Structural Classification of Proteins

Fold: Lipocalins

: barrel, closed or opened; n=8, S=12; meander

Lineage:

Root: scop
Class: All beta proteins [48724]
Fold: Lipocalins [50813]
barrel, closed or opened; n=8, S=12; meander

Superfamilies:

Lipocalins [50814] (9)
bind hydrophobic ligands in their interior
uperfamily
1. Retinol binding protein-like [50815] (30)
  barrel, closed; n=8, S=12, meander
  1. Retinol binding protein [50816]
    1. Cow (Bos taurus) [TaxId: 9913] [50817] (13)
    2. Pig (Sus scrofa domestica) [TaxId: 9823] [50818] (1)
    3. Human (Homo sapiens) [TaxId: 9606] [50819] (4)
    4. Chicken (Gallus gallus) [TaxId: 9031] [50820] (1)
    5. Chicken (Gallus gallus), plasma isoform [TaxId: 9031] [69297] (1)
  2. Odorant-binding protein [50821]
    C-termini swapping dimer
    1. Cow (Bos taurus) [TaxId: 9913] [50822] (8)
    2. Pig (Sus scrofa) [TaxId: 9823] [50823] (9)
  3. Lipocalin allergen [50824]
    1. Cow (Bos taurus), bos d 2 [TaxId: 9913] [50825] (1)
    2. Horse (Equus caballus), equ c 1 [TaxId: 9796] [50826] (1)
  4. Salivary lipocalin [74996]
    1. Pig (Sus scrofa) [TaxId: 9823] [74997] (1)
  5. Aphrodisin, a sex pheromone [63805]
    1. Golden hamster (Mesocricetus auratus) [TaxId: 10036] [63806] (1)
  6. beta-Lactoglobulin [50827]
    1. Cow (Bos taurus) [TaxId: 9913] [50828] (26)
      SQ P02754
    2. Pig (Sus scrofa) [TaxId: 9823] [50829] (1)
    3. Reindeer (Rangifer tarandus) [TaxId: 9870] [141461] (6)
      SQ P02755 19-180
  7. Retinoic acid-binding protein [50830]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50831] (2)
  8. Major urinary protein/alpha-2u-globulin [50832]
    1. Mouse (Mus musculus) [TaxId: 10090] [50833] (19)
    2. Rat (Rattus norvegicus) [TaxId: 10116] [50834] (2)
  9. Neutrophil gelatinase-associated lipocalin (NGAL) [50835]
    1. Human (Homo sapiens) [TaxId: 9606] [50836] (13)
  10. Lipocalin q83 [89364]
    activated expression by the myc oncogene
    1. Common quail (Coturnix coturnix) [TaxId: 9091] [89365] (1)
  11. Complement protein C8gamma [74998]
    1. Human (Homo sapiens) [TaxId: 9606] [74999] (2)
  12. Bilin-binding protein [50837]
    1. Cabbage butterfly (Pieris brassicae) [TaxId: 7116] [50838] (6)
  13. Alpha-crustacyanin [63807]
    1. European lobster (Homarus gammarus) [TaxId: 6707] [63808] (7)
  14. Outer membrane lipoprotein Blc [101861]
    bacterial lipocalin
    1. Escherichia coli [TaxId: 562] [101862] (1)
  15. Histamine binding protein [50839]
    1. Brown ear tick (Rhipicephalus appendiculatus) [TaxId: 34631] [50840] (2)
  16. Nitrophorin 1 [50841]
    1. Rhodnius prolixus [TaxId: 13249] [50842] (8)
  17. Nitrophorin 2 (prolixin-s) [50843]
    1. Rhodnius prolixus [TaxId: 13249] [50844] (14)
      SQ Q26241
  18. Nitrophorin 4 [50845]
    1. Rhodnius prolixus [TaxId: 13249] [50846] (34)
      SQ Q94734 22-205
  19. Von Ebner's gland protein (VEGP, tear lipocalin) [117265]
    1. Human (Homo sapiens) [TaxId: 9606] [117266] (1)
      SQ P31025 30-168
  20. Insecticyanin [141462]
    1. Tobacco hornworm (Manduca sexta) [TaxId: 7130] [141463] (1)
      SQ P00305 1-189
  21. Hypothetical protein YxeF [159228]
    1. Bacillus subtilis [TaxId: 1423] [159229] (1)
      SQ P54945 19-144
2. Fatty acid binding protein-like [50847] (28)
  ten-stranded meander beta-sheet folded upon itself
  relates to the common fold by opening the barrel and insertion of beta-hairpin
  1. Muscle fatty acid binding protein (m-fabp) [50848]
    1. Human (Homo sapiens) [TaxId: 9606] [50849] (5)
    2. Cow (Bos taurus) [TaxId: 9913] [50850] (1)
  2. Intestinal fatty acid binding protein [50851]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50852] (11)
      SQ P02693
    2. Human (Homo sapiens) [TaxId: 9606] [50853] (3)
  3. Brain fatty acid binding protein [63809]
    1. Human (Homo sapiens) [TaxId: 9606] [63810] (3)
  4. Epidermal fatty acid binding protein [50854]
    1. Human (Homo sapiens) [TaxId: 9606] [50855] (2)
  5. Adipocyte lipid-binding protein, ALBP [50856]
    1. Mouse (Mus musculus) [TaxId: 10090] [50857] (17)
    2. Human (Homo sapiens) [TaxId: 9606] [110275] (4)
      SQ P15090
  6. Fatty acid-binding protein homolog 1 [89366]
    1. Flat worm (Echinococcus granulosus) [TaxId: 6210] [89367] (1)
  7. Fatty acid-binding protein [50858]
    1. Tobacco hornworm (Manduca sexta) [TaxId: 7130] [50859] (1)
    2. Desert locust (Schistocerca gregaria) [TaxId: 7010] [50860] (1)
  8. Cellular retinoic-acid-binding protein (CRABP) [50861]
    1. Human (Homo sapiens), CRABP-II [TaxId: 9606] [50862] (12)
    2. Cow and mouse (Bos taurus) and (Mus musculus), CRABP-I, identical sequences [TaxId: 9913] [50863] (3)
  9. Cellular retinol-binding protein II (CRBP) [50864]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50865] (9)
    2. Zebrafish (Danio rerio) [TaxId: 7955] [75000] (2)
  10. Cellular retinol-binding protein III [63811]
    1. Human (Homo sapiens) [TaxId: 9606] [63812] (1)
  11. Liver fatty acid binding protein [50866]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50867] (4)
    2. Human (Homo sapiens) [TaxId: 9606] [141464] (8)
      SQ P07148 1-127
  12. Liver basic fatty acid binding protein, LB_FABP [89368]
    1. Chicken (Gallus gallus) [TaxId: 9031] [89369] (5)
      SQ P80226
    2. Argentine common toad (Bufo arenarum) [TaxId: 38577] [89370] (1)
    3. Axolotl (Ambystoma mexicanum) [TaxId: 8296] [141465] (2)
      SQ P81400 1-125
  13. Cellular retinol-binding protein IV [82157]
    1. Human (Homo sapiens) [TaxId: 9606] [82158] (1)
  14. P2 myelin protein [50868]
    1. Cow (Bos taurus), caudal spinal root myelin [TaxId: 9913] [50869] (1)
    2. Horse (Equus caballus) [TaxId: 9796] [141466] (1)
      SQ P02690 1-131
  15. Ileal lipid-binding protein [50870]
    1. Human (Homo sapiens) [TaxId: 9606] [82159] (2)
    2. Pig (Sus scrofa) [TaxId: 9823] [50871] (2)
  16. Fatty acid-binding protein Sm14 [110276]
    1. Blood fluke (Schistosoma mansoni) [TaxId: 6183] [110277] (2)
      SQ P29498
  17. Der f 13 allergen [141467]
    1. House dust mite (Dermatophagoides farinae) [TaxId: 6954] [141468] (1)
      SQ Q1M2P5 1-131
3. Thrombin inhibitor [50872] (1)
  topology permutation: strands 2 and 3 swapped their positions in the barrel
  1. Thrombin inhibitor [50873]
    1. Triatomine bug (Triatoma pallidipennis) [TaxId: 30077] [50874] (1)
4. Hypothetical protein YodA [101863] (1)
  bacterial metal-binding, lipocalin-like protein
  1. Hypothetical protein YodA [101864]
    1. Escherichia coli [TaxId: 562] [101865] (5)
      SQ P76344
5. Hypothetical protein YwiB [101866] (1)
  bacterial proteins with a fatty acid binding protein-like fold
  1. Hypothetical protein YwiB [101867]
    1. Bacillus subtilis [TaxId: 1423] [101868] (1)
6. Phenolic acid decarboxylase (PAD) [141469] (1)
  Pfam 05870; dimeric enzyme made of lipocalin-like subunits
  1. P-coumaric acid decarboxylase, pdc [141470]
    1. Lactobacillus plantarum [TaxId: 1590] [141471] (1)
      SQ Q88RY7 1-178
7. Dinoflagellate luciferase repeat [141472] (1)
  PfamB 017809; comprises a fatty acid binding protein-like fold, wrapped into the extra N- and C-terminal 'tails'
  1. Dinoflagellate luciferase [141473]
    1. Lingulodinium polyedrum [TaxId: 160621] [141474] (1)
      SQ O77206 868-1218
8. Rv2717c-like [141475] (2)
  bacterial and plant proteins with a fatty acid binding protein-like fold
  1. Hypothetical protein Rv2717c [141476]
    1. Mycobacterium tuberculosis [TaxId: 1773] [141477] (1)
      SQ O07216 4-164
  2. Hypothetical protein At1g79260 [141478]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [141479] (3)
      SQ O64527 14-166
9. All1756-like [159230] (1)
  cyanobacterial proteins with duplicated fatty acid binding protein-like domains; N-terminal and C-terminal domains correspond to PfamB 40396 and PfamB 60468, respectively
  1. Uncharacterized protein All1756 ortholog [159231]
    1. Nostoc punctiforme [TaxId: 272131] [159232] (4)