gelatinase-associated lipocalin (NGAL) [50835]
      1. Human (Homo sapiens) [TaxId: 9606] [50836] (13) picpic
    10. Lipocalin q83 [89364]
      activated expression by the myc oncogene
      1. Common quail (Coturnix coturnix) [TaxId: 9091] [89365] (1) picpic
    11. Complement protein C8gamma [74998]
      1. Human (Homo sapiens) [TaxId: 9606] [74999] (2) picpic
    12. Bilin-binding protein [50837]
      1. Cabbage butterfly (Pieris brassicae) [TaxId: 7116] [50838] (6) picpic
    13. Alpha-crustacyanin [63807]
      1. European lobster (Homarus gammarus) [TaxId: 6707] [63808] (7) picpic
    14. Outer membrane lipoprotein Blc [101861]
      bacterial lipocalin
      1. Escherichia coli [TaxId: 562] [101862] (1) picpic
    15. Histamine binding protein [50839]
      1. Brown ear tick (Rhipicephalus appendiculatus) [TaxId: 34631] [50840] (2) picpic
    16. Nitrophorin 1 [50841]
      1. Rhodnius prolixus [TaxId: 13249] [50842] (8) picpic
    17. Nitrophorin 2 (prolixin-s) [50843]
      1. Rhodnius prolixus [TaxId: 13249] [50844] (14) picpic
        SQ Q26241
    18. Nitrophorin 4 [50845]
      1. Rhodnius prolixus [TaxId: 13249] [50846] (34) picpic
        SQ Q94734 22-205
    19. Von Ebner's gland protein (VEGP, tear lipocalin) [117265]
      1. Human (Homo sapiens) [TaxId: 9606] [117266] (1) picpic
        SQ P31025 30-168
    20. Insecticyanin [141462]
      1. Tobacco hornworm (Manduca sexta) [TaxId: 7130] [141463] (1) picpic
        SQ P00305 1-189
    21. Hypothetical protein YxeF [159228]
      1. Bacillus subtilis [TaxId: 1423] [159229] (1) picpic
        SQ P54945 19-144
  2. Fatty acid binding protein-like [50847] (28)
    ten-stranded meander beta-sheet folded upon itself
    relates to the common fold by opening the barrel and insertion of beta-hairpin
    1. Muscle fatty acid binding protein (m-fabp) [50848]
      1. Human (Homo sapiens) [TaxId: 9606] [50849] (5) picpic
      2. Cow (Bos taurus) [TaxId: 9913] [50850] (1) picpic
    2. Intestinal fatty acid binding protein [50851]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [50852] (11) picpic
        SQ P02693
      2. Human (Homo sapiens) [TaxId: 9606] [50853] (3) picpic
    3. Brain fatty acid binding protein [63809]
      1. Human (Homo sapiens) [TaxId: 9606] [63810] (3) picpic
    4. Epidermal fatty acid binding protein [50854]
      1. Human (Homo sapiens) [TaxId: 9606] [50855] (2) picpic
    5. Adipocyte lipid-binding protein, ALBP [50856]
      1. Mouse (Mus musculus) [TaxId: 10090] [50857] (17) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [110275] (4) picpic
        SQ P15090
    6. Fatty acid-binding protein homolog 1 [89366]
      1. Flat worm (Echinococcus granulosus) [TaxId: 6210] [89367] (1) picpic
    7. Fatty acid-binding protein [50858]
      1. Tobacco hornworm (Manduca sexta) [TaxId: 7130] [50859] (1) picpic
      2. Desert locust (Schistocerca gregaria) [TaxId: 7010] [50860] (1) picpic
    8. Cellular retinoic-acid-binding protein (CRABP) [50861]
      1. Human (Homo sapiens), CRABP-II [TaxId: 9606] [50862] (12) picpic
      2. Cow and mouse (Bos taurus) and (Mus musculus), CRABP-I, identical sequences [TaxId: 9913] [50863] (3) picpic
    9. Cellular retinol-binding protein II (CRBP) [50864]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [50865] (9) picpic
      2. Zebrafish (Danio rerio) [TaxId: 7955] [75000] (2) picpic
    10. Cellular retinol-binding protein III [63811]
      1. Human (Homo sapiens) [TaxId: 9606] [63812] (1) picpic
    11. Liver fatty acid binding protein [50866]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [50867] (4) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [141464] (8) picpic
        SQ P07148 1-127
    12. Liver basic fatty acid binding protein, LB_FABP [89368]
      1. Chicken (Gallus gallus) [TaxId: 9031] [89369] (5) picpic
        SQ P80226
      2. Argentine common toad (Bufo arenarum) [TaxId: 38577] [89370] (1) picpic
      3. Axolotl (Ambystoma mexicanum) [TaxId: 8296] [141465] (2) picpic
        SQ P81400 1-125
    13. Cellular retinol-binding protein IV [82157]
      1. Human (Homo sapiens) [TaxId: 9606] [82158] (1) picpic
    14. P2 myelin protein [50868]
      1. Cow (Bos taurus), caudal spinal root myelin [TaxId: 9913] [50869] (1) picpic
      2. Horse (Equus caballus) [TaxId: 9796] [141466] (1) picpic
        SQ P02690 1-131
    15. Ileal lipid-binding protein [50870]
      1. Human (Homo sapiens) [TaxId: 9606] [82159] (2) picpic
      2. Pig (Sus scrofa) [TaxId: 9823] [50871] (2) picpic
    16. Fatty acid-binding protein Sm14 [110276]
      1. Blood fluke (Schistosoma mansoni) [TaxId: 6183] [110277] (2) picpic
        SQ P29498
    17. Der f 13 allergen [141467]
      1. House dust mite (Dermatophagoides farinae) [TaxId: 6954] [141468] (1) picpic
        SQ Q1M2P5 1-131
  3. Thrombin inhibitor [50872] (1)
    topology permutation: strands 2 and 3 swapped their positions in the barrel
    1. Thrombin inhibitor [50873]
      1. Triatomine bug (Triatoma pallidipennis) [TaxId: 30077] [50874] (1) picpic
  4. Hypothetical protein YodA [101863] (1)
    bacterial metal-binding, lipocalin-like protein
    1. Hypothetical protein YodA [101864]
      1. Escherichia coli [TaxId: 562] [101865] (5) picpic
        SQ P76344
  5. Hypothetical protein YwiB [101866] (1)
    bacterial proteins with a fatty acid binding protein-like fold
    1. Hypothetical protein YwiB [101867]
      1. Bacillus subtilis [TaxId: 1423] [101868] (1) picpic
  6. Phenolic acid decarboxylase (PAD) [141469] (1)
    Pfam 05870; dimeric enzyme made of lipocalin-like subunits
    1. P-coumaric acid decarboxylase, pdc [141470]
      1. Lactobacillus plantarum [TaxId: 1590] [141471] (1) picpic
        SQ Q88RY7 1-178
  7. Dinoflagellate luciferase repeat [141472] (1)
    PfamB 017809; comprises a fatty acid binding protein-like fold, wrapped into the extra N- and C-terminal 'tails'
    1. Dinoflagellate luciferase [141473]
      1. Lingulodinium polyedrum [TaxId: 160621] [141474] (1) picpic
        SQ O77206 868-1218
  8. Rv2717c-like [141475] (2)
    bacterial and plant proteins with a fatty acid binding protein-like fold
    1. Hypothetical protein Rv2717c [141476]
      1. Mycobacterium tuberculosis [TaxId: 1773] [141477] (1) picpic
        SQ O07216 4-164
    2. Hypothetical protein At1g79260 [141478]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [141479] (3) picpic
        SQ O64527 14-166
  9. All1756-like [159230] (1)
    cyanobacterial proteins with duplicated fatty acid binding protein-like domains; N-terminal and C-terminal domains correspond to PfamB 40396 and PfamB 60468, respectively
    1. Uncharacterized protein All1756 ortholog [159231]
      1. Nostoc punctiforme [TaxId: 272131] [159232] (4) picpic
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk